Reactome Functional Interaction (FI) Network
... Experiment: Gene expression profiling of pancreatic tumour (vs normal tissue). Output: list of genes that show significant changes in expression. Downstream analysis: 1. Validation of the top genes sorted by fold-change (or p-value): artificial cut-off, information loss; 2. Manual reviewing and gene ...
... Experiment: Gene expression profiling of pancreatic tumour (vs normal tissue). Output: list of genes that show significant changes in expression. Downstream analysis: 1. Validation of the top genes sorted by fold-change (or p-value): artificial cut-off, information loss; 2. Manual reviewing and gene ...
Distribution and structural variation of the she pathogenicity island in
... A third putative virulence gene, pic, encoding a mucinase with haemagglutinin activity [7], is also carried on the PAI [1]. The complete nucleotide sequence and genetic organisation of the she PAI was determined recently and revealed that it has many of the features that are characteristic of PAIs f ...
... A third putative virulence gene, pic, encoding a mucinase with haemagglutinin activity [7], is also carried on the PAI [1]. The complete nucleotide sequence and genetic organisation of the she PAI was determined recently and revealed that it has many of the features that are characteristic of PAIs f ...
zChap07_140901 - Online Open Genetics
... previously mapped genes, and then calculating the recombination frequency. If the novel gene and the previously mapped genes show complete or partial linkage, the recombination frequency will indicate the approximate position of the novel gene within the genetic map. This information is useful in is ...
... previously mapped genes, and then calculating the recombination frequency. If the novel gene and the previously mapped genes show complete or partial linkage, the recombination frequency will indicate the approximate position of the novel gene within the genetic map. This information is useful in is ...
The novel Cer-like protein Caronte mediates the establishment of
... An important factor in this regard is Lefty-1, another transforming growth factor-b (TGF-b) family member, that has been proposed to act as a molecular midline barrier that would con®ne and prevent the `X' factor from diffusing from the left to the right side of the embryo12,13. Here we show that an ...
... An important factor in this regard is Lefty-1, another transforming growth factor-b (TGF-b) family member, that has been proposed to act as a molecular midline barrier that would con®ne and prevent the `X' factor from diffusing from the left to the right side of the embryo12,13. Here we show that an ...
MEIOSIS AND CROSSING OVER
... chromosomes as the original cells. Imagine if mitosis were the only means of cell division. IF the parent organism has 14 chromosomes, it would produce gametes that contained a complete set of 14 chromosomes The offspring would have cell nuclei with 28 chromosomes, and the next generation would have ...
... chromosomes as the original cells. Imagine if mitosis were the only means of cell division. IF the parent organism has 14 chromosomes, it would produce gametes that contained a complete set of 14 chromosomes The offspring would have cell nuclei with 28 chromosomes, and the next generation would have ...
... Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differenti ...
Experimental studies of deleterious mutation in Saccharomyces
... sexual reproduction. Outcrossing coupled with recombination would result in lower mortality because a fraction of progeny would be freed from an excessive burden of mutations [47]. Another consequence would be uncoupling of the few advantageous mutations from the majority of deleterious ones [66]. T ...
... sexual reproduction. Outcrossing coupled with recombination would result in lower mortality because a fraction of progeny would be freed from an excessive burden of mutations [47]. Another consequence would be uncoupling of the few advantageous mutations from the majority of deleterious ones [66]. T ...
Lack of expression of XIST from a small ring X chromosome
... ring (X) chromosome based on the loss of paternal alleles. (B) Sequencing of DNA amplified from the patient for the promoter of the XIST gene showed a base change as marked by the vertical arrow. A primer, PM2, was designed with a sequence change (G as shown in large arrow rather than A) that would ...
... ring (X) chromosome based on the loss of paternal alleles. (B) Sequencing of DNA amplified from the patient for the promoter of the XIST gene showed a base change as marked by the vertical arrow. A primer, PM2, was designed with a sequence change (G as shown in large arrow rather than A) that would ...
Meiosis - My CCSD
... Introduces greater genetic variation, allows genetic recombination. With exception of self-fertilizing organisms (e.g. some plants), zygote has gametes from two ...
... Introduces greater genetic variation, allows genetic recombination. With exception of self-fertilizing organisms (e.g. some plants), zygote has gametes from two ...
Molecular basis of the inflammatory response to adenovirus
... cytokines and chemokines and the recruitment of effector cells to the site of infection.8 These effector cells, which include neutrophils, monocytes/macrophages and natural killer cells in turn, limit the infection directly by killing infected cells or indirectly by secreting antiviral cytokines and ...
... cytokines and chemokines and the recruitment of effector cells to the site of infection.8 These effector cells, which include neutrophils, monocytes/macrophages and natural killer cells in turn, limit the infection directly by killing infected cells or indirectly by secreting antiviral cytokines and ...
Strains of Salmonella typhimurium and Other
... here categorized at the genus level as Salmonella, there is no consensus as to how frequently it should be subdivided, and the decision not to greatly subdivide the Escherichia group is no easier to justify than the decision to do so in Salmonella. CHARACTERISTICS OF STRAIN LT2 AND SOME OF ITS DERI ...
... here categorized at the genus level as Salmonella, there is no consensus as to how frequently it should be subdivided, and the decision not to greatly subdivide the Escherichia group is no easier to justify than the decision to do so in Salmonella. CHARACTERISTICS OF STRAIN LT2 AND SOME OF ITS DERI ...
Polygenic inheritance of fruit size in red pepper
... are expressions such as yield end maturity, with which plant and animal breeders are chiefly concerned.) Iiuismuch na the success of breeding depends largely on the inheritance of such characters, an understanding of polygenic actions would be invaluable guidance to breeders in choosing appropriate ...
... are expressions such as yield end maturity, with which plant and animal breeders are chiefly concerned.) Iiuismuch na the success of breeding depends largely on the inheritance of such characters, an understanding of polygenic actions would be invaluable guidance to breeders in choosing appropriate ...
Package `acde` - USTC Open Source Software Mirror
... Description This package provides a multivariate inferential analysis method for detecting differentially expressed genes in gene expression data. It uses artificial components, close to the data's principal components but with an exact interpretation in terms of differential genetic expression, to ...
... Description This package provides a multivariate inferential analysis method for detecting differentially expressed genes in gene expression data. It uses artificial components, close to the data's principal components but with an exact interpretation in terms of differential genetic expression, to ...
Wright, Sewall Evolution in Mendelian populations. Genetics, 16:97
... The rediscovery of Mendelian heredity in 1900 came as a direct consequence of DE VRIES' investigations. Major Mendelian differences were naturally the first to attract attention. It is not therefore surprising that the phenomena of Mendelian heredity were looked upon as confirming DE VRIES' theory. ...
... The rediscovery of Mendelian heredity in 1900 came as a direct consequence of DE VRIES' investigations. Major Mendelian differences were naturally the first to attract attention. It is not therefore surprising that the phenomena of Mendelian heredity were looked upon as confirming DE VRIES' theory. ...
The Genetic Control of Apomixis: Asexual Seed Formation
... loci have also been associated with heterochromatin and/or substantial repetitive sequences. In apomictic Pennisetum squamulatum, the apospory-specific genomic region (ASGR) is located at a heterochromatic and nonsynaptic telomeric region of a single chromosome (Akiyama et al. 2004). Chromosomes carr ...
... loci have also been associated with heterochromatin and/or substantial repetitive sequences. In apomictic Pennisetum squamulatum, the apospory-specific genomic region (ASGR) is located at a heterochromatic and nonsynaptic telomeric region of a single chromosome (Akiyama et al. 2004). Chromosomes carr ...
A disproportionate role for mtDNA in DobzhanskyMuller
... Dobzhansky–Muller (DM) model nicely accounts for the evolution of such incompatibilities. Although DM incompatibilities were originally conceived as resulting of interactions between nuclear genes, recent studies have documented cases where incompatibilities have arisen between nuclear and mitochond ...
... Dobzhansky–Muller (DM) model nicely accounts for the evolution of such incompatibilities. Although DM incompatibilities were originally conceived as resulting of interactions between nuclear genes, recent studies have documented cases where incompatibilities have arisen between nuclear and mitochond ...
New functions of the Drosophila rhomboid gene
... vein material or blisters, were recovered at high frequency (Fig. 2B-D). This is consistent with previous data suggesting that even low levels of ectopic rho expression during wing development generate excess vein phenotypes (Sturtevant et al., 1993). Some lines exhibited localized wing venation def ...
... vein material or blisters, were recovered at high frequency (Fig. 2B-D). This is consistent with previous data suggesting that even low levels of ectopic rho expression during wing development generate excess vein phenotypes (Sturtevant et al., 1993). Some lines exhibited localized wing venation def ...
Epigenetic mechanisms regulate placental c-myc
... most tumor tissues, involving a highly complex differential global gene expression profile varying with gestational age. The importance of this regulatory mechanism in placental development becomes clearer in the case of aberrant trophoblastic proliferation and invasion, resulting in various pregnanc ...
... most tumor tissues, involving a highly complex differential global gene expression profile varying with gestational age. The importance of this regulatory mechanism in placental development becomes clearer in the case of aberrant trophoblastic proliferation and invasion, resulting in various pregnanc ...
Integration of QTL Information with Traditional Animal Breeding
... down LD is the process of recombination that rearranges haplotypes that exist within a parent in every generation (Figure 4). Figure 5 shows the effect of recombination on the decay of LD over generations. The rate of decay depends on the rate of recombination between the loci, i.e. on their genetic ...
... down LD is the process of recombination that rearranges haplotypes that exist within a parent in every generation (Figure 4). Figure 5 shows the effect of recombination on the decay of LD over generations. The rate of decay depends on the rate of recombination between the loci, i.e. on their genetic ...
worksheet
... between 90 and 120 days before being broken down and recycled by the body. There are more than 400 different types of anemia. These can be divided into three basic groups. Anemias caused by: ...
... between 90 and 120 days before being broken down and recycled by the body. There are more than 400 different types of anemia. These can be divided into three basic groups. Anemias caused by: ...
Ch 5 849 - Michigan State University
... If different subpopulations inhabit different macroenvironments, then these large environmental differences are likely to lead to differences in selection between subpopulations. In chapter 3 we stated that this situation is likely to lead to local adaptation and genetic differentiation at loci that ...
... If different subpopulations inhabit different macroenvironments, then these large environmental differences are likely to lead to differences in selection between subpopulations. In chapter 3 we stated that this situation is likely to lead to local adaptation and genetic differentiation at loci that ...
Methods for pattern discovery in unaligned biological sequences
... Pattern discovery in biological sequences is the problem of ®nding patterns that are overrepresented in a set of unaligned DNA or protein sequences of related biological function. Such patterns could correspond to regions of the sequences responsible for the function itself, and could be used later ...
... Pattern discovery in biological sequences is the problem of ®nding patterns that are overrepresented in a set of unaligned DNA or protein sequences of related biological function. Such patterns could correspond to regions of the sequences responsible for the function itself, and could be used later ...
Plants` Epigenetic Secrets
... There are three different types of DNA methylation in plants: CG, CHH (where H is any base except G), and CHG. In Arabidopsis, CG methylation is found on some genes, but primarily on repeat sequences that make up transposons, as well as other repeat sequences in the genome. CHH methylation is found ...
... There are three different types of DNA methylation in plants: CG, CHH (where H is any base except G), and CHG. In Arabidopsis, CG methylation is found on some genes, but primarily on repeat sequences that make up transposons, as well as other repeat sequences in the genome. CHH methylation is found ...
Transposable elements activity reveals punctuated
... the four considered parameters (1%DI, 5%DI, 1%NF, 5%NF) when studying recent speciation (Figure 3A, Table S7). On the contrary, it is the best one when considering older macroevolutionary events, such as the differentiation of the four Eutheria superorders (Figure 3B, Table S9). Hence, the divergenc ...
... the four considered parameters (1%DI, 5%DI, 1%NF, 5%NF) when studying recent speciation (Figure 3A, Table S7). On the contrary, it is the best one when considering older macroevolutionary events, such as the differentiation of the four Eutheria superorders (Figure 3B, Table S9). Hence, the divergenc ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse