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Final Review 2006
Final Review 2006

... ____ 76. What principle states that atoms tend to form compounds so that each atom can have eight electrons in its outermost energy level? a. rule of eights c. configuration rule b. Avogadro principle d. octet rule ____ 77. Multiple covalent bonds may occur in atoms that contain carbon, nitrogen, or ...
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AP Semestar Exam REVIEW

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Example - cloudfront.net

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PPT - mvhs-fuhsd.org

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... The reaction shown above occurs inside a closed flask. What action will shift the reaction to the left? (Std 9A) A. Pumping CO gas into the closed flask B. Raising the total pressure inside the flask C. Increasing the NO concentration in the flask D. Venting some CO2 gas from the flask 111. In a sea ...
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Bioorthogonal chemistry



The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins, and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry), between nitrones and cyclooctynes, oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isocyanide-based click reaction, and most recently, the quadricyclane ligation.The use of bioorthogonal chemistry typically proceeds in two steps. First, a cellular substrate is modified with a bioorthogonal functional group (chemical reporter) and introduced to the cell; substrates include metabolites, enzyme inhibitors, etc. The chemical reporter must not alter the structure of the substrate dramatically to avoid affecting its bioactivity. Secondly, a probe containing the complementary functional group is introduced to react and label the substrate.Although effective bioorthogonal reactions such as copper-free click chemistry have been developed, development of new reactions continues to generate orthogonal methods for labeling to allow multiple methods of labeling to be used in the same biosystems.
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