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Biology 102A
Biology 102A

... a. DNA fingerprint ...
Causes of Variation PPT
Causes of Variation PPT

... 2. Identify the characteristics of mutant alleles 3. Identify two types of mutations 4. Give an example of each type 5. List two agents responsible for increased mutation rates ...
3-HumanGen Linkage
3-HumanGen Linkage

... * Single Allele Traits: traits controlled by a single allele, i.e., Sickle Cell Anemia. * Polygenic Traits: traits that controlled by two or more genes. – Example… skin color in which four to seven genes control this trait. Each gene has an additive effect. ...
THE SEX CHROMOSOMES AND THEIR ABNORMALITIES
THE SEX CHROMOSOMES AND THEIR ABNORMALITIES

...  From the study of structurally abnormal, inactivated X chromosomes, the X inactivation center has been mapped to proximal Xq, in band Xq13.  The X inactivation center contains an unusual gene, XIST, that appears to be a key master regulatory locus for X inactivation.  XIST, an acronym for inacti ...
Name_______________________ Period
Name_______________________ Period

... What is a Barr body? Why do human females show a Barr body in their cells? ...
Karyotype
Karyotype

... PKU (phenylketonuria) • The body cannot break down the amino acid phenylalanine • Nutrasweet could be deadly • If not detected early, or if a specific diet is not followed, serious brain damage can occur. • 1 in 60 Caucasians are carriers of the gene that causes PKU. • The gene is found on chromoso ...
Sex-linked Traits - Perry Local Schools
Sex-linked Traits - Perry Local Schools

... Y’s and the other half of the sperm will be X’s. • Therefore, it is the sperm that determine the sex of the  baby.. ...
Document
Document

... For X-linked genes: If a+/a- mammals are functional mosaics of a+ & a- cells …are all non-functional X-linked alleles (a-) semi-dominant? (dominance depends on how phenotype is operationally defined) ...
Notes - Humble ISD
Notes - Humble ISD

... A mutation is a change in the DNA sequence. The mutation may be classified as: ______________________ or _____________ mutations. Most mutations are harmful, but a few can be beneficial or silent. A. Chromosomal Mutation 1. Chromosomal mutations involve the______________________ or _________________ ...
Chapter 13 1. is when two parents give rise to an offspring that have
Chapter 13 1. is when two parents give rise to an offspring that have

... results in cells with half the chromosome number of the original cell. This type of cell division only occurs in cells that make ______________________. In the life cycle of an organism, one ______________________ ______________________ formed by meiosis comes from each parent and when the egg is fe ...
Chapter 14, 15
Chapter 14, 15

... Thomas Hunt Morgan – 1st one to associate specific genes with specific chromosomes - studies with fruit flies, Drosophila melanogaster 1) grow rapidly 2) require small amt. of space 3) few chromosomes & these are large • 1st to discover a sex-linked gene (white eyes) X-linked ...
Chromosome Mapping The following data were collected from
Chromosome Mapping The following data were collected from

... Chromosome Mapping The following data were collected from repeated matings of fruit flies (D. melanogaster). The data record the frequency, to 0.1 percent, of the recombinant characteristics for seven genes located on the same side of the centromere on chromosome 3. The veinlet gene is located one m ...
Chapter 14 Human Genetics
Chapter 14 Human Genetics

... ▫ One X chromosome (45 total) –  sterile female whose sex organs don’t develop at puberty ...
MATTERS OF SEX
MATTERS OF SEX

... breaks down sugar  Females produce the same amount of G6PD enzyme as males  XXY and XXX individuals produce the same about of G6PD as anyone else ...
The end of the male gene pool?
The end of the male gene pool?

... and Y chromosomes were the same size. Today, the Y chromosome holds fewer than 30 genes, against the X chromosome's 800 or so. "If you draw a straight line, the Y chromosome's demise would come four or five million years from now," said Darren Griffin, professor of genetics at the University of Kent ...
Matters of Sex - Old Saybrook Public Schools
Matters of Sex - Old Saybrook Public Schools

... No SRY gene = female Defective SRY gene = female 46, XY Rarely the SRY gene is translocated to an X chromosome 46, XX male ...
chapter 15 chromosomal basis of inheritance
chapter 15 chromosomal basis of inheritance

... Genomic imprinting – Identical alleles may have different effects on offspring, depending on whether they arrive in the zygote via the ovum or via the sperm via methylation (adding of methyl groups to nucleotides at specific loci which inactivates that allele). Ex, PraderWilli syndrome (from father) ...
variation
variation

...  Gel electrophoresis is a technique that can be used in DNA profiling  Genes are inherited from parents  A gamete is a sex cell  Each gamete contains one set of genes on its chromosomes  Each organism receives two copies of each gene (one from the gamete of each parent)  Alleles are different ...
The DNA molecule exits for most of the cell cycle as
The DNA molecule exits for most of the cell cycle as

... Homologous chromosomes - contrasting chromosomes of same type, one from each parent. Chromatid - one half of the "X" chromosome shape. The two halves are sister chromatids and exact copies of each other. They will go to separate daughter cells during meiosis. Centromere - protein band that joins the ...
Secrets of Life Video Questions
Secrets of Life Video Questions

... 6. Every one of the billion cells in the body contain the same instructions. These instructions are written in 7. the _________________________________. ...
Chapter 15 Chromosomal Basis of Inheritance
Chapter 15 Chromosomal Basis of Inheritance

... • Males and females have the same amount of proteins encoded by the X-linked genes! HOW? • One X chromosome in each female cell becomes inactive during embryonic development- X -inactivation. • Males = Female X-linked gene activity. ...
Chapter 12 Inheritance Patterns and Human Genetics
Chapter 12 Inheritance Patterns and Human Genetics

... E. Edward’s Syndrome A. Trisomy 18 B. Most children only live a few months C. All major organs affected ...
Homework: Mutations
Homework: Mutations

... D a part of a chromosome was lost (deletion) 8. Which of the following is a change that could be passed on to an organism’s offspring? A Damage to the DNA of gamete cells B Damage to skin cells from exposure to sunlight C Damage to DNA in the cytoplasm of cheek cells D Damage to hair pigment cells w ...
Linkage Questions - Welcome to Cherokee High School
Linkage Questions - Welcome to Cherokee High School

... species. This is reshuffling of the genes resulting in new combinations ...
Genetics
Genetics

... X-Linked SCID Inheritance ...
< 1 ... 222 223 224 225 226 227 228 229 230 ... 241 >

Skewed X-inactivation

Skewed X chromosome inactivation occurs when the inactivation of one X chromosome is favored over the other, leading to an uneven number of cells with each chromosome inactivated. It is usually defined as one allele being found on the active X chromosome in over 75% of cells, and extreme skewing is when over 90% of cells have inactivated the same X chromosome. It can be caused by primary nonrandom inactivation, either by chance due to a small cell pool or directed by genes, or caused by secondary nonrandom inactivation, which occurs by selection. Most females will have some levels of skewing. It is relatively common in adult females; around 35% of women have skewed ratio over 70:30, and 7% of women have an extreme skewed ratio of over 90:10. This is of medical significance due to the potential for the expression of disease genes present on the X chromosome that are normally not expressed due to random X inactivation. X chromosome inactivation occurs in females to provide dosage compensation between the sexes. If females kept both X chromosomes active they would have twice the number of active X genes than males, who only have one copy of the X chromosome. At approximately the time of implantation (see Implantation (human embryo), one of the two X chromosomes is randomly selected for inactivation. The cell undergoes transcriptional and epigenetic changes to ensure this inactivation is permanent. All progeny from these initial cells will maintain the inactivation of the same chromosome, resulting in a mosaic pattern of cells in females.
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