• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
THE NATIONAL LUPRON VICTIMS NETWORK
THE NATIONAL LUPRON VICTIMS NETWORK

... Hypogonadotrophic - decreased FSH and LH [occurs with Lupron] Hypergonadotrophic - increased FSH and LH [occurs in menopause] Hypogonadism - low estrogen / testosterone levels. ...
tsh enzyme immunoassay test kit
tsh enzyme immunoassay test kit

... concentrations of serum LH. A decrease in steroid hormone production in females is a result of immature ovaries, primary ovarian failure, polycystic ovary disease, or menopause; in these cases, LH secretion is not regulated. A similar loss of regulatory hormones occurs in males when the tests develo ...
The Pituitary Gland
The Pituitary Gland

... - FSH in females: stimulates gonads/ reproduction growth of ovarian follicles in organs the ovary before the release of an egg from the follicle at ovulation • Responsible for ovulation ...
endocrinology mcq
endocrinology mcq

... A man aged 55 years presents with a 3/12 history of progressively more severe diarrhoea. Stool are frequent, watery and of large volume. There is no macroscopic blood or mucus. He feels weak, lethargic, and is constantly thirsty. Urine output is low. He has lost 3 kg during the period of his illness ...
Hormone Chart 2013 Blank
Hormone Chart 2013 Blank

... Releasing Hormone (GnRH) Growth Hormone Releasing Hormone ...
Scholars Bulletin Assessment of Serum Luteinizing hormone
Scholars Bulletin Assessment of Serum Luteinizing hormone

... respectively, p.value was (0.000) when compared with control. This results agree with the previous study(1) who stated that in response to drug metabolic stress cannabinoids transiently depress pituitary function as reflected by decrement in LH and FSH hormones, also our finding agree with [16] they ...
A case report of Sheehan`s syndrome with acute onset
A case report of Sheehan`s syndrome with acute onset

... the disease was diagnosed on average after 13.92 years from its primary obstetric cause. Hence, the importance of an early diagnosis to start adequate hormone replacement therapy as soon as possible. Generally, the presenting symptoms in patients with Sheehan’s syndrome may range from totally nonspe ...
Hormones
Hormones

... The granulosa cells of the ruptured follicle luteinize and form the corpus luteum Corpus luteum produces progesterone and some E2 Estradiol peaks about midway through the luteal phase and then declines to a very low level.The major hormone is progesterone LH is required for the early maintenance of ...
عرض تقديمي من PowerPoint
عرض تقديمي من PowerPoint

... the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. girls < 7 years. black girls 6-8 years. ...
“Common” growth problems in children
“Common” growth problems in children

... FRACP, MD ...
Overview of Pituitary Syndromes
Overview of Pituitary Syndromes

... Gonadotrophin deficiency (hypogonadism) In women Before Puberty - primary amenorrhea and failure of puberty development After Puberty - secondary amenorrhea and regression of secondary sexual characteristic, infertility In men Before Puberty - failure of puberty development ...
thyroid and reproductive hormones
thyroid and reproductive hormones

... leads to dwarfism and cretinism c) replacement therapy works only if started immediately ...
Androgen deficiency
Androgen deficiency

... desire, blood flow or nerve signals to the penis can cause erectile dysfunction. The most common causes are conditions affecting blood vessels and blood flow such as hardening of the arteries (atherosclerosis) that is linked to diabetes, obesity, smoking, high blood pressure and high ...
Airgas template - Morgan Community College :: Home
Airgas template - Morgan Community College :: Home

... In children, _____________ hormone deficiency interferes with linear bone growth, resulting in short stature or dwarfism. ...
Diagnosis and Treatment of Pituitary Gland Disorders
Diagnosis and Treatment of Pituitary Gland Disorders

... hyperthyroidism or the state of the thyroid but do not confirm the cause of the thyroid’s overactivity. 3. (A) Bromocryptine alone. Low levels of testosterone are related to increased levels of prolactin. Prolactin ...
AHS I
AHS I

... 6. Which two pituitary hormones act on the ovaries and the testes? A. ACTH and TSH B. FSH and LH C. LH and ACTH 7. Which anterior pituitary lobe hormone is responsible for the development of breasts tissue and stimulates the production of milk after childbirth? A. Prolactin (PRL) B. Luteinizing hor ...
Follitropin subunit beta, Follicle- stimulating hormone beta subunit
Follitropin subunit beta, Follicle- stimulating hormone beta subunit

... critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be cri ...
eau guidelines on male hypogonadism
eau guidelines on male hypogonadism

... the preparation with a joint decision by an informed patient and the physician. Use short-acting preparations rather than longacting depot administration when starting the initial treatment, so that therapy can be adjusted or stopped in case of adverse side-effects. Do not use testosterone therapy i ...
Understanding Premature Ovarian Failure
Understanding Premature Ovarian Failure

... it is the cycle in a woman's life when her ovaries stop producing eggs, when her periods begin to stop and when her hormone levels change. Menopause is something that typically happens between the ages of 47 and 53. It means hot flushes, no more periods, an end to a woman’s reproductive years. What ...
HH15_Reproductive organs
HH15_Reproductive organs

... When a hormone reaches its target tissue it brings about a specific effect ...
Did Junior Seau Suffer From Pituitary Dysfunction?
Did Junior Seau Suffer From Pituitary Dysfunction?

... recommended. Patients treated with growth hormone can often have dramatic improvement in their symptoms including depression, sleep problems and joint pain; therefore, it is imperative for the patient with head trauma to be properly diagnosed with growth hormone deficiency and to be treated. The sec ...
Prolactin
Prolactin

... principal source of feedback inhibition of FSH. 3. For the majority of the cycle, the reproductive system functions in a classic endocrine negative feedback mode. Estradiol and progesterone inhibit GnRH secretion, and the inhibins act at the pituitary to selectively inhibit FSH synthesis and secreti ...
should treatment with clomiphene citrate continue?
should treatment with clomiphene citrate continue?

... LH rise after CC treatment is not needed and might contribute to low quality eggs and increased abortion rates (Balen et al., 1993). The overall increase of FSH levels during CC treatment seems to be 50-60% from baseline (Polson et al., 1989; Butzow et al., 1995). If the goal of CC administration is ...
307-3285-1-SP - Journal of the ASEAN Federation of
307-3285-1-SP - Journal of the ASEAN Federation of

... responsible for their normal testicular development[8]. On the other hand, many other explanations have been given to explain the normal testicular development, in complete absence of Y chromosome. Researchers suggested theories regarding autosomal or X linked mutations which could be responsible fo ...
4-Gonads
4-Gonads

... In menopausal women (ovarian failure), the main source of oestrogen is from peripheral adrenal conversion of androstenedione to oestrone¹. The major site for conversion is adipose tissue, explaining high levels of oestrone in post-menopausal women and also the uterine bleeding that occurs in such wo ...
< 1 ... 8 9 10 11 12 13 14 15 >

Kallmann syndrome



Kallmann syndrome is a genetic condition where the primary symptom is a failure to start puberty or a failure to fully complete it. It occurs in both males and females and has the additional symptoms of hypogonadism and almost invariably infertility. Kallmann syndrome also features the additional symptom of an altered sense of smell; either completely absent (anosmia) or highly reduced (hyposmia). Kallmann syndrome occurs when the hypothalamic neurons that are responsible for releasing gonadotropin-releasing hormone (GnRH neurons) fail to migrate into the hypothalamus during embryonic development. Kallmann syndrome is a part of a group of conditions that come under the term hypogonadotropic hypogonadism (HH). The sense of smell is only affected in approximately 50% of HH cases and these cases are termed Kallmann syndrome. Apart from the sense of smell there is no difference in the diagnosis or treatment of a case of HH or a case of Kallmann syndrome.The terminology used when describing cases of HH can vary. The term congenital hypogonadotropic hypogonadism (CHH) is now often used. Other terms used include idiopathic / isolated hypogonadotropic hypogonadism (IHH), normosmic hypogonadotropic hypogonadism (nHH) or hypothalamic hypogonadism. The term HH can be used to cover all cases, including Kallmann syndrome. The term isolated GnRH deficiency (IGD) has increasingly been used to describe these group of conditions as it highlights the primary cause of these conditions and to distinguish them from other conditions such as Klinefelter syndrome or Turner syndrome which share some similar symptoms but have a totally different etiology.The term hypogonadism describes a low level of circulating sex hormones; testosterone in males and oestrogen and progesterone in females. Hypogonadism can occur through a number of different methods. The use of the term hypogonadotropic relates to the fact that the hypogonadism found in HH is caused by a disruption in the production of the gonadotropin hormones normally released by the anterior pituitary gland known as luteinising hormone (LH) and follicle stimulating hormone (FSH).LH and FSH have a direct action on the ovaries in women and testes in men. The absence of LH and FSH means that initially puberty will not commence at the correct time and subsequently the ovaries and testes will not perform their normal fertility function with the maturation and release of eggs in woman and the production of sperm in men alongside their role in producing the sex hormones.The underlying cause of the failure in production of LH and FSH is the impairment of the hypothalamus to release the hormone GnRH which in normal circumstances induces the production of LH and FSH. Without the correct release of GnRH the pituitary gland is unable to release LH and FSH which in turn prevents the ovaries and testes from functioning correctly. This failure in GnRH production can either be due to the absence of the GnRH releasing neurones inside the hypothalamus or the inability of the hypothalamus to release GnRH in the correct pulsatile manner to ensure LH and FSH release from the pituitary.HH can occur as an isolated condition with just the LH and FSH production being affected or it can occur in combined pituitary deficiency conditions such as CHARGE syndrome.To date at least twenty five different genes have so far been implicated in causing Kallmann syndrome or other forms of HH through a disruption in the production or activity of GnRH. The genes involved cover all forms of inheritance and no one gene defect has been shown to be common to all cases which makes genetic testing and inheritance prediction very problematic.Kallmann syndrome was described in a paper published in 1944 by Franz Josef Kallmann, a German-American geneticist.The link between anosmia and hypogonadism had already been noted however, in particular by the Spanish doctor Aureliano Maestre de San Juan in 1856.The condition is sometimes known by his name in Spanish speaking countries.The condition has a low prevalence, estimated at 1 in 4,000 for male HH cases overall and 1:50,000 for Kallmann syndrome. It is three to five times more common in males than females. Though whether this is a true gender imbalance or a reflection on how difficult KS / HH is to diagnose correctly in males and females has yet to be fully established.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report