• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Ch09 Lecture-DNA and Its Role in Heredity
Ch09 Lecture-DNA and Its Role in Heredity

... on by mitosis but not to sexually produced offspring. Germ line mutations occur in germ line cells that give rise to gametes. A gamete passes a mutation on at fertilization. ...
Nature With Nurture - College Test bank
Nature With Nurture - College Test bank

... 26. Damien and Ricardo are 3- and 4-year-old brothers. They both spend a lot of time at home and have many interests in common. Much of what drives their developmental similarities is likely due to their A. shared environment. B. non-shared environment. C. both shared environment and non-shared envi ...
A candidate region for Asperger syndrome defined by two
A candidate region for Asperger syndrome defined by two

... Unknown function Unknown function (probably an alternative splicing product of DKFZP566H073) Inhibitor of the actin polymerisation. The function is not well understood. PFN1 is ubiquitously expressed in mouse while its homolog PFN2 is expressed at high level in brain only. Muscle-specific glycolytic ...
5` TTACGGGTCCAGTCATGCGA 3`
5` TTACGGGTCCAGTCATGCGA 3`

... 2 phenotypes ...
Nuclear Genes That Encode Mitochondrial Proteins
Nuclear Genes That Encode Mitochondrial Proteins

... several genes in this interval were involved in similar functions. A list of the genes identified is provided in Table 1. In addition, a number of genes that encode mitochondrially targeted proteins of yet unknown function were present (data not shown). Conservatively, we have identified 50 genes w ...
Transcription and Processing
Transcription and Processing

... Glyphosate is an herbicide used to kill weeds. It is the main component of a product made by the Monsanto Company called Roundup. Glyphosate kills plants by inhibiting an enzyme in the shikimate pathway called EPSPS. This herbicide is considered safe because animals do not have the shikimate pathway ...
Hereditary Cancer Genetic Testing for BRCA1
Hereditary Cancer Genetic Testing for BRCA1

... I confirm that the possible benefits, risks, limitations and costs of genetic testing for BRCA1 and BRCA2 have been explained to me. All my questions have been answered. I have read this consent form and will be given a copy for my records. My signature below indicates my willingness to have genetic ...
Identification of disease genes by whole genome
Identification of disease genes by whole genome

... Small, submicroscopic, genomic deletions and duplications (1 kb to 10 Mb) constitute up to 15% of all mutations underlying human monogenic diseases. Novel genomic technologies such as microarraybased comparative genomic hybridization (array CGH) allow the mapping of genomic copy number alterations a ...
File
File

... Surprisingly, Morgan observed a large number of wild-type (gray-normal) and double-mutant (black-vestigial) flies among the offspring. ...
Chapter 8: Foundations of Genetics
Chapter 8: Foundations of Genetics

... –Cells are removed from a region of the placenta termed the chorion –This procedure offer advantages over amniocentesis •Used earlier in pregnancy •Yields results faster –However, it increases the risk of miscarriage ...
bivarate2
bivarate2

... (e.g. mariatal status; religious upbringing, SES). ...
Genetics Practice Problems - juan-roldan
Genetics Practice Problems - juan-roldan

... 15) A female with unattached earlobes and a widows peak hairline and a male with attached earlobes and a widows peak hairline have a child. The child has attached earlobes and a non-widows peak hairline. What are the genotypes of the parents? A) EeWw and eeww B) EeWw and eeWw C) EEWW and eeww D) EEW ...
幻灯片 1 - Wiley
幻灯片 1 - Wiley

... IV. Further analysis of 2876 F2 mutant plants delimited the mutation gene to a region of 3.1 Mbp between markers SSLP1475 and NGA8. The number of recombination events linked to markers is marked. (b) Structure of the MED16 gene (At4g04920), the MED16 mutation site, and the insertion sites of the T-D ...
Chromosomes and Inheritance - 1 Chromosome Theory of
Chromosomes and Inheritance - 1 Chromosome Theory of

... Physical damage and chemical damage can induce mutations as well, and are used by researchers to study mutations When mutations involve chromosomes or numbers of chromosomes they are referred to as chromosomal mutations. Mutations involving single genes or nucleotides will be discussed in our sectio ...
Advances in cereal gene transfer Toshihiko Komari , Yukoh Hiei
Advances in cereal gene transfer Toshihiko Komari , Yukoh Hiei

... routinely for transformation of dicotyledonous plants. The advantageous features of Agrobacterium-mediated transformation include the transfer of pieces of DNA (T-DNA) with defined ends and with minimal rearrangement, the transfer of relatively large segments of DNA, the integration of small numbers ...
Lecture Presentation to accompany Principles of Life
Lecture Presentation to accompany Principles of Life

... Mutations occur by a variety of processes. Errors that are not corrected by repair systems are passed on to daughter cells. Mutations are of two types: Somatic mutations occur in somatic (body) cells—passed on by mitosis but not to sexually produced offspring. Germ line mutations occur in germ line ...
DNA helicase deficiencies associated with cancer
DNA helicase deficiencies associated with cancer

... from individuals with these disorders in each case show inherent genomic instability. Recent studies have demonstrated direct interactions between these RecQ helicases and human nuclear proteins required for several aspects of chromosome maintenance, including p53, BRCA1, topoisomerase III, replicat ...
Editing of a tRNA anticodon in marsupial
Editing of a tRNA anticodon in marsupial

... RNA editing is a process by which RNA is post-transciptionally changed such that new genetic information not encoded in the DNA is created. In mitochondria of protozoa RNA editing results in the insertion and deletion of undine residues (1) and thus extensive modifications of many mRNAs (2). In plan ...
Chapter 13 - UM Personal World Wide Web Server
Chapter 13 - UM Personal World Wide Web Server

... B.) Chromosomal duplication is an important source of genetic variation ...
PDF
PDF

... expressed and regulate one another in complex networks before gastrulation begins (Imai et al., 2006). To dissect the architecture of these networks at the level of protein-DNA interactions, we focused on 11 TF genes that play core roles in gene regulatory networks for endomesoderm specification: Br ...
Chapter 13 DARWIN`S THEORY OF EVOLUTION
Chapter 13 DARWIN`S THEORY OF EVOLUTION

... B.) Chromosomal duplication is an important source of genetic variation ...
(A) + RNA
(A) + RNA

... Most gene expression assays are based on the comparison of two or more samples and require uniform sampling conditions for this comparison to be valid. Many factors can contribute to variability in the analysis of samples, making the results difficult to reproduce between experiments: Sample degrada ...
Local gene density predicts the spatial position of genetic loci in the
Local gene density predicts the spatial position of genetic loci in the

... virtually unknown how recombination occurs in the context of chromosome organization in the cell nucleus. The neighborhood of certain chromosomes or genes could very well affect the probability of a reciprocal exchange, and it has been suggested that the respective genes are spatially close in the h ...
Brassica genome structure
Brassica genome structure

... •B genome, n=8, B. nigra •C genome, n=9, B. oleracea •Why is this important? •Arabidopsis is within Brassica family of 3500 species, many of which have significant agricultural importance. By studying this model organism and exploiting already sequenced genome, candidate genes can be identified with ...
Genes and MS
Genes and MS

... between levels of vitamin D, genes and MS. It could be one of many factors involved in someone developing the condition. Gene therapy In some health conditions, only one gene is responsible. It might be possible to alter this gene and prevent or cure the condition - 'gene therapy'. This is not the c ...
< 1 ... 437 438 439 440 441 442 443 444 445 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report