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ECM and Drusen
ECM and Drusen

... The first clinical indication of AMD is the presence of drusen. However, with age and prior to the formation of drusen, extracellular basal deposits accumulate between the retinal pigment epithelium (RPE) and Bruch’s membrane (BrM). Many studies on the molecular composition of the basal deposits and ...
GCE AS/A Level 2400U10-1 – NEW AS BIOLOGY – Unit 1
GCE AS/A Level 2400U10-1 – NEW AS BIOLOGY – Unit 1

... 6. Pyrophosphatase is an enzyme found inside the nucleus of cells and is involved in DNA replication. The enzyme catalyses the conversion of a molecule of pyrophosphate to two phosphate ions. The diagrams below show the enzyme pyrophosphatase and its substrate pyrophosphate. Molecules of phenylalan ...
Evaluation of cell membrane integrity as a potential antimicrobial
Evaluation of cell membrane integrity as a potential antimicrobial

... Bacterial cell membranes can be used as a target for the development of new antibacterial drugs. Many plants produce secondary metabolites which contain a steroid or triterpernoid aglycon attached to one or more sugar chains that exhibit cell membrane permeabilizing properties [11]. Permeability enh ...
Vesicle trafficking dynamics and visualization of zones of exocytosis
Vesicle trafficking dynamics and visualization of zones of exocytosis

... Endocytic retrieval of excess plasma membrane must occur in tip-growing cells, as the amount of membrane inserted during exocytosis would exceed the quantity required to support new growth (Picton and Steer, 1983). These internalized vesicles could also contain membrane proteins that are recycled by ...
SCD1 is required for cell cytokinesis and polarized
SCD1 is required for cell cytokinesis and polarized

... microtubules and microfilaments, forms at the end of anaphase to guide cell plate assembly and expansion. During cytokinesis secretory vesicles carrying membrane and cell wall components are guided along the phragmoplast toward its center, where they fuse to form a membranous tubularvesicular networ ...
(GCKIII) proteins using a mechanism analogous to CCM3
(GCKIII) proteins using a mechanism analogous to CCM3

... C-terminal region of the GCKIII proteins is a key determinant for CCM3 recognition. The C-terminal tails of MST4 and STK25, when expressed as GST fusion proteins, were sufficient for robust binding to full length CCM3 (Fig. 1C). Interestingly, neither GST kinase tail fusion was able to bind to the i ...
Microbiology
Microbiology

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Human CHMP6, a myristoylated ESCRT-III protein, interacts directly
Human CHMP6, a myristoylated ESCRT-III protein, interacts directly

... often oriented closer to the nucleus. An MVB (multivesicular body) is defined as an endosome that contains a characteristic accumulation of vesicles in its lumen, as shown by morphological observation, and such bodies are often seen in late endosomes ...
Mapping of Lipid-‐Binding Proteins and Their Ligandability in Cells
Mapping of Lipid-‐Binding Proteins and Their Ligandability in Cells

... Inflammation ...
Vocab smack-down
Vocab smack-down

... RULES of the GAME: • You must keep your voice at a whisper • LISTEN/READ the correct answer on the board for EVERY question… • This game is to help you prepare for the test! • If you cannot keep yourselves under control, you will have an alternative assignment: • Write definitions/characteristics of ...
Protist
Protist

... ROOTS, STEMS, LEAVES c. Plants have specialized tissues for _____________________ d. Plant-like protists do not have the same _______________ or TISSUES THE SAME REPRODUCTIVE __________________________ parts as plants 3. Many “phytoplankton” are a huge ______________________ for FOOD SOURCE ACQUATIC ...
The Amoeboid Parabasalid Flagellate Gigantomonas herculeaof the
The Amoeboid Parabasalid Flagellate Gigantomonas herculeaof the

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Targeting of P-Selectin to Two Regulated Secretory Organelles in
Targeting of P-Selectin to Two Regulated Secretory Organelles in

... monocytes and neutrophils following its regulated appearance on the cell surface as part of the inflammatory response (24, 30). Expression in the pituicyte line AtT-20 revealed that it was targeted to the secretory granules and studies using chimeras revealed that the cytoplasmic domain was both nec ...
The Cell, 5e
The Cell, 5e

... • Laminopathies: defects in genes that encode nuclear-lamina and lamina-associated proteins – specifically A-type lamins and emerins • A mutation in the emerin gene leading to a loss of emerin from the nuclear periphery • Childhood onset of progressive muscle wasting and weakening • Early contractur ...
Ion Channels - Interactive Physiology
Ion Channels - Interactive Physiology

... Page 4. Neurotransmitters Can Act Directly on Chemically-gated Channels • Many receptors are physically part of an ion channel. • Binding neurotransmitter to a receptor on the postsynaptic cell causes a change in the shape of the ...
OF PISUM SATIVUM L. (a) Source of Material
OF PISUM SATIVUM L. (a) Source of Material

... 1 and 2). About the lOth day small vacuoles were found in the cytoplasm (Plate 6, Fig. 3). As time progressed these coalesced so that each cell contained several large vacuoles by the end of phase 2. This differentiation and expansion of the vacuolar system coincided with the expansion of the cells. ...
Document
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... A. Two pathways: Biosynthetic secretory and endocytic, Fig. 13-1 B. The process of transport between all parts of the pathway is identical, vesicular transport, Fig. 13-2. C. Experimental Methods for studying vesicular transport 1. Cell free systems 2. Genetic 3. GFP fusion proteins D Specificity of ...
The Biotechnology Century and Its Workforce
The Biotechnology Century and Its Workforce

... Phospholipid bilayer Peripheral proteins Integral proteins Transmembrane proteins Sterols Glycocalyx carbohydrates ...
PDF
PDF

... and showed many broken membranes (Fig. 5). After 3 h these cells had also replaced their vacuoles, secretory vesicles and mitochondria along with many ribosomes, small areas of Golgi apparatus and endoplasmic reticulum (Fig. 6). The mesogloea was absent from the wound margins leaving the two epithel ...
Leaf initiation: the integration of growth and cell division
Leaf initiation: the integration of growth and cell division

... LIII layers led to DEF protein accumulation in all three layers of the floral meristem, implying protein movement. Interestingly, reciprocal chimeras in which the DEF gene was only expressed in the LI layer did not lead to DEF protein accumulation in the internal layers, suggesting a restriction in p ...
Plant Cells Contain Two Functionally Distinct
Plant Cells Contain Two Functionally Distinct

Sequential inte ic resistant bacterium
Sequential inte ic resistant bacterium

... cells will be close to 1. High ratio of 0.8 was observed in the control (without Ag-SiO2NC) whereas in presence of Ag-SiO2NC, the ratio decreased close to zero (100 µgmL-1). Though metabolically active, the cultivability of the bacteria was completely lost at 80 µgmL-1 concentration of Ag-SiO2NC. Th ...
The Bacterial Nucleoid
The Bacterial Nucleoid

... replication ; OM, outer membrane; PG, peptidoglycan; CM, cytoplasmicmembrane. ...
08 Prokaryotes
08 Prokaryotes

... Many prokaryotes secrete sticky substances that form an additional protection layer – capsule outside the cell wall. Some prokaryotes adhere to one another or to substrate by surface appendages called pili. ...
The taste perception is an important function for living organisms to
The taste perception is an important function for living organisms to

... Taste perception starts with recognition of the taste substances and transmission of the external chemical information to inside of the body by taste receptors, chemosensory proteins existing in oral cavity. Toward understanding how we sense taste, it is important to understand how taste receptors r ...
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Endomembrane system

The endomembrane system is composed of the different membranes that are suspended in the cytoplasm within a eukaryotic cell. These membranes divide the cell into functional and structural compartments, or organelles. In eukaryotes the organelles of the endomembrane system include: the nuclear membrane, the endoplasmic reticulum, the Golgi apparatus, lysosomes, vesicles, endosomes and the cell membrane. The system is defined more accurately as the set of membranes that form a single functional and developmental unit, either being connected directly, or exchanging material through vesicle transport. Importantly, the endomembrane system does not include the membranes of mitochondria or chloroplasts.The nuclear membrane contains two lipid bilayers that encompass the contents of the nucleus. The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. Vacuoles, which are found in both plant and animal cells (though much bigger in plant cells), are responsible for maintaining the shape and structure of the cell as well as storing waste products. A vesicle is a relatively small, membrane-enclosed sac that stores or transports substances. The cell membrane, is a protective barrier that regulates what enters and leaves the cell. There is also an organelle known as the Spitzenkörper that is only found in fungi, and is connected with hyphal tip growth.In prokaryotes endomembranes are rare, although in many photosynthetic bacteria the plasma membrane is highly folded and most of the cell cytoplasm is filled with layers of light-gathering membrane. These light-gathering membranes may even form enclosed structures called chlorosomes in green sulfur bacteria.The organelles of the endomembrane system are related through direct contact or by the transfer of membrane segments as vesicles. Despite these relationships, the various membranes are not identical in structure and function. The thickness, molecular composition, and metabolic behavior of a membrane are not fixed, they may be modified several times during the membrane's life. One unifying characteristic the membranes share is a lipid bilayer, with proteins attached to either side or traversing them.
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