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GOALS OF THE HUMAN GENOME PROJECT
GOALS OF THE HUMAN GENOME PROJECT

... Coding strand – the strand of DNA that is NOT accessed to make mRNA. The mRNA that is made from the template strand will be identical to the coding strand (with the exception of U’s for T’s) ...
Date
Date

... 3. Shown below is a representation of a fruit fly's 10 chromosomes, 5 of which it inherited from its father (depicted in dark) and 5 of which it inherited from its mother (depicted in light). ...
Identifying human disease genes
Identifying human disease genes

...  candidate regions identified by positional cloning usually contain dozens of genes.  It can be very time-consuming to identify every transcript from the region, and excessively laborious to screen them all for mutations. ...
Ch 15b
Ch 15b

... • Alterations of chromosome number and structure are associated with some serious disorders • Some types of aneuploidy appear to upset the genetic balance less than others, resulting in individuals surviving to birth and beyond • These surviving individuals have a set of symptoms, or syndrome, chara ...
X - kendricknovak
X - kendricknovak

... colorblindness marries a female who is not colorblind but carries the (b) allele. Using a Punnett square, determine the genotypic and phenotypic probabilities for their potential offspring. ...
JF lect 5 12
JF lect 5 12

... 1902 – McClung – a particular chromosome (X) determines sex in insects (XO = male; XX = female) 1903 – Sutton and Boveri – chromosomes behave just like the ‘unit factors’ described by Mendel 1910 – Morgan – the “white” eye color gene of Drosophila is located on the X-chromosome - there are many othe ...
Differential Gene Expression
Differential Gene Expression

... - also expressed in different genes within these tissues Within these modules, transcription factors work in a combinatorial fashion. Transcription factors operate in cascades: one stimulates the production of several others. ...
Gene Section BCL11B (B-cell lymphoma/leukaemia 11B) Atlas of Genetics and Cytogenetics
Gene Section BCL11B (B-cell lymphoma/leukaemia 11B) Atlas of Genetics and Cytogenetics

... t(5;14) breakpoints are widely scattered over 1.2 Mbp downstream of BCL11B probably targeting distal enhancer(s) posited to lie in the "gene desert" separating BCL11b from VRK1. This region has been recently shown to carry multiple Dnase-I sensitive sites in T-cells which may represent a locus contr ...
Leukaemia Section t(18;21)(q21;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(18;21)(q21;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology

15 - GEOCITIES.ws
15 - GEOCITIES.ws

... c. Hemophilia; sex-linked recessive i. Lack one of the blood proteins required for clotting ii. Controlled by injections of recombinant clotting factor 17. Describe the process of X inactivation in female mammals. Explain how this phenomenon produces the tortoiseshell coloration in cats. a. Human ce ...
Regulation of Gene Expression
Regulation of Gene Expression

...  Operator: “on/off” switch, controls if RNA poly can bind or not. NO RNA POLY. BINDING = NO TRANSCTIPTION  Operon: Whole segment of DNA including the promoter, operator, and the genes they control. ...
Meiosis and Genetics
Meiosis and Genetics

... Segregation actually happens here during anaphase of meiosis I ...
Nature v nurture? Please don`t ask
Nature v nurture? Please don`t ask

... Though well-intentioned, and in some respects an important antidote to pseudoscientific genetic determinism, this view was dangerously inflexible. Any evidence that genetics might be seriously influential after all would threaten the very foundations of liberty and equality so it would have to be re ...
Chapter 11 Intro to Genetics
Chapter 11 Intro to Genetics

... Chapter 11 Intro to Genetics 11-4 Meiosis A. Principle of genetics requires 2 things 1. A single copy of every gene must be inherited 2. When gametes (sperm/egg) are formed a process must separate the 2 sets of each gene so that each gamete has only 1 set of genes B. Chromosome number 1. somatic cel ...
1 - BrainMass
1 - BrainMass

... To determine whether linkage is significant, we also need to determine the number of degrees of freedom, which by rule is equal to the number of classes (4) minus one. Therefore d.f. = 3 in this case. To determine significance, you need to refer to a contingency table (there is probably one in your ...
Document
Document

Inquiry into Life Twelfth Edition
Inquiry into Life Twelfth Edition

... microarray analysis can be used to identify DNAbinding sites for activators and other proteins • Small genome organisms - all of the intergenic regions can be included in the microarray • If genome is large, that is not practical • To narrow areas of interest can use CpG islands – These are associat ...
Chapter 11 How Genes are Controlled
Chapter 11 How Genes are Controlled

... Signal transduction pathway Transcription factor (activated) Nucleus ...
Controls Over Genes
Controls Over Genes

... controlled by three floral identity genes (A, B, and C) ...
Gene Section AF4 (ALL1 fused gene from chromosome 4)
Gene Section AF4 (ALL1 fused gene from chromosome 4)

... Typically CD19+ B-ALL, biphenotypic AL, at times ANLL (M4/M5); may be congenital; treatment related leukaemia (secondary to epipodophyllotoxins). Prognosis Median survival < 1 yr. Cytogenetics Additional chromosome anomalies are found in ¼ of cases of which is the i(7q). Hybrid/Mutated Gene 5’ MLL - ...
Ch 11 Standards Test Practice
Ch 11 Standards Test Practice

... 6 arctic fox produces enzymes that cause its fur to become reddish brown. During the cold temperatures of winter, these enzymes do not function. As a result, the fox has a white coat that blends into the snowy background. What explains this change in color? A The genes of a fox are made of unstable ...
Presentation
Presentation

... GENE THERAPY process in which an absent or faulty gene is replaced by a normal, working gene various approaches have been taken… – Bone marrow removed, modified in the laboratory and placed back in the body – Modified viruses have been used to carry replacement genes into the body – Inhalation of g ...
AP Biology Review Unit 5 and 6
AP Biology Review Unit 5 and 6

... Na/K pump - pumps Na+ OUT and K+ into the cell Repolarization (Reset) (May include multiple steps) Action potential moves to the axon terminus ...
Overture
Overture

... • Genes are switches, transcription factors are (one type of) input signals, proteins are outputs • Proteins (outputs) may be transcription factors and hence become signals for other genes (switches) • This may be the reason why humans have so few genes (the circuit, not the number of switches, carr ...
Chapter 1 Interactive Quiz
Chapter 1 Interactive Quiz

... Used to predict genetic crosses. Used to compare genetic crosses. Used to predict genetic mutations. Used to predict and compare genetic ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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