Agenda - Cardiac Safety Research Consortium
... Moderators: Thomas Force, MD (Jefferson); Aarif Khakoo, MD (MD Anderson); Theressa Wright, MD (Eli Lilly) Mitochondrial Mechanisms & Markers of Cardiotoxicity: Marco Giorgio, MD (IEO) (20 min) MAO Inhibitors for Protection & Treatment of Cardiotoxicity: Fabio Di Lisa, MD (Padova) (20 min) Does Under ...
... Moderators: Thomas Force, MD (Jefferson); Aarif Khakoo, MD (MD Anderson); Theressa Wright, MD (Eli Lilly) Mitochondrial Mechanisms & Markers of Cardiotoxicity: Marco Giorgio, MD (IEO) (20 min) MAO Inhibitors for Protection & Treatment of Cardiotoxicity: Fabio Di Lisa, MD (Padova) (20 min) Does Under ...
The Brugada ECG Pattern - Circulation: Arrhythmia and
... the right ventricle. In SCN5A mutation carriers, PVC morphologies are more diverse and often have right bundle-branch block morphology in line with a left ventricular origin.20 Like in the LQTS,21 the Brugada ECG pattern and ventricular arrhythmias appear to have specific triggers. The Brugada ECG p ...
... the right ventricle. In SCN5A mutation carriers, PVC morphologies are more diverse and often have right bundle-branch block morphology in line with a left ventricular origin.20 Like in the LQTS,21 the Brugada ECG pattern and ventricular arrhythmias appear to have specific triggers. The Brugada ECG p ...
Introducing a novel mechanism to control heart rate in the ancestral
... University of British Columbia, 2357 Main Mall, Vancouver, British Columbia, Canada V6T 1Z4. *These authors contributed equally to this work ...
... University of British Columbia, 2357 Main Mall, Vancouver, British Columbia, Canada V6T 1Z4. *These authors contributed equally to this work ...
Open and Thoracoscopic Approaches to Treat Atrial Fibrillation and
... these studies. Relevant outcomes are overall survival, medication use, and treatment-related morbidity. The most direct evidence comes from several small RCTs confirming the benefit of a modified maze procedure for patients with AF who are undergoing mitral valve surgery. These trials establish that ...
... these studies. Relevant outcomes are overall survival, medication use, and treatment-related morbidity. The most direct evidence comes from several small RCTs confirming the benefit of a modified maze procedure for patients with AF who are undergoing mitral valve surgery. These trials establish that ...
If Inhibition, Heart Rate, and Coronary Artery Disease
... heart disease is high, the total number of people with angina may reach 30 000 to 40 000 per million of the total population. Surgical and percutaneous myocardial revascularization technics have transformed the treatment of angina. However, although revascularization offers effective symptomatic rel ...
... heart disease is high, the total number of people with angina may reach 30 000 to 40 000 per million of the total population. Surgical and percutaneous myocardial revascularization technics have transformed the treatment of angina. However, although revascularization offers effective symptomatic rel ...
and Absence of Coronary Sinus
... In each of the four remaining patients (cases 3, 5, 7, and 8), in whom cardiac catheterization was done, the initial catheterization was attempted through a left antecubital vein. In each, the catheter followed a usual course in the thoracic cavity to the level of the left superior mediastinum. At t ...
... In each of the four remaining patients (cases 3, 5, 7, and 8), in whom cardiac catheterization was done, the initial catheterization was attempted through a left antecubital vein. In each, the catheter followed a usual course in the thoracic cavity to the level of the left superior mediastinum. At t ...
Early trabeculation and closure of the interventricular foramen in
... In the present study the ventricular trabeculation was found in all embryos at stage 13 (the beginning of the 5th week). This is in accordance with descriptions of O’Rahilly and Müller [26]. It has to be pointed out that the trabeculations in the left ventricle are thicker and the centripetal growth ...
... In the present study the ventricular trabeculation was found in all embryos at stage 13 (the beginning of the 5th week). This is in accordance with descriptions of O’Rahilly and Müller [26]. It has to be pointed out that the trabeculations in the left ventricle are thicker and the centripetal growth ...
Impair Efferent Sympathetic Responsiveness
... monophasic exponential shocks, synchronized to the R wave during sinus rhythm, were delivered over implantable patches sutured inside the pericardium in anesthetized open-chest dogs. Shortening of ventricular effective refractory period (ERP), produced by bilateral ansae subclaviae stimulation (SS), ...
... monophasic exponential shocks, synchronized to the R wave during sinus rhythm, were delivered over implantable patches sutured inside the pericardium in anesthetized open-chest dogs. Shortening of ventricular effective refractory period (ERP), produced by bilateral ansae subclaviae stimulation (SS), ...
A Study of Hemodynamics and Coronary Blood Flow in
... through the heart while the coronary arteries were clamped. This quantity of blood (not more than 10 to 15 ml/min) was presumed to have leaked through the aortic valve or proximal branches of the coronary vessels or both. Having measured this "artifactual" flow several times, the clamps were removed ...
... through the heart while the coronary arteries were clamped. This quantity of blood (not more than 10 to 15 ml/min) was presumed to have leaked through the aortic valve or proximal branches of the coronary vessels or both. Having measured this "artifactual" flow several times, the clamps were removed ...
Short-term exercise training can improve myocardial - AJP
... damage to the myocardium (9, 25). The exact biochemical mechanisms responsible for this protection continue to be debated. Nonetheless, it has been argued that elevated myocardial levels of heat shock protein (HSP) 72, and perhaps other HSPs (e.g., HSP10, HSP40, HSP60, and HSP90), play a significant ...
... damage to the myocardium (9, 25). The exact biochemical mechanisms responsible for this protection continue to be debated. Nonetheless, it has been argued that elevated myocardial levels of heat shock protein (HSP) 72, and perhaps other HSPs (e.g., HSP10, HSP40, HSP60, and HSP90), play a significant ...
ASSOCIATE DIRECTOR SCIENTIFIC COORDINATION FDA NATIONAL TOXICOLOGY PROGRAM LIAISON
... of Torsade Proarrhythmia, under conditions of therapeutic use. Acrylamide and Glycidamide The presence of acrylamide in processed starchy foods first came to the attention of the FDA on April 24, 2002, when researchers at the Swedish National Food Administration and Stockholm University reported fin ...
... of Torsade Proarrhythmia, under conditions of therapeutic use. Acrylamide and Glycidamide The presence of acrylamide in processed starchy foods first came to the attention of the FDA on April 24, 2002, when researchers at the Swedish National Food Administration and Stockholm University reported fin ...
Bates K, et al. Pediatric cardiovascular safety: Challenges in drug
... population. Beginning with in utero exposure to maternal medications, critical processes of anatomical and physiologic development may be affected by the introduction of a drug or device. In addition to developmental abnormalities in structure or function, cardiac toxicities include direct myocardia ...
... population. Beginning with in utero exposure to maternal medications, critical processes of anatomical and physiologic development may be affected by the introduction of a drug or device. In addition to developmental abnormalities in structure or function, cardiac toxicities include direct myocardia ...
images/Long term effects of RV pacing.pps
... The findings of the PAVE study suggest that, in order to avoid the adverse effects of cardiac dyssynchrony generated by RV pacing, a biventricular pacing should be considered for patients who require AV node ablation for management of atrial fibrillation and who have a left ventricular ejection frac ...
... The findings of the PAVE study suggest that, in order to avoid the adverse effects of cardiac dyssynchrony generated by RV pacing, a biventricular pacing should be considered for patients who require AV node ablation for management of atrial fibrillation and who have a left ventricular ejection frac ...
Endocarditis
... Patients being treated for infective endocarditis require regular follow-up echo studies to monitor progress and to watch for complications. With effective treatment the vegetations may gradually shrink and become less mobile. The sudden disappearance of a vegetation between studies should raise a s ...
... Patients being treated for infective endocarditis require regular follow-up echo studies to monitor progress and to watch for complications. With effective treatment the vegetations may gradually shrink and become less mobile. The sudden disappearance of a vegetation between studies should raise a s ...
Getting to the heart of regeneration in zebrafish
... multiple types of undifferentiated or poorly differentiated cardiac progenitor cells in the postnatal heart that have the potential to mature into contractile cells [13–15]. The presence of cardiac progenitor cells is not necessarily surprising, given findings over the years that most mammalian orga ...
... multiple types of undifferentiated or poorly differentiated cardiac progenitor cells in the postnatal heart that have the potential to mature into contractile cells [13–15]. The presence of cardiac progenitor cells is not necessarily surprising, given findings over the years that most mammalian orga ...
An Unusual Huge Coronary Artery Aneurysm with Fistula
... and coronary artery bypass grafts are definitive treatments for CAAAF.8 We have presented this case who was diagnosed with a huge RCA aneurysm and underwent surgical intervention; the operator found a fistula connecting the aneurysm with PA. This finding was compatible with CAAAF. Coronary artery fi ...
... and coronary artery bypass grafts are definitive treatments for CAAAF.8 We have presented this case who was diagnosed with a huge RCA aneurysm and underwent surgical intervention; the operator found a fistula connecting the aneurysm with PA. This finding was compatible with CAAAF. Coronary artery fi ...
valve and supravalvar mitral ring - Heart
... FIG. 2 a) Case 2. Diagrammatic representation of Fig. 2 b), to demonstrate the components of a parachute mitral valve. The chordae tendineae are drawn for clarification, but are not demonstrated angiocardiographically. The position of the ascending aorta and aortic valve are in part derivedfrom othe ...
... FIG. 2 a) Case 2. Diagrammatic representation of Fig. 2 b), to demonstrate the components of a parachute mitral valve. The chordae tendineae are drawn for clarification, but are not demonstrated angiocardiographically. The position of the ascending aorta and aortic valve are in part derivedfrom othe ...
Like
... – Inflammation of the membrane lining of the valves and chambers of the heart • Caused by direct invasion of bacteria or other organisms • Leads to deformity of valve cusps ...
... – Inflammation of the membrane lining of the valves and chambers of the heart • Caused by direct invasion of bacteria or other organisms • Leads to deformity of valve cusps ...
morphological and immunohistochemical patterns of the intrinsic
... and inhibitory parasympathetic inputs are important for control of cardiac function (Ardell et al., 1991; Pauza et al., 1997b; Smith, 1999). It is widely recognized that autonomic nervous system modulates the cardiac electrophysiology of the heart and influences the genesis of cardiac arrhythmias or ...
... and inhibitory parasympathetic inputs are important for control of cardiac function (Ardell et al., 1991; Pauza et al., 1997b; Smith, 1999). It is widely recognized that autonomic nervous system modulates the cardiac electrophysiology of the heart and influences the genesis of cardiac arrhythmias or ...
CHAPTER 13 Electrocardiography
... electrical inhomogeneities within the torso. For example, intracardiac blood has much lower resistivity (162 Ω cm) than the lungs (2150 Ω cm). When the cardiac field encounters the boundary between two tissues with differing resistivity, the field is altered. Differences in torso inhomogeneities can ...
... electrical inhomogeneities within the torso. For example, intracardiac blood has much lower resistivity (162 Ω cm) than the lungs (2150 Ω cm). When the cardiac field encounters the boundary between two tissues with differing resistivity, the field is altered. Differences in torso inhomogeneities can ...
Serum Magnesium and the Risk of Death From Coronary Heart
... probability curves for CHD mortality, nonsudden CHD mortality, and SCD adjusted for competing risk of death by other causes as proposed by Fine and Grey.35 We used Cox proportional hazard regression models to examine the relationship between serum magnesium and CHD mortality, nonsudden CHD mortality ...
... probability curves for CHD mortality, nonsudden CHD mortality, and SCD adjusted for competing risk of death by other causes as proposed by Fine and Grey.35 We used Cox proportional hazard regression models to examine the relationship between serum magnesium and CHD mortality, nonsudden CHD mortality ...
... effects were noticed after O. brevis extract application, indicating a significant decrease in the heart rate (bradycardia) accompanied by an elongation of the P-R interval indicating increasing of conduction time. In the mean time, a positive inotropic effect represented as an increase in the R wav ...
(CMR) for the diagnosis of coronary heart disease
... CMR is a medical imaging technology for the non‐invasive assessment of the function and structure of the cardiovascular system. It is derived from, and based on, the same basic principles as magnetic resonance imaging (MRI) but with optimisation for use in the cardiovascular system. CMR has been ...
... CMR is a medical imaging technology for the non‐invasive assessment of the function and structure of the cardiovascular system. It is derived from, and based on, the same basic principles as magnetic resonance imaging (MRI) but with optimisation for use in the cardiovascular system. CMR has been ...
The normal variations in heart rate and QRS complex
... the other hand QRS duration of Negro men is shorter than of Caucasians.3 With the elevation of diaphragm during pregnancy, it is not uncommon for QRS axis to move left wards. In. addition, flattening of right precordial T waves which may occur in normal subjects. Data concerning ECG, of healthy subj ...
... the other hand QRS duration of Negro men is shorter than of Caucasians.3 With the elevation of diaphragm during pregnancy, it is not uncommon for QRS axis to move left wards. In. addition, flattening of right precordial T waves which may occur in normal subjects. Data concerning ECG, of healthy subj ...