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Protein kinase A
Protein kinase A

... Simplified model of insulin signaling pathways. The insulin receptor proteins (IRS 1,2,3,4), Cbl, Shc, and the  subunits of the insulin receptor are phosphorylated on tyrosine residues by the insulin receptor kinase and serve as anchoring sites for cytosolic proteins that form signaling cascades. P ...
video slide
video slide

... daughter chromosomes move to opposite ends of the cell. The mechanism is not fully understood, but proteins may anchor the daughter chromosomes to specific sites on the plasma membrane. (b) Dinoflagellates. In unicellular protists called dinoflagellates, the nuclear envelope remains intact during ce ...
A Toc75-like protein import channel is abundant in chloroplasts
A Toc75-like protein import channel is abundant in chloroplasts

... and AY 040053. All peptides obtained by either Edman degradation or mass spectrometry showed sequence similarity to the EST clones (Figure 2). Both AF 360205 and AY 040053 locate to the same gene on chromosome V in Arabidopsis, at5g19620. The polypeptide deduced from the EST sequences has a length o ...
Chapter 4 Powerpoint
Chapter 4 Powerpoint

...  Biochemistry and cytology help correlate cell function with structure ...
A Toc75like protein import channel is abundant in
A Toc75like protein import channel is abundant in

... and AY 040053. All peptides obtained by either Edman degradation or mass spectrometry showed sequence similarity to the EST clones (Figure 2). Both AF 360205 and AY 040053 locate to the same gene on chromosome V in Arabidopsis, at5g19620. The polypeptide deduced from the EST sequences has a length o ...
Regulation of hepatic metabolism by AMPK - HAL
Regulation of hepatic metabolism by AMPK - HAL

... (1) The AMP-activated protein kinase (AMPK) is an evolutionary conserved serine/threonine protein kinase that functions as a major regulator of cellular and whole-body energy homeostasis coordinating multiple metabolic pathways to adapt cellular processes to the energy status. AMPK is an heterotrime ...
Fe Sparing and Fe Recycling Contribute to
Fe Sparing and Fe Recycling Contribute to

... Plants require water, CO2, light, and a few inorganic nutrients for growth. Changes in the availability of each/any of these essential ingredients of plant life generate system-wide changes in gene expression and metabolism. N, P, and K are major macronutrients and key components of fertilizer, wher ...
Peterson et al., PNAS, 2000 - Randall T. Peterson Lab
Peterson et al., PNAS, 2000 - Randall T. Peterson Lab

... products. Until the target of a given small molecule is identified, it will be difficult to demonstrate conclusively its specificity for that target. However, phenotypic specificity and reproducibility over a broad concentration range are suggestive of high molecular specificity for a given gene pro ...
The DNA Damage Response Signaling Cascade
The DNA Damage Response Signaling Cascade

... Establishment and maintenance of dikaryotic growth in Basidiomycete fungi is controlled by information specified at the Mating Type (MAT) loci, specialized regions of fungal genomes akin to the sex chromosomes of larger eukaryotes (Lee et al., 2010). Although the specific contribution of the MAT loc ...
Choline Esters
Choline Esters

... Release of transmitter occurs when voltagesensitive calcium channels in the terminal membrane are opened, allowing an influx of calcium. The resulting increase in intracellular calcium causes fusion of vesicles with the surface membrane and exocytotic expulsion of acetylcholine and cotransmitters in ...
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Some psychrophiles Abstract

... The lower temperature limit for psychrophiles is not clearly defined, although a limit of 12°C for reproduction and 20°C for metabolic function has been proposed [9]. Photosynthesis in the Antarctic lichen Umbilicaria aprina has been reported to occur at 17°C [10], and the yeast Rhodotolura glutinis ...
PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 Is a Plant
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... In agreement with the central role of high-affinity Pi transporters in Pi acquisition during Pi starvation in plants, most if not all plant PHT1 transporters studied to date are expressed in roots and induced by Pi starvation (Karthikeyan et al., 2002; Mudge et al., 2002). Moreover, one member, PHT1 ...
biology exam review - hrsbstaff.ednet.ns.ca
biology exam review - hrsbstaff.ednet.ns.ca

... c) Exchanges of substances at the membrane surface would take too long to diffuse throughout the interior of the cell. d) Both the first and second answers are correct. 4. In what manner do molecules such as proteins and RNA enter into or exit from the nucleus? a) diffusion through the lipid bilayer ...
mic.sgmjournals.org
mic.sgmjournals.org

... gastro-intestinal tract is also a critical parameter to obtain an optimal response. In order to get insight into the autolysis mechanism and to control it, it is necessary to identify and characterize the peptidoglycan hydrolases involved. Up to now, only the major autolysin, named AcmA, has been ch ...
Molecular basis of differential gene expression in the mouse
Molecular basis of differential gene expression in the mouse

... Hamatani et al., 2004). This indicates that much of the oocyte mRNA was for the purposes of oogenesis and the early stages of post-fertilization development. For example, it is shown that the translation of maternal RNA is required for the initiation of zygotic genome activation (Hamatani et al., 20 ...
Carbon-Based Molecules
Carbon-Based Molecules

... structure of living things and carry out most of the processes that keep organisms alive. Carbon is so important because its atomic structure gives it bonding properties that are unique among elements. Each carbon atom has four unpaired electrons in its outer energy level. Therefore, carbon atoms ca ...
Moss Systems Biology en Route
Moss Systems Biology en Route

... cyclins are the first components of the Rb pathway and function as integrators of environmental proliferation signals in G1 phase, as their transcription is stimulated by growth factors. Expression of CycD genes is stimulated by phytohormones, especially cytokinins, as well as sucrose in Arabidopsis ...
Biochem 2 Recitation #2 Spr 20152102105.pptx
Biochem 2 Recitation #2 Spr 20152102105.pptx

... Biochem 2 Recitation #2 Glycolysis & Gluconeogenesis ...
Desiccation Tolerance of Prokaryotes: Application of Principles to
Desiccation Tolerance of Prokaryotes: Application of Principles to

... reactions, are complex and in many cases the details remain lacking. Five-membered hydantoin rings in DNA derive from the oxidative decay of six-membered pyrimidines and accumulate slowly as a function of time and oxygen exposure. The occurrence of such modified bases is problematic because neither ...
Chem*3560 Lecture 11: Regulation by proteolytic cleavage
Chem*3560 Lecture 11: Regulation by proteolytic cleavage

... Lys6 and Ile7 in trypsinogen. The newly exposed N-terminal Ile is similarly positioned to make an ion pair with Asp 194, and the mechanism of activation is the same as for trypsin. The immediate product is called π -chymotrypsin and is fully active as a protease. Self-exposure to π-chymotrypsin resu ...
Reconstruction Methods - Systems Biology Research Group
Reconstruction Methods - Systems Biology Research Group

... animal genomes. We can coarsely classify them into 3 categories. •1. Circuits that deal with mass and energy handling in the cell. These genetic circuits describe metabolic and transport activity in cells. Typically, about one-third of the genes found on a genome relate to this activity. Understandi ...
Slide 1
Slide 1

... FIGURE 2.4 The citrate cycle of Krebs. In reality, the following reactions are readily reversible: citrate → isocitrate; succinate → oxaloacetate via the intervening reactions. The most important potential sites of control are citrate synthase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenas ...
Rhabdoviridae by Michelle Rodriguez
Rhabdoviridae by Michelle Rodriguez

... polymerase stuttering in the cytoplasm. 4. Replication presumably starts when enough nucleoprotein is present to encapsulate neo-synthetized antigenomes and genomes. 5. The ribonucleocapsid binds to the matrix protein and buds via host ESCRT pathway occurs at the plasma membrane, releasing new virio ...
The Plant Cell Wall Integrity Maintenance
The Plant Cell Wall Integrity Maintenance

... NCA3, which encode proteins required for cell wall biogenesis and septation (Nakayama et al. 1992, Shankarnarayan et al. 2008). The S. cerevisiae genome encodes only a single homolog of the mammalian PKC, with deletion of PKC1 causing lethality unless osmotic support is provided (Levin and BartlettH ...
Introduction to the cell cell history cell structures and functions
Introduction to the cell cell history cell structures and functions

... If cells have such an important job, why are they so small? And why are there no organisms with huge cells? The answers to these questions lie in a cell’s need for fast, easy food. The need to be able to pass nutrients and gases into and out of the cell sets a limit on how big cells can be. The larg ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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