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Question 1
Question 1

... uses the same 4 deoxyribonucleotides (dGTP, dATP, dTTP, and dCTP) that earth organisms use. You isolate the Martian DNA polymerase so you can study DNA replication in this organism. You use Martian DNA polymerase, a short DNA primer (5’ ACCCAG 3’) (DNA primers work as well as RNA primers) and the 4 ...
problem set
problem set

... The sequences in a pre-mRNA that dictate where splicing occurs are located at the exon/intron boundaries of the message (Fig. 8.7 below). These sequences are bound by the snRNA components of the snRNPs that make up spliceosomes (Fig. 8.9). Thus, the intron sequences ultimately tell the splicing mach ...
Phenotype and gene ontology enrichment as guides for
Phenotype and gene ontology enrichment as guides for

... is not offered on the same websites as GO enrichment testing, which requires users to test their data on different websites that may or may not use different methodologies to detect enrichment. Another way to use enrichment tools is for evolutionary comparison purposes. In molecular biology it is of ...
Restriction Enzymes
Restriction Enzymes

... of the phosphodiester bonds within both strands of DNA. • They require Mg+2 for activity and generate a 5 prime (5') phosphate and a 3 prime (3') hydroxyl group at the point of cleavage. ...
Hyper-eccentric structural genes in the mitochondrial genome of the
Hyper-eccentric structural genes in the mitochondrial genome of the

... Diplonemid mitochondria are considered to have very eccentric structural genes. Coding regions of individual diplonemid mitochondrial genes are fragmented into small pieces and found on different circular DNAs. Short RNAs transcribed from each DNA molecule mature through a unique RNA maturation proc ...
Wide Hybridization in Plant Breeding
Wide Hybridization in Plant Breeding

... If misdivision products of the two chromosomes (in essence, one arm from each chromosome) end up in the same cell (gamete? embryo?), they fuse to produce a centric (whole arm) translocation. ...
The connection between transcription and genomic instability
The connection between transcription and genomic instability

... One intriguing question in molecular biology is how DNA replication, repair and recombination can occur in a DNA substrate that simultaneously undergoes transcription. Thus, transcription will at times take place on a DNA segment that is simultaneously being replicated or contains lesions that need ...
Central Dogma of Molecular Biology Chapter 28 DNA Replication
Central Dogma of Molecular Biology Chapter 28 DNA Replication

... At least 15% of all genetic diseases have been associated with mutations that affect RNA splicing. Moreover, the same pre-mRNA can be spliced differently in various cell types, at different stages of development, or in response to other biological signals. (Alternative Splicing) In addition, individ ...
Obstructive sleep apnea syndrome (OSAS) in children with Class III
Obstructive sleep apnea syndrome (OSAS) in children with Class III

... consequently the protein activity. This study is of immense importance as it demonstrates for the first time that naturally occurring silent mutations can lead to the synthesis of a protein product with the same amino acid sequence but different structural and functional properties. In addition, Tom ...
Genomewide Association Studies and Human Disease
Genomewide Association Studies and Human Disease

... mutation, which in turn indicates the causative gene. Sequence motif: DNA sequences whose functions can be inferred because they are similar to sequences whose function has been biologically determined. Structural genomic variation: Variation within the genome that results from deletion or duplicati ...
Foundations of Biology - Geoscience Research Institute
Foundations of Biology - Geoscience Research Institute

... 2 LacY - Codes for a permease that lets lactose across the cell membrane 3 LacA - Transacetylase - An enzyme whose function in lactose metabolism is uncertain 4 Repressor - A protein that works with the control region to control expression of the operon ...
Document
Document

... •Rh factor is a protein called an antigen on RBC •An antigen is any substance that the body considers "foreign" and thus stimulates the body to produce antibodies against it. •Rh factor, like the blood types A, B, and O, is inherited from one's parents. •A simple blood test can determine blood type ...
Emmanuelle Génin, Josué Feingold, Françoise - HAL
Emmanuelle Génin, Josué Feingold, Françoise - HAL

... Before planning the search for genetic factors involved in any monogenic variability in disease expression, the role of familial factors must be shown by comparing the correlation of the phenotype of interest in related and unrelated patients. If genetic factors play a role, inter-family variabilit ...
BIOL100 Laboratory Assignment 5: Genetics Name: Part A: Genes
BIOL100 Laboratory Assignment 5: Genetics Name: Part A: Genes

... controlled by a single dominant gene.  There is PTC paper available at  your tables.  Touch a small piece of the paper to your tongue (it is  harmless); if you can taste PTC you will be able to taste a strong bitter  taste.  If you are unable to taste PTC you will not taste anything.   Approximately ...
Heredity - Githens Jaguars
Heredity - Githens Jaguars

... plant that produced round seeds. The stigma of the flower actually turns into seeds (peas). These seeds/peas are then planted in the ground to produce more pea plants. ...
introduction to genetics
introduction to genetics

...  Mendel’s principles  individual units, called genes, determine biological characteristics  For each gene, an organism receives one allele from each parent. ...
Editorial - Clinical Chemistry
Editorial - Clinical Chemistry

... their location on paired chromosomes, mitochondrial genes exist in numerous copies per cell, with each mitochondrion containing several copies of the genome and each cell containing many mitochondria. In the case of a nuclear gene, only a limited number of combinations of mutated genes are possible: ...
DNA
DNA

... C. Describe the process of DNA replication D. Describe the steps of translation and transcription in changing DNA into traits E. Describe the effect of DNA mutations and list genetic diseases that would result F. Debate the use of genetic technologies in ...
Abstract
Abstract

... values greater than 256 mg/L. Pseudomonas sp. FDM13 (AY464123), from the sewage lagoon, contained plasmid DNA, but was not capable of transforming E. coli strains INVF’ or XL10 Gold. No plasmid DNA was detected in the 16 isolates from the cattle farm and the Mississippi river. None of the chromoso ...
Inferring Ancestral Chloroplast Genomes with Inverted
Inferring Ancestral Chloroplast Genomes with Inverted

... Inference of ancestral genomes was mainly achieved at the DNA level, but limited to closely related ...
ppt
ppt

... V. DNA, RNA, and Chromosome Structure A. DNA and RNA Structure 1. monomers are “nucleotides” 2. polymerization occurs by ‘dehydration synthesis’ 3. most DNA exists as a ‘double-helix’ (ds-DNA) 4. RNA performs a wide variety of functions in living cells: a. m-RNA is a ‘copy’ of a gene, read by the r ...
A general method for gene isolation in tagging approaches
A general method for gene isolation in tagging approaches

Gene Prediction
Gene Prediction

... • Coding segments (exons) have typical sequences on either end and use different subwords than non-coding segments (introns). • E.g. for the bases around the transcription start site we may have the following observed frequencies (given by this position specific weight matrix (PSWM) ): Pos. -8 A ...
ppt
ppt

... Complex (non-Mendelian) diseases: Caused by the interaction between environmental factors and multiple genes with minor effects  Interactions between genes, Low heritability  Example: Heart disease, Type II diabetes, Cancer, Asthma  Tools: Association mapping, SNPs !! ...
Embryonic growth and the evolution of the mammalian Y
Embryonic growth and the evolution of the mammalian Y

... monogamous, a Y-linked sequence that can positively alter any of the above parameters could spread in a population even if it harms the prospects of other embryos. Such a selfish Y-linked gene could act as a sex ratio distorter. In contrast to autosomal imprinted loci, the patrilineal inheritance of ...
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Gene



A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.
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