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Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice

... alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transcription factors within a given cell type determines whether the predominant consequence will be transcription enhancement or repression for certain target genes (12). Because DP thymocytes ar ...
Advances in maize genomics: the emergence of positional cloning
Advances in maize genomics: the emergence of positional cloning

... maize and wheat identified quantitative trait loci (QTL). No doubt, this strategy was taken because QTL are defined by their position and are not amenable to transposon tagging. In each case, large numbers of individuals were used to define a small interval that contained the gene. Doebley and Stec ...
Genetic association between the PRKCH gene encoding protein
Genetic association between the PRKCH gene encoding protein

... 1,900 subjects by randomly assigning them to 2 independent subsets. The exploratory study consisted of 380 patients and 380 controls, while the validation study consisted of an independent sample set of 570 patients and 570 controls. There were no significant differences in any clinical parameter in ...
CHAPTER 14 DNA applications in society
CHAPTER 14 DNA applications in society

... However, the young Canadian boy was to cheat death on this occasion. He became the first person ever to receive an injection of insulin, a pancreatic hormone that regulates blood glucose levels. This injection reduced the boy’s blood and urinary glucose concentrations to normal levels and enabled hi ...
asdfs - Jefferson County Public Schools
asdfs - Jefferson County Public Schools

... by a _________________ letter. What phenotypic ratio would you expect to see in offspring from a monohybrid cross of 2 heterozygous parents? ...
Control of GL2 expression in Arabidopsis leaves and trichomes
Control of GL2 expression in Arabidopsis leaves and trichomes

... and 35S::R-GR background represents a nonspecific transcriptional activation, two additional GL2 reporter constructs were analyzed in that genetic background A. ...
Integrated analysis of whole-exome sequencing and transcriptome
Integrated analysis of whole-exome sequencing and transcriptome

... previous hypothesis which suggested that a large number of genes confer risk to ASD and reinforce the idea that much larger cohorts will be necessary to carry out this type of analyses [19]. The identification of new genes involved in ASD will eventually lead to the definition of common effects of g ...
Gene families and evolution of trehalose
Gene families and evolution of trehalose

... a sugar signal that modifies the developmental fate of axillary shoot meristems, or that it acts directly as a transcriptional regulator (Satoh-Nagasawa et al. 2006). This finding adds to the growing evidence that trehalose metabolism has an important function in plants, even in species that do not ac ...
Osteopetrosis, a Rare Cause for Bone Marrow Failure
Osteopetrosis, a Rare Cause for Bone Marrow Failure

... condition varies in presentation and severity ranging from neonatal onset with life threatening complications such as bone marrow failure to an incidental finding. The term Osteopetrosis is derived from Greek, osteo meaning bone and petros meaning stone. OP is also known as marble bone disease and A ...
Selenium - Medical Nutrition Therapy Manual
Selenium - Medical Nutrition Therapy Manual

... element are well absorbed. The usual forms absorbed are part of amino acids within proteins. The exact mechanisms of selenium transport are unclear and very debatable in the science and nutrition worlds. It is hypothesized that selenium enters red blood cells through diffusion and carried throughout ...
Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia
Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia

... Three issues must be considered when evaluating genotype-phenotype association studies in sickle cell anemia. First, most genotype-phenotype association studies have not integrated the numerous clinical and laboratory dimensions of the disease into a single measure of disease severity. By modeling t ...
Supplementary Information (doc 1628K)
Supplementary Information (doc 1628K)

... the RNeasy kit (Qiagen, Inc., Germantown, MD). Samples were analyzed using the Genechip primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the ...
1. The figure below represents a water molecule. H O H Water
1. The figure below represents a water molecule. H O H Water

... In your answer you should make clear how the steps in the process are sequenced. ...
The wbbD gene of E. coli strain VW187
The wbbD gene of E. coli strain VW187

... subunits is thought to occur at the cytosolic face of the plasma membrane (Whitfield and Valvano, 1993). Four additional sugars are subsequently added to the GlcNAc-PP-Und intermediate to complete the formation of the O7 subunits. These reactions are catalyzed by specific glycosyltransferases, which ...
Preneoplastic lesions of the lung
Preneoplastic lesions of the lung

... In contrast, we still have little information about the incidence of AAH or DIP/NECH in either smoking or nonsmoking populations. Autopsy studies of AAH are hampered by the presence of coincident pathology such as pneumonia, pneumonitis, or fibrosis, which make AAH almost impossible to find. Most st ...
Genes involved in ovulation rate and litter size in sheep
Genes involved in ovulation rate and litter size in sheep

... (FSH) and luteinizing hormone (LH). Both are gonadotrophins secreted by the anterior pituitary acting in the ovaries and stimulate ovulation (Sjaastad et al., 2003). The domesticated sheep, Ovis aries, has 54 chromosomes containing genetic material in the form of deoxyribonucleic acid (DNA). A locus ...
Pathway/Genome Navigator - Bioinformatics Research Group at SRI
Pathway/Genome Navigator - Bioinformatics Research Group at SRI

... EC number (1.3.1.26) Organism name (Escherichia coli) Frame ID (CPLX-8024) Links to other databases such as UniProt, GO, KEGG ids (O33998) An exact term using the format (Peptidase D search:exact) Limited term (hydrogen type:compound) ...
A Conserved Molecular Framework for Compound Leaf Development
A Conserved Molecular Framework for Compound Leaf Development

... sativum) RNA2. The TRV vectors were kindly provided by E. Kramer. VIGS was done as described for A. caerulea(9) and P. sativum (line NGB5839)(8). For S. lycopersicum, we vacuum infiltrated M82 10 days old plants as described for A. caerulea(9). Silencing of PDS is a good marker for VIGS because it g ...
HapTree-X: An integrative Bayesian framework for haplotype
HapTree-X: An integrative Bayesian framework for haplotype

... ∗∗ Corresponding author: [email protected] ...
Introduction
Introduction

... – BMP-15 mRNA and protein are not present until follicles have just begun to grow (the primary stage of development, type 2 follicle), and localized to oocytes of most, if not all, developing follicles – GDF-9 mRNA and protein can be identified in sheep oocytes during follicular formation, in primor ...
The Ubiquitous Nature of Epistasis in Determining Susceptibility to
The Ubiquitous Nature of Epistasis in Determining Susceptibility to

... the equilibrium allele frequency is very close to the mutation rate for that locus. Is it possible that compensatory mutations stabilize the phenotypes associated with rare Mendelian diseases? It was noted early on that the cystic fibrosis (CF) phenotype is not completely determined by mutations in ...
Physiology A Little Bit Extra Polydactyl cats have extra toes, often on
Physiology A Little Bit Extra Polydactyl cats have extra toes, often on

... and humans. In cats, all four feet are affected most of the time. the offspring will show polydactyly. "The polydactyly trait probably arose as a spontaneous mutation, and a polydactyl kitten from two normal-toed parents may represent a new mutation event," explains Dr. Pflueger. The gene for polyda ...
Hormone Autotrophic Growth and Differentiation
Hormone Autotrophic Growth and Differentiation

... cytokinin-overproducing line with only 5% of wild-type cytokinin oxidase activity was identified. These results indicate that screening for hormone-autonomous growth identifies mutants with altered hormone content or signaling. ...
1 Introduction
1 Introduction

... topoisomerase IIβ (Drake et al, 1987). DNA topoisomerase IIα is a 1531residue polypeptide, whereas DNA topoisomerase IIβ is 90 amino acids longer than the IIα-form (Austin et al, 1993). The alignment of the sequence of the IIα and IIβ isoform showed a strict homology of 86%, except in the region enc ...
credits - CiteSeerX
credits - CiteSeerX

... saw that many traits existed in either of two possible forms. A pea plant was either tall or short; its seeds were either yellow or green. Mendel studied seven different traits that appeared in the pea plants. Obviously, Mendel knew nothing of genes, chromosomes, or the processes of mitosis and meio ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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