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The dilemma of dominance
The dilemma of dominance

... Conceptual clarity may be fostered, I claim, by viewing diploid organisms as diphenic and by framing genetic causality modestly through individual alleles and their corresponding haplophenotypes. ...
Hermann Joseph Muller - National Academy of Sciences
Hermann Joseph Muller - National Academy of Sciences

... States or Germany. Muller himself was an atheist and later in life chose the American Humanist Association as an outlet for his religious feelings, serving as president of that organization in 1957. On his uncle’s side Muller’s penchant for academic life was shared by his first cousin Herbert J. Mul ...
hermann joseph muller 1890—1967
hermann joseph muller 1890—1967

... States or Germany. Muller himself was an atheist and later in life chose the American Humanist Association as an outlet for his religious feelings, serving as president of that organization in 1957. On his uncle’s side Muller’s penchant for academic life was shared by his first cousin Herbert J. Mul ...
Lesson Overview - Enfield High School
Lesson Overview - Enfield High School

...  Each of the traits Mendel studied was controlled by one gene that occurred in two contrasting varieties. These gene variations produced different expressions, or forms, of each trait.  The different forms of a gene are called alleles. ...
The one-eyed pinhead gene functions in mesoderm and endoderm
The one-eyed pinhead gene functions in mesoderm and endoderm

... site (STS) marker for the 15AH.500 locus was generated by cloning and sequencing the RAPD fragment and synthesizing primers specific for that sequence (primer WTZ97, 5′-ACTTGCAGGAGTGGATCTGAC, and primer WTZ106, 5′-CACAAAAACACCATCTGACC). In the oep mapping crosses, all of the animals display an allel ...
Ingenuity Variant Analysis
Ingenuity Variant Analysis

... HGMD Variant Type: This is the primary focus for finding interesting variants, and most interesting are the disease-causing variants. Predisposing variants tend not to have complete penetrance: one can easily harbour some, without having or ever getting the disease. It means that there is some evide ...
Creating order from chaos: epigenome dynamics in
Creating order from chaos: epigenome dynamics in

... genomes are survivors of independent “blooms” of TE activity followed by epigenetic ...
Sharp Insights and a Sharp Tongue
Sharp Insights and a Sharp Tongue

... CREDIT: COURTESY OF ROBERT TRIVERS ...
Mendelian Genetics
Mendelian Genetics

... Using pea plants, found indirect but observable evidence of how parents transmit genes to offspring ...
Mesenchymal Dysplasia: A Recessive Mutation
Mesenchymal Dysplasia: A Recessive Mutation

... human conditions (Winter 1988). With the rapidly expanding mouse genetic map, the structural genes for many mutations causing such syndromes are now being identified. Thus, each new mouse mutation that causes congenital malformations provides the potential of identifying the gene affected in compara ...
Huntingtin function during zebrafish (Danio rerio) development
Huntingtin function during zebrafish (Danio rerio) development

... neurodegenerative diseases: expansion of an existing polyglutamine tract. In each case, this repeat tract occurs within otherwise unrelated proteins. These proteins show widespread and overlapping patterns of expression in the brain and yet the diseases are distinguished by neurodegeneration in a sp ...
ABA overlysensitive5 (ABO5), encoding a pentatricopeptide repeat
ABA overlysensitive5 (ABO5), encoding a pentatricopeptide repeat

... directly accepts electrons from the ubiquinone pool for reducing ROS production. These alternative pathways increase the tolerance of plant mitochondria to respiratory defects, and loss of complex I has diverse effects on plant cells. For example, mutation in frostbite 1 (fro1), a nuclear gene encod ...
Establishing neuroblast-specific gene expression in the Drosophila
Establishing neuroblast-specific gene expression in the Drosophila

... The Drosophila ventral neuroectoderm produces a stereotyped array of central nervous system precursors, called neuroblasts. Each neuroblast has a unique identity based on its position, pattern of gene expression and cell lineage. To understand how neuronal diversity is generated, we need to learn ho ...
Investigating the functional significance of evolutionarily conserved
Investigating the functional significance of evolutionarily conserved

... Bilaterans share a common anterior-posterior (A-P) axis that is patterned by the Homeotic selector (Hox) genes. In Drosophila melanogaster, Hox gene expression in spatially restricted domains along the A-P axis of the embryo determines segmental identity. Identifying the genetic mechanisms of HOX co ...
Engineering the pentose phosphate pathway of
Engineering the pentose phosphate pathway of

... reductase (XR) and xylitol dehydrogenase (XDH) from the D-xylose-utilising yeast Pichia stipitis. In this study, the ability of endogenous genes of S. cerevisiae to enable D-xylose utilisation was evaluated. Overexpression of the GRE3 gene coding for an unspecific aldose reductase and the ScXYL2 gen ...
Rhizobium Nodulation Protein NodC Is an Important Determinant of
Rhizobium Nodulation Protein NodC Is an Important Determinant of

... the host specificity of R. meliloti, a conclusion consistent with the results of several studies which have shown that the lengths of the oligosaccharide backbones of LCOs can strongly influence their activities on host plants. synthesis of LCOs that were characterized as chitin oligosaccharides (10 ...
The Homothorax homeoprotein activates the nuclear localization of
The Homothorax homeoprotein activates the nuclear localization of

... exd has other roles in addition to its homeotic cofactor function. exd mutant clones caused ectopic eye formation in the ventral head, ventral to dorsal transformation in the imaginal abdomen, affected bristle patterning in the thorax and wing, and affected the proximal leg development (Gonzalez-Cre ...
The female-killing chromosome of the silkworm, Bombyx mori, was
The female-killing chromosome of the silkworm, Bombyx mori, was

... feminizing gene (Fem) on the W chromosome. The paternally transmitted mutant W chromosome, Df(pSa+pW+od)Fem, derived from the translocation-carrying W chromosome (pSa+pW+od), is inert as femaleness determinant. Moreover, this Df(pSa+pW+od)Fem chromosome has been thought to have a female-killing fact ...
GENETICS DEFINITION
GENETICS DEFINITION

...  Very common gene action in coat color inheritance in animals. The dilution gene in horses affects the b locus to dilute to palomino or cremelo.  The e locus in labs will result in a yellow lab if the e locus is ee and the b locus is either BB, Bb or bb. Difference is in the nose color. ...
11-2 Genetics Notes
11-2 Genetics Notes

... A Summary of Mendel’s Principles What did Mendel contribute to our understanding of genetics? Mendel’s principles of heredity, observed through patterns of inheritance, form the basis of modern genetics. ...
Genetics fill in review
Genetics fill in review

... 42. Genes may be made more accessible to RNA polymerase by a sequence of nucleotides called ____________________. 43. As an organism grows from a zygote, certain genes in each cell are allowed to be expressed and others are not. This process is called ____________________ and results in the developm ...
Leukaemia Section 3q rearrangements in myeloid malignancies Atlas of Genetics and Cytogenetics
Leukaemia Section 3q rearrangements in myeloid malignancies Atlas of Genetics and Cytogenetics

... Ectopic expression of an intact or truncated EVI1 transcript has been reported as a result of 3q26 rearrangements. Generally, 3q26 breakpoints map 3' to EVI1 in the inv(3) while the t(3;3) breakpoints more frequently reside 5' to EVI1. In addition expression of GR6/EVI1 and RPN1/EVI1 chimeras have b ...
Genetic aspects in sarcoidosis REVIEW M. Luisetti*, A. Beretta*, L. Casali*
Genetic aspects in sarcoidosis REVIEW M. Luisetti*, A. Beretta*, L. Casali*

... important to start off by saying that this issue remains questionable, not only because of the lack of an unambiguous demonstration of the nature of the putative agent, but also because of the inability to reproduce some studies or serious biases in others [22]. Several lines of evidence suggest the ...
Effete, a Drosophila chromatin-associated ubiquitin
Effete, a Drosophila chromatin-associated ubiquitin

... Many studies have shown that telomeres modulate the expression of genes located in their proximity, a phenomenon known as telomere position effect (TPE). This form of transcriptional regulation is conserved from yeast to humans, and has been implicated in numerous human pathologies (reviewed in (Ott ...
trigger - Bioconductor
trigger - Bioconductor

... gene end for all the genes in the gene expression matrix. The rows of exp.pos should match those of exp. marker: A matrix with p rows and n columns, containing genotyping information. marker.pos: A matrix with p rows and 2 columns containing the chromosome number and SNP position for all the genes i ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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