Supplementary Material (doc 28K)
... In the 5,344 non-CLL HCDR3 sequences from public-databases, TEIRESIAS discovered 1,106,692 patterns which were filtered down to 1,714, a reduction of 99.9%. This final set of patterns was smaller by 21.5% than the one in the CLL dataset although the number of sequences analyzed was almost twice as h ...
... In the 5,344 non-CLL HCDR3 sequences from public-databases, TEIRESIAS discovered 1,106,692 patterns which were filtered down to 1,714, a reduction of 99.9%. This final set of patterns was smaller by 21.5% than the one in the CLL dataset although the number of sequences analyzed was almost twice as h ...
proposal
... are 25 residue differences (over the 664 AA length of the human protein) (figure 1). The mouse has a two base pair insertion (counted as 2 differences) and a one base pair deletion compared to the human. Of the other amino acid changes about half result in replacements with similar amino acids. Of t ...
... are 25 residue differences (over the 664 AA length of the human protein) (figure 1). The mouse has a two base pair insertion (counted as 2 differences) and a one base pair deletion compared to the human. Of the other amino acid changes about half result in replacements with similar amino acids. Of t ...
File - Central Dogma of Molecular Biology
... • Begins at a site called the origin of replication. • Prokaryotes have one origin of replication. • Eukaryotes have hundreds of thousands of origins of replication. ...
... • Begins at a site called the origin of replication. • Prokaryotes have one origin of replication. • Eukaryotes have hundreds of thousands of origins of replication. ...
coexpression database for animal species by
... shown as the number of stars according to the following P-value thresholds: 1E-04 for one star, 1E-16 for two stars and 1E-32 for three stars (example: http://coxpresdb.jp/cgibin/coex list.cgi?gene=7535&sp=Hsa). Detail explanation for supportability is shown in the COXPRESdb help page [http://coxpre ...
... shown as the number of stars according to the following P-value thresholds: 1E-04 for one star, 1E-16 for two stars and 1E-32 for three stars (example: http://coxpresdb.jp/cgibin/coex list.cgi?gene=7535&sp=Hsa). Detail explanation for supportability is shown in the COXPRESdb help page [http://coxpre ...
Title CHROMOSOMAL ASSIGNMENT OF
... Recently, further development of sorting techniques using a dual-laser cell ...
... Recently, further development of sorting techniques using a dual-laser cell ...
Genetic polymorphisms of T-1131C APOA5 and ALOX5AP
... Frequencies of T-1131C APOA5 and ALOX5AP SG13S114 polymorphisms in IS subjects and controls study population. These differences could be explained by the sample size and the criteria for selection of patients. With traditional risk factors such as hypertension, diabetes, smoking and alcoholism, we ...
... Frequencies of T-1131C APOA5 and ALOX5AP SG13S114 polymorphisms in IS subjects and controls study population. These differences could be explained by the sample size and the criteria for selection of patients. With traditional risk factors such as hypertension, diabetes, smoking and alcoholism, we ...
PPT File
... – Traits are inherited as discrete units. – Organisms inherit two copies of each gene, one from each parent. – The two copies segregate during gamete formation. – The last two conclusions are called the law of segregation. purple ...
... – Traits are inherited as discrete units. – Organisms inherit two copies of each gene, one from each parent. – The two copies segregate during gamete formation. – The last two conclusions are called the law of segregation. purple ...
ppt - Chair of Computational Biology
... The input function fi() The input function describes the relative activation of the gene, which is between 0 (the gene is shut off) and 1 (the gene is maximally activated), given the transcription-factor (TF) concentrations y. We assume that binding of TFs to cis-regulatory sites on the DNA is in q ...
... The input function fi() The input function describes the relative activation of the gene, which is between 0 (the gene is shut off) and 1 (the gene is maximally activated), given the transcription-factor (TF) concentrations y. We assume that binding of TFs to cis-regulatory sites on the DNA is in q ...
Determining the cause of patchwork HBA1 and HBA2 genes
... the latter interestingly being a characteristic of the wildtype HBA2 IVSII sequence. The nucleotide at IVSII,55, however, remained wildtype HBA1. We therefore conclude that we have identified a variant allele of HBA1 in the heterozygous state in patient AP, whereby a short stretch of IVSII has been ...
... the latter interestingly being a characteristic of the wildtype HBA2 IVSII sequence. The nucleotide at IVSII,55, however, remained wildtype HBA1. We therefore conclude that we have identified a variant allele of HBA1 in the heterozygous state in patient AP, whereby a short stretch of IVSII has been ...
Opposite deletions/duplications of the X chromosome: two
... identical parental origin of the abnormal chromosomes led us to suspect that a common mechanism was responsible for the two reciprocal rearrangements. We postulate that inverted repeated sequences are located at the breakpoints allowing, at paternal meiosis, synapses and recombination between the sh ...
... identical parental origin of the abnormal chromosomes led us to suspect that a common mechanism was responsible for the two reciprocal rearrangements. We postulate that inverted repeated sequences are located at the breakpoints allowing, at paternal meiosis, synapses and recombination between the sh ...
Disrupting antibiotic resistance propagation by inhibiting
... events explain the reported low-frequency generation of greater than unit-length conjugative plasmids (44). Although CPR may not be the primary conjugative pathway, plasmids with relaxases capable of resolving CPR intermediates would be expected to have a selective advantage. Single-tyrosine relaxas ...
... events explain the reported low-frequency generation of greater than unit-length conjugative plasmids (44). Although CPR may not be the primary conjugative pathway, plasmids with relaxases capable of resolving CPR intermediates would be expected to have a selective advantage. Single-tyrosine relaxas ...
1 Combining Gene Expression with Marker Genotypes in Poultry
... In a number of cases traditional QTL studies have been supplemented with microarray data in an attempt to move from a functional QTL to the underlying gene(s) (Wayne & McIntyre 2002). Below, we outline a case study where detection of functional QTL was followed up by a gene expression analysis. In t ...
... In a number of cases traditional QTL studies have been supplemented with microarray data in an attempt to move from a functional QTL to the underlying gene(s) (Wayne & McIntyre 2002). Below, we outline a case study where detection of functional QTL was followed up by a gene expression analysis. In t ...
Cell-cycle control in Caenorhabditis elegans: how the worm
... separated by Gap phases. As in embryogenesis, the length of the interphase varies greatly between different cell types. Divisions frequently follow each other within 1 h, but some cells remain quiescent for 20 h, before dividing again two larval stages later (Sulston and Horvitz, 1977). At least som ...
... separated by Gap phases. As in embryogenesis, the length of the interphase varies greatly between different cell types. Divisions frequently follow each other within 1 h, but some cells remain quiescent for 20 h, before dividing again two larval stages later (Sulston and Horvitz, 1977). At least som ...
Genetics 184 - Ronin Genetics
... patroclinous XO male. This hypothesis was proved cytologically for both classes of exception. Somewhat later, Bridges (1921) demonstrated that nondisjunction was not unique to the X chromosomes but also occurred with the small fourth chromosome. The foregoing investigations by Morgan, Sturtevant, an ...
... patroclinous XO male. This hypothesis was proved cytologically for both classes of exception. Somewhat later, Bridges (1921) demonstrated that nondisjunction was not unique to the X chromosomes but also occurred with the small fourth chromosome. The foregoing investigations by Morgan, Sturtevant, an ...
Slide 1
... Let’s review mitosis = a form of nuclear division, whereby the chromosome number and genetic content in the organism remains the same in both parent and daughter cells. Meiosis = A form of nuclear division that results in the reduction of chromosome number by half (from diploid cell to a haploid ce ...
... Let’s review mitosis = a form of nuclear division, whereby the chromosome number and genetic content in the organism remains the same in both parent and daughter cells. Meiosis = A form of nuclear division that results in the reduction of chromosome number by half (from diploid cell to a haploid ce ...
nucleic acids 3115
... grow on the upper body and even cover the face, ears, nose, cheeks, forehead, even eyelids-much like a picture of a werewolf. This gene does not affect personality. In fact, there are pictures of a family in Europe that passed this gene on from generation to generation. They were regarded with great ...
... grow on the upper body and even cover the face, ears, nose, cheeks, forehead, even eyelids-much like a picture of a werewolf. This gene does not affect personality. In fact, there are pictures of a family in Europe that passed this gene on from generation to generation. They were regarded with great ...
Expression of the Mitochondrial ATPase6 Gene and Tfam in Down
... Furthermore, we have shown that decreased Tfam expression may cause nondisjunction because the required energy for spindle assembly has not been supplied. Therefore, our research suggests that mitochondrial dysfunction due to various extrinsic or intrinsic influences can induce aneuploidies such as ...
... Furthermore, we have shown that decreased Tfam expression may cause nondisjunction because the required energy for spindle assembly has not been supplied. Therefore, our research suggests that mitochondrial dysfunction due to various extrinsic or intrinsic influences can induce aneuploidies such as ...
ASIP 2016 Journal CME Programs JMD 2016 CME Program in
... The most consistent molecular finding in lower grade tumors is the high frequency of TERT promoter mutations and hypermethylation of the MGMT gene promoter. Lower grade gliomas cluster in three main molecular subgroups, which are more strongly associated with prognosis than traditional histology. Th ...
... The most consistent molecular finding in lower grade tumors is the high frequency of TERT promoter mutations and hypermethylation of the MGMT gene promoter. Lower grade gliomas cluster in three main molecular subgroups, which are more strongly associated with prognosis than traditional histology. Th ...
Developmental Psychobiology - Champagne Lab
... transmitted unequally from one parent or the other that contribute significantly to offspring development. This article shall review four major sources of such parentof-origin effects. Firstly, there is increasing evidence that genes inherited on the sex chromosomes including the nonpseudoautosomal ...
... transmitted unequally from one parent or the other that contribute significantly to offspring development. This article shall review four major sources of such parentof-origin effects. Firstly, there is increasing evidence that genes inherited on the sex chromosomes including the nonpseudoautosomal ...
Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting Open Access
... Figure 4 Allelic expression analysis of tammar PHLDA2. (A) The difference of genomic structure by the length polymorphism is described. The open boxes represent exonic regions. Each black arrow represents a single 31 bp repeat unit. The longer allele has two units as a tandem repeat while the shorte ...
... Figure 4 Allelic expression analysis of tammar PHLDA2. (A) The difference of genomic structure by the length polymorphism is described. The open boxes represent exonic regions. Each black arrow represents a single 31 bp repeat unit. The longer allele has two units as a tandem repeat while the shorte ...
EPB PHC 6000 EPIDEMIOLOGY FALL, 1997
... a) Statistical: Coefficient of the product term of 2 or more risk factors (e.g. extent to which the coefficient departs from a multiplicative model). b) Biological: Co-participation between 2 factors in the same causal mechanism to disease development (e.g. extent to which coefficient departs from a ...
... a) Statistical: Coefficient of the product term of 2 or more risk factors (e.g. extent to which the coefficient departs from a multiplicative model). b) Biological: Co-participation between 2 factors in the same causal mechanism to disease development (e.g. extent to which coefficient departs from a ...
File
... 2). No second copy of another allele to mask effects of another allele (all recessive alleles expressed) ...
... 2). No second copy of another allele to mask effects of another allele (all recessive alleles expressed) ...
ENHANCING GENETIC RESISTANCE TO SOYBEAN
... however, greater genotypic effects compared to environmental effects for soybean rust severity and sporulation across the five test environments, although genetic systems of severity and sporulation rate acted independently. Additive and additive × additive epistatic gene effects were the most commo ...
... however, greater genotypic effects compared to environmental effects for soybean rust severity and sporulation across the five test environments, although genetic systems of severity and sporulation rate acted independently. Additive and additive × additive epistatic gene effects were the most commo ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse