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KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES

... of renal function and often renal biopsy. The thorough clinician should personally review microscopic urinalysis in any case in which there is a reasonable index of suspicion of immune-mediated renal disease. In this article we propose to highlight recent developments, with particular reference to r ...
NERVOUS SYSTEM: MATCHING EXERCISE
NERVOUS SYSTEM: MATCHING EXERCISE

... 7. ureterostenosis 8. hematuria 9. hydronephrosis 10. enuresis 11. inflammation of a kidney 12. urination at night 13. sugar in the urine 14. abnormal condition of the renal pelvis 15. pain in the bladder 16. distention of kidney to bladder tube 17. abnormal softening of kidney 18. hernia of bladder ...
Glomerular Diseases
Glomerular Diseases

... Prognosis of MCD • Mostly patients are children < 16yrs. • Respond to corticosteroids. • Remissions may be there, but overall prognosis is excellent. ...
KCa 3.1: A Potential Anti Fibrotic Target In IgA Nephropathy
KCa 3.1: A Potential Anti Fibrotic Target In IgA Nephropathy

... KCa 3.1: A POTENTIAL ANTI FIBROTIC TARGET IN IgA NEPHROPATHY ABSTRACT Introduction Chronic kidney disease (CKD) is a common condition worldwide. It is known that fibrosis plays an important role in the progression of CKD to end stage renal failure (ESRF). Despite much research, the mechanisms contro ...
PATHOLOGY OF INFECTIOUS RENAL DISEASES IN SOUTH
PATHOLOGY OF INFECTIOUS RENAL DISEASES IN SOUTH

... Herpes simplex virus (HSV) infection usually occurs in immunocompromised or severely debilitated patients. It is not so common in patients with renal transplants. The diagnosis can be made histologically. HSV mainly affects tubular cells causing necrosis, a major reason for functional deterioration. ...
Bibliografia di approfondimento Holley JL, Foulks CJ, Moss AH
Bibliografia di approfondimento Holley JL, Foulks CJ, Moss AH

... Holley JL, Foulks CJ, Moss AH, Willard D. Ultrasound as a tool in the diagnosis and management of exit-site infections in patients undergoing continuous ambulatory peritoneal dialysis. Am J Kidney Dis 14 1989; 14: 211–6. Domico j, Warman M, Jaykamur S, Sorkin MI. Is ultrasonography useful in predict ...
Kidney-lect-2010-2-Glomer
Kidney-lect-2010-2-Glomer

... IgA immune complex deposits in mesangium, mesangial cell proliferation – Inability to regulate mucosal IgA synthesis and clearance in response to viral, bacterial or food antigens – Alternate complement pathway - no C1q, C4 – Coeliac disease, dermatitis herpetiformis, liver disease ...
Chap 46 - TeacherWeb
Chap 46 - TeacherWeb

...  All children who had impetigo, strept infections should have a urinalysis 2 weeks post infection to evaluate for glomerulonephritis  Sudden onset of hematuria & proteinuriaurine appears tea colored, reddish-brown or smokey ...
The Aging Urinary System
The Aging Urinary System

... The Aging Urinary System kidneys show lots of atrophy in old age ‡ from ages 25 to 85; number of nephrons ...
Structure and Function of the Kidney
Structure and Function of the Kidney

... renal cell carcinomas • Highly exposed workers exhibit nephrosis and an increased incidence of renal cancer • TCE and other renal neoplasms have a high incidence of mutations in the von Hipple-Lindau (VHL) tumor suppressor gene. This requires mutation of one allele and deletion of the other • TCE mu ...
Quiz-Quiz
Quiz-Quiz

... The outer layer of a kidney. ...
Minimal Change Disease
Minimal Change Disease

... type IV collagen c) usually does not present with nephrotic syndrome and proteinuria d) more severe in men i) die by age 40 e) progressive hearing loss (high frequencies) f) ocular defects most often  the lens ...
L1 Nephritis 2013
L1 Nephritis 2013

... the immune deposits are distributed in the capillary loops in a granular, bumpy pattern because of the focal nature of the deposition process. ...
URINARY DISEASES
URINARY DISEASES

... and taking over (BUN is normal)  Stage II – called renal insuffiency – remaining nephrons can’t handle urea load and BUN climbs – also have polyruria and dehydration  Stage III – called uremia – very high BUN due to loss of kidney function – fluids retained by the body so get hypertension and edem ...
PPT - Med Study Group
PPT - Med Study Group

... 1. Anti-GBM antibody-mediated disease: - Characterized by linear deposits of IgG and, in many cases, C3 in the Glomerular basement membrane(GBM) - In some of these patients, the anti-GBM antibodies cross-react with pulmonary alveolar basement membranes to produce the clinical picture of pulmonary h ...
Chronic Renal Failure
Chronic Renal Failure

... Chronic Kidney Disease: A Clinical Action Plan Stage ...
Objectives
Objectives

... Urinary dysfunction Cystitis – inflammation of the urinary bladder. Caused by bacterial infection or injury due to chemical exposure or mechanical injury. Renal calculi – kidney stones (excessive calcium crystals). Painful as the multi-faceted sediment moves through the ureters. ...
Influence of Linex and Enterosgel on humoral immunity in patients
Influence of Linex and Enterosgel on humoral immunity in patients

... level in the first clinical group increased by 2.35 times (p <0.01), on day 14 of the treatment - 3.04 times (p <0.001), after a month of starting treatment - 2.4 times (p <0.01). Similar changes of serum IgA at the appropriate research stages were reported in the second clinical group. No statistic ...
DKD Introduction Globally, diabetes mellitus is a major reason of
DKD Introduction Globally, diabetes mellitus is a major reason of

... A 58-year-old man with a 7-year history of T2DM a walk-in clinic due to increasing swelling in his LL that began about 6m previously and has worsened over the past 6w. The patient’s medical Hx. is significant for HTN, T2DM. His medications include gliclazide 80 mg twice/d, metformin 500 tds, amlodip ...
NEPHRITIS
NEPHRITIS

...  Whether you have an acute or chronic form of the disease.  The underlying cause  The type and severity of your signs and symptoms ...
Immune complex formation in IgA nephropathy
Immune complex formation in IgA nephropathy

... With the identification and characterization of anti-IgA1 IgG autoantibodies we have a better appreciation of the interrelationship between IgA1 O-glycosylation and immune complex formation in IgAN. However, to fully understand the implications of these data, the pathogenic importance of IgA1–IgG im ...
Membranoproliferative Glomerulonephritis
Membranoproliferative Glomerulonephritis

... • It develops in a child 1-4 wks after the individual recovers from a group A streptococcal infection. • Only certain "nephritogenic" strains of β-hemolytic streptococci are capable of evoking glomerular disease. • In most cases the initial infection is localized to the pharynx or skin. ...
Microbial Cell Wall Oligomannan Inhibits
Microbial Cell Wall Oligomannan Inhibits

... regression analysis to determine whether different marker alleles vary in terms of their probability for being transmitted from a heterozygous parent to an affected offspring. Results The SNPs showed no evidence of association,and these two polymorphisms are unlikely to account for disease susceptib ...
A138PN AFFINITY PURIFIED ANTIBODIES
A138PN AFFINITY PURIFIED ANTIBODIES

... 1: 10,000 by direct ELISA. Optimal working dilution must be determined by end user in their individual assay system. ...
PowerPoint 演示文稿
PowerPoint 演示文稿

... the delicate network of the normal glomerular tugt. ...
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IgA nephropathy



IgA nephropathy (also known as IgA nephritis, IgAN, Berger disease (/bɛərˈʒeɪ/), Berger's disease, Berger's syndrome, Berger syndrome, or synpharyngitic glomerulonephritis) is a form of glomerulonephritis (inflammation of the glomeruli of the kidney).IgA nephropathy is the most common glomerulonephritis throughout the world. Primary IgA nephropathy is characterized by deposition of the IgA antibody in the glomerulus. There are other diseases associated with glomerular IgA deposits, the most common being Henoch-Schönlein purpura (HSP), which is considered by many to be a systemic form of IgA nephropathy. HSP presents with a characteristic purpuric skin rash, arthritis, and abdominal pain and occurs more commonly in young adults (16-35 yrs old). HSP is associated with a more benign prognosis than IgA nephropathy. In IgA nephropathy there is a slow progression to chronic kidney failure in 25-30% of cases during a period of 20 years.
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