Vertebrate genomics : More fishy tales about Hox genes
... temporal expression patterns. Thus, at one end of a cluster are located the ‘anterior’ Hox genes, which are expressed earlier in development and more anteriorly along the main body axis, whereas at the other end of a cluster are the ‘posterior’ genes, which are switched on later in development and i ...
... temporal expression patterns. Thus, at one end of a cluster are located the ‘anterior’ Hox genes, which are expressed earlier in development and more anteriorly along the main body axis, whereas at the other end of a cluster are the ‘posterior’ genes, which are switched on later in development and i ...
A defense-offense multi-layered regulatory switch in a pathogenic
... starts at the OFF state, when the level of the sRNA regulator is 0 and the TF is expressed and active (A), leading to a high level of protein 1 and a low level of protein 2 (B). Upon change in condition (ON step, at t = 10 h) the sRNA is activated, leading to a decrease in the level of the TF (A) as ...
... starts at the OFF state, when the level of the sRNA regulator is 0 and the TF is expressed and active (A), leading to a high level of protein 1 and a low level of protein 2 (B). Upon change in condition (ON step, at t = 10 h) the sRNA is activated, leading to a decrease in the level of the TF (A) as ...
Animal Behaviour SPECIAL ISSUE: KIN SELECTION
... expression analyses could identify shared molecular functions or biological processes that are repeatedly associated with a behavioural phenotype, and inferences at this level may also provide evidence for a behavioural toolkit. For example, in the honeybee, transcriptomic analyses with microarrays ...
... expression analyses could identify shared molecular functions or biological processes that are repeatedly associated with a behavioural phenotype, and inferences at this level may also provide evidence for a behavioural toolkit. For example, in the honeybee, transcriptomic analyses with microarrays ...
Mergers and acquisitions: malaria and the great chloroplast heist
... been to compare genes from the plastid genome of the secondary plastid with the candidates from the pool of primary plastid-containing organisms. For malaria parasites this was no problem since the entire plastid genome was already sequenced by Iain Wilson and colleagues [2], but, until recently, no ...
... been to compare genes from the plastid genome of the secondary plastid with the candidates from the pool of primary plastid-containing organisms. For malaria parasites this was no problem since the entire plastid genome was already sequenced by Iain Wilson and colleagues [2], but, until recently, no ...
Transcription Regulation in Eukaryotes
... The HFSP workshops were initiated by Michel Cuénod (Secretary-General, HFSPO) with the support of the Board of Trustees and the Council of Scientists. The workshops, held in English, are organized at the HFSPO office in Strasbourg on specific scientific topics of particular timeliness in the two fie ...
... The HFSP workshops were initiated by Michel Cuénod (Secretary-General, HFSPO) with the support of the Board of Trustees and the Council of Scientists. The workshops, held in English, are organized at the HFSPO office in Strasbourg on specific scientific topics of particular timeliness in the two fie ...
Sorting Out the Genome
... a mathematical point of view, however, the pancake problem remains unsolved: The exact number of flips needed to sort n pancakes is unknown. Gene flipping has a lot in common with the pancake problem, but there are differences as well. With pancakes, you are not allowed to reach into the middle of t ...
... a mathematical point of view, however, the pancake problem remains unsolved: The exact number of flips needed to sort n pancakes is unknown. Gene flipping has a lot in common with the pancake problem, but there are differences as well. With pancakes, you are not allowed to reach into the middle of t ...
DROSOPHILA: GENETICS MEETS BEHAVIOUR
... analysis? Because they carry subtle alterations in a gene, such as HYPOMORPHIC MUTATIONS, that probably allow them to survive in nature. By comparison, single-gene mutant studies have shown that when null alleles are generated they often cause pleiotropic effects and so produce unrelated phenotypes ...
... analysis? Because they carry subtle alterations in a gene, such as HYPOMORPHIC MUTATIONS, that probably allow them to survive in nature. By comparison, single-gene mutant studies have shown that when null alleles are generated they often cause pleiotropic effects and so produce unrelated phenotypes ...
Sex Linked Inheritance, Chromosome Mapping
... Euploidy is lethal in most animal species, but often tolerated in plants, where it has played a role in speciation and diversification. Monoploidy and polyploidy can result when either round of meiotic division lacks cytokinesis, or when meiotic nondisjunction occurs for all chromosomes. Punjab EDU ...
... Euploidy is lethal in most animal species, but often tolerated in plants, where it has played a role in speciation and diversification. Monoploidy and polyploidy can result when either round of meiotic division lacks cytokinesis, or when meiotic nondisjunction occurs for all chromosomes. Punjab EDU ...
The Classical Genetic Switch in Lambda Phage- Lysis and
... made and it activates its own transcription from PRM. This switches OFF the other phage genes including CII. Thus we see the establishment of lysogeny in lambda phage, even in the absence of the inducer signal. ...
... made and it activates its own transcription from PRM. This switches OFF the other phage genes including CII. Thus we see the establishment of lysogeny in lambda phage, even in the absence of the inducer signal. ...
Defining the Epigenetic Mechanism of Asymmetric Cell Division of
... the DSB in the specific chromatid, which initiates recombination required for mat1 switching. Most interestingly, it takes two consecutive cell divisions to complete the entire developmental program of this single-celled organism. Specifically, the one-in-four cell-type switching pattern of S. pombe r ...
... the DSB in the specific chromatid, which initiates recombination required for mat1 switching. Most interestingly, it takes two consecutive cell divisions to complete the entire developmental program of this single-celled organism. Specifically, the one-in-four cell-type switching pattern of S. pombe r ...
Evolution of Disintegrin Cysteine-Rich and
... It has recently become apparent that a number of cysteine-rich proteins with similar structural organizations occur in the mammalian male reproductive tract. The best characterized of these are Fertilin (formerly PH-30), a guinea pig sperm surface protein involved in sperm– egg fusion (Blobel et al. ...
... It has recently become apparent that a number of cysteine-rich proteins with similar structural organizations occur in the mammalian male reproductive tract. The best characterized of these are Fertilin (formerly PH-30), a guinea pig sperm surface protein involved in sperm– egg fusion (Blobel et al. ...
Unexpected Complexity of Poly(A)-Binding Protein Gene Families in
... raises the question as to which of them is essential for viability. Using cross-species complementation of the yeast pab1 null mutant by the Arabidopsis PAB3 cDNA, it was shown that rescue of viability required neither the restoration of poly(A)-dependent translation nor the protection of the 5⬘ cap ...
... raises the question as to which of them is essential for viability. Using cross-species complementation of the yeast pab1 null mutant by the Arabidopsis PAB3 cDNA, it was shown that rescue of viability required neither the restoration of poly(A)-dependent translation nor the protection of the 5⬘ cap ...
Gene Section LIMK1 (LIM domain kinase 1) Atlas of Genetics and Cytogenetics
... Overexpression of Her2/neu oncogene product is considered to be associated with worse prognosis. LIMK1 expression may have a prognostic value for metastatic breast cancer as overexpression of LIMK1 has been noted in metastatic breast cancer cells. Cytogenetics CGH analysis indicated a gain in chromo ...
... Overexpression of Her2/neu oncogene product is considered to be associated with worse prognosis. LIMK1 expression may have a prognostic value for metastatic breast cancer as overexpression of LIMK1 has been noted in metastatic breast cancer cells. Cytogenetics CGH analysis indicated a gain in chromo ...
Summary - WordPress.com
... acting as a negative regulator clueless prevents the interaction between pink1 and parkin. In conclusion, the researchers suggest that healthy mitochondria have associated Clueless particles, undergo normal mitochondrial protein import and have low levels of PINK1. Whereas under disrupted protein im ...
... acting as a negative regulator clueless prevents the interaction between pink1 and parkin. In conclusion, the researchers suggest that healthy mitochondria have associated Clueless particles, undergo normal mitochondrial protein import and have low levels of PINK1. Whereas under disrupted protein im ...
Homologous recombination in budding yeast expressing the human
... genes, and Rad51-MYC, Rad52-MYC or HsRAD52-MYC from fusion genes on plasmids containing the appropriate combination of tagged alleles were used to inoculate cultures of synthetic complete medium lacking uracil and grown overnight. The overnight cultures were used to inoculate YPD cultures that were ...
... genes, and Rad51-MYC, Rad52-MYC or HsRAD52-MYC from fusion genes on plasmids containing the appropriate combination of tagged alleles were used to inoculate cultures of synthetic complete medium lacking uracil and grown overnight. The overnight cultures were used to inoculate YPD cultures that were ...
Document
... • In the beginning of telophase I, each half of the cell has a haploid set of chromosomes; each chromosome still consists of two sister chromatids ...
... • In the beginning of telophase I, each half of the cell has a haploid set of chromosomes; each chromosome still consists of two sister chromatids ...
Genomic Consequences of Background Effects on scalloped Mutant
... UCSF Spot ( Jain et al. 2002). These results were compared with the histogram-based approach and found to have similar, though somewhat more reliable, results (not shown). Global normalization and gene-specific models: Log2-transformed signal intensities were normalized using the linear mixed model ...
... UCSF Spot ( Jain et al. 2002). These results were compared with the histogram-based approach and found to have similar, though somewhat more reliable, results (not shown). Global normalization and gene-specific models: Log2-transformed signal intensities were normalized using the linear mixed model ...
Genetics of Male Infertility - the Infertility Center of St. Louis
... Y (NRY), there are many “Y deletions” that are of no consequence. Only if these deletions in the infertile male are not present in his fertile male relatives, nor in hundreds of normal controls, could they be implicated as a cause of the infertility. The fertile fathers of the Y-deleted, infertile m ...
... Y (NRY), there are many “Y deletions” that are of no consequence. Only if these deletions in the infertile male are not present in his fertile male relatives, nor in hundreds of normal controls, could they be implicated as a cause of the infertility. The fertile fathers of the Y-deleted, infertile m ...
Using Transcriptional Control To Increase Titers of Secreted
... measuring secreted titer, cultures were grown for 8 h. For all other experiments, cultures were grown for 6 h. Supernatant samples were harvested from the cell culture by two sequential centrifugation steps of 2,272 ⫻ g for 10 min. Samples were precipitated in 20% trichloroacetic acid (TCA) overnigh ...
... measuring secreted titer, cultures were grown for 8 h. For all other experiments, cultures were grown for 6 h. Supernatant samples were harvested from the cell culture by two sequential centrifugation steps of 2,272 ⫻ g for 10 min. Samples were precipitated in 20% trichloroacetic acid (TCA) overnigh ...
Full-Text PDF
... properties of ubiquitin were positively selected and fixed in early stages of evolution of an eukaryotic ancestor [3]. Moreover, the structure of ubiquitin genes, organized in tandems and in multiple loci, facilitated a strong concerted evolution [4,5]. The ubiquitin signaling system is mediated by ...
... properties of ubiquitin were positively selected and fixed in early stages of evolution of an eukaryotic ancestor [3]. Moreover, the structure of ubiquitin genes, organized in tandems and in multiple loci, facilitated a strong concerted evolution [4,5]. The ubiquitin signaling system is mediated by ...
Hypoxia-inducible factor 1 is a new target of microphthalmia
... positive control and again the effect of Co2 and cAMP appeared additive (Fig. 1 D). Among the multiple HIF1 target genes containing an HRE core sequence in their promoter region, Vegf has been largely studied because it is required for tumor angiogenesis. We therefore analyzed the effects of cAMP i ...
... positive control and again the effect of Co2 and cAMP appeared additive (Fig. 1 D). Among the multiple HIF1 target genes containing an HRE core sequence in their promoter region, Vegf has been largely studied because it is required for tumor angiogenesis. We therefore analyzed the effects of cAMP i ...
Floral Symmetry - Coen Lab
... profound alterations in the basic plan of the flower could be produced without any apparent effect on the rest of the plant. The mutations were clearly affecting genes with very specific and fundamental roles in flower development. I had previously done a Ph.D on Drosophila with Gabby Dover, on the ...
... profound alterations in the basic plan of the flower could be produced without any apparent effect on the rest of the plant. The mutations were clearly affecting genes with very specific and fundamental roles in flower development. I had previously done a Ph.D on Drosophila with Gabby Dover, on the ...