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Lecture 21: Gene Set Enrichment Analysis
Lecture 21: Gene Set Enrichment Analysis

... Sample Phenotype File A sample phenotype (.cls) file is a text file containing three lines. The first line contains three numbers separated by spaces. The first number is the number of samples. The second and third numbers are the constants 2 and 1, respectively. The second line begins with # and is ...
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant

... mCry2−/− mice, PER1 can substitute PER2 in the core clock mechanism but not in the light input signaling pathway. As a note of caution, one should keep in mind that the phenotypic effect of genetic modifications of genetically altered animals in a nonhomogeneous genetic background are prone to epige ...
00Exem hard
00Exem hard

... family in a genome, Sankoff (1999) proposes the estimation of true exemplars, a selection of one gene from each gene family in both genomes such that the distance between the resulting exemplar strings is minimized. This is the exemplar distance. Here we show that the calculation of the exemplar dis ...
Chapter 10
Chapter 10

... types of alleles from the female gametes can be produced. ...
AP Biology Exam Review Put Your Knowledge to the Test
AP Biology Exam Review Put Your Knowledge to the Test

... • Click on the button of the right answer • If you are wrong you go back to the start, if you answer correctly, you move on. **Click on the buttons only, not the page*** ...
Genetics…
Genetics…

... two (RrTt) that work together on one trait. • These alleles or gene pairs don’t result in an either/or phenotype, but a range of phenotypes…the smallest to the biggest. • Phenotypes of many different forms • Examples: human height, skin color, etc ...
Document
Document

... 1967 Doi et al. detected under electron microscope phytoplasmas in aster and other plants with "yellows" symptoms opening phytoplasmology history. Like other mollicutes, phytoplasmas lack cell walls, are pleomorphic and reside endocellularly in insects and plant phloem. Onion yellows phytoplasma is ...
Chap 25
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...  Independent assortment of chromosomes during ...
Trachemys scripta elegans Red-Eared Turtle ( Fc)
Trachemys scripta elegans Red-Eared Turtle ( Fc)

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... pCR2.1-ACF1-flag using the Site-directed Mutagenesis Kit (Stratagene). The following pairs of oligonucleotides were used to delete the PHD1 or PHD2, respectively: PHD1F, 5⬘-ACCAATAAGTCATTAGTCGACGTAAAGAGTCTGGGTCTCAGC-3⬘; PHD1R, 5⬘-ACCCAGACTCTTTACGTCGACTAATGACTTATTGGTGGAACGC-3⬘; PHD2F, 5⬘-GATGAGGAAAAG ...
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here. - Signet

... Traditionally it has been believed that scurs are sex-influenced due to the fact that they have been shown to be more common in bulls than cows. An example of this is that when Aberdeen Angus cattle are crossed with Brown Swiss the result is scurred bulls and smooth polled (non-scurred) cows. Simil ...
evolution and mechanism of translation in chloroplasts
evolution and mechanism of translation in chloroplasts

... of the large IR (112). No such IR has been observed in cyanobacterial genomes analyzed so far. The genomes of Synechococcus 6301 (49) and of Synechocystis PCC 6803 (50) contain two copies of rRNA gene clusters in the inverse orientation, but no additional genes are present in the repeats. Therefore, ...
Lecture 2 Turunen 14.9. - MyCourses
Lecture 2 Turunen 14.9. - MyCourses

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Figure 2 - GEP Community Server

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Becker Muscular Dystrophy (BMD)
Becker Muscular Dystrophy (BMD)

... The symptoms of BMD vary greatly from one person to another. Some people lose their ability to walk in early adulthood. Others are able to continue walking throughout their lives. Life expectancy can be reduced, but many people with BMD live into their 70s and 80s. Some may develop heart problems ea ...
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module 3: transcription part ii
module 3: transcription part ii

... nucleus ‘as is’? Or do changes have to occur? (Hint: introns vs. exons) (Discuss with a partner then as a class). Mini-presentation illustrating that during pre-mRNA processing, three events occur: ...
TRPGR: Sequencing the barley gene-space
TRPGR: Sequencing the barley gene-space

... (http://www.jgi.doe.gov/sequencing/why/CSP2007/switchgrass.html). Thus, sequencing the barley gene space will not only provide an excellent genomic resource for the Triticeae tribe but also for the grass family (Poaceae) in general. ...
Interactions of Mitochondrial and Nuclear Genes
Interactions of Mitochondrial and Nuclear Genes

... strategy is to compare cytoplasmic genomes in fertile and CMS lines. Unfortunately, with a few exceptions, the comparative genomics strategy has not been successful. Differences between two cytoplasms often may reflect evolutionary divergence and have no correlation with CMS. What is needed, therefo ...
Mendelian Genetics notes
Mendelian Genetics notes

... are mated. Assuming independent assortment of the B/b and D/d genes, write the genotypes of all possible offspring from this cross and use the rules of probability to calculate the chance of ...
"Genetic Redundancy".
"Genetic Redundancy".

... typically thought of as involving separate mechanisms to those producing redundancy at the level of the gene, and hence these concepts are kept separate. However, redundancy can also be present at levels above that of the gene. Whole sets of co-localized genes (syntenic blocks), or more frequently, ...
AP Biology Unit 4 --Cell Reproduction--Mitosis
AP Biology Unit 4 --Cell Reproduction--Mitosis

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... RNA Polymerase binds to promoter Reads one base at a time synthesizing single stranded mRNA from the DNA template mRNA transported to the cytoplasm through the nuclear ...
Discovery Of Genetic Mutations That Cause Stuttering
Discovery Of Genetic Mutations That Cause Stuttering

... stuttering in family PKST72 • The same mutation occurs in affected individuals in Pakistani families PKST 05, 25, 41 – 4/41 families suggests this mutation could account for ~10% of stuttering families in Pakistan • The same mutation occurs in unrelated people who stutter from Pakistan and India • M ...
Slide 1
Slide 1

... 1. High homogeneity: homogeneity measures the similarity between genes assigned to the same cluster. 2. High separation: separation measures the distance/dissimilarity between clusters. (If two clusters have similar expression patterns, then they should probably be merged into one cluster). ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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