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SI - Evolocus LLC
SI - Evolocus LLC

... mutants will survive and even can replace normal animals, otherwise they will be eliminated from population completely and irreversibly. The placement of laboratory mice into stressful semi-natural environment leads to the enhancement of viability of homozygous mutant females and, simultaneously, to ...
The Role of Genetic Diversity in Restoration Success for
The Role of Genetic Diversity in Restoration Success for

... Implications for Restoration Practice • How extensive are clones within locations? • How many different individuals are there at individual locations? • Is there any evidence for local adaptation within the Bay? – Are occurrences of Vallisneria genetically isolated or are levels of gene flow high e ...
chapter 15 chromosomal basis of inheritance
chapter 15 chromosomal basis of inheritance

... Linked genes – genes located on the same chromosome that tend to be inherited together. Genetic recombination – the production of offspring with new combinations of traits inherited from two parents. 2 types of offspring can be produced:  Parental types – offspring matching a parental phenotype.  ...
Chromosome Microarray (CMA) Pre-Test Patient
Chromosome Microarray (CMA) Pre-Test Patient

... told that your chromosomes were normal, but there may still be very small gains or losses that  were not found. A new enhanced test for looking at chromosomes is available and is called  chromosome microarray analysis.    What is Chromosome Microarray Analysis (CMA)?   CMA is an advance in technolog ...
Merry Christmas for Patients with Hemophilia B
Merry Christmas for Patients with Hemophilia B

... DNA virus from the parvovirus family. The vector was generated by replacing the coding sequence for the cap and rep genes of the virus with a liver-specific promoter and the FIX coding sequence. The vector was packaged in cells that express cap and rep from a different piece of DNA that does not ent ...
Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy

... Duchenne Muscular Dystrophy Facts  DMD affects mostly males at a rate of 1 in 3,500 births.  There are over 200 types of mutations that can cause any one of the forms of muscular dystrophy. ...
Slide 1
Slide 1

... A green pea sead (gg) is crossed with a hybrid yellow seed (Gg). What will be the genotypic and phenotypic ratios of the offspring? ...
AP Biology Chapter 15 Notes The Chromosomal - Pomp
AP Biology Chapter 15 Notes The Chromosomal - Pomp

... v. If  this  always  was  the  case,  no  non-­‐ parental  phenotypes  would  be  observed   vi. Both  of  the  non  parental  phenotypes  were   observed  which  suggests  that  body  color   and  wing  size  are  only  partially  linked ...
letter EJHG - HAL
letter EJHG - HAL

... systematic linkage screenings of the genome, Risch and Merinkangas argued that “the future of the genetics of complex diseases is likely to require large scale testing by association studies” 1. If linkage studies have low power to detect common variants with small odds ratios (OR), they are also do ...
Missense mutations in the PAX6 gene in aniridia.
Missense mutations in the PAX6 gene in aniridia.

... exon 8 of patient 3 and his affected mother but not in unaffected members of the immediate families or in more than 100 healthy control subjects. The SSCP pattern indicated a heterozygous mutation. Sequencing analyses revealed the following mutations on one allele in each patient; no other changes w ...
60Ch14DNAhistory2008..
60Ch14DNAhistory2008..

... “The Most Beautiful Experiment in Biology” ...
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... quickly, making an inducible response even more economical ...
New New Developments Gene Therapy
New New Developments Gene Therapy

... Gene therapy is a difficult and complex process which is currently in an early stage of development and is used in the treatment of a limited number of medical conditions. Protein therapy has been successful for many medical problems such as Pompe disease. Originally, the particular therapeutic prot ...
Schedule
Schedule

... Admittance to the Final Test To the final test are admitted students who collected all required credits and whose final average grade for the semester (arithmetic average of small test grades) is at least “C” (3 points) or higher. Credit for the course To successfully complete the course a student i ...
Inheritance [Repaired]
Inheritance [Repaired]

... There are 223 different ways: that’s over 8 million. So if you have a sister, there’s a one-in-8-million chance that the egg that grew into you contained the same set of chromosomes as the egg that grew into your sister; and another one-in-8-million chance that the sperm that fertilised your egg con ...
Last Update: 12/10/2016 How to do a quick check of student
Last Update: 12/10/2016 How to do a quick check of student

... biarmipes and D. elegans), even a single amino acid indel should be viewed with suspicion and defended with evidence (i.e. RNA-seq). Where there is no RNA-seq data, our annotation protocol calls for a model with minimal differences between the D. melanogaster gene product and that of the new species ...
Veritas myGenome Informed Consent Form
Veritas myGenome Informed Consent Form

... time. Genetic counseling is available to me to learn more about new developments in WGS, associations of genomic information with diseases or variants and how these changes may impact the understanding of my DNA, and whether further interpretation is desirable. 8. Medical Care. I understand that the ...
Missense mutations in the PAX6 gene in aniridia.
Missense mutations in the PAX6 gene in aniridia.

... exon 8 of patient 3 and his affected mother but not in unaffected members of the immediate families or in more than 100 healthy control subjects. The SSCP pattern indicated a heterozygous mutation. Sequencing analyses revealed the following mutations on one allele in each patient; no other changes w ...
The role of DNA damage in laminopathy progeroid syndromes
The role of DNA damage in laminopathy progeroid syndromes

... of dysmophic nuclei, without extending lifespan [22]. These findings argue strongly that processes other those promoting the formation of dysmorphic nuclei account for the aging phenotypes in laminopathy progerias and has led to a number of investigations into the causes and effects of the accumulat ...
Cells, Mitosis and Meiosis Lab
Cells, Mitosis and Meiosis Lab

... their identity as distinct chromosomes and becoming uncondensed chromatin again. Because of the plane of sectioning used to prepare this slide, you may only be able to see 2 cells. However, remember that 4 daughter cells have been produced from each original parent cell. Is the genetic material with ...
Chapter 14 Mendel and the Gene Idea
Chapter 14 Mendel and the Gene Idea

... with a dominant phenotype is a Het. or Homo.? • To determine whether an individual is a Het or Homo., cross the individual with a known homozygous recessive- Testcross. ...
coat and colour - The Dachshund Breed Council UK
coat and colour - The Dachshund Breed Council UK

... Dilutes (Blues and Isabellas) are also seldom seen in the UK, however some have recently been imported and a few people are trying to breed them. About 15-20+ years ago there were some Blues registered; however these were not (I believe) the steel blue seen in true dilutes. The Dilution gene “dd” is ...
lecture 14
lecture 14

... strands of DNA is proportional to % genetic base mismatches - Chromosome sequencing - Mitochondrial DNA sequencing ...
Cystic Fibrosis - Rady Children`s Hospital
Cystic Fibrosis - Rady Children`s Hospital

... If you think you or someone you know has CF, ask your doctor about your concerns. The staff of the Children’s Hospital and Health Center/University of California, San Diego Cystic Fibrosis Center can be reached at 858-966-6790. Call the Adult CF Program at 858-657-8628 for questions about adults wit ...
The Secret of DNA - University Writing
The Secret of DNA - University Writing

... Scientists now had a concrete substance to search for which described why children look like their parents. Furthermore, they knew where to begin looking--in the nucleus of the cell. The Transforming Principal In 1928, Frederick Griffith, Jr., an American biologist, worked with the bacterium pneumoc ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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