Macromolecules
... strikingly and obviously different in appearance. You could see the difference if it were out of focus, and you could feel the differences in the dark. This is critically important, because SO CAN AN ENZYME! Such as the enzymes that control the expression of genetic information. DNA usually exists i ...
... strikingly and obviously different in appearance. You could see the difference if it were out of focus, and you could feel the differences in the dark. This is critically important, because SO CAN AN ENZYME! Such as the enzymes that control the expression of genetic information. DNA usually exists i ...
Structure and assembly of the spliceosomal small nuclear
... Recently, the crystal structures of two Sm protein subcomplexes, D1D2 and D3B, have been solved [32••]. The four Sm proteins show a common fold containing a short, N-terminal α helix followed by a five-stranded, antiparallel β sheet (Figure 1a, b). Strands 1–3 of the β sheet are made from residues w ...
... Recently, the crystal structures of two Sm protein subcomplexes, D1D2 and D3B, have been solved [32••]. The four Sm proteins show a common fold containing a short, N-terminal α helix followed by a five-stranded, antiparallel β sheet (Figure 1a, b). Strands 1–3 of the β sheet are made from residues w ...
Sophistication of foldamer form and function in
... acids into a-peptides has been reviewed previously [28], but new work by Muller and co-workers [29] expands the idea to the incorporation of aza-b3-amino acids, which contain nitrogen in the backbone, into a model peptide that mimics a CD4 T cell epitope. These peptides were recognized by T cells ge ...
... acids into a-peptides has been reviewed previously [28], but new work by Muller and co-workers [29] expands the idea to the incorporation of aza-b3-amino acids, which contain nitrogen in the backbone, into a model peptide that mimics a CD4 T cell epitope. These peptides were recognized by T cells ge ...
Mutation analysis of a recombinant NS replicon shows that influenza
... response, while NEP pertains to assisting nucleo-cytoplasmic transport of viral RNPs and can be found as a minor structural protein in the virion. Recent evidence further demonstrates that NS1 negatively regulates NEP production through inhibition of alternative splicing of the NS1 mRNA; however, it ...
... response, while NEP pertains to assisting nucleo-cytoplasmic transport of viral RNPs and can be found as a minor structural protein in the virion. Recent evidence further demonstrates that NS1 negatively regulates NEP production through inhibition of alternative splicing of the NS1 mRNA; however, it ...
Overview of Microarray Types
... stamps. They are based printed on a glass substrate containing as many as 400,000 tiny cells each containing a microscopic spot of DNA. Each microscopic spot holds a short, synthetic, single-stranded DNA sequence from a different human gene. This makes it possible to carry out a very large number of ...
... stamps. They are based printed on a glass substrate containing as many as 400,000 tiny cells each containing a microscopic spot of DNA. Each microscopic spot holds a short, synthetic, single-stranded DNA sequence from a different human gene. This makes it possible to carry out a very large number of ...
Stitching proteins into membranes, not sew simple
... an N-terminal domain consisting of dihydrofolate reductase (DHFR, approximately 200 amino acids) could be controlled by the addition of methotrexate (MTX). In the absence of MTX, ‘loosely folded’ DHFR could be efficiently transported into the ER lumen, driven by a hydrophobic domain; while in the pr ...
... an N-terminal domain consisting of dihydrofolate reductase (DHFR, approximately 200 amino acids) could be controlled by the addition of methotrexate (MTX). In the absence of MTX, ‘loosely folded’ DHFR could be efficiently transported into the ER lumen, driven by a hydrophobic domain; while in the pr ...
Affinity Proteomics for Phosphatase Interactions in Atrial
... tion partners had previously been designated as pu- ...
... tion partners had previously been designated as pu- ...
Expression and Purification of Functional Ligand
... To quantify the interaction of sweet ligands with the NTD of T1Rs, it was necessary to design an expression and purification protocol that would permit the isolation of purified, soluble T1R NTD proteins in sufficient quantities for biochemical studies. We took advantage of two bacterial expression ...
... To quantify the interaction of sweet ligands with the NTD of T1Rs, it was necessary to design an expression and purification protocol that would permit the isolation of purified, soluble T1R NTD proteins in sufficient quantities for biochemical studies. We took advantage of two bacterial expression ...
Detailed Computational Study of Point Mutations of the TP53 Tumor-Suppressor Protein
... Tumor-specific p53 mutations were first identified in 1989.3 Loss of p53 function is the most common event in human cancer, with more than half of all invasive tumors involving the decrease or total loss of p53 functions. In contrast to many other tumor suppressors, which are often inactivated by de ...
... Tumor-specific p53 mutations were first identified in 1989.3 Loss of p53 function is the most common event in human cancer, with more than half of all invasive tumors involving the decrease or total loss of p53 functions. In contrast to many other tumor suppressors, which are often inactivated by de ...
The plant formin AtFH4 interacts with both actin and microtubules
... independent convergence towards similar functions rather than the ancient conservation of a shared function. Formins of animals associate with the plus ends of microtubules using intermediates such as CLIP170, APC and EB1 (Lewkowicz et al., 2008; Wen et al., 2004). Our data do not exclude such addit ...
... independent convergence towards similar functions rather than the ancient conservation of a shared function. Formins of animals associate with the plus ends of microtubules using intermediates such as CLIP170, APC and EB1 (Lewkowicz et al., 2008; Wen et al., 2004). Our data do not exclude such addit ...
Protein Creation Pathway Tutorial
... Directions: Download and then open the PowerPoint from my website. Press the F5 button to start the presentation. ...
... Directions: Download and then open the PowerPoint from my website. Press the F5 button to start the presentation. ...
In this section of the tutorial you will
... different forms of a given protein in order to describe the various reactions in the pathway. Each of these forms is a protein object in PRO and will have a distinct ID (e.g. PRO ID for smad2 isoform 1 and a PRO ID for smad2 isoform 1 phosphorylated in a given residue). By creating a RACE-PRO entry, ...
... different forms of a given protein in order to describe the various reactions in the pathway. Each of these forms is a protein object in PRO and will have a distinct ID (e.g. PRO ID for smad2 isoform 1 and a PRO ID for smad2 isoform 1 phosphorylated in a given residue). By creating a RACE-PRO entry, ...
The Structure of Amino Acids in Proteins
... When amino acids are joined together, a peptide bond (see red line below) is made and water comes off. ...
... When amino acids are joined together, a peptide bond (see red line below) is made and water comes off. ...
The Dock and Lock Method: A Novel
... human carcinoembryonic antigen (CEACAM5). The first A, C-DDD1-Fab-hMN-14, was generated by linking the DDD1 peptide sequence, which is composed of amino acids 1 to 44 of human RIIa, to the COOH-terminal end of the Fd chain via a 14-residue flexible peptide linker (Fig. 2B). This construct was modifi ...
... human carcinoembryonic antigen (CEACAM5). The first A, C-DDD1-Fab-hMN-14, was generated by linking the DDD1 peptide sequence, which is composed of amino acids 1 to 44 of human RIIa, to the COOH-terminal end of the Fd chain via a 14-residue flexible peptide linker (Fig. 2B). This construct was modifi ...
- Information Extraction and Text Mining Group
... occur before and after tagged proteins in a training corpus selections from the training corpus …gene encoding
... occur before and after tagged proteins in a training corpus selections from the training corpus …gene encoding
gamma-glutamyl kinase
was… …recognized genes encodingvimentin
, heat… …found thatE2F
binds specifically… …IleRS
binds to the acceptor… …ofCPB II
binds 1 ...
Mapping the Intramolecular Vibrational Energy Flow in Proteins
... ibrational energy transfer in proteins is particularly complex because proteins can be simultaneously highly anisotropic and strongly correlated environments at a molecular level. Highresolution protein structures carry functional information that is hidden from immediate inspection, particularly fo ...
... ibrational energy transfer in proteins is particularly complex because proteins can be simultaneously highly anisotropic and strongly correlated environments at a molecular level. Highresolution protein structures carry functional information that is hidden from immediate inspection, particularly fo ...
WWOX, a Novel WW Domain-containing Protein
... Interestingly, the NH2 terminus of the putative WWOX protein showed homology to ubiquitin ligases such as NEDD4, YES-associated protein YAP65, and other WW domain-containing proteins (data not shown). Further amino acid sequence analysis using the PROSITE database identified two regions within the p ...
... Interestingly, the NH2 terminus of the putative WWOX protein showed homology to ubiquitin ligases such as NEDD4, YES-associated protein YAP65, and other WW domain-containing proteins (data not shown). Further amino acid sequence analysis using the PROSITE database identified two regions within the p ...
Pig local foods bklt LAB006 - PNG National Agricultural Research
... readily eaten by pigs. One meal of the day can be made up of household leftovers and wastes, stable crops, fruits, fish wastes or coconut while the other meal can be green leaves such as sweet potato, various legumes, breadfruit, banana, waste vegetables or other locally known edible leaves. Also it ...
... readily eaten by pigs. One meal of the day can be made up of household leftovers and wastes, stable crops, fruits, fish wastes or coconut while the other meal can be green leaves such as sweet potato, various legumes, breadfruit, banana, waste vegetables or other locally known edible leaves. Also it ...
Cell and Organelle Movement
... A. Myosin II, first identified in skeletal muscle, fig. 16-51 1. Responsible for generating force for muscle contraction and cytokenesis 2. Elongated protein composed of two heavy chains and two light chains a. Heavy chain composed of a globular head domain followed by an extended long amino acid se ...
... A. Myosin II, first identified in skeletal muscle, fig. 16-51 1. Responsible for generating force for muscle contraction and cytokenesis 2. Elongated protein composed of two heavy chains and two light chains a. Heavy chain composed of a globular head domain followed by an extended long amino acid se ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.