The obstruction of adaptation in diploids by recessive deleterious
... inbreeding depression is pervasive across sexually reproducing diploids and is mainly caused by recessive deleterious variation (reviewed in ref. 14). For example, in natural populations of Drosophila, approximately 30% of chromosomes carry a recessive lethal, and chromosomes that do not carry a rec ...
... inbreeding depression is pervasive across sexually reproducing diploids and is mainly caused by recessive deleterious variation (reviewed in ref. 14). For example, in natural populations of Drosophila, approximately 30% of chromosomes carry a recessive lethal, and chromosomes that do not carry a rec ...
Signaling Pathways of Heme Oxygenase
... iron-binding protein (Ponka, 1997). In accordance with this concept synthesis of the ironbinding protein ferritin has been demonstrated to be induced in coordination with HO-1 activity during the cellular stress response of skin fibroblast (Vile and Tyrrell, 1993; Ryter and Tyrrell, 2000). This coor ...
... iron-binding protein (Ponka, 1997). In accordance with this concept synthesis of the ironbinding protein ferritin has been demonstrated to be induced in coordination with HO-1 activity during the cellular stress response of skin fibroblast (Vile and Tyrrell, 1993; Ryter and Tyrrell, 2000). This coor ...
Quantitative analysis of SMN1 and SMN2 genes based on DHPLC
... gene as well as 309 control individuals from the general population and the family members of patients with SMA were analyzed. By DHPLC analysis, we could detect the SMA-affected cases efficiently just by recognizing an SMN2-only peak. Furthermore, after specific primer amplification and adjustment ...
... gene as well as 309 control individuals from the general population and the family members of patients with SMA were analyzed. By DHPLC analysis, we could detect the SMA-affected cases efficiently just by recognizing an SMN2-only peak. Furthermore, after specific primer amplification and adjustment ...
Pristionchus pacificus
... P. pacificus belongs to the family Diplogastridae, which includes about 300 described free-living species in 28 genera (Fürst v. Lieven & Sudhaus, 2000; Sudhaus & Fürst v. Lieven, 2003). The exact phylogenetic relationship to the Rhabditidae is still debated and several studies suggest that the Dipl ...
... P. pacificus belongs to the family Diplogastridae, which includes about 300 described free-living species in 28 genera (Fürst v. Lieven & Sudhaus, 2000; Sudhaus & Fürst v. Lieven, 2003). The exact phylogenetic relationship to the Rhabditidae is still debated and several studies suggest that the Dipl ...
Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc. Natl. Acad. Sci. USA 102: 17014-17019. pdf
... tubes that transport vital fluids or gases. The proper size and shape of tubes are crucial for their transport function, but the molecular processes that govern tube size and shape are not well understood. Here we show that three genes required for tracheal tube morphogenesis in Drosophila melanogas ...
... tubes that transport vital fluids or gases. The proper size and shape of tubes are crucial for their transport function, but the molecular processes that govern tube size and shape are not well understood. Here we show that three genes required for tracheal tube morphogenesis in Drosophila melanogas ...
1999 Dekkers: BREEDING IN THE 21st CENTURY
... evaluations, providing best linear unbiased predictors (BLUP) of EBV for identified QTL and for the collective effect of polygenes. Kennedy et al (1992) suggested inclusion of genotype as a fixed effect in an animal model to estimate the effects of known genes, capitalizing on population-wide disequ ...
... evaluations, providing best linear unbiased predictors (BLUP) of EBV for identified QTL and for the collective effect of polygenes. Kennedy et al (1992) suggested inclusion of genotype as a fixed effect in an animal model to estimate the effects of known genes, capitalizing on population-wide disequ ...
The Genetic Principles of Crossbreeding
... The relative values of the direct and maternal effects will depend upon the biological mechanism for the traits. Some traits, such as postweaning average daily gain, are largely determined by the genotype of the individual. These traits will have relatively small contributions from maternal effects. ...
... The relative values of the direct and maternal effects will depend upon the biological mechanism for the traits. Some traits, such as postweaning average daily gain, are largely determined by the genotype of the individual. These traits will have relatively small contributions from maternal effects. ...
PDF full-Text - Journal of Investigational Allergology and Clinical
... with chromosome 18 abnormalities. The association of IgA deficiency and specific polysaccharide antibody deficiency is recognized in patients without defined chromosomal abnormalities, and may have significant implications, as those patients with isolated IgA deficiency had fewer lower respiratory t ...
... with chromosome 18 abnormalities. The association of IgA deficiency and specific polysaccharide antibody deficiency is recognized in patients without defined chromosomal abnormalities, and may have significant implications, as those patients with isolated IgA deficiency had fewer lower respiratory t ...
Genome-Wide Copy Number Variation in Epilepsy: Novel
... some cases, the epilepsy has a clear cause such as an abnormality in the brain or a head injury. However, in many cases there is no obvious cause. Numerous studies have shown that genetic factors are important in these types of epilepsy, but although several epilepsy genes are known, we can still on ...
... some cases, the epilepsy has a clear cause such as an abnormality in the brain or a head injury. However, in many cases there is no obvious cause. Numerous studies have shown that genetic factors are important in these types of epilepsy, but although several epilepsy genes are known, we can still on ...
A new defense of adaptationism
... that the big waves in these diagrams correspond to significant adaptations among the genotypes. We can see this clearly in Figure 1 by comparing a typical Evita evolutionary activity graph (above) with an activity graph of its neutral shadow (below). These graphs are strikingly different.22 Leaving ...
... that the big waves in these diagrams correspond to significant adaptations among the genotypes. We can see this clearly in Figure 1 by comparing a typical Evita evolutionary activity graph (above) with an activity graph of its neutral shadow (below). These graphs are strikingly different.22 Leaving ...
Tutorial - Chemistry
... In Taverna, new tools can be ‘added’ very easily because we are often actually calling external tools Go to http://www.biocatalogue.org and look around. Biocatalogue is a registry of available Web Services for the Life Sciences. You can use any of these tools in Taverna Search for the ‘ontology ...
... In Taverna, new tools can be ‘added’ very easily because we are often actually calling external tools Go to http://www.biocatalogue.org and look around. Biocatalogue is a registry of available Web Services for the Life Sciences. You can use any of these tools in Taverna Search for the ‘ontology ...
Trait to gene analysis reveals that allelic variation in three genes
... forms that were coincident with altered abscisic acid (ABA) sensitivity. We identified a further QTL, Reduced ABscisic Acid 1 (RABA1) that influenced ABA content and provide evidence that this results from the activity of a homologue of the ABA catabolic gene AtCYP707A2 at this locus. Lines contai ...
... forms that were coincident with altered abscisic acid (ABA) sensitivity. We identified a further QTL, Reduced ABscisic Acid 1 (RABA1) that influenced ABA content and provide evidence that this results from the activity of a homologue of the ABA catabolic gene AtCYP707A2 at this locus. Lines contai ...
Ethanol exposure affects gene expression in the embryonic
... identified numerous genes active in this embryonic structure. Among the organizer-specific genes are transcription factors, growth factors and secreted proteins. It is known that the interactions between these organizer-specific genes and others expressed around the blastopore will determine many as ...
... identified numerous genes active in this embryonic structure. Among the organizer-specific genes are transcription factors, growth factors and secreted proteins. It is known that the interactions between these organizer-specific genes and others expressed around the blastopore will determine many as ...
45 Online Planning for Large Markov Decision Processes
... space before the agent is actually interacting with the environment. In practice, offline algorithms often suffer from the problem of scalability due to the well-known “curse of dimensionality”—that is, the size of state space grows exponentially with the number of state variables [Littman et al. 19 ...
... space before the agent is actually interacting with the environment. In practice, offline algorithms often suffer from the problem of scalability due to the well-known “curse of dimensionality”—that is, the size of state space grows exponentially with the number of state variables [Littman et al. 19 ...
DOCX version of Questions and Answers on Bayer Cropscience
... greater reliance on native bushland and forest in the off farm environment. In addition, weeds controlled on Australian farms are usually exotic and are not considered environmentally valuable or important in maintaining biodiversity. Therefore, the results from the UK Farm Scale study cannot be use ...
... greater reliance on native bushland and forest in the off farm environment. In addition, weeds controlled on Australian farms are usually exotic and are not considered environmentally valuable or important in maintaining biodiversity. Therefore, the results from the UK Farm Scale study cannot be use ...
Gro and Eve co-regulate early boundaries - Development
... underlined. (B) Pull-down assay of full-length Groucho by Histagged Eve and derivatives: positive control, GST-En (GST-tagged En; amino acids 1-348); negative control, F→E (GST-En with a single point mutation in the eh1 GID; F175→E; Tolkunova et al., 1998). In vitro transcribed and translated (label ...
... underlined. (B) Pull-down assay of full-length Groucho by Histagged Eve and derivatives: positive control, GST-En (GST-tagged En; amino acids 1-348); negative control, F→E (GST-En with a single point mutation in the eh1 GID; F175→E; Tolkunova et al., 1998). In vitro transcribed and translated (label ...
Exclusion of known corneal dystrophy genes in an autosomal
... stroma. The majority of patients are asymptomatic. Recurrent erosions are not a typical feature, although photophobia is reported [3,4]. In vivo confocal microscopy of fleck dystrophies highlights small bright deposits in and around keratocyte nuclei that occur throughout the stroma despite the clin ...
... stroma. The majority of patients are asymptomatic. Recurrent erosions are not a typical feature, although photophobia is reported [3,4]. In vivo confocal microscopy of fleck dystrophies highlights small bright deposits in and around keratocyte nuclei that occur throughout the stroma despite the clin ...
mic.sgmjournals.org
... of each oligonucleotide primer, and 0.5 units of DynaZyme II DNA polymerase (Finnzymes). PCRs were also carried out using the BD Advantage Taq polymerase (BD Biosciences), 16 Advantage PCR buffer and otherwise the same conditions as above. The primer pair NMT-F (59-CTCACAAATTCATTTCTCATTCCT-39)/NMT-R ...
... of each oligonucleotide primer, and 0.5 units of DynaZyme II DNA polymerase (Finnzymes). PCRs were also carried out using the BD Advantage Taq polymerase (BD Biosciences), 16 Advantage PCR buffer and otherwise the same conditions as above. The primer pair NMT-F (59-CTCACAAATTCATTTCTCATTCCT-39)/NMT-R ...
Atlas of Genetics and Cytogenetics in Oncology and Haematology Scope
... (infections, haemorrhages), leukaemia, or solid cancer. It has recently been shown that significant phenotypic differences were found between the various complementation groups. In FA group A, patients homozygous for null mutations had an earlier onset of anemia and a higher incidence of leukemia th ...
... (infections, haemorrhages), leukaemia, or solid cancer. It has recently been shown that significant phenotypic differences were found between the various complementation groups. In FA group A, patients homozygous for null mutations had an earlier onset of anemia and a higher incidence of leukemia th ...
Association of KCNQ1, KCNE1, KCNH2 and SCN5A Polymorphisms
... We found that the alleles KCNQ1 rs757092 G and KCNH2 rs3815459 A were more frequent in the group of subjects with the longest QTc, which confirm the initial association described in a German population18. We found that allele SCN5A IVS24+116 A was more frequent in the group of subjects with the shor ...
... We found that the alleles KCNQ1 rs757092 G and KCNH2 rs3815459 A were more frequent in the group of subjects with the longest QTc, which confirm the initial association described in a German population18. We found that allele SCN5A IVS24+116 A was more frequent in the group of subjects with the shor ...
Risk assessment - Office of the Gene Technology Regulator
... are modified for altered plant architecture, enhanced water use efficiency or improved nitrogen use efficiency into the environment, in respect of application (DIR 070/2006) from the BSES Limited. The DIR070/2006 licence permits the release of up to 2500 genetically modified (GM) sugarcane lines on ...
... are modified for altered plant architecture, enhanced water use efficiency or improved nitrogen use efficiency into the environment, in respect of application (DIR 070/2006) from the BSES Limited. The DIR070/2006 licence permits the release of up to 2500 genetically modified (GM) sugarcane lines on ...
Genetic factors affecting dental caries risk
... This article reviews the literature on genetic aspects of dental caries and provides a framework for the rapidly changing disease model of caries. The scope is genetic aspects of various dental factors affecting dental caries. The PubMed database was searched for articles with keywords ‘caries’, ‘ge ...
... This article reviews the literature on genetic aspects of dental caries and provides a framework for the rapidly changing disease model of caries. The scope is genetic aspects of various dental factors affecting dental caries. The PubMed database was searched for articles with keywords ‘caries’, ‘ge ...
Rates of Spontaneous Mutation
... measured target vary by many orders of magnitude depending on the mutational target size (from 1 to .10 10 b, where b stands for base or base pair as appropriate), the average mutability per b (from 1024 to 102 11 per b per replication), and the specific mutability of a particular b (which can vary ...
... measured target vary by many orders of magnitude depending on the mutational target size (from 1 to .10 10 b, where b stands for base or base pair as appropriate), the average mutability per b (from 1024 to 102 11 per b per replication), and the specific mutability of a particular b (which can vary ...