ARTICLES - Weizmann Institute of Science
... to bend sharply, as required by the nucleosome structure. However, it is not known whether these sequence preferences have a significant influence on nucleosome position in vivo, and thus regulate the access of other proteins to DNA. Here we isolated nucleosome-bound sequences at high resolution fro ...
... to bend sharply, as required by the nucleosome structure. However, it is not known whether these sequence preferences have a significant influence on nucleosome position in vivo, and thus regulate the access of other proteins to DNA. Here we isolated nucleosome-bound sequences at high resolution fro ...
Two Waves of Nuclear Factor κB Recruitment to Target Promoters
... quence of the NF-B site in MIP-2 (a gene with immediate NF-B recruitment) is identical to the sequence of one of the two NF-B sites in MCP-1 (a gene with delayed NF-B recruitment). Overall, this suggests that the observed differences in the kinetic of NF-B recruitment to the genes under investi ...
... quence of the NF-B site in MIP-2 (a gene with immediate NF-B recruitment) is identical to the sequence of one of the two NF-B sites in MCP-1 (a gene with delayed NF-B recruitment). Overall, this suggests that the observed differences in the kinetic of NF-B recruitment to the genes under investi ...
Quantitative expression of cholera toxin mRNA in Vibrio cholerae
... with permission from John Wiley & Sons. ...
... with permission from John Wiley & Sons. ...
A gain of function mutation causing skeletal overgrowth in the
... Fig. 2. Cloning of rapunzelc14. (A) A meiotic map representing approximately 47 kb of the rapunzelc14 region on chromosome 16. The critical region contains three paralogous genes (rpz, rpz2 and rpz3). Two additional paralogues (rpz4 and rpz5) are also present on chromosome 16, outside of the critica ...
... Fig. 2. Cloning of rapunzelc14. (A) A meiotic map representing approximately 47 kb of the rapunzelc14 region on chromosome 16. The critical region contains three paralogous genes (rpz, rpz2 and rpz3). Two additional paralogues (rpz4 and rpz5) are also present on chromosome 16, outside of the critica ...
Rethinking heredity, again
... factors tend to induce particular changes in the DNA sequence. Environmental inheritance: the transmission from parents to offspring of variation in the ambient environment, such as a tendency to encounter particular chemicals or micro-organisms, or a tendency to develop at a particular range of tem ...
... factors tend to induce particular changes in the DNA sequence. Environmental inheritance: the transmission from parents to offspring of variation in the ambient environment, such as a tendency to encounter particular chemicals or micro-organisms, or a tendency to develop at a particular range of tem ...
PDF - 2.3 MB
... (c 12 pts.) Suppose that one of the T4 mutants (which can only grow on an E. coil strain carrying a UGA nonsense suppressor) was generated by a mutagen that causes transition mutations (CoG to T°A or ToA to COG). Using the genetic code (on the front of the exam) determine which codon(s) in wild type ...
... (c 12 pts.) Suppose that one of the T4 mutants (which can only grow on an E. coil strain carrying a UGA nonsense suppressor) was generated by a mutagen that causes transition mutations (CoG to T°A or ToA to COG). Using the genetic code (on the front of the exam) determine which codon(s) in wild type ...
Rather than test an unmapped gene successively for linkage to... groups, it is advantageous to test all linkage groups in... alcoy David Perkins
... FIGURE 1. Linkage relations in a cross of the linkage tester alcoy; csp-2 × Normal sequence. Chromosomes are shown paired as in meiotic prophase I. The alcoy; csp-2 chromosomes are drawn as heavy lines, and those from the standard-sequence parent are shown as thin lines. Segments from odd-numbered l ...
... FIGURE 1. Linkage relations in a cross of the linkage tester alcoy; csp-2 × Normal sequence. Chromosomes are shown paired as in meiotic prophase I. The alcoy; csp-2 chromosomes are drawn as heavy lines, and those from the standard-sequence parent are shown as thin lines. Segments from odd-numbered l ...
DYAD in meiotic chromosome organisation - Development
... A set of 7 SSLP and 9 CAPS (Konieczny and Ausubel, 1993) markers were developed based on the sequence of the genomic DNA for the region south of the nga129 marker on chromosome 5 where dyad maps. Details of markers are available on request. In the case of CAPS markers, primers were designed to PCR a ...
... A set of 7 SSLP and 9 CAPS (Konieczny and Ausubel, 1993) markers were developed based on the sequence of the genomic DNA for the region south of the nga129 marker on chromosome 5 where dyad maps. Details of markers are available on request. In the case of CAPS markers, primers were designed to PCR a ...
The Molecular Basis of Imidazolinone Herbicide Resistance in
... Somerville, 1986). The precursor of the mature enzyme contains a transit peptide at the N terminus and the mature enzyme is presumably located in plastids (Jones et al., 1985; Miflin, 1974). The first eukaryotic ALS gene was isolated from a herbicide-resistant yeast by screening plasmid DNA librarie ...
... Somerville, 1986). The precursor of the mature enzyme contains a transit peptide at the N terminus and the mature enzyme is presumably located in plastids (Jones et al., 1985; Miflin, 1974). The first eukaryotic ALS gene was isolated from a herbicide-resistant yeast by screening plasmid DNA librarie ...
Quick Quiz 1 - child-development-2011
... Rationale: The trait within an organism that is present but not expressed is known as the recessive trait. In this example, the blonde hair would be a recessive trait. 3.24 A trait within an organism that is present but not expressed is called the ___________ trait. a. dizygotic c. dominant b. monoz ...
... Rationale: The trait within an organism that is present but not expressed is known as the recessive trait. In this example, the blonde hair would be a recessive trait. 3.24 A trait within an organism that is present but not expressed is called the ___________ trait. a. dizygotic c. dominant b. monoz ...
Finding New Clock Components: Past and Future
... seen with the cryptochromeb mutation in Drosophila (Stanewsky et al., 1998) or with compound mutations of the mammalian visual system involving melanopsin (Hattar et al., 2003; Panda et al., 2003). Output mutations can produce overt arrhythmicity, but strong effects on period or phase should not occ ...
... seen with the cryptochromeb mutation in Drosophila (Stanewsky et al., 1998) or with compound mutations of the mammalian visual system involving melanopsin (Hattar et al., 2003; Panda et al., 2003). Output mutations can produce overt arrhythmicity, but strong effects on period or phase should not occ ...
htp Pseudomonas aeruginosa AMANDA SWANEPOEL
... opportunistic pathogen of humans, causing infections in immunocompromised patients such as those with cancer or AIDS and those suffering from cystic fibrosis and burns (Van Delden and Iglewski, 1998; Ramsey and Wozniak, 2005), but it has also been shown to infect plants and insects (Schroth et al., ...
... opportunistic pathogen of humans, causing infections in immunocompromised patients such as those with cancer or AIDS and those suffering from cystic fibrosis and burns (Van Delden and Iglewski, 1998; Ramsey and Wozniak, 2005), but it has also been shown to infect plants and insects (Schroth et al., ...
Noise in transcription negative feedback loops
... loop should be mainly owing to elimination of the fluctuations introduced by changes in the plasmid number. This would suggest that negative feedback loops do not suppress intrinsic noise, but rather eliminate external noise that might arise for example from plasmid variation, or other external sourc ...
... loop should be mainly owing to elimination of the fluctuations introduced by changes in the plasmid number. This would suggest that negative feedback loops do not suppress intrinsic noise, but rather eliminate external noise that might arise for example from plasmid variation, or other external sourc ...
Genetics - Brook Biology
... Multicellular organisms need a variety of cell types to perform specific functions for the organism; therefore, individual cells differentiate and become specialized in structure and function. • Differentiation happens due to selective gene expression – some genes are turned off, some are turned o ...
... Multicellular organisms need a variety of cell types to perform specific functions for the organism; therefore, individual cells differentiate and become specialized in structure and function. • Differentiation happens due to selective gene expression – some genes are turned off, some are turned o ...
Integration of omics data with biochemical reaction
... systems biology, which seeks the understanding of complex biological systems. Constraint-based modeling is one modeling formalism applied in systems biology, which relies on genome-scale network reconstructions. Metabolic reconstructions are increasingly used to understand normal cellular and diseas ...
... systems biology, which seeks the understanding of complex biological systems. Constraint-based modeling is one modeling formalism applied in systems biology, which relies on genome-scale network reconstructions. Metabolic reconstructions are increasingly used to understand normal cellular and diseas ...
An Agony in Five Fits (R
... makes fascinating reading today, and I cannot resist quoting him at some length: My dear Darwin, — I have been so repeatedly struck by the utter inability of numbers of intelligent persons to see clearly, or at all, the selfacting and necessary effects of Natural Selection, that I am led to conclude ...
... makes fascinating reading today, and I cannot resist quoting him at some length: My dear Darwin, — I have been so repeatedly struck by the utter inability of numbers of intelligent persons to see clearly, or at all, the selfacting and necessary effects of Natural Selection, that I am led to conclude ...
Rethinking heredity, again
... factors tend to induce particular changes in the DNA sequence. Environmental inheritance: the transmission from parents to offspring of variation in the ambient environment, such as a tendency to encounter particular chemicals or micro-organisms, or a tendency to develop at a particular range of tem ...
... factors tend to induce particular changes in the DNA sequence. Environmental inheritance: the transmission from parents to offspring of variation in the ambient environment, such as a tendency to encounter particular chemicals or micro-organisms, or a tendency to develop at a particular range of tem ...
Potential virulence and antimicrobial susceptibility of
... Aeromonas were also present in the strains of A. popo¤i tested (Table 3). All strains had the genes for DNases, GCAT and lipases and showed DNase and lipase activity. Although the role of DNases is unknown in Aeromonas pathogenicity, these genes are involved in Streptococcus infections [25], and are ...
... Aeromonas were also present in the strains of A. popo¤i tested (Table 3). All strains had the genes for DNases, GCAT and lipases and showed DNase and lipase activity. Although the role of DNases is unknown in Aeromonas pathogenicity, these genes are involved in Streptococcus infections [25], and are ...
A Novel Mouse Chromosome 17 Hybrid Sterility Locus
... 1991). The genotypes of all hybrid mice used in this study are described by a notation which takes the following form: X. [Y/Z]. The first letter, outside the brackets, is indicative of the genetic background of the animal. Letters inside the brackets, separated by a "/," symbolize the chromosome I7 ...
... 1991). The genotypes of all hybrid mice used in this study are described by a notation which takes the following form: X. [Y/Z]. The first letter, outside the brackets, is indicative of the genetic background of the animal. Letters inside the brackets, separated by a "/," symbolize the chromosome I7 ...
Familial Adenomatous Polyposis (FAP)
... Some people develop benign growths in their abdomen called desmoid tumours. These tumours sometimes need to be removed if they cause symptoms but they do not become cancerous. There is no need to have regular checks for desmoids but if you have any lumps or unexplained symptoms, you should discuss t ...
... Some people develop benign growths in their abdomen called desmoid tumours. These tumours sometimes need to be removed if they cause symptoms but they do not become cancerous. There is no need to have regular checks for desmoids but if you have any lumps or unexplained symptoms, you should discuss t ...
Cytogenetics with special reference to domestic animals
... Conserved synteny between the human and mouse genomes. Regions from different mouse chromosomes (indicated by the colors of each mouse in B) show conserved synteny (gene order) with the indicated regions of the human genome (A). For example the genes present in the upper portion of human chromosome ...
... Conserved synteny between the human and mouse genomes. Regions from different mouse chromosomes (indicated by the colors of each mouse in B) show conserved synteny (gene order) with the indicated regions of the human genome (A). For example the genes present in the upper portion of human chromosome ...
HapTree-X: An integrative Bayesian framework for haplotype
... By running standard genotype calling tools, it is possible to accurately identify the number of “wild type” and “mutant” alleles for each single-nucleotide polymorphism (SNP) site [1]. However, in the case of two heterozygous SNP sites, genotype calling tools cannot determine whether “mutant” allele ...
... By running standard genotype calling tools, it is possible to accurately identify the number of “wild type” and “mutant” alleles for each single-nucleotide polymorphism (SNP) site [1]. However, in the case of two heterozygous SNP sites, genotype calling tools cannot determine whether “mutant” allele ...
Gene Section USP1 (ubiquitin specific peptidase 1) Atlas of Genetics and Cytogenetics
... overlapping alternative last exons and 9 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, overlapping exons with different boundaries. Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AU ...
... overlapping alternative last exons and 9 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, overlapping exons with different boundaries. Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AU ...
Document
... Concept 14.3: Inheritance patterns are often more complex than predicted by simple Mendelian genetics • The relationship between genotype and phenotype is rarely as simple as in the pea plant characters Mendel studied • Many heritable characters are not determined by only one gene with two alleles ...
... Concept 14.3: Inheritance patterns are often more complex than predicted by simple Mendelian genetics • The relationship between genotype and phenotype is rarely as simple as in the pea plant characters Mendel studied • Many heritable characters are not determined by only one gene with two alleles ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.