Adaptive value of sex in microbial pathogens
... that reside in the host’s reproductive system can also directly affect the reproductive potential of the host. Indeed, infection of the male genital tract can cause inflammation (as measured by increased leukocyte concentration in semen) leading to oxidative damage of the DNA within spermatozoa (Ait ...
... that reside in the host’s reproductive system can also directly affect the reproductive potential of the host. Indeed, infection of the male genital tract can cause inflammation (as measured by increased leukocyte concentration in semen) leading to oxidative damage of the DNA within spermatozoa (Ait ...
Molecular genetics of vascular malformations
... same mutation ŽCalvert et al., 1999.. On the other hand, a different mutation, Y897S, located in the same kinase domain, has been identified in a fourth family ŽCalvert et al., 1999.. As both TIE2 mutations are single amino acid substitutions, their effect on receptor function is not obvious. Theref ...
... same mutation ŽCalvert et al., 1999.. On the other hand, a different mutation, Y897S, located in the same kinase domain, has been identified in a fourth family ŽCalvert et al., 1999.. As both TIE2 mutations are single amino acid substitutions, their effect on receptor function is not obvious. Theref ...
Evolutionary Genomics of Fast Evolving Tunicates
... Interestingly, five Hox genes are missing in the Oikopleura, two of which (Hox7 and Hox8 belonging to the central group) are shared losses, thus indicating that these losses most likely took place at the base of tunicate lineage (Seo et al. 2004; Monteiro and Ferrier 2006). The biological factors un ...
... Interestingly, five Hox genes are missing in the Oikopleura, two of which (Hox7 and Hox8 belonging to the central group) are shared losses, thus indicating that these losses most likely took place at the base of tunicate lineage (Seo et al. 2004; Monteiro and Ferrier 2006). The biological factors un ...
What is a functional genetic polymorphism?
... genotype association study of class 2 or above polymorphisms may be more productive than a study of individual polymorphisms or genome-wide associations of polymorphisms of unknown function. Conversely, a strong association identified and replicated in genome-wide association studies would provide a ...
... genotype association study of class 2 or above polymorphisms may be more productive than a study of individual polymorphisms or genome-wide associations of polymorphisms of unknown function. Conversely, a strong association identified and replicated in genome-wide association studies would provide a ...
Document
... genomics to genetics in model organisms © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
... genomics to genetics in model organisms © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
Topic 10: « MODERN METHODS OF DNA DIAGNOSIS OF
... called DNA polymerase. This enzyme makes the complementary strand by finding the correct base through complementary base pairing, and bonding it onto the original strand. As DNA polymerases can only extend a DNA strand in a 5′ to 3′ direction, different mechanisms are used to copy the antiparallel str ...
... called DNA polymerase. This enzyme makes the complementary strand by finding the correct base through complementary base pairing, and bonding it onto the original strand. As DNA polymerases can only extend a DNA strand in a 5′ to 3′ direction, different mechanisms are used to copy the antiparallel str ...
Study protocol to investigate the environmental and genetic
... prevalence of AD in South East Asian populations, which are indeed scarce, especially in early childhood. The frequent clinical follow-ups including physical exams every three months, additional monthly telephone interviews, and evaluations of any skin eruptions by skilled clinicians will provide su ...
... prevalence of AD in South East Asian populations, which are indeed scarce, especially in early childhood. The frequent clinical follow-ups including physical exams every three months, additional monthly telephone interviews, and evaluations of any skin eruptions by skilled clinicians will provide su ...
Enlis Genome Research - Release Notes
... import tool will identify the regions of the genome that were successfully sequenced and those regions that were not. - Genome Import - Fix handling of a rare case where an insertion or deletion into a stop codon still creates a stop codon - Now characterized as SYNONYMOUS instead of FRAMESHIFT - Ge ...
... import tool will identify the regions of the genome that were successfully sequenced and those regions that were not. - Genome Import - Fix handling of a rare case where an insertion or deletion into a stop codon still creates a stop codon - Now characterized as SYNONYMOUS instead of FRAMESHIFT - Ge ...
Identification and quantification of mycotoxigenic fungi
... segment of DNA which can be referred to as a probe, is targeted to anneal with the piece of DNA of interest (the target). This is extended to equal the number of kb of the product to be amplified and to yield doubled DNA. The process is cycled approximately 40 times to give the desired quantity of D ...
... segment of DNA which can be referred to as a probe, is targeted to anneal with the piece of DNA of interest (the target). This is extended to equal the number of kb of the product to be amplified and to yield doubled DNA. The process is cycled approximately 40 times to give the desired quantity of D ...
The Chicken (Gallus gallus) Z Chromosome Contains at Least Three
... Birds have female heterogamety with Z and W sex chromosomes. These evolved from different autosomal precursor chromosomes than the mammalian X and Y. However, previous work has suggested that the pattern and process of sex chromosome evolution show many similarities across distantly related organism ...
... Birds have female heterogamety with Z and W sex chromosomes. These evolved from different autosomal precursor chromosomes than the mammalian X and Y. However, previous work has suggested that the pattern and process of sex chromosome evolution show many similarities across distantly related organism ...
Biochemical and Biophysical Research Communications
... using a Venn diagram (Fig. 3). Interestingly, as shown in Table 1, the changes in expression of many genes under one PCD condition appeared to be opposite to the other type of PCD. No gene was found to be commonly downregulated, while total five genes were up-regulated in both proteasome-mediated and ...
... using a Venn diagram (Fig. 3). Interestingly, as shown in Table 1, the changes in expression of many genes under one PCD condition appeared to be opposite to the other type of PCD. No gene was found to be commonly downregulated, while total five genes were up-regulated in both proteasome-mediated and ...
Genes for Cognitive Function: Developments on the X
... of the seven known MRX genes, two candidate MRX genes [isolated from X; autosome translocation breakpoints, indicated by an asterisk(*)], and four additional nonoverlapping intervals shown by corresponding MRX family linkage intervals. These data indicate that a minimum number of 11 (or 12 when incl ...
... of the seven known MRX genes, two candidate MRX genes [isolated from X; autosome translocation breakpoints, indicated by an asterisk(*)], and four additional nonoverlapping intervals shown by corresponding MRX family linkage intervals. These data indicate that a minimum number of 11 (or 12 when incl ...
Genetics, genomics, and fertility
... Coulson developed a method of DNA sequencing, that is, determining the sequence of the building blocks of DNA, referred to as nucleotides. A nucleotide consists of three components: a sugar molecule (deoxyribose in DNA), a phosphate group and a nitrogen-containing base. The nitrogenous bases include ...
... Coulson developed a method of DNA sequencing, that is, determining the sequence of the building blocks of DNA, referred to as nucleotides. A nucleotide consists of three components: a sugar molecule (deoxyribose in DNA), a phosphate group and a nitrogen-containing base. The nitrogenous bases include ...
as a PDF
... reenter the cycle, the amounts of cdc2 mRNA and protein increase (Lee et al., 1988; Furakawa et al., 1990; Welch and Wang, 1992). This form of regulation may have specific consequences for animal development because there is a positive To whom correspondence should be addressed. ...
... reenter the cycle, the amounts of cdc2 mRNA and protein increase (Lee et al., 1988; Furakawa et al., 1990; Welch and Wang, 1992). This form of regulation may have specific consequences for animal development because there is a positive To whom correspondence should be addressed. ...
Asthma: an inherited dysfunction of ... · . r
... can be transmitted in bone marrow transplants. AaosTt et al. [7] showed that positive skin tests to specific allergens can be transmitted from donors to recipients of allogenic bone marrow transplants as can asthma itself. The effect extended beyond one year, suggesting that proliferating cells from ...
... can be transmitted in bone marrow transplants. AaosTt et al. [7] showed that positive skin tests to specific allergens can be transmitted from donors to recipients of allogenic bone marrow transplants as can asthma itself. The effect extended beyond one year, suggesting that proliferating cells from ...
A systemic gene silencing method suitable for high throughput
... [17-20], indicating that they share a common and evolutionarily conserved mechanism that is likely to be present in all plants, including ferns. One striking feature of gene silencing is that the silencing effects are non-cell autonomous and spread to neighboring cells. For this reason, transient ex ...
... [17-20], indicating that they share a common and evolutionarily conserved mechanism that is likely to be present in all plants, including ferns. One striking feature of gene silencing is that the silencing effects are non-cell autonomous and spread to neighboring cells. For this reason, transient ex ...
cdc2a Expression in Arabidopsis 1s Linked with
... reenter the cycle, the amounts of cdc2 mRNA and protein increase (Lee et al., 1988; Furakawa et al., 1990; Welch and Wang, 1992). This form of regulation may have specific consequences for animal development because there is a positive To whom correspondence should be addressed. ...
... reenter the cycle, the amounts of cdc2 mRNA and protein increase (Lee et al., 1988; Furakawa et al., 1990; Welch and Wang, 1992). This form of regulation may have specific consequences for animal development because there is a positive To whom correspondence should be addressed. ...
Why Mitochondrial Genes are Most Often Found in Nuclei
... 1998). More to the point, an experimental system to study and quantify the transfer of sequences between mitochondrial and nuclear genomes in the yeast S. cerevisiae has been developed by Thorsness and Fox (1990, 1993). Thorsness and his collaborators have used this system to study a number of mutan ...
... 1998). More to the point, an experimental system to study and quantify the transfer of sequences between mitochondrial and nuclear genomes in the yeast S. cerevisiae has been developed by Thorsness and Fox (1990, 1993). Thorsness and his collaborators have used this system to study a number of mutan ...
This article was published in an Elsevier journal. The attached copy
... culture media was replaced with media containing 150 g/ml dluciferin (Xenogen, Alameda, CA). After incubation at 37 ◦ C for 10 min, the bioluminescent signals were quantified and recorded using an IVIS Imaging System (Xenogen) following the manufacturer’s instructions. The conditioned cell culture ...
... culture media was replaced with media containing 150 g/ml dluciferin (Xenogen, Alameda, CA). After incubation at 37 ◦ C for 10 min, the bioluminescent signals were quantified and recorded using an IVIS Imaging System (Xenogen) following the manufacturer’s instructions. The conditioned cell culture ...
Exploring the Mode-of-Action of Bioactive Compounds by Chemical
... and proteins affected, we applied both a hierarchical clustering and a factorgram method, which allows a gene or compound to be associated with more than one group. In particular, tamoxifen, a breast cancer therapeutic, was found to disrupt calcium homeostasis and phosphatidylserine (PS) was recogni ...
... and proteins affected, we applied both a hierarchical clustering and a factorgram method, which allows a gene or compound to be associated with more than one group. In particular, tamoxifen, a breast cancer therapeutic, was found to disrupt calcium homeostasis and phosphatidylserine (PS) was recogni ...
Chapter 1 Notes
... Concept 15.1 In 1902 Sutton noted the parallels between the behavior of chromosomes and the behavior of Mendel’s factors. Chromosomal theory of inheritance: genes have specific loci on chromosomes, and the chromosomes undergo segregation and independent ...
... Concept 15.1 In 1902 Sutton noted the parallels between the behavior of chromosomes and the behavior of Mendel’s factors. Chromosomal theory of inheritance: genes have specific loci on chromosomes, and the chromosomes undergo segregation and independent ...
Genet Mol Res, 13 - Funpec-RP
... Several population-based epidemiological studies in Japan have reported a prevalence of OPLL ranging from 1.5 to 2.4% (Okamoto and Yasuma, 1967; Izawa, 1980; Matsunaga and Sakou, 2011), although most of these studies were conducted over 30 years ago and were based on low-quality plain films. A Japan ...
... Several population-based epidemiological studies in Japan have reported a prevalence of OPLL ranging from 1.5 to 2.4% (Okamoto and Yasuma, 1967; Izawa, 1980; Matsunaga and Sakou, 2011), although most of these studies were conducted over 30 years ago and were based on low-quality plain films. A Japan ...
Introduction and Mendelian Analysis
... www.genomenewsnetwork.org A model organism is a species that has been widely studied, usually because it is easy to maintain and breed in a lab and/or has particular experimental advantages. Remember: processes are conserved!!!!! Model organisms are used to obtain information about other species – i ...
... www.genomenewsnetwork.org A model organism is a species that has been widely studied, usually because it is easy to maintain and breed in a lab and/or has particular experimental advantages. Remember: processes are conserved!!!!! Model organisms are used to obtain information about other species – i ...
transcription factor binding site
... ChIP–seq should allow for a small number of mismatches due to sequencing errors, SNPs and indels or the difference between the genome of interest and the reference genome. This is simpler than in RNA–seq, for example, in which large gaps corresponding to introns must be considered. Popular aligners ...
... ChIP–seq should allow for a small number of mismatches due to sequencing errors, SNPs and indels or the difference between the genome of interest and the reference genome. This is simpler than in RNA–seq, for example, in which large gaps corresponding to introns must be considered. Popular aligners ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse