• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Lecture 11: Reproduction III
Lecture 11: Reproduction III

... addition rules to predict the outcome of crosses involving multiple characters • A dihybrid or other multi-character cross is equivalent to two or more independent monohybrid crosses occurring simultaneously • In calculating the chances for various genotypes, each character is considered separately, ...
11.3 Notes
11.3 Notes

... copy of each chromosome One allele of each gene Different combinations of alleles for different genes along the chromosome ...
Document
Document

... outcome for two traits. • What results if an Angus bull that is homozygous black and polled (BBPP) is bred with a red shorthorn cow which is homozygous red and horned (bbpp). • The bull BBPP can be simplified to BP (black & polled is the only possible contribution for the bull). • The cow bbpp can b ...
The Mammalian Mismatch Repair Pathway Removes DNA 8
The Mammalian Mismatch Repair Pathway Removes DNA 8

... status also influenced the amount of DNA 8-oxoG introduced by exposure to an oxidizing agent (Figure 1B). Following treatment of wild-type cells with 10 or 20 mM H2O2, the level of 8-oxoG increased to 1.7 and 3.3 per 106 guanines, respectively. By comparison, the same treatment produced 3-fold more ...
Molecular analysis of putative genetic factors affecting BSE
Molecular analysis of putative genetic factors affecting BSE

... contemporaries from the farm from which cases were obtained. Inheritance of alleles from the sire was tested for transmission distortion between affected and control progeny within the families. Analyse of data from the affected group alone revealed over 30 loci with transmission distortion. When da ...
Dankesrede von Prof. Dr. Charles Dinarello anlässlich der
Dankesrede von Prof. Dr. Charles Dinarello anlässlich der

... only a few nanograms per kilogram of this protein were needed to cause a fever. A few nanograms is one-milliard of a gram. So endogenous pyrogen appeared to be an incredibly potent molecule, far more potent than any hormone. Of course, typical of scientists, many were skeptical and some criticized o ...
Example 13.2
Example 13.2

... ratio of 9 red-eyed, straight-wing (x):3 red-eyed, curly wing (y):3 white-eyed, straight (z):l white-eyed, curly (w) offspring. In order to test their hypothesis about the distribution of offspring, the biologists mate the fruit flies. Of 200 offspring, 101 had red eyes and straight wings, 42 had re ...
Defective sister-chromatid cohesion, aneuploidy
Defective sister-chromatid cohesion, aneuploidy

... a mouse model carrying a mutant Recql4 allele that lacks an intact RecQ helicase domain. We replaced a 1075 bp fragment spanning from within exon 9 through exon 13 of the Recql4 gene and encoding the conserved helicase domain (35), with a PGKHprt mini-gene (Fig. 1A). Heterozygous mice carrying the R ...
Ch13Exampl13_2
Ch13Exampl13_2

... gene will have straight wings. So based on this Punnett square, the biologists predict a ratio of 9 red-eyed, straight-wing (x):3 red-eyed, curly wing (y):3 white-eyed, straight (z):l white-eyed, curly (w) offspring. In order to test their hypothesis about the distribution of offspring, the biologis ...
Nucleotide sequence changes in the MSX1 and IRF6 genes in
Nucleotide sequence changes in the MSX1 and IRF6 genes in

... (MIM 607199; length: 18,217 bp; coding part: 9 exons; product: 297 amino acids protein, which is a member of the interferon regulatory transcription factor (IRF) family and is involved in palate formation) being responsible for VWS and popliteal pterygium (PPS; MIM 119500), another syndrome includin ...
What makes us human?
What makes us human?

... • One X chromosome may have an allele for orange spots and the other may have an allele for black spots. • In cells in some parts of the body, one X chromosome is switched off. In other parts of the body, the other X chromosome is switched off. ...
Haemochromatosis gene mutations and risk of coronary
Haemochromatosis gene mutations and risk of coronary

... The lack of association between HFE mutations and CAD may indicate that these genetic variants are not related to increased atherosclerosis. Similar conclusions were reached by Franco et al20 who did not detect any excess frequency of HFE mutations in a group of younger patients ( < 50 years old) wi ...
Spontaneous mutagenesis in exponentially growing and sta
Spontaneous mutagenesis in exponentially growing and sta

... changes in spontaneous mutagenesis in replicating bacteria. It has also been shown that mutations in dnaE modify the level of spontaneous mutations in stationary-phase cultures. Foster and coworkers (1995) have shown that dnaE915, an antimutator allele of dnaE, causes a 3-fold decrease in adaptive L ...
Chapter 13 Guided Notes - Meiosis and Life Cycles
Chapter 13 Guided Notes - Meiosis and Life Cycles

... ○ The four daughter cells at the end of meiosis have only _____________________ as many chromosomes as the original parent cell. ...
Genetics Project
Genetics Project

... 1. What is the structure of DNA? How does the structure allow the DNA to be replicated easily? 2. What are the base-pairing rules for DNA? a. Explain how the base-pairing rules allow DNA to make two exact copies of itself. 3. Explain the role that enzymes play in replication. 4. What is a mutation? ...
11转基因鼠的产生
11转基因鼠的产生

... embryonic stem (ES) cells (胚胎干细胞囊胚注射) ...
Evolution of RH Genes in Hominoids: Characterization of a Gorilla
Evolution of RH Genes in Hominoids: Characterization of a Gorilla

... and RhcE polypeptides were 29 and 25, respectively ( Table 2). Differences between gorilla RHCE-like polypeptide and two other gorilla Rh-like polypeptides were almost identical (24 and 25, respectively) ( Table 2). The topology of the phylogenetic tree obtained from the alignment shown in Figure 4 ...
SERK and APOSTART. Candidate Genes for
SERK and APOSTART. Candidate Genes for

... mosome numbers (x 5 7, 2n 5 28–147; Speckmann and van Dijk, 1972). Despite the difficulties mapping such complex systems might present, their highly flexible reproductive mode should permit genotypes recombinant for features of apomixis to be isolated (Matzk et al., 2005). Such recombinants should p ...
Effects of cis and trans Genetic Ancestry on Gene Expression in
Effects of cis and trans Genetic Ancestry on Gene Expression in

... analyze gene expression levels in African American cell lines, which differ from previously analyzed cell lines in that individuals from this population inherit variable proportions of two continental ancestries. We first relate gene expression levels in individual African Americans to their genome- ...
Coats and Genes - Oklahoma 4-H
Coats and Genes - Oklahoma 4-H

... 1. Divide students into pairs, and give each pair a coin and a copy of the “Dominant or Recessive?” worksheet. —Students will take turns flipping the coins—one to determine the mother’s traits and one to determine the father’s traits. —If the coin lands on heads, the student will circle the dominan ...
Human Heredity - Lyndhurst School
Human Heredity - Lyndhurst School

... of genetics, would you choose one that produced lots of offspring? How about one that was easy to grow in the lab? Would you select one with a short life span in order to do several crosses per month? How about all of the above? You certainly would not choose an organism that produced very few offsp ...
Origin of New Genes: Evidence from Experimental
Origin of New Genes: Evidence from Experimental

... an evolutionary birth and death process for coding portions in genomes. New genes arise at various points in evolutionary time; they confer novel functions on organisms enabling them to confront the challenges of changing environments. Novel genes can be created by the juxtaposition of various preex ...
DATE:
DATE:

... 1. Which of the following is the correct order in sexual reproduction? A. meiosis, gamete, fertilization, embryo B. gamete, meiosis, fertilization, embryo C. fertilization, meiosis, gamete, embryo D. gamete, fertilization, meiosis, embryo 2. Mitosis is similar to meiosis II because A. in both proces ...
A Novel Human BTB-kelch Protein KLHL31, Strongly Expressed in
A Novel Human BTB-kelch Protein KLHL31, Strongly Expressed in

... protein-protein interaction domain that is found in many zinc finger transcription factors. BTB containing proteins play important roles in a variety of cellular functions including regulation of transcription, regulation of the cytoskeleton, protein ubiquitination, angiogenesis, and apoptosis. Here ...
Detection of Inherited Mutations for Breast and Ovarian
Detection of Inherited Mutations for Breast and Ovarian

... University of Washington ...
< 1 ... 315 316 317 318 319 320 321 322 323 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report