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The Homothorax homeoprotein activates the nuclear localization of
The Homothorax homeoprotein activates the nuclear localization of

... bind to specific DNA sequences (Lu and Kamps 1996), suggesting that it can act as a transcription factor by itself in vivo. We report the cloning and characterization of the homothorax (hth) gene in Drosophila. hth was found to act as a homeotic cofactor in embryonic development, similar to exd (Rie ...
LACTOSE INTOLERANCE – CURRENT STATE OF
LACTOSE INTOLERANCE – CURRENT STATE OF

... Small intestine biopsy is the only diagnostic procedure allowing for the direct measurement of lactase activity. However, due to invasive nature it is hardly accepted by patients unless they have to undergo gastrointestinal endoscopy for other reasons. Therefore, lactase persistence/nonpersistence s ...
Genetic Modifications of Saccharomyces cerevisiae for Ethanol
Genetic Modifications of Saccharomyces cerevisiae for Ethanol

... glucoamylase) treatment before the main fermentation process [7]. This is a relatively expensive application as 30-40% of the total cost for the fermentation process is spent for the liquefaction and saccharification necessary for this popular microbe to be used [26]. Moreover, adding caustic soda, ...
Creating order from chaos: epigenome dynamics in
Creating order from chaos: epigenome dynamics in

... dimensional organization of genomic DNA, recombination, and DNA repair. There are a ...
Retinopathy of Prematurity
Retinopathy of Prematurity

... o Myopia occurs in about 80% of infants with ROP 47 level 6. o Strabismus and amblyopia are also common residual findings. The prevalence of strabismus ranges from 23% to 47% in infants with ROP and found to be 20% in a regional study 47 level 6; 48 level 8. o Retinal detachment has been seen in 22% ...
The Center for Organogenesis | University of Michigan, Ann Arbor
The Center for Organogenesis | University of Michigan, Ann Arbor

... Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis April N. Smith1, Leigh-Anne Miller1, Glenn Radice2,*, Ruth Ashery-Padan3 and Richard A. Lang1,4,5,† The transcription factors Pax6 and Sox2 have been implicated in early events in lens induction and have bee ...
The presence of an RHD pseudogene containing a
The presence of an RHD pseudogene containing a

... hybrid genes encoding partial D antigens may predict a D-negative phenotype, and the presence of some RHD regions in genes encoding no D antigen may predict a D-positive phenotype. In order to avoid these complications, methods where more than 1 region of RHD is detected in a single PCR were introdu ...
Auxin Biosynthesis and Its Role in Plant Development
Auxin Biosynthesis and Its Role in Plant Development

... to the hypothesis that IAA is mainly produced through a trp-independent pathway in Arabidopsis and in maize (42, 69). Although the early studies on trp mutants were informative, they did not identify the genes responsible for auxin biosynthesis in plants. Furthermore, interpretation of the experimen ...
Auxin Biosynthesis and Its Role in Plant Development
Auxin Biosynthesis and Its Role in Plant Development

Rhizobium Nodulation Protein NodC Is an Important Determinant of
Rhizobium Nodulation Protein NodC Is an Important Determinant of

... various Rhizobium species. We expressed the cloned nodC genes of Rhizobium meliloti, R. leguminosarum bv. viciae, and R. loti in Escherichia coli. The in vivo activities of the various NodC proteins differed with respect to the length of the major chitin oligosaccharide produced. The clearest differ ...
Literature Study
Literature Study

PDF
PDF

... just before fusion, and is often coincident with Kirre or Rst at points of cell-cell contact (Bour et al., 2000; Galletta et al., 2004). Hbs is also restricted to the FCMs, where it declines slightly before Sns. In cells that express both proteins, Sns and Hbs co-localize at discrete points on the c ...
Time to asthma onset Asthma score Bivariate analysis - Hal-CEA
Time to asthma onset Asthma score Bivariate analysis - Hal-CEA

Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. Neurogenetics. 2012 Feb;11(1):53-71. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.
Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. Neurogenetics. 2012 Feb;11(1):53-71. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.

... standard pathological examination [6, 7]. However, a subtle, but significant, dilation of the lateral ventricles has been detected with high-resolution magnetic resonance imaging [58]. Interestingly, breeding L1KO mice onto a C57BL/6J background enhances the L1KO phenotype and results in severe hydr ...
Pollen developmental biology
Pollen developmental biology

... and microspore degeneration. In dex1, the tapetum appears normal, and a callose wall and primexine are present. Therefore it was concluded that primexine and the callose wall do not play a direct role in pattern formation, but the plasma membrane is likely to be important (Paxson-Sowders et al.1997 ...
(Pan) Salmonella and Salmonella Serotype Typhi–Specific Real
(Pan) Salmonella and Salmonella Serotype Typhi–Specific Real

... throughout the world. In addition, Salmonella enterica serotypes Typhi and Paratyphi are important causes of enteric fever in underdeveloped countries that lack adequate sewage disposal and water treatment facilities.1,2 It is standard practice in many clinical microbiology laboratories to culture f ...
NO sensing by FNR: regulation of the Escherichia coli NO
NO sensing by FNR: regulation of the Escherichia coli NO

... Anaerobically, Hmp serves as an NO reductase, generating nitrous oxide (Hausladen et al., 1998; Kim et al., 1999). Consistent with the role of Hmp in NO detoxi®cation, the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 199 ...
MHC, mechanisms and
MHC, mechanisms and

... subject to heterozygote advantage, one may therefore expect to observe associations between MHC heterozygosity and both pathogen load and diversity. Nonetheless, heterozygote advantage may be best understood when considered in the context of multiple pathogens, as MHC alleles conferring resistance t ...
How pathogens drive genetic diversity: MHC, mechanisms and
How pathogens drive genetic diversity: MHC, mechanisms and

... subject to heterozygote advantage, one may therefore expect to observe associations between MHC heterozygosity and both pathogen load and diversity. Nonetheless, heterozygote advantage may be best understood when considered in the context of multiple pathogens, as MHC alleles conferring resistance t ...
The growth hormone auxin
The growth hormone auxin

... characterization of mutants resistant to exogenous auxin and auxin polar transport inhibitors. axr mutants, tir mutants ...
Genetic Analysis of Variation in Human Meiotic Recombination
Genetic Analysis of Variation in Human Meiotic Recombination

... and males, respectively. The remaining four loci were not known to contribute to individual variation in genome-wide recombination rates. These results provide new information to study the regulation of meiotic recombination. ...
Cytogenetic Analysis Shows that the Unusually Large Chromosome
Cytogenetic Analysis Shows that the Unusually Large Chromosome

... strain was variable. Evidently, the W chromosome of the TWPB strain is attached to another chromosome. The composition of the W chromosome, the second chromosome fragment, and the fifth chromosome was studied through linkage analysis for these three chromosomes. We used two strains derived from the ...
Real-time PCR Handbook
Real-time PCR Handbook

... cycling with fluorescent dye scanning capability. By plotting fluorescence against the cycle number, the real-time PCR instrument generates an amplification plot that represents the accumulation of product over the duration of the entire PCR reaction (Figure 1). The advantages of real-time PCR inclu ...
High grade B-cell lymphomas (HGBL): Altered terminology in the
High grade B-cell lymphomas (HGBL): Altered terminology in the

... BCR/proliferation: Has more abundant expression of cell-cycle regulatory genes (CDK2, MCM family members, etc.); increased expression of DNA repair genes (PMS2, H2AX, PTIP, P53); higher levels of BCR signaling cascade components (CD19, Ig, CD79a, SYK, BLK) and B-cell-related transcription factors (P ...
The glandular aspects of the tabby syndrome in the
The glandular aspects of the tabby syndrome in the

... others involving the same organs will ultimately help in understanding the underlying causalities. The gene for tabby has in recent years figured often in the 'inactive ^-chromosome' controversy. The present study is mainly concerned with the tabby male; but a few new facts concerning its manifestat ...
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Designer baby

Designer baby is a term that refers to the product of a genetically engineered baby. These babies are ""designed"" (fixed/changed) while still in the womb to achieve more desired looks, skills, or talents.
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