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The role of variable DNA tandem repeats in bacterial adaptation
The role of variable DNA tandem repeats in bacterial adaptation

... regions, probably because they have a higher probability to rearrange and cause frameshift mutations in genes (Coenye & Vandamme, 2005; Ackermann & Chao, 2006; Orsi et al., 2010; Lin & Kussell, 2012). In contrast, SSRs whose unit size is a multiple of three nucleotides (3, 6, 9 …) are overrepresente ...
Multiple Testing Multiple Testing
Multiple Testing Multiple Testing

... • A. Reiner, D. Yekutieli & Y. Benjamini (2003) Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19, 368-375 • Westfall, P. H. & Young, S. S. (1993). Resampling-based multiple testing: Examples and methods for p-value adjustment, John Wiley ...
FEBS Letters
FEBS Letters

... within the gene cluster (ORF3 between h o x Y and hoxH and O R F 8 between hoxU and hoxY," see Fig. 1 and [7]). O R F 3 could not be detected on genomic D N A from A. nidulans by heterologous probing even at the low hybridization temperature of 56°C. In addition, sequences homologous to the A. varia ...
Lecture Outline
Lecture Outline

Meiosis
Meiosis

... In male animals, these gametes are called sperm. In some plants, pollen grains contain haploid sperm cells. In female animals, generally only one of the cells produced by meiosis is involved in reproduction. The female gamete is called an egg in animals and an egg cell in some plants. ...
Promega Notes: T4 RNA Ligase: A Molecular Tool for RNA and DNA
Promega Notes: T4 RNA Ligase: A Molecular Tool for RNA and DNA

... amber suppressor tRNA lacking the terminal 3´-CA sequence to a CA dinucleotide that had been chemically modified with an unnatural amino acid. This improvement greatly simplified the original anticodon loop replacement procedure, and they demonstrated that, while lacking post-transcriptional base mo ...
gene_prediction_20040930
gene_prediction_20040930

... prediction tools – where coding exons are defined by similarities and not codon bias  GAZE (Howe) is an extension of Phil Green’s Genefinder in which transcript data is used to define coding exons. Other features are scored as in the original Genefinder implementation. This is being evaluated and u ...
Gene Section JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))
Gene Section JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

File
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... –Flip heads for X and tails for Y. Remember one flip per person •When getting to multiple alleles, flip for one of each letter. –Example: hair color has 2 different alleles •One partner flips for A AND B and the other partner flips A AND B. •Result should have two A’s and two B’s **ULTIMATE GOAL = D ...
Key transcriptional regulators of the vasoprotective effects of shear
Key transcriptional regulators of the vasoprotective effects of shear

... cells sense shear stress and convey these signals. For example, using shear stress exposure of less than one hour, Tzima and colleagues identified a cell-cell junctional complex-dependent sensory complex that detects acute shear stress changes (4). Transcriptional changes specific for an acute shear ...
What constitutes an `alternative TSS`? Example 1: Alternative TSS at
What constitutes an `alternative TSS`? Example 1: Alternative TSS at

... What if the event involves a terminal exon? 1. Long (‘on’) exon? No – APA! ...
Genetics Problems
Genetics Problems

... Homologous chromosomes move to opposite poles of the cell. The two cells formed this division have one-half the number of chromosomes and one copy of each gene. Mendel’s law of independent assortment relates to the lining up of synapsed chromosomes at the equatorial plate in a random fashion during ...
papaya X-specific BACs monoica corresponding
papaya X-specific BACs monoica corresponding

... It has long been thought that, while the hemizygous Y chromosome changes drastically over time, the X chromosome conserves the ancestral autosome content and structure. To determine whether the X chromosome remains unchanged compared to its ancestral autosome, BAC sequences of Carica papaya and Vasc ...
Molecular characterization of dioxygenases from polycyclic aromatic
Molecular characterization of dioxygenases from polycyclic aromatic

... PYR-GCK (ATCC 700033), M. gilvum BB1 (DSM 9487) and M. frederiksbergense FAn9T (DSM 44346), all previously known PAH degraders, were positive in both tests. From the three positive strains, complete open reading frames of the nidA and nidB genes were amplified by PCR, using primers designed accordin ...
Gene Section RPL26 (ribosomal protein L26)  Atlas of Genetics and Cytogenetics
Gene Section RPL26 (ribosomal protein L26) Atlas of Genetics and Cytogenetics

Chp. 15
Chp. 15

...  In humans and other mammals, there are two varieties of sex chromosomes: a larger X chromosome and a smaller Y chromosome  A person with two X chromosomes develops as a female, while a male develops from a zygote with one X and one Y  Only the ends of the Y chromosome have regions that are homol ...
October 25, 2012
October 25, 2012

... b) Briefly describe meiosis I and meiosis II. Meiosis I: The duplicated chromosomes divide into two cells, each with half the number of chromosomes. Meiosis II: The two cells divide once more, producing sex cells that have half as many chromosomes as the body cells. c) Use the events of meiosis to e ...
Evidence, Mechanisms and Models for the Inheritance of Acquired
Evidence, Mechanisms and Models for the Inheritance of Acquired

... Models similar to that proposed for the inheritance of methylation patterns have been suggested to explain the propagation of other chromatin modifications such as those involving DNA-protein interactions. For example, Groudine & Weintraub (1982) proposed that protein subunits are symmetrically boun ...
Organisms modeling: The question of radial basis function
Organisms modeling: The question of radial basis function

... of activity [1] and reactive organisms [2]. The behavior of reactive organisms is considered as a set of input/output pairs. The structure of such organisms consists of an usual sensor-to-actuator network where each node can be an analogy of a gene or a sensory neuron. These analogies between artific ...
Interacting Gene Clusters and the Evolution of the Vertebrate
Interacting Gene Clusters and the Evolution of the Vertebrate

... with the origin of adaptive immunity within the vertebrate lineage suggests that novel evolutionary and regulatory constraints were associated with the operation of the immune system. ...
A protein-based phylogenetic tree for Gram
A protein-based phylogenetic tree for Gram

... Fig. 1. Almost the same set of organisms are used. The resolution and the discrepancies in the branching order in the three trees are clear. The order of branching among Gram-positive bacteria with low G + C DNA content could not be resolved on the basis of 16s rRNA sequences. The tree based on Hsp7 ...
2013 Holiday Lectures on Science Medicine in the Genomic Era
2013 Holiday Lectures on Science Medicine in the Genomic Era

... 1. Are cancer genes only present in people who have cancer? The genes on the Cancer Patient Cards and Cancer Gene Cards are normal genes that are part of the genomes of all people. People with cancer have mutations in subsets of these genes. When these genes are mutated, they can contribute to cance ...
msb201035-sup
msb201035-sup

... development and have a CRM bound at either early (green) or late (red) stages of development. (a) The correlation between the timing of each TF separately to the timing of its target genes expression: the target genes for each TF were divided into early or late based on the timing of TF occupancy to ...
209 Original Scientific Article THE INFLUENCE OF
209 Original Scientific Article THE INFLUENCE OF

... ooplasm (iSCNTp) only the primers for bovine DNMTs (bDNMT1, bDNMT3a) showed positive signals (Fig. 2A; Fig. 2B). Considering the different timing of EGA during the embryonic development in bovine and porcine embryos, the intense effect of ooplasm on transferred fibroblast was expected. Despite the m ...
Package `geneplotter`
Package `geneplotter`

... Arguments points ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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