Supplementary Information (doc 1628K)
... the RNeasy kit (Qiagen, Inc., Germantown, MD). Samples were analyzed using the Genechip primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the ...
... the RNeasy kit (Qiagen, Inc., Germantown, MD). Samples were analyzed using the Genechip primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the ...
Woods Hole – Zebrafish Genetics and Development Bioinformatics
... The genetic map length of the zebrafish genome is 3000 cM total, and the total physical length of the genome is 1.7 x 109 bp. Is the actual physical (basepair) distance between Z15270 and scube2 surprising? What factors might account for any differences in expected distance? Zoom in and move the win ...
... The genetic map length of the zebrafish genome is 3000 cM total, and the total physical length of the genome is 1.7 x 109 bp. Is the actual physical (basepair) distance between Z15270 and scube2 surprising? What factors might account for any differences in expected distance? Zoom in and move the win ...
1 Biology 1 Curriculum Map – Instructional Focus Calendar (Version
... knowing, such as art, philosophy, and religion. SC.912.N.3.1 explain that a scientific theory is the culmination of many scientific investigations drawing together all the current evidence concerning a substantial range of phenomena; thus, a scientific theory represents the most powerful explanation ...
... knowing, such as art, philosophy, and religion. SC.912.N.3.1 explain that a scientific theory is the culmination of many scientific investigations drawing together all the current evidence concerning a substantial range of phenomena; thus, a scientific theory represents the most powerful explanation ...
Practice exam 3 key
... (3 pts) Leaves single-stranded overhangs (or 'sticky ends') (1 pt); these ends are complementary (will hybridize) (1 pt); can be used to join 2 DNA fragments cut with EcoRI (with the same restriction enzyme) (1 pt). ...
... (3 pts) Leaves single-stranded overhangs (or 'sticky ends') (1 pt); these ends are complementary (will hybridize) (1 pt); can be used to join 2 DNA fragments cut with EcoRI (with the same restriction enzyme) (1 pt). ...
Chapter 3 Clustering Microarray Data
... genes may be represented by a gene cluster and an associated subset of the samples which distinguishes the cluster. If the samples in the data set were taken over time, then gene clusters should be based on all the samples, but it may be more appropriate to use a clustering method that is designed f ...
... genes may be represented by a gene cluster and an associated subset of the samples which distinguishes the cluster. If the samples in the data set were taken over time, then gene clusters should be based on all the samples, but it may be more appropriate to use a clustering method that is designed f ...
American College of Medical Genetics and Genomics
... that is IBD is 6.25%, the SD is 2.43%.5 The expected percentages are based on a single common ancestor; however, multiple loops of consanguinity or multiple generations of breeding within a relatively closed community could complicate the estimation of the degree of relationship. These variations fr ...
... that is IBD is 6.25%, the SD is 2.43%.5 The expected percentages are based on a single common ancestor; however, multiple loops of consanguinity or multiple generations of breeding within a relatively closed community could complicate the estimation of the degree of relationship. These variations fr ...
D:\My Documents\WordPerfect\WordPerfect 8.0\2001Report
... critical questions to be reformulated. In fact, the new information suggests that radiation is less likely to have adverse genetic effects than had hitherto been assumed and that it is possible to reconcile the empirical results from human studies of genetic risks of radiation with predictions of su ...
... critical questions to be reformulated. In fact, the new information suggests that radiation is less likely to have adverse genetic effects than had hitherto been assumed and that it is possible to reconcile the empirical results from human studies of genetic risks of radiation with predictions of su ...
simposi sobre infertilitat masculina: genètica i ambient
... chromosome pairing and alignment mechanisms, which can generally be divided into mechanisms that require DNA double strand break (DSB) formation and those that are DSB-independent. The DSB-dependent class of mechanisms likely involves a homology search that is directly based on DNA sequence. In S. c ...
... chromosome pairing and alignment mechanisms, which can generally be divided into mechanisms that require DNA double strand break (DSB) formation and those that are DSB-independent. The DSB-dependent class of mechanisms likely involves a homology search that is directly based on DNA sequence. In S. c ...
c2 Allele Frequency and Evolution
... independent assortment. In linked genes, recombination can occur through a process called crossover. In crossover, segments of DNA are exchanged between non-sister chromatids of homologous pairs. The diagram below shows how crossover can occur. The chance of crossover happening is directly proportio ...
... independent assortment. In linked genes, recombination can occur through a process called crossover. In crossover, segments of DNA are exchanged between non-sister chromatids of homologous pairs. The diagram below shows how crossover can occur. The chance of crossover happening is directly proportio ...
... The PCR for the simultaneous detection (multiplex PCR) of the sulfonamide, chloramphenicol and beta-lactams resistance genes (sul1, cat1 and SHV) was performed in a total volume of 25 μl reaction containing 10ng of DNA extracted from each isolated strain, with final concentration of 3.0 mM MgCl2. Th ...
Chapter 5
... • Genes and Chromosomes as Sources of Genetic Information – Chromosomes are rodlike structures visible in the nucleus, which store and transmit genetic information. – There are 23 pairs of chromosomes residing in each human cell, one is inherited from the mother and one from the father. – The 23 pai ...
... • Genes and Chromosomes as Sources of Genetic Information – Chromosomes are rodlike structures visible in the nucleus, which store and transmit genetic information. – There are 23 pairs of chromosomes residing in each human cell, one is inherited from the mother and one from the father. – The 23 pai ...
Slide 1
... Funded in part by the Restless Legs Syndrome Foundation in collaboration with deCODE Genetics, Reykjavik, Iceland ...
... Funded in part by the Restless Legs Syndrome Foundation in collaboration with deCODE Genetics, Reykjavik, Iceland ...
Exceptionally high levels of recombination
... larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate. [Supplemental ma ...
... larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate. [Supplemental ma ...
A gene expression atlas of a bicoid-depleted
... expression atlas, we used the ‘maternal Gal4 shRNA’ system to deplete bcd mRNA in the female germ line (Ni et al., 2011; Staller et al., 2013). shRNAs are genetically dominant, a feature that ensures all embryos are affected while avoiding labor-intensive sorting of mutant females. The fly husbandry ...
... expression atlas, we used the ‘maternal Gal4 shRNA’ system to deplete bcd mRNA in the female germ line (Ni et al., 2011; Staller et al., 2013). shRNAs are genetically dominant, a feature that ensures all embryos are affected while avoiding labor-intensive sorting of mutant females. The fly husbandry ...
AtMetExpress Development: A Phytochemical
... (AtMetExpress development) demonstrated that Arabidopsis has the capability of producing diverse metabolites with high tissue specificity. The AtMetExpress development dataset also makes it possible to understand the mechanism behind the variations in metabolic profiles among plant tissues by invest ...
... (AtMetExpress development) demonstrated that Arabidopsis has the capability of producing diverse metabolites with high tissue specificity. The AtMetExpress development dataset also makes it possible to understand the mechanism behind the variations in metabolic profiles among plant tissues by invest ...
is the population size of a species relevant to its evolution?
... are slightly deleterious, then protein variation should be insensitive to population size. However, her theory does not easily account for the insensitivity of the rate of protein evolution to N. Cherry (1998), building on the work of Hartl et al. (1985), described an epistatic model that evolves to ...
... are slightly deleterious, then protein variation should be insensitive to population size. However, her theory does not easily account for the insensitivity of the rate of protein evolution to N. Cherry (1998), building on the work of Hartl et al. (1985), described an epistatic model that evolves to ...
Polycomb Group silencers collaborate with Notch pathway to cause
... For the isolation of novel tumour-initiating genes in Drosophila melanogaster we used the Gene Search (GS) gain-of-expression system. The P-element-based GS transposon contains five tandem copies of the Gal4 binding (upstream activating sequences -UAS-) sites capable of over- or misexpressing gene(s ...
... For the isolation of novel tumour-initiating genes in Drosophila melanogaster we used the Gene Search (GS) gain-of-expression system. The P-element-based GS transposon contains five tandem copies of the Gal4 binding (upstream activating sequences -UAS-) sites capable of over- or misexpressing gene(s ...
Medical Genetics
... centromere is constant, which means that that the ratio of the lengths of the two arms is constant for each chromosome. This ratio is an important parameter for chromosome identification, and also, the ratio of lengths of the two arms allows classification of chromosomes into several basic morpholog ...
... centromere is constant, which means that that the ratio of the lengths of the two arms is constant for each chromosome. This ratio is an important parameter for chromosome identification, and also, the ratio of lengths of the two arms allows classification of chromosomes into several basic morpholog ...
PDF
... of tilt' W'llC pairs. illld that c\omini1l1t g('lleS lind !L gl'cllter effect in tlU',;C' gt' I1otypt's thiUl they did in genotypes hn\'ing nt least one gene pill I' 1'('('(Is;~,in'. Frolll titblt' :2 it ('lInbe S('C'Il tIutt 21.5 pcrC'ent of the plnnts; of Porter and 9,1 IWrCt'nL or tht, plants of ...
... of tilt' W'llC pairs. illld that c\omini1l1t g('lleS lind !L gl'cllter effect in tlU',;C' gt' I1otypt's thiUl they did in genotypes hn\'ing nt least one gene pill I' 1'('('(Is;~,in'. Frolll titblt' :2 it ('lInbe S('C'Il tIutt 21.5 pcrC'ent of the plnnts; of Porter and 9,1 IWrCt'nL or tht, plants of ...
Rich Probabilistic Models for Genomic Data
... Reduce the residual variation and obtain greater power to detect additional QTLs. Identification of (epistatic) interactions between QTLs requires the joint modeling of multiple QTLs. ...
... Reduce the residual variation and obtain greater power to detect additional QTLs. Identification of (epistatic) interactions between QTLs requires the joint modeling of multiple QTLs. ...
- Journal of Clinical Neurology
... for detecting mutation in the RYR1 gene difficult and laborious.11-13 Most of the detected mutations linked to MH and CCD are concentrated in three defined regions of the RYR1 gene: between amino acids 35 and 614 (MH/CCD region 1), 2,129 and 2,458 (MH/CCD region 2) and 4,214 and 4,914 (MH/ CCD regio ...
... for detecting mutation in the RYR1 gene difficult and laborious.11-13 Most of the detected mutations linked to MH and CCD are concentrated in three defined regions of the RYR1 gene: between amino acids 35 and 614 (MH/CCD region 1), 2,129 and 2,458 (MH/CCD region 2) and 4,214 and 4,914 (MH/ CCD regio ...
Annotation mapping functions
... For org.Bt.eg.db there is a data object for each set of data, such as mapping from Entrez Gene IDs to chromosome, org.Bt.egCHR. Some of the objects comes in pairs, such as Entrez and RefSeq there is org.Bt.egREFSEQ and org.Bt.egREFSEQ2EG. The latter can also be obtained with revmap(org.Bt.egREFSEQ). ...
... For org.Bt.eg.db there is a data object for each set of data, such as mapping from Entrez Gene IDs to chromosome, org.Bt.egCHR. Some of the objects comes in pairs, such as Entrez and RefSeq there is org.Bt.egREFSEQ and org.Bt.egREFSEQ2EG. The latter can also be obtained with revmap(org.Bt.egREFSEQ). ...
Chromosomal breakpoint positions suggest a direct role for radiation
... Gerdes et al., 1994). Moreover, it has been shown that for two random chromosomal loci the relationship between interphase distance and genomic separation was not always linear, leading to a model of chromatin arrangement in ¯exible loops of several Mbp arranged along the chromosomal backbone (Yokot ...
... Gerdes et al., 1994). Moreover, it has been shown that for two random chromosomal loci the relationship between interphase distance and genomic separation was not always linear, leading to a model of chromatin arrangement in ¯exible loops of several Mbp arranged along the chromosomal backbone (Yokot ...
An Update on the Hereditary Spastic Paraplegias: New Genes and
... other disorders (Table 2), further emphasizing the overlap between HSP and other clinical phenotypes. It can be hard to distinguish between these disorders according to the clinical manifestations alone. For example, HSP complicated by neuropathy can be difficult to differentiate from a hereditary n ...
... other disorders (Table 2), further emphasizing the overlap between HSP and other clinical phenotypes. It can be hard to distinguish between these disorders according to the clinical manifestations alone. For example, HSP complicated by neuropathy can be difficult to differentiate from a hereditary n ...
CIBI3031-070 Midterm Examination III November 2005
... ____ 27. If ALL offspring of a cross have the genotype Aa, the parents of the crosses are most likely a. Aa x aa. b. AA x aa. c. Aa x Aa. ____ 28. The chromatids separate from one another and become individual chromosomes during a. metaphase. b. prophase. c. anaphase. ____ 29. Mendel found that pea ...
... ____ 27. If ALL offspring of a cross have the genotype Aa, the parents of the crosses are most likely a. Aa x aa. b. AA x aa. c. Aa x Aa. ____ 28. The chromatids separate from one another and become individual chromosomes during a. metaphase. b. prophase. c. anaphase. ____ 29. Mendel found that pea ...