Sharp Insights and a Sharp Tongue
... Having dissected friendship and love in geous in evolutionary terms because relatives ants, geese, or other animals and then extend quick succession, publishing key papers in share many of one’s genes. Survival in the their conclusions to humans later in life. 1971 and 1972, Trivers turned in 1974 t ...
... Having dissected friendship and love in geous in evolutionary terms because relatives ants, geese, or other animals and then extend quick succession, publishing key papers in share many of one’s genes. Survival in the their conclusions to humans later in life. 1971 and 1972, Trivers turned in 1974 t ...
hematology case study: a hypochromic, microcytic anemia
... Anemia is profound – Hb 2-3 g/dl (Hb 20 to 30 g/L). Hematocrit and RBC count are also decreased, hence the indices are uniformly depressed. The MCV, MCH and MCHC are all decreased. The RDW is increased due to anisocytosis. The blood smear shows marked hypochromia and microcytosis with extreme anisoc ...
... Anemia is profound – Hb 2-3 g/dl (Hb 20 to 30 g/L). Hematocrit and RBC count are also decreased, hence the indices are uniformly depressed. The MCV, MCH and MCHC are all decreased. The RDW is increased due to anisocytosis. The blood smear shows marked hypochromia and microcytosis with extreme anisoc ...
Lanosterol Biosynthesis in the Prokaryote
... Recently, we have isolated and characterized the M. capsulatus lanosterol 14a-demethylase (MCCYP51FX) (other names CYP51, P45014DM) (Jackson et al. 2002). This protein was, surprisingly, a soluble form, unlike the membrane-bound eukaryotic counterparts (Lamb et al. 1999), and represented a new class ...
... Recently, we have isolated and characterized the M. capsulatus lanosterol 14a-demethylase (MCCYP51FX) (other names CYP51, P45014DM) (Jackson et al. 2002). This protein was, surprisingly, a soluble form, unlike the membrane-bound eukaryotic counterparts (Lamb et al. 1999), and represented a new class ...
Mendelian Genetics
... Many early beliefs about how characteristics are transmitted. Blending theory ...
... Many early beliefs about how characteristics are transmitted. Blending theory ...
Gene replacement with the human BRCA1 locus
... protein was correctly translated and stabilized following exposure to DNA damage. From these results, it is apparent that signi®cant conservation of function exists between human and mouse genes. This is notable since the mature proteins are only 60% identical at the amino acid level (Lane et al., 1 ...
... protein was correctly translated and stabilized following exposure to DNA damage. From these results, it is apparent that signi®cant conservation of function exists between human and mouse genes. This is notable since the mature proteins are only 60% identical at the amino acid level (Lane et al., 1 ...
Perrin 2012
... normally. In the following, I would like to expand on this insightful “trigger” hypothesis, and suggest that the first and main function of mating types is indeed that of controlling key developmental switches along the haploid–diploid life cycle. This includes the ploidy-assessment function (mediat ...
... normally. In the following, I would like to expand on this insightful “trigger” hypothesis, and suggest that the first and main function of mating types is indeed that of controlling key developmental switches along the haploid–diploid life cycle. This includes the ploidy-assessment function (mediat ...
Pathogenesis of type 1 diabetes: lessons from natural history studies
... children who developed autoantibodies by age two were compared with 22 children who seroconverted after age eight and to autoantibody-negative children (matched for age, date of birth, and HLA genotype). Autoantibody-positive children had elevated odd-chain triglycerides and polyunsaturated fatty ac ...
... children who developed autoantibodies by age two were compared with 22 children who seroconverted after age eight and to autoantibody-negative children (matched for age, date of birth, and HLA genotype). Autoantibody-positive children had elevated odd-chain triglycerides and polyunsaturated fatty ac ...
Overview of comments received on `Guideline on - EMA
... in the gene of interest. Individually the frequency is low but all together these might explain a larger proportion of the patients that ...
... in the gene of interest. Individually the frequency is low but all together these might explain a larger proportion of the patients that ...
Inhibition of RNA Synthesis by Anthracycline Analogs
... of anthracyclines in the treatment of leukemias and other forms of cancer. The biological and pharmacological activities of these drugs appear to be, at least in part, due to their ability to interact with DNA. ...
... of anthracyclines in the treatment of leukemias and other forms of cancer. The biological and pharmacological activities of these drugs appear to be, at least in part, due to their ability to interact with DNA. ...
Virp1 Is a Host Protein with a Major Role in Potato - IMBB
... a target of posttranscriptional gene silencing (PTGS) in infected plants (19, 32). Double-stranded intermediates are presumably present in the nucleus only during replication. However, PSTVd-derived short interfering RNAs (siRNAs) were shown to accumulate in the cytoplasm but not in the nucleus (3). ...
... a target of posttranscriptional gene silencing (PTGS) in infected plants (19, 32). Double-stranded intermediates are presumably present in the nucleus only during replication. However, PSTVd-derived short interfering RNAs (siRNAs) were shown to accumulate in the cytoplasm but not in the nucleus (3). ...
a complex voyage to the X chromosome
... complex localization to the X chromosomes and dosage compensation, suggesting that females carry all of the information necessary for MSL targeting (Kelley et al., 1995). This finding implies that specific sequence elements are associated with the X chromosome that distinguish it from other chromoso ...
... complex localization to the X chromosomes and dosage compensation, suggesting that females carry all of the information necessary for MSL targeting (Kelley et al., 1995). This finding implies that specific sequence elements are associated with the X chromosome that distinguish it from other chromoso ...
Boundless Study Slides
... • filial of a generation or generations descending from a specific previous one • genetics the branch of biology that deals with the transmission and variation of inherited characteristics, in particular chromosomes and DNA • genotype the specific genetic information of a cell or organism, usually a ...
... • filial of a generation or generations descending from a specific previous one • genetics the branch of biology that deals with the transmission and variation of inherited characteristics, in particular chromosomes and DNA • genotype the specific genetic information of a cell or organism, usually a ...
Control of DNA excision efficiency in Paramecium
... Therefore, at least 8 of the 15 DNAs (DNAs 156/1–7 and 156/15) harbored a ψG pseudogene macronuclear content large enough to analyze IES 156ψG-11 excision. No ∼300 bp PCR product was detected for DNAs 156/1–7, 156/9, 156/11–12 and 156/15 (Fig. 2B); instead, a PCR product of ∼330 bp was detected. In ...
... Therefore, at least 8 of the 15 DNAs (DNAs 156/1–7 and 156/15) harbored a ψG pseudogene macronuclear content large enough to analyze IES 156ψG-11 excision. No ∼300 bp PCR product was detected for DNAs 156/1–7, 156/9, 156/11–12 and 156/15 (Fig. 2B); instead, a PCR product of ∼330 bp was detected. In ...
In silico method for inferring genotypes in pedigrees
... 83% and 77% of genotypes for SNPs with minor allele frequencies of 0.10, 0.30 and 0.50, respectively (Supplementary Methods online). To determine the accuracy of the method, we compared the inferred genotypes with those generated experimentally by PCR-based SNP genotyping. Among the 3,210 genotypes ...
... 83% and 77% of genotypes for SNPs with minor allele frequencies of 0.10, 0.30 and 0.50, respectively (Supplementary Methods online). To determine the accuracy of the method, we compared the inferred genotypes with those generated experimentally by PCR-based SNP genotyping. Among the 3,210 genotypes ...
Genome Biology - Department of Computer Science and
... opportunity to investigate their underlying relationships with TFBSs [22, 23]. Many chromatin modifications have been shown to be associated with transcription activation and repression [3, 4]. Recent studies have shown that incorporating histone modification data improves prediction of TFBS in mous ...
... opportunity to investigate their underlying relationships with TFBSs [22, 23]. Many chromatin modifications have been shown to be associated with transcription activation and repression [3, 4]. Recent studies have shown that incorporating histone modification data improves prediction of TFBS in mous ...
Signaling Pathways of Heme Oxygenase
... The toxic effects of CO have been known for many years. Since CO binds hemoglobin with higher affinity than O2, O2 delivery to tissues and organs is blocked by this gaseous molecule. More recently, HO-derived CO has been recognized to be an important cellular messenger with various physiological fun ...
... The toxic effects of CO have been known for many years. Since CO binds hemoglobin with higher affinity than O2, O2 delivery to tissues and organs is blocked by this gaseous molecule. More recently, HO-derived CO has been recognized to be an important cellular messenger with various physiological fun ...
Lab Manual - GRCC Instructional Home Page
... observed the natural world and have asked, “Why?” Those that have advanced our biological knowledge the most, whether the great scientists of the centuries before us, such as Robert Hooke (discovered cells in 1665) and Charles Darwin (co-developer of the theory of evolution by natural selection in 1 ...
... observed the natural world and have asked, “Why?” Those that have advanced our biological knowledge the most, whether the great scientists of the centuries before us, such as Robert Hooke (discovered cells in 1665) and Charles Darwin (co-developer of the theory of evolution by natural selection in 1 ...
Direct fitness or inclusive fitness: How shall we model kin selection?
... In our experience, the difficulties that often arise in the formulation of inclusive and direct fitness arguments, and in their comparison, have to do with the wide range of notations and assumptions found in the literature, and it seems to us that there is a real need for a simple general scheme an ...
... In our experience, the difficulties that often arise in the formulation of inclusive and direct fitness arguments, and in their comparison, have to do with the wide range of notations and assumptions found in the literature, and it seems to us that there is a real need for a simple general scheme an ...
adenomi ipofisari familiari
... FAMILIAL FORMS of PITUITARY ADENOMA FAMILIAL ACROMEGALY Clinical features In more than half of FA families the disease is not transmitted to a succeeding generation by an affected individual, probably because of the early onset of the disorder and the moderately aggressive behavior of the pituitary ...
... FAMILIAL FORMS of PITUITARY ADENOMA FAMILIAL ACROMEGALY Clinical features In more than half of FA families the disease is not transmitted to a succeeding generation by an affected individual, probably because of the early onset of the disorder and the moderately aggressive behavior of the pituitary ...
Investigating the functional significance of evolutionarily conserved
... identity. Identifying the genetic mechanisms of HOX control of development is essential for understanding body patterning in animals. I identified and characterized the role of evolutionarily conserved protein domains of the HOX protein, Sex combs reduced (SCR), in protein function. SCR is required ...
... identity. Identifying the genetic mechanisms of HOX control of development is essential for understanding body patterning in animals. I identified and characterized the role of evolutionarily conserved protein domains of the HOX protein, Sex combs reduced (SCR), in protein function. SCR is required ...
Understanding Reads in RNA-Seq Analysis
... exonic, the read is labeled “exonic”, and the same goes for partially overlaps exon, intronic and intergenic. In the other words, exonic takes precedence over partially overlaps exon, partially overlaps exon takes precedence over intronic, and intronic takes precedence over intergenic. Exonic: A rea ...
... exonic, the read is labeled “exonic”, and the same goes for partially overlaps exon, intronic and intergenic. In the other words, exonic takes precedence over partially overlaps exon, partially overlaps exon takes precedence over intronic, and intronic takes precedence over intergenic. Exonic: A rea ...
View - OhioLINK ETD
... to test the robustness of these methods. In genetic studies, one of the major objectives is to apply statistical models to identify genes contributing to variations in specific quantitative traits. In order to correlate such quantitative phenotypes with underlying genotypes, the method of analysis o ...
... to test the robustness of these methods. In genetic studies, one of the major objectives is to apply statistical models to identify genes contributing to variations in specific quantitative traits. In order to correlate such quantitative phenotypes with underlying genotypes, the method of analysis o ...
Amber Extract
... resin which has succinic acid - COOH(CH2)2COOH15 present in its chemical makeup. Baltic amber can have succinic acid present between the ranges of 3 to 8 percent. Composition of amber can vary greatly depending on the type of tree, though all have terpenes or compounds that are linked as the resin h ...
... resin which has succinic acid - COOH(CH2)2COOH15 present in its chemical makeup. Baltic amber can have succinic acid present between the ranges of 3 to 8 percent. Composition of amber can vary greatly depending on the type of tree, though all have terpenes or compounds that are linked as the resin h ...
Sideroblastic Anemias Disorder Subdivisions Idiopathic Sideroblastic Anemia
... produce a feedback loop of escalating mitochondrial injury. The hydroxyl radical, for instance, promotes lipid and protein peroxidation as well as cross-links in DNA strands. The latter phenomenon could be particularly injurious given the dearth of DNA repair enzymes in mitochondria. Hereditary Side ...
... produce a feedback loop of escalating mitochondrial injury. The hydroxyl radical, for instance, promotes lipid and protein peroxidation as well as cross-links in DNA strands. The latter phenomenon could be particularly injurious given the dearth of DNA repair enzymes in mitochondria. Hereditary Side ...