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Reveal—visual eQTL analytics
Reveal—visual eQTL analytics

... confidence in the affected and unaffected groups. The ‘genome reference sequence’ box is colored according to the SNP’s reference nucleotide. The ‘individual patient alleles’ box shows an individual’s allelic combination encoded with the same solid and hashed fills used for the cohort genotype distr ...
The Heritability of happiness
The Heritability of happiness

... Happiness and personality: a common genetic background? • Edinburgh psychologists • Found no genetic effects that were specific to subjective well-being. • Instead they identified common genes that result in certain personality traits, which in turn predispose people to happiness. • Those who have ...
6.3 Mendel and Heredity
6.3 Mendel and Heredity

... • Genetics is the study of biological inheritance patterns and variation. • Gregor Mendel showed that traits are inherited as discrete units. – Like different colored marbles mixed together that can still be picked out separately. ...
123 Author`s personal copy
123 Author`s personal copy

... when this technique was designed, the construction and analysis of the genetic maps of Drosophila melanogaster became the object of a research program on which the geneticists’ efforts concentrated for at least two decades. At the same time, debates arose in the geneticists’ community about how to c ...
fog-1, a Regulatory Gene Required for Specification of
fog-1, a Regulatory Gene Required for Specification of

... In wild-type Caenorhabditis elegans, the X 0 male germ line makes only sperm and the XX hermaphrodite germ line makes sperm and then oocytes. In contrast, the germ line of either a male or a hermaphrodite carrying a mutation of the fog-1 (feminization of the germ line) locus is sexually transformed: ...
Automatically Generating Gene Summaries from Biomedical
Automatically Generating Gene Summaries from Biomedical

... to gene product, sequence information, genetical interaction, etc. More importantly, verbs such as “encode”, “sequence” and “interact” in the text are very indicative of which category the sentence is related to. Based on the regular structure of these text summaries, we decompose each paragraph int ...
123 Author`s personal copy
123 Author`s personal copy

... when this technique was designed, the construction and analysis of the genetic maps of Drosophila melanogaster became the object of a research program on which the geneticists’ efforts concentrated for at least two decades. At the same time, debates arose in the geneticists’ community about how to c ...
Balancer Chromosomes – An Optional Minitutorial What follows is a
Balancer Chromosomes – An Optional Minitutorial What follows is a

... This cross would yield three possible genotypes, Cy/Cy (all die), Cy/m (live unless m is a dominant lethal; these flies have the curly wings) and m/m (might survive; but won’t have the curly wings). The fact that there are inversions built into the balancer chromosome means that crossover cannot occ ...
Phylogenetic analysis of phytoplasmas based on sequences
Phylogenetic analysis of phytoplasmas based on sequences

... Previous analysis based primarily on the 16S rDNA gene has indicated that the aster yellows group phytoplasmas (16SrI) form a distinct subclade within the phytoplasma clade, and further analyses of this subclade using genes such as secY and tuf have subdivided this group into distinct lineages (Lee ...
Interplay between the transcription factors acting on
Interplay between the transcription factors acting on

... DNA was normalized to input DNA and calculated as a signal to noise ratio over an IgG control ChIP. The DDCt method was used to calculate fold change of binding to the promoter of interest (Livak & Schmittgen, 2001). Results are expressed as the mean±SEM of three independent experiments. ...
Codon usage in the Mycobacterium tuberculosis corn
Codon usage in the Mycobacterium tuberculosis corn

... although its genomic G C content is rather lower than in these other species (about 65 mol%, compared to about 75 mol YO). Second, M. tuberculosis multiplies almost exclusively in macrophages, with a doubling time of about 24 h : if codon selection were mediated by the need for efficient use of ribo ...
Flexible expressed region analysis for RNA
Flexible expressed region analysis for RNA

... aligned to each base in the genome) to identify differential expression signal at each individual base and merges adjacent bases with similar signal into candidate regions. However, the software for our first version was limited to small sample sizes, the ability to interrogate targeted genomic loci ...
The Mouse Prolactin Gene Family Locus
The Mouse Prolactin Gene Family Locus

... anterior pituitary during the second half of gestation in the mouse or rat was consistent with continued development of the mammary glands and corpus luteum (another target of PRL; Refs. 6 and 7). These studies suggested an extrapituitary source of a PRL-like hormone and were followed by the discove ...
B. Intralocular Interactions
B. Intralocular Interactions

... produce the same alternative ‘null’. For example, two strains of white flowers may be white for different reasons; each lacking a different necessary enzyme to make color. So there must be a dominant gene at both loci to produce color. Indeed, by mating two strains together, we can determine whether ...
Comparative genomic analysis of carbon and nitrogen assimilation
Comparative genomic analysis of carbon and nitrogen assimilation

... Background: Carbon and nitrogen fixation are essential pathways for autotrophic bacteria living in extreme environments. These bacteria can use carbon dioxide directly from the air as their sole carbon source and can use different sources of nitrogen such as ammonia, nitrate, nitrite, or even nitrog ...
Is maize B chromosome preferential fertilization controlled by a
Is maize B chromosome preferential fertilization controlled by a

... obtained by scoring for B number in hundreds of plants, show that the native B undergoes nondisjunction in 100% of the cases because in 0B ´ 2B crosses not a single 1B plant was found. From our present results it can be concluded that the behaviour of the native B during gametogenesis is consistentl ...
General Biology I (BIOLS 102)
General Biology I (BIOLS 102)

... has a variety of heritable mutations, this insect has been used extensively in genetic research  Allele that occurs most frequently in population (normal) is known as wild type  Two mutations displayed by this fly are wing length and body color  Wild type (normal) flies have long wings (L) and gr ...
Presentation @9:30am
Presentation @9:30am

Document
Document

... C1. Mendel’s work showed that genetic determinants are inherited in a dominant/recessive manner. This was readily apparent in many of his crosses. For example, when he crossed two true-breeding plants for a trait such as height (i.e., tall versus dwarf), all the F1 plants were tall. This is inconsis ...
Mutator Transposon in Maize and MULEs in the Plant Genome
Mutator Transposon in Maize and MULEs in the Plant Genome

... and future directions of related research are also discussed. Understanding Mu will help us elucidate the dynamic genome. Key words: Mutator; transposon; genome evolution; MULE; Pack-MuLE ...
Genetic Causes of Phenotypic Adaptation to the Second
Genetic Causes of Phenotypic Adaptation to the Second

... ABSTRACT Hybridization is known to improve complex traits due to heterosis and phenotypic robustness. However, these phenomena have been rarely explained at the molecular level. Here, the genetic determinism of Saccharomyces cerevisiae fermentation performance was investigated using a QTL mapping ap ...
C1. Mendel`s work showed that genetic determinants are inherited in
C1. Mendel`s work showed that genetic determinants are inherited in

... C1. Mendel’s work showed that genetic determinants are inherited in a dominant/recessive manner. This was readily apparent in many of his crosses. For example, when he crossed two true-breeding plants for a trait such as height (i.e., tall versus dwarf), all the F1 plants were tall. This is inconsis ...
introduction
introduction

... McFadden, 2003). It has been suggested that these lineages have diverged from their last common ancestor, which possessed a plastid several hundred million years ago. It has been very hard to trace the evolutionary origin of the apicoplast. Phylogenetic analysis of the 35kb plDNA of P. Jalciparum ha ...
Document
Document

... All the experimental evidence generated on the biosynthesis of queuosine and other 7-deazapurine natural products point to a GTP cyclohydrolase(GCYHI) or cyclohydrolase-like reaction as the first step in the biosynthesis. While we demonstrated that YkvM was not the expected cyclohydrolase enzyme, fu ...
Yeast as a Model Genetic Organism
Yeast as a Model Genetic Organism

... When diploid budding yeast are starved of nutrients, they can undergo meiosis to generate four haploid spores (Figures 1 and 2). Spores are more resistant to the environment than are vegetatively dividing cells. The four spores of a single meiosis are held together in an ascus, or tetrad, surrounded ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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