INVESTIGATION INTO THE ALLOSTERIC REGULATION OF MITOTIC KINESIN EG5 Introduction Results
... The long distance allosteric network observed originally in Eg5 is conserved in Klp61F. The networks of amino acid residues involved in allosteric communication between the L5 loop and the other two sites (ATP-, & MT-binding sites) may also be conserved across other kinesin family members. Conserved ...
... The long distance allosteric network observed originally in Eg5 is conserved in Klp61F. The networks of amino acid residues involved in allosteric communication between the L5 loop and the other two sites (ATP-, & MT-binding sites) may also be conserved across other kinesin family members. Conserved ...
- DigitalCommons@Linfield
... film shows that BSA is orienting itself in the same manor such that the same amino acid residues are interacting with the colloids. SERS is an important process to explore because label free detection of molecules can form a hypothesis about the functions and interactions of the compound in its envi ...
... film shows that BSA is orienting itself in the same manor such that the same amino acid residues are interacting with the colloids. SERS is an important process to explore because label free detection of molecules can form a hypothesis about the functions and interactions of the compound in its envi ...
Gene Section PTK7 (PTK7 protein tyrosine kinase 7)
... PTK7 crosstalks with active receptor tyrosine kinase family members such as VEGFR1, and regulates migration of endothelial cells. In endothelial cells, VEGF-A triggers VEGFR1 phosphorylation and association with PTK7. This interaction is needed for optimal phosphorylation and activation of downstrea ...
... PTK7 crosstalks with active receptor tyrosine kinase family members such as VEGFR1, and regulates migration of endothelial cells. In endothelial cells, VEGF-A triggers VEGFR1 phosphorylation and association with PTK7. This interaction is needed for optimal phosphorylation and activation of downstrea ...
corneagene_cm
... of type I lattice (Haab-Dimmer) dystrophy, which is one of the 5q31 related corneal dystrophies in 1995. The purpose of their former studies was the identification of the amyloid precursor in LCDI and its biochemical characterization. They also carried out immunohistochemical investigations in scarr ...
... of type I lattice (Haab-Dimmer) dystrophy, which is one of the 5q31 related corneal dystrophies in 1995. The purpose of their former studies was the identification of the amyloid precursor in LCDI and its biochemical characterization. They also carried out immunohistochemical investigations in scarr ...
Identification of Both Shared and Distinct Proteins in the Major and
... have been identified. Here, the human U11/U12 small nuclear ribonucleoprotein (snRNP), a subunit of the minor (U12-dependent) spliceosome, was isolated. Twenty U11/U12 proteins were identified, including subsets unique to the minor spliceosome or common to both spliceosomes. Common proteins include ...
... have been identified. Here, the human U11/U12 small nuclear ribonucleoprotein (snRNP), a subunit of the minor (U12-dependent) spliceosome, was isolated. Twenty U11/U12 proteins were identified, including subsets unique to the minor spliceosome or common to both spliceosomes. Common proteins include ...
蛋白质结构基础(Introduction of Protein Structure)
... Distortions of a-helices The majority of a-helices in globular proteins are curved or distorted somewhat compared with the standard Pauling-Corey model. Why? 1. The packing of buried helices against other secondary structure elements in the core of the protein 2. Proline residues induce distortions ...
... Distortions of a-helices The majority of a-helices in globular proteins are curved or distorted somewhat compared with the standard Pauling-Corey model. Why? 1. The packing of buried helices against other secondary structure elements in the core of the protein 2. Proline residues induce distortions ...
Mouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag)
... Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic facto ...
... Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic facto ...
Characterization of serine/threonine protein phosphatases in
... microcystin-LR, calyculin-A and nodularin, were more potent inhibitors of RINm5F cell PPases, exhibiting IC50 values of ~ 5 - 1 0 - 1 ~ and IC1oo of ~ 5 . 1 0 - 9 M . These findings indicate that such inhibitors can be used pharmacologically to evaluate a possible role of different PPases in the reg ...
... microcystin-LR, calyculin-A and nodularin, were more potent inhibitors of RINm5F cell PPases, exhibiting IC50 values of ~ 5 - 1 0 - 1 ~ and IC1oo of ~ 5 . 1 0 - 9 M . These findings indicate that such inhibitors can be used pharmacologically to evaluate a possible role of different PPases in the reg ...
The Sense of Smell Notes
... A. A sarcomere is a portion of a myofibrils (from one Z line to another) B. Myofibrils are made of 2 types of protein myofilament The thick filament is made of the protein myosin and the thin filament is made of the protein actin C. The darker region of the A band in the sarcomere is produced by ove ...
... A. A sarcomere is a portion of a myofibrils (from one Z line to another) B. Myofibrils are made of 2 types of protein myofilament The thick filament is made of the protein myosin and the thin filament is made of the protein actin C. The darker region of the A band in the sarcomere is produced by ove ...
Peroxisomes - University of California San Diego
... only in yeast. It is an intraperoxisomal organizer of the peroxisomal import machinery in S. cerevisiae. A 44 kDa integral PMP found only in the yeast Yarrowia lipolytica. A ,35 kDa integral PMP with a carboxy-terminal, cytoplasmically-exposed, zinc binding RING domain. Has been identified in yeasts ...
... only in yeast. It is an intraperoxisomal organizer of the peroxisomal import machinery in S. cerevisiae. A 44 kDa integral PMP found only in the yeast Yarrowia lipolytica. A ,35 kDa integral PMP with a carboxy-terminal, cytoplasmically-exposed, zinc binding RING domain. Has been identified in yeasts ...
22. Analysis of Haloarchaeal Genomes
... but not in other archaea)? ● What are the organism-specific genes in each genome? ● Have some genomes recently lost genes? ● Are there genes found in water halophiles but not in soil/sediment halophiles? ● Are there genes found in soil/sediment halophiles but not in water halophiles? ...
... but not in other archaea)? ● What are the organism-specific genes in each genome? ● Have some genomes recently lost genes? ● Are there genes found in water halophiles but not in soil/sediment halophiles? ● Are there genes found in soil/sediment halophiles but not in water halophiles? ...
Animal Dicer and plant Dicer-like proteins
... et al., 2012a). This offers significant potential to influence the nuclease activity of the enzyme; yet the functions of both domains appear highly diverse. The helicase domain has been shown to have an inhibitory effect on dsRNA processing by human Dicer (Ma et al., 2008). This domain is also cruci ...
... et al., 2012a). This offers significant potential to influence the nuclease activity of the enzyme; yet the functions of both domains appear highly diverse. The helicase domain has been shown to have an inhibitory effect on dsRNA processing by human Dicer (Ma et al., 2008). This domain is also cruci ...
bayesian-integration
... interact with ciliary proteins divided by the fraction of non-ciliary proteins that do not interact with ciliary proteins P M1 data1, 2 Pdata1 M1 Pdata2 M1 ...
... interact with ciliary proteins divided by the fraction of non-ciliary proteins that do not interact with ciliary proteins P M1 data1, 2 Pdata1 M1 Pdata2 M1 ...
Neurotransmitter Transporter homologue A.Yamashita(RIKEN)
... neurotransmitters from the synaptic cleft to the cytoplasm of neurons and glia catalyzed by specific transporters. Na+/Cl--dependent neurotransmitter transporters (also referred to as neurotransmitter sodium symporters; NSS) employ sodium and chloride electrochemical gradients to drive transport of ...
... neurotransmitters from the synaptic cleft to the cytoplasm of neurons and glia catalyzed by specific transporters. Na+/Cl--dependent neurotransmitter transporters (also referred to as neurotransmitter sodium symporters; NSS) employ sodium and chloride electrochemical gradients to drive transport of ...
Supplemental Methods 1. Amino acid conformation clustering Amino
... and the distribution information of the members in the clusters are listed in Table S6. 2. Protein atomistic non-covalent interacting database Atomistic contact interactions in proteins of known structures were organized into a database containing non-covalent atomistic interaction information for a ...
... and the distribution information of the members in the clusters are listed in Table S6. 2. Protein atomistic non-covalent interacting database Atomistic contact interactions in proteins of known structures were organized into a database containing non-covalent atomistic interaction information for a ...
PPARγ Regulated Fatty Acid Metabolism Antibody Sampler Kit
... Like 2 (GCN5L2) is a transcription adaptor protein and a histone acetyltransferase (HAT) that functions as the catalytic subunit of the STAGA and TFTC transcription coactivator complexes (8). GCN5L2 is 73% homologous to the p300/CBP-associated factor PCAF, another HAT protein found in similar comple ...
... Like 2 (GCN5L2) is a transcription adaptor protein and a histone acetyltransferase (HAT) that functions as the catalytic subunit of the STAGA and TFTC transcription coactivator complexes (8). GCN5L2 is 73% homologous to the p300/CBP-associated factor PCAF, another HAT protein found in similar comple ...
Conserved Key Amino Acid Positions (CKAAPs) Derived From the
... model is supported by a number of mutation studies in which most of single-residue mutations were found to provide no measurable effect on protein function and presumably structure.12,13 This view is also supported by structural studies. Russell and Barton14 report that for many proteins with simila ...
... model is supported by a number of mutation studies in which most of single-residue mutations were found to provide no measurable effect on protein function and presumably structure.12,13 This view is also supported by structural studies. Russell and Barton14 report that for many proteins with simila ...
Shetti, a simple tool to parse, manipulate and search large datasets
... sequences. The Shetti tool can be used to search for a sequence, species, protein/gene or pattern/motif. Moreover, it can also be used to construct a universal consensus or molecular signatures for proteins based on their physical characteristics. Shetti is an efficient and fast tool that can deal w ...
... sequences. The Shetti tool can be used to search for a sequence, species, protein/gene or pattern/motif. Moreover, it can also be used to construct a universal consensus or molecular signatures for proteins based on their physical characteristics. Shetti is an efficient and fast tool that can deal w ...
Extension Article for students who scored 85 or above
... chemical compound. Molecules can be made of single types of atoms or of different types. For example, the oxygen in the air is made of two oxygen atoms (O2), but water is made of two hydrogen atoms and one oxygen atom (H2O). ...
... chemical compound. Molecules can be made of single types of atoms or of different types. For example, the oxygen in the air is made of two oxygen atoms (O2), but water is made of two hydrogen atoms and one oxygen atom (H2O). ...
Full Text
... We have developed a novel representation of protein motifs that permits the rapid discovery of structural features in sets of protein sequences with a common structure or function. Many popular methods for representing protein motifs (consensus sequences, weight matrices, profiles, etc.) emphasize c ...
... We have developed a novel representation of protein motifs that permits the rapid discovery of structural features in sets of protein sequences with a common structure or function. Many popular methods for representing protein motifs (consensus sequences, weight matrices, profiles, etc.) emphasize c ...
Molecular Weight Estimation - Bio-Rad
... are visible following development of the chemiluminescent signal. Additionally, the ability to visualize protein standards (for example, by using prestained standards) during the electrophoresis run and directly on the blot following the transfer step is also advantageous. Prestained protein standar ...
... are visible following development of the chemiluminescent signal. Additionally, the ability to visualize protein standards (for example, by using prestained standards) during the electrophoresis run and directly on the blot following the transfer step is also advantageous. Prestained protein standar ...
Role of Bioinformatics Tools in Biological Research GPS
... Drug: Kill invaders/pathogens and/or Inhibit the growth of pathogens ...
... Drug: Kill invaders/pathogens and/or Inhibit the growth of pathogens ...
S100 Protein (P)
... the qualitative identification of S100 protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the c ...
... the qualitative identification of S100 protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the c ...
Understanding the complexity of Protein Function
... • Discovered over 20 years ago • Enzyme Class: Isomerase • Is a member of the cytochrome P450 enzyme family • P450s belong to a large family of proteins containing a heme cofactor • P450 enzymes have been identified in all domains of life • Prostaglandins are derivative of Arachidonic acid and produ ...
... • Discovered over 20 years ago • Enzyme Class: Isomerase • Is a member of the cytochrome P450 enzyme family • P450s belong to a large family of proteins containing a heme cofactor • P450 enzymes have been identified in all domains of life • Prostaglandins are derivative of Arachidonic acid and produ ...
nutrient composition of dandelions and its potential as human food
... Two thirds of the world’s populations are suffering from protein malnutrition and about 36 million people die every year due to hunger. Expansion of present agriculture practices into marginal land is not expected to solve the problem of increasing the food supply. New methods of feeding the ever in ...
... Two thirds of the world’s populations are suffering from protein malnutrition and about 36 million people die every year due to hunger. Expansion of present agriculture practices into marginal land is not expected to solve the problem of increasing the food supply. New methods of feeding the ever in ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.