Pseudogene function: regulation of gene expression
... purifying selection*. This is a result of the fact that most proteins cannot tolerate more than a few alterations without a marked detriment to their functional performance. The usually high nucleotide sequence variance of pseudogene copies, relative to each other and to their protein-coding gene or ...
... purifying selection*. This is a result of the fact that most proteins cannot tolerate more than a few alterations without a marked detriment to their functional performance. The usually high nucleotide sequence variance of pseudogene copies, relative to each other and to their protein-coding gene or ...
brief review - AJP
... concentrating and diluting capacity. Moreover, the classic and antenatal Bartter’s variants are accompanied by hypercalciuria, whereas in Gitelman’s syndrome hypocalciuria is found. Some of these mutations are missense, resulting in alterations in single amino acids, whereas others result in deletio ...
... concentrating and diluting capacity. Moreover, the classic and antenatal Bartter’s variants are accompanied by hypercalciuria, whereas in Gitelman’s syndrome hypocalciuria is found. Some of these mutations are missense, resulting in alterations in single amino acids, whereas others result in deletio ...
University of Groningen Soft tissue sarcoma at the turn of the
... relevance of specific chromosomal aberrations [23-25]. In the present study, univariate analysis of involved chromosomal changes revealed many regions with chromosomal alterations as negative prognostic factors. Several studies have identified cytogenetic bands in these regions involved in human tum ...
... relevance of specific chromosomal aberrations [23-25]. In the present study, univariate analysis of involved chromosomal changes revealed many regions with chromosomal alterations as negative prognostic factors. Several studies have identified cytogenetic bands in these regions involved in human tum ...
ZytoLight ® CLL I Probe SPEC TP53/ATM Dual Color Probe
... The ATM (ataxia telangiectasia mutated) gene is located on 11q22.3 and encodes a protein kinase which is involved in cell cycle regulation, including TP53 activation. CLL patients with 11q deletion exhibit rapid disease progression and inferior survival. The most frequent aberration in CLL is the de ...
... The ATM (ataxia telangiectasia mutated) gene is located on 11q22.3 and encodes a protein kinase which is involved in cell cycle regulation, including TP53 activation. CLL patients with 11q deletion exhibit rapid disease progression and inferior survival. The most frequent aberration in CLL is the de ...
controlling flowering time and plant height in
... more additional QTL in the same linkage group as the QTL detected by marker-regression. The sizes and locations of the additional QTL are not known. ...
... more additional QTL in the same linkage group as the QTL detected by marker-regression. The sizes and locations of the additional QTL are not known. ...
procedure - eweb.furman.edu
... If the donor and the recipient strains are mixed and conjugation takes place, the plasmid will move from donor to recipient, with all of its genes. The gene lac+ on the F plasmid of the donor thus enters into the recipient, and the recipient now has two copies of lac genes: the lac+ allele on the F ...
... If the donor and the recipient strains are mixed and conjugation takes place, the plasmid will move from donor to recipient, with all of its genes. The gene lac+ on the F plasmid of the donor thus enters into the recipient, and the recipient now has two copies of lac genes: the lac+ allele on the F ...
Analysis of Tetrads from the yeast Saccaromyces
... When normally haploid yeast cells of two different mating types encounter each other, they fuse to form a diploid zygote (this constitutes a cross), which immediately undergoes meiosis to regenerate four individual haploid spores – a tetrad (the equivalent of an F1 generation). Since each meiotic te ...
... When normally haploid yeast cells of two different mating types encounter each other, they fuse to form a diploid zygote (this constitutes a cross), which immediately undergoes meiosis to regenerate four individual haploid spores – a tetrad (the equivalent of an F1 generation). Since each meiotic te ...
Supplementary Notes for the work: "Evolutionary Rate and Gene
... mean protein length of the remaining cortical genes and the sub-cortical genes is identical. The ER of the cortical genes was still lower (0.0966 vs 0.1363 in the cortical and the sub cortical regions respectively, p-value < 10-16). When considering the length of the entire genes (including introns) ...
... mean protein length of the remaining cortical genes and the sub-cortical genes is identical. The ER of the cortical genes was still lower (0.0966 vs 0.1363 in the cortical and the sub cortical regions respectively, p-value < 10-16). When considering the length of the entire genes (including introns) ...
Meiosis and Sexual Reproduction
... cytoplasmic division of immature reproductive cells in sexually-reproducing eukaryotic species ...
... cytoplasmic division of immature reproductive cells in sexually-reproducing eukaryotic species ...
Unit 5 Notes - heckgrammar.co.uk
... In humans it is the Y chromosome that actually determines sex: all embryos start developing as females, but if the sex-determining “SRY” gene on the Y chromosome is expressed, male hormones are produced in the embryo, causing the development of male characteristics. In the absence of male hormones, ...
... In humans it is the Y chromosome that actually determines sex: all embryos start developing as females, but if the sex-determining “SRY” gene on the Y chromosome is expressed, male hormones are produced in the embryo, causing the development of male characteristics. In the absence of male hormones, ...
Frequent and histological type-specific inactivation of 14-3
... may lead to chromosomal aberrations, and increase the sensitivity to the DNA damaging events. In this context, it is of interest that SCLC is highly sensitive to irradiation and chemotherapeutic agents. It will also be intriguing to investigate the integrity of G2 checkpoint in large cell carcinomas ...
... may lead to chromosomal aberrations, and increase the sensitivity to the DNA damaging events. In this context, it is of interest that SCLC is highly sensitive to irradiation and chemotherapeutic agents. It will also be intriguing to investigate the integrity of G2 checkpoint in large cell carcinomas ...
RRYY - My CCSD
... 5. Homozygous dominant genotypes = two dominant alleles for a trait. (BB) 6. Homozygous recessive genotypes = possess two recessive alleles for a trait (bb) ...
... 5. Homozygous dominant genotypes = two dominant alleles for a trait. (BB) 6. Homozygous recessive genotypes = possess two recessive alleles for a trait (bb) ...
what is galls
... relation between different P. savastanoi strains and particular plant hosts of the Oleaceae family can in part be correlated with different levels of auxins produced by the pathogen (54,70,124,132). In E. herbicola, auxins are also involved in pathogenicity but, as for cytokinins, they are not indis ...
... relation between different P. savastanoi strains and particular plant hosts of the Oleaceae family can in part be correlated with different levels of auxins produced by the pathogen (54,70,124,132). In E. herbicola, auxins are also involved in pathogenicity but, as for cytokinins, they are not indis ...
Computational Biology
... These clusters, or CpG islands, are targets for proteins that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patte ...
... These clusters, or CpG islands, are targets for proteins that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patte ...
History of Disease Gene Mapping
... Later confirmed by Elston, Berg. This demonstrated existence of a disease gene in the vicinity of C3 (chrom. 19) Work by Joe Goldstein and Michael Brown (Nobel prize in 1985) identified disease as defect in LDL receptor; located on chromosome 19. Now drugs (statins) have been developed for lowering ...
... Later confirmed by Elston, Berg. This demonstrated existence of a disease gene in the vicinity of C3 (chrom. 19) Work by Joe Goldstein and Michael Brown (Nobel prize in 1985) identified disease as defect in LDL receptor; located on chromosome 19. Now drugs (statins) have been developed for lowering ...
Plants in Action
... (c)??Determination of shoot meristem and organ identity Genes controlling meristem identity What determines whether a meristem is vegetative or re-productive has long been a vexing question. Now, by using molecular technology and studying the transition of meristems from vegetative to reproductive i ...
... (c)??Determination of shoot meristem and organ identity Genes controlling meristem identity What determines whether a meristem is vegetative or re-productive has long been a vexing question. Now, by using molecular technology and studying the transition of meristems from vegetative to reproductive i ...
The influence of genomic imprinting on brain
... Like other mammalian genes, imprinted genes are transmitted in accordance with Mendelian Laws of Inheritance (Solter, 1988). As with unimprinted genes, pairs of alleles at imprinted genes are separated randomly into gametes during meiosis. However, the imprinted gene is altered to reflect the type o ...
... Like other mammalian genes, imprinted genes are transmitted in accordance with Mendelian Laws of Inheritance (Solter, 1988). As with unimprinted genes, pairs of alleles at imprinted genes are separated randomly into gametes during meiosis. However, the imprinted gene is altered to reflect the type o ...
10.1 - My Haiku
... between pairs of alleles long before the details of meiosis were known. Where Mendel states that pairs of alleles of a gene separate independently during gamete production, we can now attribute this to random orientation of chromosomes during metaphase I. Mendel made this deduction when working with ...
... between pairs of alleles long before the details of meiosis were known. Where Mendel states that pairs of alleles of a gene separate independently during gamete production, we can now attribute this to random orientation of chromosomes during metaphase I. Mendel made this deduction when working with ...
the genetics of the budgerigar
... factors" exist, and that they exert their action and produce visible results by influencing developmental processes. But since it is impossible to tell how many such factors are related to any one developmental process, we shall not assigp particular functions to particular genes; we shall not speak ...
... factors" exist, and that they exert their action and produce visible results by influencing developmental processes. But since it is impossible to tell how many such factors are related to any one developmental process, we shall not assigp particular functions to particular genes; we shall not speak ...
Gene Section ERG (v-ets erythroblastosis virus E26 oncogene like (avian))
... endothelial cells. In the GNF SymAtlas database, the major ERG expression was found to be in CD34+ cells (that include both hematopoietic stem cells and endothelial cells). ERG was also reported to be expressed in during early T and B cell development, and to be down-regulated in later stages of B a ...
... endothelial cells. In the GNF SymAtlas database, the major ERG expression was found to be in CD34+ cells (that include both hematopoietic stem cells and endothelial cells). ERG was also reported to be expressed in during early T and B cell development, and to be down-regulated in later stages of B a ...
Prof. Kamakaka`s Lecture 7 Notes
... meiotic prophase, when homologs recognize each other and form stable pairs (bivalents) that can line up in the metaphase I spindle. In most eukaryotes, including mouse and yeast, both the recognition of homologs and the formation of stable bivalents depend on recombinational interactions between hom ...
... meiotic prophase, when homologs recognize each other and form stable pairs (bivalents) that can line up in the metaphase I spindle. In most eukaryotes, including mouse and yeast, both the recognition of homologs and the formation of stable bivalents depend on recombinational interactions between hom ...
Mendel: Not a clue about chromosomes!
... Applied to Monohybrid Crosses • The multiplication rule states that the probability that two or more independent events will occur together is the product of their individual probabilities • Probability in an F1 monohybrid cross can be determined using the multiplication rule • Segregation in a hete ...
... Applied to Monohybrid Crosses • The multiplication rule states that the probability that two or more independent events will occur together is the product of their individual probabilities • Probability in an F1 monohybrid cross can be determined using the multiplication rule • Segregation in a hete ...
X-inactivation
X-inactivation (also called lyonization) is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome.