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Catalyst - SharpSchool
Catalyst - SharpSchool

... Look around the room at the posted pictures. How many different skin colors do you see? What do you believe is happening at a genetic level to produce the variety of skin color we see in the human species? Use your new understanding of genes and alleles to make an ...
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... The explanation of this paradox lies in a normal process called Xinactivation. In order that boys and girls have the same amount of ephrinB1 (which is important for it to work properly) one of the girls’ X chromosomes is turned off. This “switching off” occurs randomly so in a girl with CFNS, her bo ...
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SEX-LINKED INHERITANCE
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... which means it is usually passed down from your parents. Colour blindness is usually passed from mother to son on the 23rd chromosome, which is the sex chromosome. The X chromosome is the sex chromosome: males have an X chromosome and a Y chromosome and females have two X chromosomes. For a male to ...
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... used to say that it was a good thing we don’t have to know how our brains work in order to use them. The same thing, luckily, goes for our genes. Now we’re going to cover the “selected” speech, language, and hearing disorders from the title. We’ve already discussed Angelman, so let’s move on to atax ...
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Chromosome



A chromosome (chromo- + -some) is a packaged and organized structure containing most of the DNA of a living organism. It is not usually found on its own, but rather is complexed with many structural proteins called histones as well as associated transcription (copying of genetic sequences) factors and several other macromolecules. Two ""sister"" chromatids (half a chromosome) join together at a protein junction called a centromere. Chromosomes are normally visible under a light microscope only when the cell is undergoing mitosis. Even then, the full chromosome containing both joined sister chromatids becomes visible only during a sequence of mitosis known as metaphase (when chromosomes align together, attached to the mitotic spindle and prepare to divide). This DNA and its associated proteins and macromolecules is collectively known as chromatin, which is further packaged along with its associated molecules into a discrete structure called a nucleosome. Chromatin is present in most cells, with a few exceptions - erythrocytes for example. Occurring only in the nucleus of eukaryotic cells, chromatin composes the vast majority of all DNA, except for a small amount inherited maternally which is found in mitochondria. In prokaryotic cells, chromatin occurs free-floating in cytoplasm, as these cells lack organelles and a defined nucleus. The main information-carrying macromolecule is a single piece of coiled double-stranded DNA, containing many genes, regulatory elements and other noncoding DNA. The DNA-bound macromolecules are proteins, which serve to package the DNA and control its functions. Chromosomes vary widely between different organisms. Some species such as certain bacteria also contain plasmids or other extrachromosomal DNA. These are circular structures in the cytoplasm which contain cellular DNA and play a role in horizontal gene transfer.Compaction of the duplicated chromosomes during cell division (mitosis or meiosis) results either in a four-arm structure (pictured to the right) if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. Chromosomal recombination during meiosis and subsequent sexual reproduction plays a vital role in genetic diversity. If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe and die, or it may unexpectedly evade apoptosis leading to the progression of cancer.In prokaryotes (see nucleoids) and viruses, the DNA is often densely packed and organized. In the case of archaea by homologs to eukaryotic histones, in the case of bacteria by histone-like proteins. Small circular genomes called plasmids are often found in bacteria and also in mitochondria and chloroplasts, reflecting their bacterial origins.
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