Nature Genetics: doi:10.1038/ng.3791
... Creating a Universal Mappability Map (UMM) for the DGRP lines Sequence variation between individuals or lines can induce variation in the ability to correctly map short sequence reads back to their location in a reference genome. Such sequence-specific biases in mapping can lead to artificial associ ...
... Creating a Universal Mappability Map (UMM) for the DGRP lines Sequence variation between individuals or lines can induce variation in the ability to correctly map short sequence reads back to their location in a reference genome. Such sequence-specific biases in mapping can lead to artificial associ ...
Comparative Genomics
... Comparative Genomics Allows us to achieve a greater understanding of vertebrate evolution Tells us what is common and what is unique between different species at the genome level The function of human genes and other regions may be revealed by studying their counterparts in lower organisms ...
... Comparative Genomics Allows us to achieve a greater understanding of vertebrate evolution Tells us what is common and what is unique between different species at the genome level The function of human genes and other regions may be revealed by studying their counterparts in lower organisms ...
The Arabidopsis NAC Transcription Factor VNI2
... Among the NAC transcription factor genes identified in Arabidopsis, VNI2 (AT5G13180) is of particular interest in that it is influenced by both developmental and environmental cues. Gene expression analysis using the GENEVESTIGATOR database (https://www.genevestigator.com/gv/index.jsp) revealed that ...
... Among the NAC transcription factor genes identified in Arabidopsis, VNI2 (AT5G13180) is of particular interest in that it is influenced by both developmental and environmental cues. Gene expression analysis using the GENEVESTIGATOR database (https://www.genevestigator.com/gv/index.jsp) revealed that ...
Non-additive genome-wide association scan reveals a new gene
... imputation on the INGI cohorts was conducted after standard QC using SHAPEIT223 for the phasing step and IMPUTE224 for the imputation using the1000 Genomes phase I v3 reference set25. ERF has been genotyped with different genotyping platforms: Illumina 318 k, 350 k, 610 k and Affymetrix 200 k. Genot ...
... imputation on the INGI cohorts was conducted after standard QC using SHAPEIT223 for the phasing step and IMPUTE224 for the imputation using the1000 Genomes phase I v3 reference set25. ERF has been genotyped with different genotyping platforms: Illumina 318 k, 350 k, 610 k and Affymetrix 200 k. Genot ...
... chicken and pork meat. The isolated strains were resistant to at least four antimicrobial agents, especially to ampicillin, tetracycline, gentamicin and kanamycin. Qiongfen et al. (2011), in a study of stool samples from pigs reared on a farm located in eastern China, found a single P. mirabilis str ...
Slide 1
... A tRNA molecule. In this series of diagrams, the same tRNA molecule—in this case a tRNA specific for the amino acid phenylalanine (Phe)—is depicted in various ways. (A) The cloverleaf structure, a convention used to show the complementary base-pairing (red lines) that creates the double-helical reg ...
... A tRNA molecule. In this series of diagrams, the same tRNA molecule—in this case a tRNA specific for the amino acid phenylalanine (Phe)—is depicted in various ways. (A) The cloverleaf structure, a convention used to show the complementary base-pairing (red lines) that creates the double-helical reg ...
Genetic Analysis of Apomixis
... research has followed three main approaches. The first of these approaches is mapping and gene discovery to identify loci controlling apomixis in apomictic plants (Spillane et al., 2001). Molecular markers, such as RFLPs, RAPDs, and AFLPs are screened onto segregating apomictic populations and their ...
... research has followed three main approaches. The first of these approaches is mapping and gene discovery to identify loci controlling apomixis in apomictic plants (Spillane et al., 2001). Molecular markers, such as RFLPs, RAPDs, and AFLPs are screened onto segregating apomictic populations and their ...
Genetics 1 - National Open University of Nigeria
... observations that “Like begets like”, that children tend to resemble their parents as well as their siblings (or sibs i.e. their brothers and sisters), but they also tend to vary or look different from one another in many ways. Genetics is the science, which tries to account for similarities and var ...
... observations that “Like begets like”, that children tend to resemble their parents as well as their siblings (or sibs i.e. their brothers and sisters), but they also tend to vary or look different from one another in many ways. Genetics is the science, which tries to account for similarities and var ...
lecture
... leads to a glu val substitution ( RFLP!) In North America, heterozygosity for mutant allele is largely asymptomatic (sickle cell trait), because concentration of hemoglobin S is not high enough for the erythrocytes to sickle. In areas with high incidence of malaria, the fitness of heterozygotes i ...
... leads to a glu val substitution ( RFLP!) In North America, heterozygosity for mutant allele is largely asymptomatic (sickle cell trait), because concentration of hemoglobin S is not high enough for the erythrocytes to sickle. In areas with high incidence of malaria, the fitness of heterozygotes i ...
the loci of evolution: how predictable is genetic
... variation, whereas others have considered all kinds of phenotypic changes (morphology, behavior, physiology, etc.). Second, the predominance of cis-regulatory mutations has been invoked either relative to coding mutations, what we call the “narrow cis-regulatory hypothesis,” or relative to any other ...
... variation, whereas others have considered all kinds of phenotypic changes (morphology, behavior, physiology, etc.). Second, the predominance of cis-regulatory mutations has been invoked either relative to coding mutations, what we call the “narrow cis-regulatory hypothesis,” or relative to any other ...
Module 7 – Microbial Molecular Biology and Genetics
... thymine in RNA and differs from thymine by lacking a methyl group on its ring. Uracil is not usually found in DNA, occurring only as a breakdown product of cytosine. In addition to RNA and DNA a large number of artificial nucleic acid analogues have also been created to study the proprieties of nucl ...
... thymine in RNA and differs from thymine by lacking a methyl group on its ring. Uracil is not usually found in DNA, occurring only as a breakdown product of cytosine. In addition to RNA and DNA a large number of artificial nucleic acid analogues have also been created to study the proprieties of nucl ...
Summary of lesson
... heterozygous, one of each allele is present. An organism’s phenotype is the trait that is outwardly expressed by the organism. The example explored here, height in pea plants, is determined by one pair of alleles: tall (T) is dominant and short (t) is recessive. The letters “T” and “t” are used to d ...
... heterozygous, one of each allele is present. An organism’s phenotype is the trait that is outwardly expressed by the organism. The example explored here, height in pea plants, is determined by one pair of alleles: tall (T) is dominant and short (t) is recessive. The letters “T” and “t” are used to d ...
Exam #4_REVIEW-11042016-LW
... 59) Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C nucleotides and chemical histone changes to silence a given gene. If this depends on the sex of the parent who transmits the gene, which of the following must be true? Section: 15.5 60) Correns found that the inheri ...
... 59) Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C nucleotides and chemical histone changes to silence a given gene. If this depends on the sex of the parent who transmits the gene, which of the following must be true? Section: 15.5 60) Correns found that the inheri ...
THE LOCI OF EVOLUTION: HOW PREDICTABLE IS GENETIC
... variation, whereas others have considered all kinds of phenotypic changes (morphology, behavior, physiology, etc.). Second, the predominance of cis-regulatory mutations has been invoked either relative to coding mutations, what we call the “narrow cis-regulatory hypothesis,” or relative to any other ...
... variation, whereas others have considered all kinds of phenotypic changes (morphology, behavior, physiology, etc.). Second, the predominance of cis-regulatory mutations has been invoked either relative to coding mutations, what we call the “narrow cis-regulatory hypothesis,” or relative to any other ...
Gener , Evolution and Environment
... Epigenetics (1 of 2) • Many people think of the genome as a static blueprint, a set of coded messages that never changes over a person’s lifetime. • But this is a big misconception. • The genome changes over time because of: – mutations that arise before or after birth – epigenetic changes that aff ...
... Epigenetics (1 of 2) • Many people think of the genome as a static blueprint, a set of coded messages that never changes over a person’s lifetime. • But this is a big misconception. • The genome changes over time because of: – mutations that arise before or after birth – epigenetic changes that aff ...
disease revealed by a metagenomic approach Reduced diversity of
... nder certain circumstances, the indigenous gut microbes will be determinant in the onset and maintenance of inflammatory bowel disease, especially Crohn’s disease (CD), to which genetic susceptibility and disorders in mucosal immunity could also be implicated.1 Mutations in the CARD15/NOD2 gene have ...
... nder certain circumstances, the indigenous gut microbes will be determinant in the onset and maintenance of inflammatory bowel disease, especially Crohn’s disease (CD), to which genetic susceptibility and disorders in mucosal immunity could also be implicated.1 Mutations in the CARD15/NOD2 gene have ...
Targeting gene expression to cones with human cone opsin
... genomic deletion or missense mutation of the cone cyclic nucleotide-gated cation channel b-subunit (CNGB3).4 CNGB3 is also mutated in about 50% of human patients with achromatopsia.17 On the other hand, XLPRA is caused by microdeletions in exon ORF15 of RPGR, and the mutation causing a frameshift ha ...
... genomic deletion or missense mutation of the cone cyclic nucleotide-gated cation channel b-subunit (CNGB3).4 CNGB3 is also mutated in about 50% of human patients with achromatopsia.17 On the other hand, XLPRA is caused by microdeletions in exon ORF15 of RPGR, and the mutation causing a frameshift ha ...
Practice exam 2 key
... a) Assuming that the first homolog is the normal chromosome, draw an arrow(s) at that breakpoint(s) that gave rise to the abnormal chromosome (2 pts) See above. If shown on inverted chromosome (1 pt). b) The homologs undergo recombination between genes B and D. Draw a clear sketch depicting the chro ...
... a) Assuming that the first homolog is the normal chromosome, draw an arrow(s) at that breakpoint(s) that gave rise to the abnormal chromosome (2 pts) See above. If shown on inverted chromosome (1 pt). b) The homologs undergo recombination between genes B and D. Draw a clear sketch depicting the chro ...
Ingestion of bacterially expressed dsRNAs can produce specific and
... that are de®cient in RNaseIII, an enzyme that normally degrades a majority of dsRNAs in the bacterial cell. Bacteria de®cient for RNaseIII were engineered to produce high quantities of speci®c dsRNA segments. When fed to C. elegans, such engineered bacteria were found to produce populations of RNAi- ...
... that are de®cient in RNaseIII, an enzyme that normally degrades a majority of dsRNAs in the bacterial cell. Bacteria de®cient for RNaseIII were engineered to produce high quantities of speci®c dsRNA segments. When fed to C. elegans, such engineered bacteria were found to produce populations of RNAi- ...
Meiosis
... • Living organisms are distinguished by their ability to reproduce their own kind • Genetics (遺傳學) is the scientific study of heredity (遺傳) and variation (變異)。 • Heredity (遺傳) is the transmission of traits from one generation to the next • Variation (變異) is demonstrated by the differences in appeara ...
... • Living organisms are distinguished by their ability to reproduce their own kind • Genetics (遺傳學) is the scientific study of heredity (遺傳) and variation (變異)。 • Heredity (遺傳) is the transmission of traits from one generation to the next • Variation (變異) is demonstrated by the differences in appeara ...
7. Mendelian Genetics
... and his colleagues at the monastery to study variation in plants. He had carried out artificial fertilization on plants many times in order to grow a plant with a new color or seed shape. Artificial fertilization is the process of transferring pollen from the male part of the flower to the female pa ...
... and his colleagues at the monastery to study variation in plants. He had carried out artificial fertilization on plants many times in order to grow a plant with a new color or seed shape. Artificial fertilization is the process of transferring pollen from the male part of the flower to the female pa ...
1 - SMIC Biology
... While genotype will influence phenotype, remember that environmental factors can also influence how/whether a gene is expressed. (Read about western white butterflies on page 321.) Remember that humans have (#?) chromosomes in every cell. Of these, pairs are autosomes. An autosome is any chromosome ...
... While genotype will influence phenotype, remember that environmental factors can also influence how/whether a gene is expressed. (Read about western white butterflies on page 321.) Remember that humans have (#?) chromosomes in every cell. Of these, pairs are autosomes. An autosome is any chromosome ...
What is a Gene?
... bunch of words unless you can test it, preferably with quantitation. 11. How could you test your hypothesis, at least with respect to Avar? Consider, you formed your hypothesis just looking at a small fraction of the genes. Maybe they’re not representative of the whole. Maybe you’re being fooled by ...
... bunch of words unless you can test it, preferably with quantitation. 11. How could you test your hypothesis, at least with respect to Avar? Consider, you formed your hypothesis just looking at a small fraction of the genes. Maybe they’re not representative of the whole. Maybe you’re being fooled by ...
Genetic mapping and manipulation: Chapter 8
... haploinsufficiency, one can directly examine animals that are heterozygous for a chromosomal deficiency that removes the entire gene (as well as a number of other genes presumably). Alternatively, if a deletion or null allele of the gene exists, placing this mutation over the wild-type chromosome co ...
... haploinsufficiency, one can directly examine animals that are heterozygous for a chromosomal deficiency that removes the entire gene (as well as a number of other genes presumably). Alternatively, if a deletion or null allele of the gene exists, placing this mutation over the wild-type chromosome co ...