Dominika Czaplińska Department of Medical Biotechnology
... effectors of MAPK/ERK pathway that regulate diverse cellular processes including cell growth, proliferation and survival. In carcinogenesis, RSKs are thought to modulate cell motility, invasion and metastasis. Herein, we have studied an involvement of RSKs in FGF2/FGFR2-driven behaviours of mammary ...
... effectors of MAPK/ERK pathway that regulate diverse cellular processes including cell growth, proliferation and survival. In carcinogenesis, RSKs are thought to modulate cell motility, invasion and metastasis. Herein, we have studied an involvement of RSKs in FGF2/FGFR2-driven behaviours of mammary ...
answers_ch06
... 5) When the Ras protein is activated, it has an autocatalytic property which means that it has a catalytic property which leads to its own deactivation without the need for any external influence. If the autocatalytic property was lost, the Ras protein would remain permanantly activated and this wou ...
... 5) When the Ras protein is activated, it has an autocatalytic property which means that it has a catalytic property which leads to its own deactivation without the need for any external influence. If the autocatalytic property was lost, the Ras protein would remain permanantly activated and this wou ...
ppt
... Researchers found that the cytoplasmic enzyme could be activated by the membrane-bound epinephrine in broken cells, as long as all parts were present. They discovered that another molecule delivered the message from the “first messenger,” epinephrine, to the enzyme. The second messenger was later d ...
... Researchers found that the cytoplasmic enzyme could be activated by the membrane-bound epinephrine in broken cells, as long as all parts were present. They discovered that another molecule delivered the message from the “first messenger,” epinephrine, to the enzyme. The second messenger was later d ...
SIGNAL TRANSDUCTION PATHWAYS Outline
... Chemical messenger binds to cytoplasmic receptor protein (as opposed to receptor protein in membrane). Hormone-Receptor complex enters nucleus and serves as a transcription factor. Transcription Factors determine which genes on a chromosome should be transcribed into a protein. The steroid receptor ...
... Chemical messenger binds to cytoplasmic receptor protein (as opposed to receptor protein in membrane). Hormone-Receptor complex enters nucleus and serves as a transcription factor. Transcription Factors determine which genes on a chromosome should be transcribed into a protein. The steroid receptor ...
SIGNAL TRANSDUCTION PATHWAYS Student Version Outline
... ligand itself crosses the nuclear member to form the receptor-ligand complex. Once the receptor-ligand complex is inside the nucleus, it functions to: 1) Transcribe genes/synthesize mRNA 2) Regulate gene function (determine which genes are turned on/off) 3) Regulate many different genes at the same ...
... ligand itself crosses the nuclear member to form the receptor-ligand complex. Once the receptor-ligand complex is inside the nucleus, it functions to: 1) Transcribe genes/synthesize mRNA 2) Regulate gene function (determine which genes are turned on/off) 3) Regulate many different genes at the same ...
As Powerpoint Slide
... 1 Department of Biology, McMaster University, Hamilton, Ontario, Canada ; ...
... 1 Department of Biology, McMaster University, Hamilton, Ontario, Canada ; ...
Cell Signalling Pathways
... unplug phosphatase domain. Phosphotyrosines compete for SH2 domains, gets rid of phosphates on JAK and bring back down to ground state. Long term: In event of increased cytokine signalling, SOCS transcribed from STAT. They bind to phosphotyrosines in activated receptors or via SH2 domain + target th ...
... unplug phosphatase domain. Phosphotyrosines compete for SH2 domains, gets rid of phosphates on JAK and bring back down to ground state. Long term: In event of increased cytokine signalling, SOCS transcribed from STAT. They bind to phosphotyrosines in activated receptors or via SH2 domain + target th ...
The elements of G protein-coupled receptor systems
... Termination/desensitization of the signal transduction process ...
... Termination/desensitization of the signal transduction process ...
ch 11 mc focus
... B) regulate gene expression by serving as a transcription factor. C) inactivate second messengers such as cAMP. D) activate protein kinases or other relay molecules in a series. 19) A drug designed to inhibit the response of cells to testosterone would almost certainly result in which of the followi ...
... B) regulate gene expression by serving as a transcription factor. C) inactivate second messengers such as cAMP. D) activate protein kinases or other relay molecules in a series. 19) A drug designed to inhibit the response of cells to testosterone would almost certainly result in which of the followi ...
AP Biology - wlhs.wlwv.k12.or.us
... (overview): What triggers a ligand-gated ion channel to open/close? What then passes through the channel once it is open? ...
... (overview): What triggers a ligand-gated ion channel to open/close? What then passes through the channel once it is open? ...
CELL SIGNALING
... PROTEIN KINASES = KINASES ACTIVATION OF PROTEINS = PHOSPHORYLATION (ATP is used as a donor of phosphate group) ...
... PROTEIN KINASES = KINASES ACTIVATION OF PROTEINS = PHOSPHORYLATION (ATP is used as a donor of phosphate group) ...
BPS 502
... dimeric proteins. They mediate a wide range of biological functions in animals: proliferation, differentiation, ECM production, cell death, tissue repair and immune regulation. They act through receptor serine/threonine kinases type I and type II Smad family members are directly phosphorylated by th ...
... dimeric proteins. They mediate a wide range of biological functions in animals: proliferation, differentiation, ECM production, cell death, tissue repair and immune regulation. They act through receptor serine/threonine kinases type I and type II Smad family members are directly phosphorylated by th ...
Abstract
... Abstract Protein kinases mediate most intracellular signal transduction via the reversible phosphorylation on serine, threonine, or tyrosine residue of specific protein/peptide substrates. Such phosphorylation is employed by all eukaryotes in regulation of enzyme activity, protein-protein interactio ...
... Abstract Protein kinases mediate most intracellular signal transduction via the reversible phosphorylation on serine, threonine, or tyrosine residue of specific protein/peptide substrates. Such phosphorylation is employed by all eukaryotes in regulation of enzyme activity, protein-protein interactio ...
Cell Signaling - Erlenbeck`s Science Room
... A signaling molecule (hormone) travels through the plasma membrane and attaches to a receptor protein in the cytoplasm. The hormone-receptor complex then moves into the nucleus and bind to specific genes. The complex acts as a transcription factor, causing the gene it binds with to be transcribed in ...
... A signaling molecule (hormone) travels through the plasma membrane and attaches to a receptor protein in the cytoplasm. The hormone-receptor complex then moves into the nucleus and bind to specific genes. The complex acts as a transcription factor, causing the gene it binds with to be transcribed in ...
![Biochemistry Chapter 11 [10-2-13].](http://s1.studyres.com/store/data/001491986_1-28945f6beadb86fb208c56f0103a35db-300x300.png)
Biochemistry Chapter 11 [10-2-13].
... b. also has intracellular domain for signal transd. 2. when ligand bindscauses conformational change 3. polar molecules-cannot diffuse across membrane 4. pathway of signal transd. Has 2 major effects: a. rapid effects on ion levels or activation/inhibition of enzymes b. slower changes in the rate o ...
... b. also has intracellular domain for signal transd. 2. when ligand bindscauses conformational change 3. polar molecules-cannot diffuse across membrane 4. pathway of signal transd. Has 2 major effects: a. rapid effects on ion levels or activation/inhibition of enzymes b. slower changes in the rate o ...
Ch 10
... Receptor Tyrosine Kinases • Second major class of receptors – Insulin binding as prototype – Mostly monomers that bind ligand and then dimerize • One subunit binds ligand • Second subunit become active kinases ...
... Receptor Tyrosine Kinases • Second major class of receptors – Insulin binding as prototype – Mostly monomers that bind ligand and then dimerize • One subunit binds ligand • Second subunit become active kinases ...
CELL SIGNALLING
... cAMP second messenger activates variety of targets. cAMP broken down by phosphodiesterase – switches activation off. The G protein remains active whilst GTP is bound – G protein hydrolyses GTP GDP and thus becomes inactive. ...
... cAMP second messenger activates variety of targets. cAMP broken down by phosphodiesterase – switches activation off. The G protein remains active whilst GTP is bound – G protein hydrolyses GTP GDP and thus becomes inactive. ...
Abstract
... Abstract Protein kinases mediate most intracellular signal transduction via the reversible phosphorylation on serine, threonine, or tyrosine residue of specific protein/peptide substrates. Such phosphorylation is employed by all eukaryotes in regulation of enzyme activity, protein-protein interactio ...
... Abstract Protein kinases mediate most intracellular signal transduction via the reversible phosphorylation on serine, threonine, or tyrosine residue of specific protein/peptide substrates. Such phosphorylation is employed by all eukaryotes in regulation of enzyme activity, protein-protein interactio ...
G-protein-mediated pathway
... Non-G-protein-mediated pathway Receptor tyrosine kinase mediated pathway Receptor serine/threonine kinase mediated pathway Receptor guanilate cyclase mediated pathway Intracellular (unclear) receptor mediated pathway Receptor tyrosine kinase mediated pathway Receptor tyrosine kinases transmit signa ...
... Non-G-protein-mediated pathway Receptor tyrosine kinase mediated pathway Receptor serine/threonine kinase mediated pathway Receptor guanilate cyclase mediated pathway Intracellular (unclear) receptor mediated pathway Receptor tyrosine kinase mediated pathway Receptor tyrosine kinases transmit signa ...
CRYSTAL STRUCTURE OF AN ENZYME INVOLVED IN THE
... Isoprenoids are a diverse family of compounds consisting of isoprene units (fivecarbons units) and are involved in many biological functions such as electron transport, hormone based signaling, apoptosis, also they provide structural components of cell membranes. In contrast to mammals, some pathoge ...
... Isoprenoids are a diverse family of compounds consisting of isoprene units (fivecarbons units) and are involved in many biological functions such as electron transport, hormone based signaling, apoptosis, also they provide structural components of cell membranes. In contrast to mammals, some pathoge ...
MB207_14 - MB207Jan2010
... Signaling through G-protein linked cell-surface receptors G-protein linked-receptors: • Largest family of cell-surface receptors and found in all eukaryotes. • Mediate the responses to an enormous diversity of signal molecules including hormones, neurotransmitters and local mediators. • Signals mol ...
... Signaling through G-protein linked cell-surface receptors G-protein linked-receptors: • Largest family of cell-surface receptors and found in all eukaryotes. • Mediate the responses to an enormous diversity of signal molecules including hormones, neurotransmitters and local mediators. • Signals mol ...
No Slide Title
... - membrane-bound (contactdependent signaling) - released into extracellular space local (paracrine) or long-distance (endocrine) signaling Signals for intracellular receptors (hydrophobic, on carrier proteins): - pass directly through plasma membrane - receptors in cytosol or nucleus ...
... - membrane-bound (contactdependent signaling) - released into extracellular space local (paracrine) or long-distance (endocrine) signaling Signals for intracellular receptors (hydrophobic, on carrier proteins): - pass directly through plasma membrane - receptors in cytosol or nucleus ...
Concept 11.2 Reception: A signaling molecule binds to a receptor
... - The part of the receptor protein going inside the cytoplasm functions as a tyrosine kinase, an enzyme that catalyzes the transfer of a phosphate group from ATP to the amino acid tyrosine. ...
... - The part of the receptor protein going inside the cytoplasm functions as a tyrosine kinase, an enzyme that catalyzes the transfer of a phosphate group from ATP to the amino acid tyrosine. ...
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an ""on"" or ""off"" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase.The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division. Protein kinases can become mutated, stuck in the ""on"" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. Therefore, kinase inhibitors, such as imatinib, are often effective cancer treatments. Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group.