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Autosomal & Chromosomal Disorders
Autosomal & Chromosomal Disorders

...  Because of the faulty protein, cells can not transport chloride ions across their membranes.  Children with CF have serious digestive problems as well as producing a thick mucus that clogs lungs & breathing passageways. ...
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... (Meiosis to create sperm or egg can sometimes occur with “accidents” in dividing the chromosomes evenly.) I. Down Syndrome A. Karyotype – can show abnormal numbers of chromosomes, or problems with chromosomes parts B. Trisomy 21 = Down Syndrome 1. Karyotype shows 3 chromosomes of chrom. 21, instead ...
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... When Mendel crossed his F1 generation: PpRr x PpRr, he got a 9:3:3:1 ratio. He would have not seen this pattern if the alleles had been located on the same chromosome and inherited together. ...
Living Cells Original lyrics penned 1993, © 2004 by Jim Nelson
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... What are the symptoms of PKU? Tay-sachs is also caused by recessive alleles found on the autosomes. What are the symptoms of Tay-Sachs? There is no cure but the gene can be detected. Cystic Fibrosis (autosomal recessive) causes a build-up of mucus in the lungs causing death usually before the age of ...
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Principles of Genetics

... fertilized, the new baby will have 46 chromosomes in each of its cells, which is the correct number of chromosomes for a human. ...
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Polyploid



Polyploid cells and organisms are those containing more than two paired (homologous) sets of chromosomes. Most species whose cells have nuclei (Eukaryotes) are diploid, meaning they have two sets of chromosomes—one set inherited from each parent. However, polyploidy is found in some organisms and is especially common in plants. In addition, polyploidy occurs in some tissues of animals that are otherwise diploid, such as human muscle tissues. This is known as endopolyploidy. Species whose cells do not have nuclei, that is, Prokaryotes, may be polyploid organisms, as seen in the large bacterium Epulopicium fishelsoni [1]. Hence ploidy is defined with respect to a cell. Most eukaryotes have diploid somatic cells, but produce haploid gametes (eggs and sperm) by meiosis. A monoploid has only one set of chromosomes, and the term is usually only applied to cells or organisms that are normally diploid. Male bees and other Hymenoptera, for example, are monoploid. Unlike animals, plants and multicellular algae have life cycles with two alternating multicellular generations. The gametophyte generation is haploid, and produces gametes by mitosis, the sporophyte generation is diploid and produces spores by meiosis.Polyploidy refers to a numerical change in a whole set of chromosomes. Organisms in which a particular chromosome, or chromosome segment, is under- or overrepresented are said to be aneuploid (from the Greek words meaning ""not"", ""good"", and ""fold""). Therefore the distinction between aneuploidy and polyploidy is that aneuploidy refers to a numerical change in part of the chromosome set, whereas polyploidy refers to a numerical change in the whole set of chromosomes.Polyploidy may occur due to abnormal cell division, either during mitosis, or commonly during metaphase I in meiosis.Polyploidy occurs in some animals, such as goldfish, salmon, and salamanders, but is especially common among ferns and flowering plants (see Hibiscus rosa-sinensis), including both wild and cultivated species. Wheat, for example, after millennia of hybridization and modification by humans, has strains that are diploid (two sets of chromosomes), tetraploid (four sets of chromosomes) with the common name of durum or macaroni wheat, and hexaploid (six sets of chromosomes) with the common name of bread wheat. Many agriculturally important plants of the genus Brassica are also tetraploids.Polyploidy can be induced in plants and cell cultures by some chemicals: the best known is colchicine, which can result in chromosome doubling, though its use may have other less obvious consequences as well. Oryzalin will also double the existing chromosome content.
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