Molecular studies of major depressive disorder
... psychomotor and emotional processes. As is the norm for aetiological studies into the majority of psychiatric phenotypes, particular focus has fallen on the interplay between genetic and environmental factors. There are, however, several epidemiological, clinical and molecular peculiarities associat ...
... psychomotor and emotional processes. As is the norm for aetiological studies into the majority of psychiatric phenotypes, particular focus has fallen on the interplay between genetic and environmental factors. There are, however, several epidemiological, clinical and molecular peculiarities associat ...
lactase persistence: evidence for selection
... allele (and surrounding DNA) to be passed on from one generation to the next. Evidence for this selective sweep can be seen as a large area of homozygosity in all lactase-persistent individuals. Because selection occurred recently, recombination has not had sufficient time to break up the linkage bl ...
... allele (and surrounding DNA) to be passed on from one generation to the next. Evidence for this selective sweep can be seen as a large area of homozygosity in all lactase-persistent individuals. Because selection occurred recently, recombination has not had sufficient time to break up the linkage bl ...
Regional DNA Hypermethylation at D17S5
... Our present data for renal cancers, together with our previous studies of colon (2) and brain tumors (1), establish that D17S5 hy permethylation is tightly coupled to 17p deletions and p53 gene mu tations in human cancers. Our results in renal cancer strongly suggest that this hypermethylation prece ...
... Our present data for renal cancers, together with our previous studies of colon (2) and brain tumors (1), establish that D17S5 hy permethylation is tightly coupled to 17p deletions and p53 gene mu tations in human cancers. Our results in renal cancer strongly suggest that this hypermethylation prece ...
Dairy cattle reproduction is a tightly regulated genetic process
... so-called “Omics” in various dairy cattle breeds. Omics refers to the highthroughput technologies such as microarrays or new sequencing technologies (NGS) used to explore the genome structure (genomics) and function (transcriptomics, proteomics, and metabolomics). Epigenetics studies also provide so ...
... so-called “Omics” in various dairy cattle breeds. Omics refers to the highthroughput technologies such as microarrays or new sequencing technologies (NGS) used to explore the genome structure (genomics) and function (transcriptomics, proteomics, and metabolomics). Epigenetics studies also provide so ...
Name - IISME Community Site
... controls run in every reaction. The positive control is to ensure the reaction is running properly. A common positive control to run in reverse transcriptase RT-PCR reactions is RNase P. This assays for the presence of the RNA transcript of the gene RNase P, a gene expressed in most cells throughout ...
... controls run in every reaction. The positive control is to ensure the reaction is running properly. A common positive control to run in reverse transcriptase RT-PCR reactions is RNase P. This assays for the presence of the RNA transcript of the gene RNase P, a gene expressed in most cells throughout ...
Chpt9_Transposition.doc
... instance, some retroviruses can integrate into a host genome to form endogenous retroviruses. Indeed, some viruses may be derived from natural transposable elements and vice versa. Since viruses move between individuals, at least some transposable elements can move between genomes (between individua ...
... instance, some retroviruses can integrate into a host genome to form endogenous retroviruses. Indeed, some viruses may be derived from natural transposable elements and vice versa. Since viruses move between individuals, at least some transposable elements can move between genomes (between individua ...
Male-Specific Diseases
... to a family history being a major risk factor, which may be responsible for an estimated 5-10% of all prostate cancers. ...
... to a family history being a major risk factor, which may be responsible for an estimated 5-10% of all prostate cancers. ...
On the monophyly of chromalveolates using a six
... molecular phylogenetics. Currently, there are five hypothesized major lineages or ‘supergroups’ of eukaryotes. One of these, the chromalveolates, represents a large fraction of protist and algal diversity. The chromalveolate hypothesis was originally based on similarities between the photosynthetic ...
... molecular phylogenetics. Currently, there are five hypothesized major lineages or ‘supergroups’ of eukaryotes. One of these, the chromalveolates, represents a large fraction of protist and algal diversity. The chromalveolate hypothesis was originally based on similarities between the photosynthetic ...
Test Review Genetics08-09
... heterozygous. Represented by an upper case letter 33. ______: the allele that is not expressed when the alleles are heterozygous. Represented by a lower case letter. To be expressed the cell must have 2 copies of the recessive allele 34. ______: the physical appearance of a trait in an organism 35. ...
... heterozygous. Represented by an upper case letter 33. ______: the allele that is not expressed when the alleles are heterozygous. Represented by a lower case letter. To be expressed the cell must have 2 copies of the recessive allele 34. ______: the physical appearance of a trait in an organism 35. ...
Van, C., Williams, J.S., Kunkel, T.A., and
... Spontaneous mutation rates were measured in SWR1 and swr1Δ strains harboring either wild type replicase genes or alleles that affect Pol α (pol1-L868M), Pol ε (pol2-M644G) or Pol δ (pol3-L612M). Forward mutation rates were determined at two loci, URA3 and CAN1, by monitoring the frequency of 5-FOA o ...
... Spontaneous mutation rates were measured in SWR1 and swr1Δ strains harboring either wild type replicase genes or alleles that affect Pol α (pol1-L868M), Pol ε (pol2-M644G) or Pol δ (pol3-L612M). Forward mutation rates were determined at two loci, URA3 and CAN1, by monitoring the frequency of 5-FOA o ...
On the Theoretical Role of "Genetic Coding" - Peter Godfrey
... I will argue for two set of claims. First, I claim that the concept of genetic coding does make a theoretical contribution to solving a specific, important problem about how cells work. So I disagree with those, like Kitcher, who see the concept of genetic coding as intended to bear no explanatory w ...
... I will argue for two set of claims. First, I claim that the concept of genetic coding does make a theoretical contribution to solving a specific, important problem about how cells work. So I disagree with those, like Kitcher, who see the concept of genetic coding as intended to bear no explanatory w ...
Cancer What is cancer? Properties of cancer cells Properties of
... gene, which is the archetype of the tumor suppressor genes, the p53 gene has some original features. In particular, more than 95 % of alterations in the p53 gene are point mutations that produce a mutant protein, which in all cases has lost its transactivational activity (see above). Nevertheless, t ...
... gene, which is the archetype of the tumor suppressor genes, the p53 gene has some original features. In particular, more than 95 % of alterations in the p53 gene are point mutations that produce a mutant protein, which in all cases has lost its transactivational activity (see above). Nevertheless, t ...
Gene Therapy, Genetics and Epigenetics in Child Neurology
... significant original results. Team 3 projects mainly rely on the identification of genes and genetic variants with WES that will be completed by functional experiments in mouse and zebrafish models, as well as cellular models. This team has access to unique resource of orphan diseases. Overall, the ...
... significant original results. Team 3 projects mainly rely on the identification of genes and genetic variants with WES that will be completed by functional experiments in mouse and zebrafish models, as well as cellular models. This team has access to unique resource of orphan diseases. Overall, the ...
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... (NRRL deposit no. B-l8292) was cloned as a 4.5 Kbp tose or glucose present in the cell. For example, in the BamHI to PstI fragment in the vector pTJ S260. Not all presence or absence of IPTG or lactose, a new protein the sequence of pTJS260 or of the 3' ?anking sequences band corresponding to the ma ...
... (NRRL deposit no. B-l8292) was cloned as a 4.5 Kbp tose or glucose present in the cell. For example, in the BamHI to PstI fragment in the vector pTJ S260. Not all presence or absence of IPTG or lactose, a new protein the sequence of pTJS260 or of the 3' ?anking sequences band corresponding to the ma ...
Genetically modified soybean
... crops.” Since amino acids are directly used in the genetic formation of proteins and fatty acids, this makes the soybean invaluable in oil production. The food industry wanted both an increase in soy oil per soybean and an alteration in the types of oils the soybean produced. Tom E. Clemente, from t ...
... crops.” Since amino acids are directly used in the genetic formation of proteins and fatty acids, this makes the soybean invaluable in oil production. The food industry wanted both an increase in soy oil per soybean and an alteration in the types of oils the soybean produced. Tom E. Clemente, from t ...
Genomic overview of serine proteases
... (Fig. 3A). In order to study the extent of each locus, we examined all identified genes on either side of each cluster, for sequence similarity with, or for the presence of, the characteristic trypsin domain of serine proteases. No other related genes could be found. The possibility still exists, how ...
... (Fig. 3A). In order to study the extent of each locus, we examined all identified genes on either side of each cluster, for sequence similarity with, or for the presence of, the characteristic trypsin domain of serine proteases. No other related genes could be found. The possibility still exists, how ...
Forces that change gene frequency
... b) Non-recurrent -- mutations that arise only once in the history of a lineage 2. Changes to gene (allele) frequencies are minimal: a) Non-recurrent mutations are of little consequence relative to changing gene (allele) frequencies; most non-recurrent are deleterious and usually outnumbered by gazil ...
... b) Non-recurrent -- mutations that arise only once in the history of a lineage 2. Changes to gene (allele) frequencies are minimal: a) Non-recurrent mutations are of little consequence relative to changing gene (allele) frequencies; most non-recurrent are deleterious and usually outnumbered by gazil ...
Microarrays
... 0.1 ng gDNA and 104 cfu/mL in a pure culture. Even though the authors reported reliable detection from binary and ternary mixtures, data on the relative sensitivity of the microarray have not been provided. Analysis of mock spiked PIF samples revealed sensitivity in the range of 1–10 cfu/25 g sample ...
... 0.1 ng gDNA and 104 cfu/mL in a pure culture. Even though the authors reported reliable detection from binary and ternary mixtures, data on the relative sensitivity of the microarray have not been provided. Analysis of mock spiked PIF samples revealed sensitivity in the range of 1–10 cfu/25 g sample ...
Mining medical data using multiple corpora
... biomedicine arise because there are many databases in this field (records, news) and most of the time, every database has its own vocabulary, which distorts the query even though the concept behind the term is well known. "The Metathesaurus is a database of information on concepts that appear in one ...
... biomedicine arise because there are many databases in this field (records, news) and most of the time, every database has its own vocabulary, which distorts the query even though the concept behind the term is well known. "The Metathesaurus is a database of information on concepts that appear in one ...
Future Dog Breeding for Genetic Soundness
... Molecular genetics creates options. Until recently available molecular diagnostic methods began to be used, there was little chance of eliminating all normal appearing carriers from a breeding program. This is because they could not be identified until affected offspring were produced. Genetic marke ...
... Molecular genetics creates options. Until recently available molecular diagnostic methods began to be used, there was little chance of eliminating all normal appearing carriers from a breeding program. This is because they could not be identified until affected offspring were produced. Genetic marke ...
Molecular evidence for the existence of additional members of the
... and nucleotide sequencing for identification is only useful when one species is expected (Goldenberger et al., 1997; Greisen et al., 1994). The presence of more than one species would necessitate lengthy cloning and sequencing procedures. Therefore, this approach cannot be applied to detect bacteria ...
... and nucleotide sequencing for identification is only useful when one species is expected (Goldenberger et al., 1997; Greisen et al., 1994). The presence of more than one species would necessitate lengthy cloning and sequencing procedures. Therefore, this approach cannot be applied to detect bacteria ...
Exam 2 (pdf - 65.57kb)
... Homologous chromosomes are a pair of chromosomes that carry the same gene loci. As the form of the gene at a particular locus may vary, homologous chromosomes do not necessarily have the same alleles, so alternative C is incorrect. Different forms of a gene are made after events such as base substit ...
... Homologous chromosomes are a pair of chromosomes that carry the same gene loci. As the form of the gene at a particular locus may vary, homologous chromosomes do not necessarily have the same alleles, so alternative C is incorrect. Different forms of a gene are made after events such as base substit ...
AzotoOxidativePhosphorylation
... Azotobacter vinelandii exhibits redundancy for two ATP synthase F1 sector subunits, alpha and beta. Avin19740 shows strong similarity (e-105) to the alpha subunit Avin52180. Avin19670 shows strong similarity (e-114 ) to the beta subunit Avin52160. Redundancy is seen for some F0 subunits, but with ...
... Azotobacter vinelandii exhibits redundancy for two ATP synthase F1 sector subunits, alpha and beta. Avin19740 shows strong similarity (e-105) to the alpha subunit Avin52180. Avin19670 shows strong similarity (e-114 ) to the beta subunit Avin52160. Redundancy is seen for some F0 subunits, but with ...
I. The Effect of Puromycin on the Duplication of DNA*
... [email protected] 4.—Suppression by puromycin of leucine-1-C―incor poration into HeLa protein. Replicate monolayer cultures in the logarithmic phase of growth, prepared as described under “Methods,―were overlaid with S ml. prewarmed BERM con taming puromycin at the indicated concentrations and 10 pg. ...
... [email protected] 4.—Suppression by puromycin of leucine-1-C―incor poration into HeLa protein. Replicate monolayer cultures in the logarithmic phase of growth, prepared as described under “Methods,―were overlaid with S ml. prewarmed BERM con taming puromycin at the indicated concentrations and 10 pg. ...
VI. CHROMOSOMAL BASIS OF INHERITANCE, cont
... o For example, AABBCC = very dark skin; aabbcc = very light skin. o Intensity based on units; in other words, AaBbCc and AABbcc individuals would have the same pigmentation ...
... o For example, AABBCC = very dark skin; aabbcc = very light skin. o Intensity based on units; in other words, AaBbCc and AABbcc individuals would have the same pigmentation ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse