A method to detect single-nucleotide
... We evaluate an approach to detect single-nucleotide polymorphisms (SNPs) that account for a linkage signal with covariate-based affected relative pair linkage analysis in a conditional-logistic model framework using all 200 replicates of the Genetic Analysis Workshop 17 family data set. We begin by ...
... We evaluate an approach to detect single-nucleotide polymorphisms (SNPs) that account for a linkage signal with covariate-based affected relative pair linkage analysis in a conditional-logistic model framework using all 200 replicates of the Genetic Analysis Workshop 17 family data set. We begin by ...
Using Genetic Algorithms with Sexual or Asexual Transposition: a
... compared the GA performance when using 1-point, 2-point, uniform crossover or a simple form of transposition. Transposition allowed the GA to reach better results than crossover, even with smaller populations. Later, this preliminary work was enlarged to a test bed containing eighteen test functions ...
... compared the GA performance when using 1-point, 2-point, uniform crossover or a simple form of transposition. Transposition allowed the GA to reach better results than crossover, even with smaller populations. Later, this preliminary work was enlarged to a test bed containing eighteen test functions ...
PDF
... a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candi ...
... a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candi ...
Genomic analysis of clinical samples with serologic ABO blood
... by a missense or nonsense mutation for which screening by allele-specific primer polymerase chain reaction was performed. The novel mutations were encountered in 28 of the remaining 60 A and B subgroup samples but not among normal donors. As a result of this study, the number of definable alleles as ...
... by a missense or nonsense mutation for which screening by allele-specific primer polymerase chain reaction was performed. The novel mutations were encountered in 28 of the remaining 60 A and B subgroup samples but not among normal donors. As a result of this study, the number of definable alleles as ...
Redalyc.Molecular Epidemiology and Evolution of Avian Infectious
... 2007), despite not normally producing clinical disease Collectively, the pathological effects of IBV make it one of the most important single causes of infectious disease-related economic loss in poultry production (Cavanagh, 2007). Its distribution is virtually global. First described in the 1930s ...
... 2007), despite not normally producing clinical disease Collectively, the pathological effects of IBV make it one of the most important single causes of infectious disease-related economic loss in poultry production (Cavanagh, 2007). Its distribution is virtually global. First described in the 1930s ...
Genetic of PWS – Explanation for the Rest of Us - Prader
... mother’s imprint turns them off. In Prader-Willi syndrome, these critical genes are either missing (deleted) from the father’s chromosome 15, functioning improperly because of an imprinting defect, or the entire chromosome 15 from the father is missing and both chromosome 15s come from the mother. ( ...
... mother’s imprint turns them off. In Prader-Willi syndrome, these critical genes are either missing (deleted) from the father’s chromosome 15, functioning improperly because of an imprinting defect, or the entire chromosome 15 from the father is missing and both chromosome 15s come from the mother. ( ...
Mendelian Genetics
... In 1853 and 1854, Mendal published two papers on crop damage by insects. However, he is best known for his later studies of the pea plant Pisum sativum. Mendel was inspired by both his professors at university and his colleagues at the monastery to study variation in plants. He had carried out artif ...
... In 1853 and 1854, Mendal published two papers on crop damage by insects. However, he is best known for his later studies of the pea plant Pisum sativum. Mendel was inspired by both his professors at university and his colleagues at the monastery to study variation in plants. He had carried out artif ...
PHA (Pulmonary Hypoplasia with Anasarca)
... or function. Genes are the basic units of the hereditary information that is passed from one generation to the next, and they can have alternate versions. The alternate versions of any specific gene are called alleles. Genes occur in pairs. For each pair of alleles, one is inherited from the sire, a ...
... or function. Genes are the basic units of the hereditary information that is passed from one generation to the next, and they can have alternate versions. The alternate versions of any specific gene are called alleles. Genes occur in pairs. For each pair of alleles, one is inherited from the sire, a ...
Revisiting the Impact of Inversions in Evolution
... where the interacting loci reside (Nei 1967, Pepper 2003). Because inversion polymorphisms generate low recombination rates among the standard (noninverted) and inverted arrangements, they facilitate the spread of the coadapted alleles. Inversions carrying favorable alleles then spread to fixation un ...
... where the interacting loci reside (Nei 1967, Pepper 2003). Because inversion polymorphisms generate low recombination rates among the standard (noninverted) and inverted arrangements, they facilitate the spread of the coadapted alleles. Inversions carrying favorable alleles then spread to fixation un ...
The Strength of Phenotypic Selection in Natural Populations
... or correlational selection common? Is selection more intense on life history than on morphological traits? What is the relative importance of direct versus indirect selection on correlated traits? The answers to these and similar questions are fundamental to understanding the role of selection in de ...
... or correlational selection common? Is selection more intense on life history than on morphological traits? What is the relative importance of direct versus indirect selection on correlated traits? The answers to these and similar questions are fundamental to understanding the role of selection in de ...
Equine Reproduction and Genetics
... and ribs cannot be scene but felt with some fat in between. ...
... and ribs cannot be scene but felt with some fat in between. ...
The Strength of Phenotypic Selection in Natural
... or correlational selection common? Is selection more intense on life history than on morphological traits? What is the relative importance of direct versus indirect selection on correlated traits? The answers to these and similar questions are fundamental to understanding the role of selection in de ...
... or correlational selection common? Is selection more intense on life history than on morphological traits? What is the relative importance of direct versus indirect selection on correlated traits? The answers to these and similar questions are fundamental to understanding the role of selection in de ...
Genetic Algorithm for Solving Simple Mathematical
... want to be solved. These chromosomes will undergo a process called fitness function to measure the suitability of solution generated by GA with problem. Some chromosomes in population will mate through process called crossover thus producing new chromosomes named offspring which its genes compositio ...
... want to be solved. These chromosomes will undergo a process called fitness function to measure the suitability of solution generated by GA with problem. Some chromosomes in population will mate through process called crossover thus producing new chromosomes named offspring which its genes compositio ...
oculocutaneous albinism and analysis of tyrosinase gene in
... manner similar to that of type I OCA to those whose mild depigmentation is appreciated only in comparison with normal family members. With time, pigmented nevi and lentigines may develop, and pigmented freckles are seen in exposed areas with repeated sun exposure. The hair slowly turns darker throug ...
... manner similar to that of type I OCA to those whose mild depigmentation is appreciated only in comparison with normal family members. With time, pigmented nevi and lentigines may develop, and pigmented freckles are seen in exposed areas with repeated sun exposure. The hair slowly turns darker throug ...
Evolving patch-based terrains for use in video games
... chromosome is copied to the offspring. Each patch slot is then randomly given a crossover probability. If that probability is greater than a crossover rate parameter, which is provided at the start of the run, then the patch from the base parent is kept, otherwise it is switched for the patch in the ...
... chromosome is copied to the offspring. Each patch slot is then randomly given a crossover probability. If that probability is greater than a crossover rate parameter, which is provided at the start of the run, then the patch from the base parent is kept, otherwise it is switched for the patch in the ...
Molecular Genetics of Bipolar Disorder and Related Traits
... environmental homogeneity in this population than in many other populations is an advantage in gene localization. A genome-wide scan was performed identifying possible genomic susceptibility regions for bipolar disorder. The strongest evidence of linkage was provided by a locus on 16p12 in the two-p ...
... environmental homogeneity in this population than in many other populations is an advantage in gene localization. A genome-wide scan was performed identifying possible genomic susceptibility regions for bipolar disorder. The strongest evidence of linkage was provided by a locus on 16p12 in the two-p ...
Non-conflict theories for the evolution of genomic imprinting
... development of an unfertilized egg still in the ovary. Moreover, if the level of gene product in a zygote were critical, maternal upregulation might need to be balanced by downregulation of the paternal copy, a situation that is effectively imprinting. Iwasa’s (1998) mathematical modelling backed th ...
... development of an unfertilized egg still in the ovary. Moreover, if the level of gene product in a zygote were critical, maternal upregulation might need to be balanced by downregulation of the paternal copy, a situation that is effectively imprinting. Iwasa’s (1998) mathematical modelling backed th ...
Cytoplasmic male sterility
... 79BS14-3 is a carrier of a recessive or semidominant restorer gene. The Fa seed was produced in bagged F1 spikes. Seventy-one accessions of spontaneum barleys have been tested for restoration both in m s m l and msm2 cytoplasms with an Adorra-like seed parent background produced by repeated backcros ...
... 79BS14-3 is a carrier of a recessive or semidominant restorer gene. The Fa seed was produced in bagged F1 spikes. Seventy-one accessions of spontaneum barleys have been tested for restoration both in m s m l and msm2 cytoplasms with an Adorra-like seed parent background produced by repeated backcros ...
PowerPoint Presentation - Meningitis Research Foundation
... respectively of all isolates during 2007. Cases due to N. meningitidis strains belonging to serogroup Y are, on the contrary, very rare. However, meningitis and septicaemia cases due to this serogroup have increased in the country, particularly in 2006. Interestingly, over the last decade different ...
... respectively of all isolates during 2007. Cases due to N. meningitidis strains belonging to serogroup Y are, on the contrary, very rare. However, meningitis and septicaemia cases due to this serogroup have increased in the country, particularly in 2006. Interestingly, over the last decade different ...
Chapter 7: Genetics Lesson 7.2: Gregor Mendel and Genetics
... Blending Theory of Inheritance During Mendel’s time, the blending theory of inheritance was popular. This is the theory that offspring have a blend, or mix, of the characteristics of their parents. Mendel noticed plants in his own garden that weren’t a blend of the parents. For example, a tall plant ...
... Blending Theory of Inheritance During Mendel’s time, the blending theory of inheritance was popular. This is the theory that offspring have a blend, or mix, of the characteristics of their parents. Mendel noticed plants in his own garden that weren’t a blend of the parents. For example, a tall plant ...
Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.
... simulated only for typed subjects. Analyses of the simulated data were completed using the same methods as for the real data (BP model). Genomewide empirical P-value thresholds for the NPL scores were then determined by a tally of the number of NPL peaks in these replicates generated under the null ...
... simulated only for typed subjects. Analyses of the simulated data were completed using the same methods as for the real data (BP model). Genomewide empirical P-value thresholds for the NPL scores were then determined by a tally of the number of NPL peaks in these replicates generated under the null ...
Polymorphic Variation in the Structure of Aerial
... formed, and only the structure of aerial sclerotia produced by the monokaryon HI was described in detail. Further investigations of the phenotype of aerial sclerotia produced by different isolates from the wild have shown that two distinct structures can be found. The structure which has previously ...
... formed, and only the structure of aerial sclerotia produced by the monokaryon HI was described in detail. Further investigations of the phenotype of aerial sclerotia produced by different isolates from the wild have shown that two distinct structures can be found. The structure which has previously ...
FRIZZY PANICLE Drives Supernumerary
... of six-rowed barley (Hordeum vulgare) lines (Tanno and Takeda, 2004). The mrs1 gene, on chromosome 2DS, may be the major determinant of the MRS trait in two genetically related bread wheat lines derived from genotypes obtained by chemical mutation (Dobrovolskaya et al., 2008, 2009). This gene is als ...
... of six-rowed barley (Hordeum vulgare) lines (Tanno and Takeda, 2004). The mrs1 gene, on chromosome 2DS, may be the major determinant of the MRS trait in two genetically related bread wheat lines derived from genotypes obtained by chemical mutation (Dobrovolskaya et al., 2008, 2009). This gene is als ...
Two concepts of natural selection and their explanatory powers
... But the aim of this paper can be stated more modestly: even if the replicationinteraction model did not have any immediate explanatory advantages over the heritable variation of fitness model (although I will argue in the last section that it does), if we manage to formulate a version of the replica ...
... But the aim of this paper can be stated more modestly: even if the replicationinteraction model did not have any immediate explanatory advantages over the heritable variation of fitness model (although I will argue in the last section that it does), if we manage to formulate a version of the replica ...
Chapter 5 Gases
... – The original source for new alleles. – Lethal mutation • Mutation that drastically alters phenotype • Causes death ...
... – The original source for new alleles. – Lethal mutation • Mutation that drastically alters phenotype • Causes death ...
Population genetics
Population genetics is the study of the distribution and change in frequency of alleles within populations, and as such it sits firmly within the field of evolutionary biology. The main processes of evolution (natural selection, genetic drift, gene flow, mutation, and genetic recombination) form an integral part of the theory that underpins population genetics. Studies in this branch of biology examine such phenomena as adaptation, speciation, population subdivision, and population structure.Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics.Traditionally a highly mathematical discipline, modern population genetics encompasses theoretical, lab and field work. Computational approaches, often utilising coalescent theory, have played a central role since the 1980s.