Epzicom Tablets
... a higher risk of abacavir hypersensitivity reactions; although, patients who do not carry the HLA-B*5701 allele have developed hypersensitivity reactions. Hypersensitivity to abacavir was reported in approximately 206 (8%) of 2,670 patients in 9 clinical trials with abacavir-containing products wher ...
... a higher risk of abacavir hypersensitivity reactions; although, patients who do not carry the HLA-B*5701 allele have developed hypersensitivity reactions. Hypersensitivity to abacavir was reported in approximately 206 (8%) of 2,670 patients in 9 clinical trials with abacavir-containing products wher ...
US Product Labeling @std Template for PLR
... Serious and sometimes fatal hypersensitivity reactions have occurred with ZIAGEN (abacavir). These hypersensitivity reactions have included multi-organ failure and anaphylaxis and typically occurred within the first 6 weeks of treatment with ZIAGEN (median time to onset was 9 days); although abacavi ...
... Serious and sometimes fatal hypersensitivity reactions have occurred with ZIAGEN (abacavir). These hypersensitivity reactions have included multi-organ failure and anaphylaxis and typically occurred within the first 6 weeks of treatment with ZIAGEN (median time to onset was 9 days); although abacavi ...
Handbook of Anti-Tuberculosis Agents
... important information as a comprehensive source of such data is lacking. Recognizing this need, the TB Alliance is developing a TB drug database as a resource for the TB drug research community. The materials published in this issue of Tuberculosis represent our initial effort towards this goal. In ...
... important information as a comprehensive source of such data is lacking. Recognizing this need, the TB Alliance is developing a TB drug database as a resource for the TB drug research community. The materials published in this issue of Tuberculosis represent our initial effort towards this goal. In ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... have been reported with the use of nucleoside analogs, including VIREAD, a component of TRUVADA, in combination with other antiretrovirals [see Warnings and Precautions (5.1)]. TRUVADA is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy of TRUVA ...
... have been reported with the use of nucleoside analogs, including VIREAD, a component of TRUVADA, in combination with other antiretrovirals [see Warnings and Precautions (5.1)]. TRUVADA is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy of TRUVA ...
Product Information - Therapeutic Goods Administration
... In Clinical Studies: Tenofovir disoproxil fumarate, emtricitabine and elvitegravir/cobicistat: In a pooled analysis of antiretroviral-naïve patients receiving STRIBILD in clinical trials GS-US236-0102 and GS-US-236-0103, genotyping was performed on plasma HIV-1 isolates from all patients with confir ...
... In Clinical Studies: Tenofovir disoproxil fumarate, emtricitabine and elvitegravir/cobicistat: In a pooled analysis of antiretroviral-naïve patients receiving STRIBILD in clinical trials GS-US236-0102 and GS-US-236-0103, genotyping was performed on plasma HIV-1 isolates from all patients with confir ...
BoNT_A Presentation UMass Dartmouth 081029
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
Truvada - Gilead Sciences, Inc.
... nucleoside analog HIV-1 reverse transcriptase inhibitors. TRUVADA is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 17 kg. (1) TRUVADA is indicated in combination with safer sex practices for pre-e ...
... nucleoside analog HIV-1 reverse transcriptase inhibitors. TRUVADA is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 17 kg. (1) TRUVADA is indicated in combination with safer sex practices for pre-e ...
PREZISTA® - Janssen
... and any of those antiretrovirals. Resistance in vitro In vitro selection of darunavir-resistant virus from wildtype HIV-1 was lengthy (>3 years). The selected viruses were unable to grow in the presence of darunavir concentrations above 400 nM. Viruses selected in these conditions and showing decrea ...
... and any of those antiretrovirals. Resistance in vitro In vitro selection of darunavir-resistant virus from wildtype HIV-1 was lengthy (>3 years). The selected viruses were unable to grow in the presence of darunavir concentrations above 400 nM. Viruses selected in these conditions and showing decrea ...
Accelerating antimalarial drug discovery through repositioning Holly
... the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due reference to the literature and acknowledgement of collaborative research and discussions. The conte ...
... the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due reference to the literature and acknowledgement of collaborative research and discussions. The conte ...
Tenofovir disoproxil fumarate / Emtricitabine
... Genotypic analysis of the resistant isolates showed the K65R mutation in the HIV-1 reverse transcriptase gene. Emtricitabine: Emtricitabine-resistant isolates of HIV have been selected in vitro. Genotypic analysis of these isolates showed that the reduced susceptibility to emtricitabine was associat ...
... Genotypic analysis of the resistant isolates showed the K65R mutation in the HIV-1 reverse transcriptase gene. Emtricitabine: Emtricitabine-resistant isolates of HIV have been selected in vitro. Genotypic analysis of these isolates showed that the reduced susceptibility to emtricitabine was associat ...
US Product Labeling @std Template for PLR
... exacerbations have been detected primarily by serum ALT elevations in addition to re-emergence of hepatitis B viral DNA (HBV DNA). Although most events appear to have been self-limited, fatalities have been reported in some cases. Similar events have been reported from post-marketing experience afte ...
... exacerbations have been detected primarily by serum ALT elevations in addition to re-emergence of hepatitis B viral DNA (HBV DNA). Although most events appear to have been self-limited, fatalities have been reported in some cases. Similar events have been reported from post-marketing experience afte ...
Final Program - International Society for Antiviral Research
... Please join us for an informal career discussion and networking at the 28th ICAR meeting. This year we will again host an excellent group of moderators who are recognized experts in various areas of antiviral research and have pursued successful career in academia, government, or industry. As a part ...
... Please join us for an informal career discussion and networking at the 28th ICAR meeting. This year we will again host an excellent group of moderators who are recognized experts in various areas of antiviral research and have pursued successful career in academia, government, or industry. As a part ...
Targeting proteases: successes, failures and future prospects
... thiol ligand or carboxylate) that binds to the zinc moiety in the enzyme’s active site; and they target only the S1, S1′ and S2′ subsites of ACE with high affinity (IC50 = 0.4–23 nM for the active metabolite). To achieve good oral bioavailability, most of the inhibitors (except captopril, lisinopril ...
... thiol ligand or carboxylate) that binds to the zinc moiety in the enzyme’s active site; and they target only the S1, S1′ and S2′ subsites of ACE with high affinity (IC50 = 0.4–23 nM for the active metabolite). To achieve good oral bioavailability, most of the inhibitors (except captopril, lisinopril ...
HAART - Forum for Collaborative HIV Research
... such as fasting and high-fat or high-protein meals.1-2 Adherence is a central issue of concern in antiretroviral (AR) therapy, but a gold standard by which patients should be measured is lacking. This paper highlights relevant findings from an extensive, but not exhaustive review of peerreview journ ...
... such as fasting and high-fat or high-protein meals.1-2 Adherence is a central issue of concern in antiretroviral (AR) therapy, but a gold standard by which patients should be measured is lacking. This paper highlights relevant findings from an extensive, but not exhaustive review of peerreview journ ...
Charles University in Prague Faculty of Pharmacy in Hradec Králové
... pathway. Four general classes of glucuronides have been established, the O-, N-, S- and Cglucuronides. Sulphate conjugation occurs less frequently than glucuronidation. The main substrates involved in sulphatation are phenols but alcohols, amines and to a much lesser extent, thiols are also sulphate ...
... pathway. Four general classes of glucuronides have been established, the O-, N-, S- and Cglucuronides. Sulphate conjugation occurs less frequently than glucuronidation. The main substrates involved in sulphatation are phenols but alcohols, amines and to a much lesser extent, thiols are also sulphate ...
LIPOPHILICITY с METHODS OF DETERMINATION AND ITS ROLE
... Up to now, a great number of QSAR models have been published, the majority of which include lipophilicity as described by octanolñwater partition coeficient. Lipophilicity is thus one of the most important factors in research aimed at rational design of new drugs, what is of great and still growing ...
... Up to now, a great number of QSAR models have been published, the majority of which include lipophilicity as described by octanolñwater partition coeficient. Lipophilicity is thus one of the most important factors in research aimed at rational design of new drugs, what is of great and still growing ...
Triumeq - ViiV Healthcare
... other abacavir-containing product because more severe symptoms can occur within hours and may include life-threatening hypotension and death. When therapy with TRIUMEQ has been discontinued for reasons other than symptoms of a hypersensitivity reaction, and if reinitiation of TRIUMEQ or any other ab ...
... other abacavir-containing product because more severe symptoms can occur within hours and may include life-threatening hypotension and death. When therapy with TRIUMEQ has been discontinued for reasons other than symptoms of a hypersensitivity reaction, and if reinitiation of TRIUMEQ or any other ab ...
EMBL-EBI Powerpoint Presentation - European Bioinformatics Institute
... • A small molecule is defined as a low molecular weight organic compound. • Most drugs are small molecules to allow passage over cell membranes and oral bioavailability. • They are also able to bind to proteins and enzymes, thereby altering function, which can lead to a therapeutic effect. • Small m ...
... • A small molecule is defined as a low molecular weight organic compound. • Most drugs are small molecules to allow passage over cell membranes and oral bioavailability. • They are also able to bind to proteins and enzymes, thereby altering function, which can lead to a therapeutic effect. • Small m ...
Complaint Filed in US District Court, Midland
... Commissioner of the United States Food and Drug Administration (“FDA”) (collectively, “Defendants” or “Government”), as follows: OVERVIEW Plaintiffs are state licensed pharmacies which, at all times, have been and remain in good standing with the Boards of Pharmacy of their respective states. This i ...
... Commissioner of the United States Food and Drug Administration (“FDA”) (collectively, “Defendants” or “Government”), as follows: OVERVIEW Plaintiffs are state licensed pharmacies which, at all times, have been and remain in good standing with the Boards of Pharmacy of their respective states. This i ...
assessment of the opiate properties of two constituents of a toxic
... The tail flick results (Fig. 2) confirmed the analgesic activity of MPPP, while revealing that MPTP has no analgesic effect and, in fact, causes a sensitization of the tail flick response. Higher doses of MPTP than that shown in Fig. 2 (40 PM/kg) did not lower the tail flick latency further and lowe ...
... The tail flick results (Fig. 2) confirmed the analgesic activity of MPPP, while revealing that MPTP has no analgesic effect and, in fact, causes a sensitization of the tail flick response. Higher doses of MPTP than that shown in Fig. 2 (40 PM/kg) did not lower the tail flick latency further and lowe ...
- Wiley Online Library
... partner antibiotic against b-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressu ...
... partner antibiotic against b-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressu ...
HIV Research Inventory
... MEDICATION TRIALS: Treatment experienced (history of Current or Past Use of Antiretroviral Therapy) Eligibility: Men and women > 18 years of age who are available for 148 weeks. Undetectable viral load, detectable HCV RNA and/or Hepatitis B positive. Treatment with antiretroviral therapy excluding R ...
... MEDICATION TRIALS: Treatment experienced (history of Current or Past Use of Antiretroviral Therapy) Eligibility: Men and women > 18 years of age who are available for 148 weeks. Undetectable viral load, detectable HCV RNA and/or Hepatitis B positive. Treatment with antiretroviral therapy excluding R ...
Asif, M., 2015. Pharmacological activities and
... the traditional use of these plants are discussed. Aegopodium podagraria showed only modest activity. Pure coumarins found in it, angelicin and apterin, failed to show any anti-inflammatory activity, and the total coumarin content was low, therefore the traditional use described in the literature as ...
... the traditional use of these plants are discussed. Aegopodium podagraria showed only modest activity. Pure coumarins found in it, angelicin and apterin, failed to show any anti-inflammatory activity, and the total coumarin content was low, therefore the traditional use described in the literature as ...
Gentamicin
... by a large number of gram-negative organisms. It usually is used in combination with a second agent, because an aminoglycoside alone may not be effective for infections outside the urinary tract. • Gentamicin is of the first choice when these infections occurs 1) urinary tract infections, bacteremia ...
... by a large number of gram-negative organisms. It usually is used in combination with a second agent, because an aminoglycoside alone may not be effective for infections outside the urinary tract. • Gentamicin is of the first choice when these infections occurs 1) urinary tract infections, bacteremia ...
Synopsis of Some Recent Tactical Application of Bioisosteres in
... for the mechanism-based HCV NS3 protease inhibitor telaprevir (12).39 The (S)-R-ketoamide in 12 readily racemizes at higher pH and, most notably, in human plasma to afford the(R)diastereomer, which exhibits 30-fold weaker biological activity (Figure 2). The (R)-diastereomer of 12 is the primary meta ...
... for the mechanism-based HCV NS3 protease inhibitor telaprevir (12).39 The (S)-R-ketoamide in 12 readily racemizes at higher pH and, most notably, in human plasma to afford the(R)diastereomer, which exhibits 30-fold weaker biological activity (Figure 2). The (R)-diastereomer of 12 is the primary meta ...
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development.Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).