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Differential Network Analysis
Differential Network Analysis

... pval1=(logicalSum1+1)/(no.perms+1) pval1 pval2=(logicalSum2+1)/(no.perms+1) pval2 pval3=(logicalSum3+1)/(no.perms+1) pval3 pval4=(logicalSum4+1)/(no.perms+1) pval4 pval5=(logicalSum5+1)/(no.perms+1) pval5 pval6=(logicalSum6+1)/(no.perms+1) pval6 pval7=(logicalSum7+1)/(no.perms+1) pval7 pval8=(logica ...
Foundations of Biology
Foundations of Biology

... A single transcription factor (or group of transcription factors) may regulate expression of a group of genes (i.e., heat shock proteins) A single gene may be regulated by a number of independent transcription factors (i.e., metallothionein) Eukaryotic regulation does not seem to involve repression ...
Toward a Unified Genetic Map of Higher Plants, Transcending the
Toward a Unified Genetic Map of Higher Plants, Transcending the

... biotic evolution, as already demonstrated across 65 Myr of divergence1 8, may have many important consequences. In medicine, comparative analysis might shed new light on convergent or parallel evolution of functionally similar structures, such as the eyes of invertebrates and vertebrates, which evol ...
M-protein and other intrinsic virulence factors of Streptococcus
M-protein and other intrinsic virulence factors of Streptococcus

... tes present a bidirectional replication starting from the origin of replication and reading in both directions until reaching a terminus (replication inset). The bidirectional replication therefore defines a leading and a lagging strand in the double helix. In the contrary, nucleotide sequence readi ...
Microdeletions on the long arm of the Y chromosome
Microdeletions on the long arm of the Y chromosome

... The treatment of male infertility has been revolutionised by the development of intracytoplasmic sperm injection (ICSI). In this procedure, only oocyte quality and individual sperm viability have been shown to affect fertilisation rates.1 In conventional in vitro fertilisation (IVF), approximately 5 ...
Supplementary Online Material
Supplementary Online Material

... target groups (Supp. Table 11), while the 133 synthetic lethal pairs formed 44 target groups (Supp. Table 12). The target group that specifically inhibits cholesterol production consists of a long chain of enzymes directly involved in cholesterol biosynthesis (in accordance with the pathway annotati ...
The Fifties and the Renaissance in Human and
The Fifties and the Renaissance in Human and

... HE period from 1956 to 1962 was seminal for human and mammalian cytogenetics. The human chromosome number and normalhuman karyotype were established, along with those of many other mammals. The high incidence and severe effects of human aneuploidy were discovered, along with the critical importance ...
Keystone2011poster
Keystone2011poster

... The sequencing and phylogenetic analysis of rRNA molecules demonstrated that all organisms could be placed on a single tree of life. Highly conserved, homologous 16S rRNA genes' presence in all organismal lineages makes them the only universal marker that has been adopted by biologist. Unfortunately ...
Expression analysis of a chicory fructan 1‐exohydrolase gene
Expression analysis of a chicory fructan 1‐exohydrolase gene

... genes during cold induction and proposed a physiological role for the deletion of the b-fructofuranosidase DPN motif. Interestingly, since fructans are proposed to be localized in the vacuoles, it might be expected that plant 1FEH cDNAs would be more closely related to the vacuolar invertases; howev ...
Chp 13 Meiosis and Sexual Life Cycles
Chp 13 Meiosis and Sexual Life Cycles

... Independent assortment = The random distribution of maternal and paternal homologues to the gametes. (In a more speciDc sense, assortment refers to the random distribution of genes located on different chromosomes.) ï Since each homologous pair assorts independently from all the others, the process ...
Evolution by the birth-and-death process in multigene
Evolution by the birth-and-death process in multigene

... mouse class Ia genes are not orthologous with the human class Ia genes (24–26), and therefore different gene symbols are used for them (Fig. 2). Actually, most different orders of mammals seem to have nonorthologous class Ia genes. The number of class Ia genes in mammals is usually 1–3, but there ar ...
1 Hello, my name is Gary Cutting, and I`m going to speak on the
1 Hello, my name is Gary Cutting, and I`m going to speak on the

... There is one caveat that should be obvious to most in the audience that, obviously, genes located close together, on the same chromosome for example, would not assort, because they’re going to go together if they’re on the same chromosome. In most cases, the genes are on separate chromosomes, and th ...
The Modular Structure and Function of the Wheat HI Promoter with S
The Modular Structure and Function of the Wheat HI Promoter with S

... TH315 protein with other plant His showed that similarity was rather restricted to the central globular domain (Fig. 3A), ranging from 80% for wcHl-1 (Yang et al. 1991) to 50% for Arabidopsis Hisl-3 (Ascenzi and Gantt 1997). In a phylogenetic tree, plant HI proteins can be classified into at least t ...
Document
Document

... plants with spherical seeds were crossed with true-breeding plants with dented seeds. (Spherical seeds are the dominant characteristic.) Mendel collected the seeds from this cross, grew F1-generation plants, let them self-pollinate to form a second generation, and analyzed the seeds of the resulting ...
FAMOUS SCIENTISTS
FAMOUS SCIENTISTS

... separate and only one allele from each parent passes to an offspring is Mendel's principle of: ...
The Work of Gregor Mendel:
The Work of Gregor Mendel:

... Mixture of all the traits? NO, all hybrids had characteristics of only ONE parents  In each cross, the character of the other parent seemed to disappear! ...
Genome Evolution, Chromosomal Mutations, Paralogy
Genome Evolution, Chromosomal Mutations, Paralogy

Tweak to molecular scissors cuts path to turn on genes —
Tweak to molecular scissors cuts path to turn on genes —

... noted in gene and exon maps, whereas others may code for regulatory RNAs. The researchers investigated whether changes in gene expression over different life stages correlate with shifts in the brain, such as an increase in the proportion of support cells called glia. Instead, they found that the ch ...
Additional file 4 - Springer Static Content Server
Additional file 4 - Springer Static Content Server

... quantifying genomic sites with microarrays or by sequencing to analyze total dissolved DNAs because the total number of DNA targets per cell all doubled during genomewide tetraploidization to maintain the relative ratios of any genomewide targets. The difference in the number of DNA sequences per ce ...
Document
Document

... It contains a total of about 2,000 genetic diseases [and another ~11,000 genetic loci with known phenotypes - but not necessarily known gene sequences] It is designed for use by physicians:  can search by disease name  contains summaries from clinical studies ...
Cluster analysis
Cluster analysis

... Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diagnosis. Also, it is likely that the existing classes are heterogeneous. DNA microarrays may be used to characteri ...
Lac A
Lac A

... CIS dominant mutation: it expresses the dominant phenotype but it affects only the expression of genes on the same DNA molecule where the mutation occurs. LacOc, affects only neighbouring genes (for exemple a plasmid) To demonstrate it we construct an heterozygote (diploid) with: The mutation lacZ- ...
The Complete Genome Sequence of Clostridium aceticum: a
The Complete Genome Sequence of Clostridium aceticum: a

... spectroscopy at room temperature and ⫺196°C in cell-free extracts of C. aceticum (15). The bands obtained indicated a c-type cytochrome. Indeed, all genes required for synthesis of a cytochrome c could be identified in the genome of C. aceticum (hemACDBL [CACET_c00470-CACET_c00520], hemE [CACET_ c22 ...
PCB5065 Exam 2 - UF Plant Pathology
PCB5065 Exam 2 - UF Plant Pathology

... a) mitotic recombination results in crossing over half the time. F b) mitotic recombination is usually the result of gene conversion T c) in Drosophila and most organisms, mitotic recombination differs from meiotic in that the homology search during mitotic recombination must cover the whole genome. ...
bb2013_03 - Territory Stories
bb2013_03 - Territory Stories

... gene) for the horn/poll gene (they get one copy from each parent). The gene for polledness (P) is dominant to the gene for horns (H) and so when an animal has copy of the polled gene it will be polled even if its other copy of the gene is for horns. Animals with one of each copy of the gene (i.e. PH ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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