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Title - The University of Liverpool Repository
Title - The University of Liverpool Repository

... (de Magalhaes et al. 2012). Indeed, dozens of studies have been performed in recent years in model organisms to assay compounds for longevity effects. The growing amount of data being generated increases the complexity of its analysis and the difficulty of placing findings in the context of previous ...
compEpiTools - Bioconductor
compEpiTools - Bioconductor

... GRanges objects, GRanges metadata, putative methylation sites and their associated absolute and relative methylation level. All these data types are highly relevant for epigenomics integrative analyses and can include but they are not limited to: base-resolution or low-resolution DNA methylation dat ...
Mendelian Genetics Lecture
Mendelian Genetics Lecture

... dominant, so when they are put together, they make a new blood type called AB. ...
Adaptive Evolution of Proteins Secreted during Sperm Maturation
Adaptive Evolution of Proteins Secreted during Sperm Maturation

... genes were differentially expressed across the epididymis (significant variation in gene expression among segments, with expression in 1 segment at least 4-fold greater than at least one other segment). These 4 groups of genes were defined solely from the Johnston et al. (2005) data. We use the term ...
The aquaporin-Z water channel gene of Escherichia co/i
The aquaporin-Z water channel gene of Escherichia co/i

... codon was investigated with SiteFinder, a computer program devised by Webb Miller and Kenneth Rudd. Possible extensive secondary structures of aqpZeco were explored with the RNA folding program mfold (Jaeger et al, 1989). Database searches for homologs of aqpZ, as well as of the surrounding genes yb ...
Evolution Acts on the Phenotype
Evolution Acts on the Phenotype

Plant derived medicines to treat cancer
Plant derived medicines to treat cancer

... to sequence all the messenger RNA within a plant, and thus sequence all the genes that are actually expressed. RNA-seq also allows tracking of the expression levels of each of those genes in different plant tissues. These patterns of expression can be used to identify genes that are likely to be inv ...
document
document

... non-null mutations, a valuable point to stress as we approach a post-genomic sequencing project era. Classical forward genetics will be as useful as ever for isolating such special alleles because genetic screens can select out relatively rare, but informative, mutations. Of course, rare alleles can ...
So you say you want extra credit…
So you say you want extra credit…

... 8. Gamete — male and female sex cells, sperm and eggs 9. Genetic recombination — major source of genetic variation among organisms caused by reassortment or crossing over during meiosis 10. Genetics — branch of biology that studies heredity 11. Genotype — combination of genes in an organism 12. Hapl ...
Leukaemia Section t(8;14)(q24;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(8;14)(q24;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... t(8;14)(q24;q11) G-banding - courtesy Charles Bangs and Leena Borkar, and R-banding (right) - courtesy Jacques Boyer. ...
Ans: A friar, from the Latin “frater” meaning brother, is a priest or a
Ans: A friar, from the Latin “frater” meaning brother, is a priest or a

... Alleles are variations of genes. Genes contain information about specific characteristic and can either be dominant or recessive. An alternative ...
The Body in Motion
The Body in Motion

... Infection cycle of an RNA tumor virus ...
Document
Document

... The enzymes required for lactose metabolism are shut off! Once the glucose is completely metabolized, the genes responsible for glucose metabolism are shut down. Then the genes for the enzymes involved in lactose metabolism are turned on. How does a cell turn on and off these genes? How does E. coli ...
CHAPTER 8 Applications of Recombinant DNA Technology
CHAPTER 8 Applications of Recombinant DNA Technology

... 2. Genetic screening experiments have identified genes controlling aspects of Drosophila sexual behavior. An example is fruitless (fru): a. In homozygotes, later steps of courtship (singing to copulation) are abnormal or absent. b. Sexual organs and sperm are normal in these males, but they are fun ...
Document
Document

... Rapid ID of yeasts by gene sequences • Domains 1 and 2 (D1/D2) of LSU rDNA •Easy to PCR (universal primers), sequence, align… •Short (400-650 bp) but variable enough to distinguish most of yeast species •Universally available database for all known yeast species Kurtzman and Robnett (1998) - ascomyc ...
Problems (pts.)
Problems (pts.)

... 9. ( pts.) R-spondin revisted. See pg 2 of data sheet for info taken from a paper entitled: Rspondin1 is essential in sex determination, skin differentiation and malignancy. Here is the abstract of the paper: R-spondins are a recently characterized small family of growth factors. Here we show that ...
Operons
Operons

... The co-repressor is the amino acid tryptophan. Thus, when tryptophan is abundant, the repressor is active and will bind to the Operator, preventing transcription of these genes. But if tryptophan levels fall, the repressor will lose its trp co-repressor and will fall off the Operator, and the genes ...
Genetic Analysis: the Terminology *
Genetic Analysis: the Terminology *

... If limbless phenotype, then nls phenotype does NOT depend on wild type gene product of xlb, so xlb is NOT downstream of nls. The epistasis result is consistent with xlb --------l nls xlb could also function in parallel to nls If ectopic limbs, then xlb phenotype does NOT depend on nls, thus nls is N ...
Genetics 101 - VHL Alliance
Genetics 101 - VHL Alliance

... Your body is made up of trillions of tiny cells. Almost every cell in your body has a nucleus, a sort of headquarters that contains all our genetic information, or DNA. DNA is packaged into structures called chromosomes. We have 23 chromosome pairs (for a total of 46 chromosomes) in each cell. Think ...
Solid Tumour Section Thyroid: Papillary carcinoma Atlas of Genetics and Cytogenetics
Solid Tumour Section Thyroid: Papillary carcinoma Atlas of Genetics and Cytogenetics

Chromosomal Basis of Inheritance
Chromosomal Basis of Inheritance

... us to see the relationship between Mendel’s laws and chromosome transmission – Mendel’s law of segregation can be explained by the homologous pairing and segregation of chromosomes during meiosis – Mendel’s law of independent assortment can be explained by the relative behavior of different (nonhomo ...
SUNLIBB Work Packages, Aims and Achievements
SUNLIBB Work Packages, Aims and Achievements

... Recently, deep transcriptome sequencing data (Illumina and 454 pyrosequencing) of Miscanthus sinensis have been released, which redirected our work to a bioinformatics focus using these datasets. OrthoMCL was used to create a multi-species ortholog database, using these RNA-seq data and the predicte ...
Duplication 8q12: confirmation of a novel recognizable
Duplication 8q12: confirmation of a novel recognizable

... that gene dosage of the CHD7 gene may have an effect on the regulated genes.23 To our knowledge, no information is available in the literature regarding pathological effects secondary to overexpression of the CHD7 gene. However, loss of function of this gene leads to CHARGE syndrome24 possibly by dy ...
BIO II: Mendelian/Human Genetics Test Review Sheet A couple who
BIO II: Mendelian/Human Genetics Test Review Sheet A couple who

... 2. What is Pleiotropy? Give an example of a disease which fits this description. 3. What type of cell would you typically be able to find a Barr Body in? 4. What is a test-cross? Why is it used? 5. Give an example of polygenic inheritance. 6. Explain Mendel’s Law of Independent Assortment. How was t ...
Mendelian Genetics Test Review Sheet
Mendelian Genetics Test Review Sheet

... 2. What is Pleiotropy? Give an example of a disease which fits this description. 3. What type of cell would you typically be able to find a Barr Body in? 4. What is a test-cross? Why is it used? 5. Give an example of polygenic inheritance. 6. Explain Mendel’s Law of Independent Assortment. How was t ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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