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ª2010 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2010.06.022
ª2010 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2010.06.022

... selection. Ecological isolation and DM interaction can independently contribute to speciation. Among fully fledged species, the majority of genes identified as components of DM interactions are unrelated to adaptation [6]. An exception is the DM interaction between a nuclear gene AEP2 in Saccharomyc ...
Posterior uncertainty for rank data aggregation and a priori plans for
Posterior uncertainty for rank data aggregation and a priori plans for

... Prob ( member Nils likes movie A better than movie B? ) Prob ( for member Nils movie A will be among his top 5 preferences ?) MovieLens uses collaborative filtering to generate recommendations. It matches users with similar opinions about movies. Each user has a 'neighbourhood' of other like-minded ...
Chapter 15 final
Chapter 15 final

... (EG. Positive or negative blood factor, right or left handed, ear lobe shape, dimpled chin, hand clasp) ...
MIDDLE SCHOOL GENETICS
MIDDLE SCHOOL GENETICS

... Mendel crossed true breeding plants that had two distinct and contrasting traits, like purple and white flowers. After the first cross, the plants self-fertilized. ...
Social implications of gene therapy
Social implications of gene therapy

... changes. At present, however, such discussion is necessarily vague and speculative because the technology does not exist and may never be used. There will doubtless be continued public interest in ensuring fair and open debate on whether human germ line gene therapy would be appropriate. It is impos ...
TRPGR: Sequencing the barley gene-space
TRPGR: Sequencing the barley gene-space

... hybridize against the barley Morex BAC library to select clones that contain expressed sequences. Typically, EST sequencing only identifies up to 60% of the genes for a given genome because the transcription of many genes is highly regulated {Barbazuk, 2005 #25}. Genomic-based gene-targeted approach ...
Case Report Section
Case Report Section

MEIOSIS Notes
MEIOSIS Notes

... Why do we have meiosis? - to generate haploid gametes - to make new combinations of genes -How? random (independent) assortment ...
Genit 6
Genit 6

... have a mosaic type of this disease because cells are not the same; part of the active genes supposed to give certain enzyme are paternal & the other part is maternal so the products are not exactly the same. Another example is what we see in cats, in female cat you'll see the expression of hair colo ...
Genetic Analysis of RpL38 and RpL5, Two Minute Genes Located in
Genetic Analysis of RpL38 and RpL5, Two Minute Genes Located in

... location on the chromosome that is hard to correlate with a specific RP gene predicted from the physical, sequence-based genome. Furthermore, as deletions often remove many genes, some Minute deficiencies may uncover two or more RP genes located in close proximity, leading to an underestimation of t ...
UNIFR Rusconi 2002
UNIFR Rusconi 2002

... Excellent source of working hypotheses about functionally ...
Analyzing Text Structure
Analyzing Text Structure

... had “found the secret of life.” But James Watson and Francis Crick’s claim was a valid one, for they had in fact discovered the structure of DNA, the chemical that encodes instructions for building and replicating almost all living things. Watson and Crick’s discovery didn’t come out of the blue. ...
Sample Exam 1b answer key
Sample Exam 1b answer key

... First son: aaff – albino with attached ear lobes Probability that their next child will be a normally pigmented, free-lobed son? 3/4 x 3/4 x 1/2 = 9/32 4) A flower breeder is working with lines in which flower color is controlled by two separate genes. Plants having the genotypes (A/-, b/b) or (a/a, ...
Poster Abstracts - Ecological Genomics Institute
Poster Abstracts - Ecological Genomics Institute

... of these organisms are very similar showing only a small increase in the number of genes as morphological complexity increases, the number of histones genes is reduced as morphological complexity increases. Compared to Chlamydomonas reinhardtii, unicellular, and Gonium pectorale, colonial multicellu ...
making sense out of all the genetic defect buzz
making sense out of all the genetic defect buzz

... have hidden in populations for centuries before selection and or circumstances bring their effects to bear.  Often by that  time the defect has spread to so many lines and individuals its effects on breeding populations are substantial.     Let’s go over the list of some high profile defects with so ...
Genotypes to Phenotypes
Genotypes to Phenotypes

... D.) cigarette smoking ...
ppt - University of Illinois at Urbana
ppt - University of Illinois at Urbana

... • Step 1: 1 6 2 3 4 5 • Step 2: 1 2 6 3 4 5 • Step 3: 1 2 3 6 4 5 ...
Read the article
Read the article

... The following are just a few simple examples of methods to identify the genetic information behind a trait. There are several more techniques already available and more will come since this research area is expanding rapidly. The traits an organism exhibit can be described as the response of the gen ...
Rapid Evolution and Gene-Specific Patterns of
Rapid Evolution and Gene-Specific Patterns of

... with larger numbers of nonsynonymous to synonymous differences between species than polymorphisms. Although this could be interpreted as evidence for positive selection at all three genes, formal tests of selection do not support such a conclusion. Departures from neutrality were detected only for d ...
Glycosylphosphatidyl inositol-anchored protein (GPI
Glycosylphosphatidyl inositol-anchored protein (GPI

... amplification with oligonucleotide primers specific for the constitutively expressed gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and data were normalized with respect to this value. All PCR reactions were performed using LightCycler-FastStart DNA Master SYBR Green I kit (Roche Molecular Bi ...
Multiple Regulatory Roles for SELF
Multiple Regulatory Roles for SELF

... (SP) gene and claim that (1) SP is expressed in all nongrowing axillary meristems, not only sympodial meristems, and (2) SP is not expressed at all in all major organ primordia, contrary to what we published (Pnueli et al., 1998). Based solely on this evidence and a selected subset of the available ...
Identification of the equine herpesvirus type 1 glycoprotein 17/18 as
Identification of the equine herpesvirus type 1 glycoprotein 17/18 as

... gD was confirmed by sequence analysis of the DNA upstream of the gI and gE genes (Audonnet et al., 1990; Elton et al., 1991 b). The complete nucleotide sequence of the EHV-1 strain Abl gD homologue was obtained from both strands of the D N A by sequencing a 1602 bp Sinai to HindlII region from the U ...
Not-so-Simple Inheritance Patterns
Not-so-Simple Inheritance Patterns

... Polygenic Traits #13 &14 • Result of the interaction of several genes • Human skin, hair, and eye color – Influenced by more than one gene at different locations on the chromosomes ...
Ch. 7 (part 2)
Ch. 7 (part 2)

... You set up a panel of these hybrid cells that include a random selection of human chromosomes ...
Regulation of secondary metabolism in streptomycetes
Regulation of secondary metabolism in streptomycetes

... secondary metabolic gene clusters that they regulate (those for virginiamycin M and virginiamycin S [27]). Similarly, although initially recognized by their role in regulating Act and Red production, the corresponding genes of S. coelicolor, scbA and scbR, are adjacent to, and directly regulate, a ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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