Ionotropic glutamate receptors
... By combining the techniques of genetics, molecular biology and electrophysiology in C. elegans we have the potential to identify and characterize the molecules that contribute to the function of glutamatergic synapses. In C. elegans both excitatory and inhibitory ionotropic glutamate receptors are l ...
... By combining the techniques of genetics, molecular biology and electrophysiology in C. elegans we have the potential to identify and characterize the molecules that contribute to the function of glutamatergic synapses. In C. elegans both excitatory and inhibitory ionotropic glutamate receptors are l ...
Fig. - Journal of Cell Science
... substrate interaction domains, such as Kelch, MATH, PHR or zinc fingers (Stogios et al., 2005). No such domains have been described for KCTD proteins, yet the region comprising residues 114–237, which is located directly after its BTB domain, is sufficient for interaction with USP21 (Fig. 3A). The c ...
... substrate interaction domains, such as Kelch, MATH, PHR or zinc fingers (Stogios et al., 2005). No such domains have been described for KCTD proteins, yet the region comprising residues 114–237, which is located directly after its BTB domain, is sufficient for interaction with USP21 (Fig. 3A). The c ...
Signal Sequences Specify the Targeting Route to the Endoplasmic
... signal recognition particle (SRP) 1 and its membrane-localized receptor. The translocation events are carried out by a multi-subunit membrane protein complex, the translocon or Sec61p complex (G6rlich and Rapoport, 1993). Mechanistically, translocation is cotranslational: SRP binds signal sequences ...
... signal recognition particle (SRP) 1 and its membrane-localized receptor. The translocation events are carried out by a multi-subunit membrane protein complex, the translocon or Sec61p complex (G6rlich and Rapoport, 1993). Mechanistically, translocation is cotranslational: SRP binds signal sequences ...
Phragmoplastin dynamics: multiple forms
... during embryogenesis (Strompen et al., 2002). Phragmoplast microtubules are essentially normal in these mutants and KNOLLE-containing vesicles are present on the cell plate (Strompen et al., 2002). This suggests that HINKEL is not involved in vesicle transport. Other kinesin-related motor proteins, ...
... during embryogenesis (Strompen et al., 2002). Phragmoplast microtubules are essentially normal in these mutants and KNOLLE-containing vesicles are present on the cell plate (Strompen et al., 2002). This suggests that HINKEL is not involved in vesicle transport. Other kinesin-related motor proteins, ...
Caldicellulosiruptor tāpirins bind to crystalline cellulose! ! 1 Discrete
... the mechanisms by which microorganisms degrade and utilize plant biomass. To date, most attention has been focused on cellulolytic enzymes implicated in this process, but it has been established for some time that non-catalytic, biomolecular contributions are critical to the degradation of crystalli ...
... the mechanisms by which microorganisms degrade and utilize plant biomass. To date, most attention has been focused on cellulolytic enzymes implicated in this process, but it has been established for some time that non-catalytic, biomolecular contributions are critical to the degradation of crystalli ...
Np73 is capable of inducing apoptosis by co
... Key words: Np73, apoptosis, BH3-only proteins, Fanconi anaemia, p53, specificity protein 1 (Sp1). Cite this article as: Bioscience Reports (2015) 35, e00198, doi:10.1042/BSR20150039 ...
... Key words: Np73, apoptosis, BH3-only proteins, Fanconi anaemia, p53, specificity protein 1 (Sp1). Cite this article as: Bioscience Reports (2015) 35, e00198, doi:10.1042/BSR20150039 ...
Linking Cataracts to Cancer
... The cell line derives from a fibrocystic disease isolated in 1984 from a 36 year old Caucasian female. The cell line is also applied as a transfection host and is non-tumorigenic, meaning that the cell line will not readily form tumors unless forced to with the addition of a chemical reagent. This m ...
... The cell line derives from a fibrocystic disease isolated in 1984 from a 36 year old Caucasian female. The cell line is also applied as a transfection host and is non-tumorigenic, meaning that the cell line will not readily form tumors unless forced to with the addition of a chemical reagent. This m ...
Ultrastructure of the Infectious and Reproductive
... the external face was almost devoid of intramembranous particles (IMPs), and only a few particles were present on the protoplasmic face (Fig. 3a, b). Also, freeze-etching preparations of the IF exhibited a smooth particle-free external surface (Fig. 3c). In contrast, the protoplasmic face of the out ...
... the external face was almost devoid of intramembranous particles (IMPs), and only a few particles were present on the protoplasmic face (Fig. 3a, b). Also, freeze-etching preparations of the IF exhibited a smooth particle-free external surface (Fig. 3c). In contrast, the protoplasmic face of the out ...
Maize streak virus coat protein binds single
... Expression of proteins in E. coli has proven useful for functional studies of many plant virus proteins. We therefore expressed both full-length and truncated MSV CPs in the pET expression system. The expressed wt and truncated proteins had the expected molecular masses as calculated by computer ana ...
... Expression of proteins in E. coli has proven useful for functional studies of many plant virus proteins. We therefore expressed both full-length and truncated MSV CPs in the pET expression system. The expressed wt and truncated proteins had the expected molecular masses as calculated by computer ana ...
Roles of FGFs as adipokines in adipose tissue development
... acids (~30-60% identity). Phylogenetic analysis of the Fgf gene family identifies seven subfamilies, indicating potential evolutionary relationships in this gene family. FGFs are also classified as intracrine, paracrine, and endocrine FGFs by their action mechanisms (Figure 1). Intracrine FGFs, whic ...
... acids (~30-60% identity). Phylogenetic analysis of the Fgf gene family identifies seven subfamilies, indicating potential evolutionary relationships in this gene family. FGFs are also classified as intracrine, paracrine, and endocrine FGFs by their action mechanisms (Figure 1). Intracrine FGFs, whic ...
PROTEIN EXTRACTION AND PURIFICATION
... 2) Salting out is dependent on the hydrophobic nature of the surface of the protein. The hydrophobic patches consist of the side chains of Phe, Tyr, Trp, Met, Leu, Ile, Val. Protein with large or more hydrophobic patches will aggregate and precipitate before those with smaller and fewer patches, thu ...
... 2) Salting out is dependent on the hydrophobic nature of the surface of the protein. The hydrophobic patches consist of the side chains of Phe, Tyr, Trp, Met, Leu, Ile, Val. Protein with large or more hydrophobic patches will aggregate and precipitate before those with smaller and fewer patches, thu ...
Lipid Domain Theory of General Anesthesia - Deep Blue
... and their targets8; however, this idea has been a large subject of debate for the past few decades. ...
... and their targets8; however, this idea has been a large subject of debate for the past few decades. ...
REFLECTIONS
... farnesylation was blocked, K-Ras became an alternative substrate for another enzyme that we characterized, namely geranylgeranyltransferase (now known as GGTase I) (Ref. 41; see below). Realizing that it would be difficult to prevent all prenylation of K-Ras, we reluctantly gave up our quest to cure ...
... farnesylation was blocked, K-Ras became an alternative substrate for another enzyme that we characterized, namely geranylgeranyltransferase (now known as GGTase I) (Ref. 41; see below). Realizing that it would be difficult to prevent all prenylation of K-Ras, we reluctantly gave up our quest to cure ...
Membrane Transport Lecture
... – The movement of water from an area of low solute concentration to an area of high solute concentration or…. – The movement of water from an area of high water concentration to an area of low water concentration ...
... – The movement of water from an area of low solute concentration to an area of high solute concentration or…. – The movement of water from an area of high water concentration to an area of low water concentration ...
12079_2017_389_MOESM1_ESM
... SUPPLEMENTARY FIGURE 7. Figure 5 from the main text but without error bars. Cellular proliferation of (A) MDA-MB-231 and (B) 184A1L5 cells over 7-day duration when Akt was inhibited alone or together with other proteins. Plots show the proliferation profiles when no protein was inhibited (solid bla ...
... SUPPLEMENTARY FIGURE 7. Figure 5 from the main text but without error bars. Cellular proliferation of (A) MDA-MB-231 and (B) 184A1L5 cells over 7-day duration when Akt was inhibited alone or together with other proteins. Plots show the proliferation profiles when no protein was inhibited (solid bla ...
A C E B D Match A. Nucleus B. Cell membrane C. Vacuole D
... C. the light microscope D. the telescope ...
... C. the light microscope D. the telescope ...
Oxidants, antioxidants and the current incurability of
... sure whether resistance to JQ1 will compromise its clinical utility. Unfortunately, the answer is probably yes because artificially turning up Myc by means that bypass BRD4 causes JQ1 resistance. Moreover, there are already known multiple ways to turn on Myc expression in normal cells, each starting ...
... sure whether resistance to JQ1 will compromise its clinical utility. Unfortunately, the answer is probably yes because artificially turning up Myc by means that bypass BRD4 causes JQ1 resistance. Moreover, there are already known multiple ways to turn on Myc expression in normal cells, each starting ...
BR22, a 26 kDa thyroid transcription factor-1 associated protein
... Institute and the James M. Collins Center for Biomedical Research to J.C. Weissler. ...
... Institute and the James M. Collins Center for Biomedical Research to J.C. Weissler. ...
The Incredible Edible Cell!!!
... Part 3: The Model- 200 points This is the fun part! EACH TEAM needs to build your cell model. Each part needs to be made of the food part listed on the data table. You will be graded on how accurate your model is and how close your actual model was to the drawing - i.e. if the nucleus was in the ...
... Part 3: The Model- 200 points This is the fun part! EACH TEAM needs to build your cell model. Each part needs to be made of the food part listed on the data table. You will be graded on how accurate your model is and how close your actual model was to the drawing - i.e. if the nucleus was in the ...
Therapeutic Restoration of Spinal Inhibition via
... (GABAARs) are ligand-gated chloride (Cl−) channels whose effect on membrane potential (Vm) depends on intracellular Cl− concentration ([Cl−]i). When GABAAR channels are opened, the Vm is pulled toward the Cl− equilibrium potential (ECl), which is determined by [Cl−]i and the extracellular Cl− concen ...
... (GABAARs) are ligand-gated chloride (Cl−) channels whose effect on membrane potential (Vm) depends on intracellular Cl− concentration ([Cl−]i). When GABAAR channels are opened, the Vm is pulled toward the Cl− equilibrium potential (ECl), which is determined by [Cl−]i and the extracellular Cl− concen ...
Function and specificity of 14-3-3 proteins in the regulation of
... reduced in vitro by 5¢-AMP which interacts with 14-3-3s and directly reduces their binding to target ligands (Kaiser and Spill, 1991; Athwal et al., 1998b). It is noteworthy that there is evidence for an AMP binding site in a spinach 14-3-3 isoform. Thus 14-3-3 protein activity might also be under m ...
... reduced in vitro by 5¢-AMP which interacts with 14-3-3s and directly reduces their binding to target ligands (Kaiser and Spill, 1991; Athwal et al., 1998b). It is noteworthy that there is evidence for an AMP binding site in a spinach 14-3-3 isoform. Thus 14-3-3 protein activity might also be under m ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.