Recurrent patterns of DNA copy number alterations in tumors reflect
... and pentose phosphate pathway were most predictive..."; p. 14: "p53-/- cells did not undergo senescence and exhibited less strong copy-number alterations than wild-type signature A MEFs" these statements need to be omitted if no significant p-value can be provided, or alternatively included with the ...
... and pentose phosphate pathway were most predictive..."; p. 14: "p53-/- cells did not undergo senescence and exhibited less strong copy-number alterations than wild-type signature A MEFs" these statements need to be omitted if no significant p-value can be provided, or alternatively included with the ...
PDF
... Maternal effects have been genetically defined by mutations that affect the next generation when inherited from the mother. Maternal effect genes play an essential role in early development in many animal species (Riechmann and Ephrussi, 2001; Sardet et al., 2004). In plants, the maternal contributi ...
... Maternal effects have been genetically defined by mutations that affect the next generation when inherited from the mother. Maternal effect genes play an essential role in early development in many animal species (Riechmann and Ephrussi, 2001; Sardet et al., 2004). In plants, the maternal contributi ...
Evolutionary relationships of the Tas2r receptor gene families in
... (ftp://ftp.ncbi.nlm.nih.gov/blast). HSPs found by the same query sequence, and lying in proximity to each other on a single chromosome, were assembled into complete genes using the publicly available software GeneWise from the Wise2 package by Ewan Birney at the Sanger Centre, Hinxton, UK (http://ww ...
... (ftp://ftp.ncbi.nlm.nih.gov/blast). HSPs found by the same query sequence, and lying in proximity to each other on a single chromosome, were assembled into complete genes using the publicly available software GeneWise from the Wise2 package by Ewan Birney at the Sanger Centre, Hinxton, UK (http://ww ...
Bridging structural biology and genomics: assessing protein
... into baculoviruses as either a glutathione-Stransferase (GST)-tagged or an untagged protein. Every combination of individual GST-tagged subunits and non-tagged subunits were co-expressed and precipitated, generating a comprehensive set of inter-subunit pairwise interactions [20–24]. This is a common ...
... into baculoviruses as either a glutathione-Stransferase (GST)-tagged or an untagged protein. Every combination of individual GST-tagged subunits and non-tagged subunits were co-expressed and precipitated, generating a comprehensive set of inter-subunit pairwise interactions [20–24]. This is a common ...
Investigation of Four Genes Responsible for Autosomal Recessive
... brain, kidney, and pancreas. In adult brain, GCNT2 is much more prominent in cerebellum than the other parts of brain [15]. Crystallins (α-crystallin family and the β/γ-crystallin superfamily) are highly stable major constituents of the vertebrate eye lens and comprise approximately 90% of the water ...
... brain, kidney, and pancreas. In adult brain, GCNT2 is much more prominent in cerebellum than the other parts of brain [15]. Crystallins (α-crystallin family and the β/γ-crystallin superfamily) are highly stable major constituents of the vertebrate eye lens and comprise approximately 90% of the water ...
NEW EVIDENCE FOR THE HOMOLOGY OF THE SHORT
... Small spots. In spite of the fact that the Sms duplication covers the region of the distal break of the inversion in the Ce mutant line, the Ce;Sms males have the distinctive phenotypic complex of males of the Ce line expressed without any changes. Thus the appearance of these males in the progeny o ...
... Small spots. In spite of the fact that the Sms duplication covers the region of the distal break of the inversion in the Ce mutant line, the Ce;Sms males have the distinctive phenotypic complex of males of the Ce line expressed without any changes. Thus the appearance of these males in the progeny o ...
Multiple Mechanisms Contribute to Lateral Transfer of an
... isolated by following the Currier Nester protocol with minor modifications (Currier and Nester 1976; Pandeeti et al. 2011). The plasmid preparation made from Sphingobium fuliginis ATCC 27551 was directly used for tagging with minitransposon EZ-Tn5,R6Kgori/KAN-2. using the EZTn5 ,R6Kgori/KAN-2. insert ...
... isolated by following the Currier Nester protocol with minor modifications (Currier and Nester 1976; Pandeeti et al. 2011). The plasmid preparation made from Sphingobium fuliginis ATCC 27551 was directly used for tagging with minitransposon EZ-Tn5,R6Kgori/KAN-2. using the EZTn5 ,R6Kgori/KAN-2. insert ...
Figure 15 - GEP Community Server
... header) is selected and the diagram will only show the motif instances that were used to construct each motif. Because we have previously specified in our search parameters that we expect to find zero or one instance of each motif within each sequence, each sequence in the block diagram will contain ...
... header) is selected and the diagram will only show the motif instances that were used to construct each motif. Because we have previously specified in our search parameters that we expect to find zero or one instance of each motif within each sequence, each sequence in the block diagram will contain ...
Alternative Splicing
... Alternative splicing plays an important role in regulating gene expression. In the last decade it has been shown that alternative splicing determines binding properties, intracellular localization, enzymatic activity, protein stability and posttranslational modifications of a large number of protein ...
... Alternative splicing plays an important role in regulating gene expression. In the last decade it has been shown that alternative splicing determines binding properties, intracellular localization, enzymatic activity, protein stability and posttranslational modifications of a large number of protein ...
The role of regulatory variation in complex traits and
... Expression quantitative trait loci (eQTLs) are regions of the genome containing DNA sequence variants that influence the expression level of one or more genes. They are identified by studying a population of genetically different individuals (FIG. 1). These individuals can be members of an outbred p ...
... Expression quantitative trait loci (eQTLs) are regions of the genome containing DNA sequence variants that influence the expression level of one or more genes. They are identified by studying a population of genetically different individuals (FIG. 1). These individuals can be members of an outbred p ...
Birefringence imaging of spermatozoa, spindle and zona pellucida
... indicator of oocyte competence Cumulus and granulosa cells: regulate oocyte growth and acquisition q of oocyte y developmental competence Oocyte secreted factors: direct differentiation and function of cumulus cells Bidirectional communication via transzonal projections with formation of gap junctio ...
... indicator of oocyte competence Cumulus and granulosa cells: regulate oocyte growth and acquisition q of oocyte y developmental competence Oocyte secreted factors: direct differentiation and function of cumulus cells Bidirectional communication via transzonal projections with formation of gap junctio ...
v5_02_alcoholism_and_our_genes
... one neuron that control the activity of another neuron. • Neurotransmitters bind to receptor molecules on the surface of responsive cells. • Variants in genes that influence neurotransmitter receptors influence susceptibility to alcoholism. • The receptors important in alcoholism control excitation ...
... one neuron that control the activity of another neuron. • Neurotransmitters bind to receptor molecules on the surface of responsive cells. • Variants in genes that influence neurotransmitter receptors influence susceptibility to alcoholism. • The receptors important in alcoholism control excitation ...
Reduced expression of the SHORT-ROOT gene increases the rates
... endodermis differentiation and stem cell maintenance in the root, SHR and SCR primarily function as general regulators of cell proliferation in leaves [16]. The spatiotemporal activation of specific cell-cycle genes by SHR/SCR has been shown to be required for proper root pattern formation, providin ...
... endodermis differentiation and stem cell maintenance in the root, SHR and SCR primarily function as general regulators of cell proliferation in leaves [16]. The spatiotemporal activation of specific cell-cycle genes by SHR/SCR has been shown to be required for proper root pattern formation, providin ...
Clustering short time series gene expression data
... – Greedy algorithm to partition the graph into cliques • Initially cluster Ci={pi} • Next, look for a profile pj such that pj is the closet profile to pi that is not already included in Ci . • If d(pj ,pi )≤ for all profiles pk we add pj to Ci and repeat this process, otherwise we stop and declare ...
... – Greedy algorithm to partition the graph into cliques • Initially cluster Ci={pi} • Next, look for a profile pj such that pj is the closet profile to pi that is not already included in Ci . • If d(pj ,pi )≤ for all profiles pk we add pj to Ci and repeat this process, otherwise we stop and declare ...
What stay-green mutants tell us about nitrogen remobilization in leaf
... Downloaded from http://jxb.oxfordjournals.org/ at Pennsylvania State University on February 27, 2014 Fig. 5. (a) Genomic in situ hybridization of Lolium temulentum Ceres stay-green introgression line. The location of the pair of alien segments derived from Festuca pratensis is indicated. (b) Norther ...
... Downloaded from http://jxb.oxfordjournals.org/ at Pennsylvania State University on February 27, 2014 Fig. 5. (a) Genomic in situ hybridization of Lolium temulentum Ceres stay-green introgression line. The location of the pair of alien segments derived from Festuca pratensis is indicated. (b) Norther ...
The Journal of Experimental Medicine
... Culture Collection. CT498 transfectants were generated by retroviral transduction of BALB/c 3T3 cells. A plasmid encoding MCMV m155 cDNA in pMX-neo was transfected into Phoenix A ecotrophic viral-packaging cells using Lipofectamine 2000 Reagent (Invitrogen). After 48 h, the virus was used to infect ...
... Culture Collection. CT498 transfectants were generated by retroviral transduction of BALB/c 3T3 cells. A plasmid encoding MCMV m155 cDNA in pMX-neo was transfected into Phoenix A ecotrophic viral-packaging cells using Lipofectamine 2000 Reagent (Invitrogen). After 48 h, the virus was used to infect ...
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key
... transport requires soluble ER-resident proteins to either have a KDEL-like motif at their C terminus or to form a complex with ER-resident proteins that do3,4. Consistently, it has been reported that KDELR modulates ER stress responses, at least in HeLa cells5. A more recent study has suggested that ...
... transport requires soluble ER-resident proteins to either have a KDEL-like motif at their C terminus or to form a complex with ER-resident proteins that do3,4. Consistently, it has been reported that KDELR modulates ER stress responses, at least in HeLa cells5. A more recent study has suggested that ...
Control of Chromosome Pairing and Genome Evolution in Disomic
... the parents? Why do the F5s sometimes differ from the F2s? All of their data are summarized in Table 1. They suggested the following mechanisms for the observed results: They suggested the following mechanisms for the observed results: “The changes we observed could have resulted from several differ ...
... the parents? Why do the F5s sometimes differ from the F2s? All of their data are summarized in Table 1. They suggested the following mechanisms for the observed results: They suggested the following mechanisms for the observed results: “The changes we observed could have resulted from several differ ...
Meiosis - MrMsciences
... – Green Seeds X Yellow Seeds • Started with P1 – Parents • Offspring were call F1 – Filial (son/daughter) – 1st generation • F1 X F1 = F2 – 2nd generation ...
... – Green Seeds X Yellow Seeds • Started with P1 – Parents • Offspring were call F1 – Filial (son/daughter) – 1st generation • F1 X F1 = F2 – 2nd generation ...
Extended Life-Span and Stress Resistance in Drosophila
... dwarfs with low fertility, but some long-lived InR mutants have normal size and fertility, indicating that longevity may be regulated independently of body size and fertility. • daf-2 and InR are structural homologs of a family of vertebrate receptors that includes the insulin receptor and the insul ...
... dwarfs with low fertility, but some long-lived InR mutants have normal size and fertility, indicating that longevity may be regulated independently of body size and fertility. • daf-2 and InR are structural homologs of a family of vertebrate receptors that includes the insulin receptor and the insul ...
1 Title: Long-term natural selection affects patterns of
... Interestingly, while divergence increases monotonically on the autosomes, this is not true for the X chromosome (Figure 1). We observe that divergence initially increases with increasing distance from genes, then observe a dip in divergence in the bin [0.10.2] cM from genes on the X chromosome (Figu ...
... Interestingly, while divergence increases monotonically on the autosomes, this is not true for the X chromosome (Figure 1). We observe that divergence initially increases with increasing distance from genes, then observe a dip in divergence in the bin [0.10.2] cM from genes on the X chromosome (Figu ...
Preneoplastic lesions of the lung
... a tumor classification system that defines three different preneoplastic lesions of the bronchial epithelium: squamous dysplasia (SD) and carcinoma in situ (CIS), which may be precursors to squamous cell carcinoma; atypical adenomatous hyperplasia (AAH), which may be the progenitor lesion for adenoc ...
... a tumor classification system that defines three different preneoplastic lesions of the bronchial epithelium: squamous dysplasia (SD) and carcinoma in situ (CIS), which may be precursors to squamous cell carcinoma; atypical adenomatous hyperplasia (AAH), which may be the progenitor lesion for adenoc ...
Identifying 3D expression domains by graph clustering
... environment regarding gene expression. If it is in a tight winding, there isn’t room for transcription factors to bind (or at least becomes far more difficult). ...
... environment regarding gene expression. If it is in a tight winding, there isn’t room for transcription factors to bind (or at least becomes far more difficult). ...
Full Text PDF - Mary Ann Liebert, Inc. publishers
... could be, essentially, elements that would interrupt interactions between enhancers and promoters. As a result of this situation, they would have been selected against if they occurred within a given expression domain, but not at the limits of it. As a consequence, insulators would often be found at ...
... could be, essentially, elements that would interrupt interactions between enhancers and promoters. As a result of this situation, they would have been selected against if they occurred within a given expression domain, but not at the limits of it. As a consequence, insulators would often be found at ...
Control of the proliferation versus meiotic development decision in
... identified in a mutant screen, functions redundantly with gld2 to promote the rise in GLD-1 that is necessary for entry into meiosis. Genetic experiments indicate that repression of GLD1 accumulation by FBF is acting through nos-3, while regulation of gld-2 in this processes is likely by something ...
... identified in a mutant screen, functions redundantly with gld2 to promote the rise in GLD-1 that is necessary for entry into meiosis. Genetic experiments indicate that repression of GLD1 accumulation by FBF is acting through nos-3, while regulation of gld-2 in this processes is likely by something ...