5 Genetic Analysis of Kidney Disease in Mice
... with small effects. This is true for many of the QTLs identified for autoimmune phenotypes. Therefore, we developed two novel strategies to dissect a complex locus; The partial advanced intercross (PAI) strategy, with which we recently found the Cia5 region to consist of three loci, Cia5, Cia21 and ...
... with small effects. This is true for many of the QTLs identified for autoimmune phenotypes. Therefore, we developed two novel strategies to dissect a complex locus; The partial advanced intercross (PAI) strategy, with which we recently found the Cia5 region to consist of three loci, Cia5, Cia21 and ...
Article On the Complexity of Chloroplast RNA
... There may be multiple reasons for the remarkable complexity of chloroplast RNA metabolism. One is the need for regulation in response to developmental or environmental changes, in coordination with nuclear gene expression. An example is provided in Chlamydomonas by two proteins required for petA exp ...
... There may be multiple reasons for the remarkable complexity of chloroplast RNA metabolism. One is the need for regulation in response to developmental or environmental changes, in coordination with nuclear gene expression. An example is provided in Chlamydomonas by two proteins required for petA exp ...
Translational Repression of C. elegans p53 by GLD
... 2003; Vassilev et al., 2004). Such a therapeutic approach highlights the need to uncover additional pathways and mechanisms that negatively regulate p53 levels or activity. Most studies on p53 signaling have been conducted in cell culture-based systems, and their translation into mouse models is oft ...
... 2003; Vassilev et al., 2004). Such a therapeutic approach highlights the need to uncover additional pathways and mechanisms that negatively regulate p53 levels or activity. Most studies on p53 signaling have been conducted in cell culture-based systems, and their translation into mouse models is oft ...
- Zurich Open Repository and Archive
... consecutive removal from chl of phytol and the Mg atom by chlorophyllase and a metal-chelating substance, respectively. Loss of the green color occurs during the subsequent opening of the porphyrin macrocycle of pheophorbide (pheide) a by the coupled action of pheide a oxygenase (PAO) and red chl c ...
... consecutive removal from chl of phytol and the Mg atom by chlorophyllase and a metal-chelating substance, respectively. Loss of the green color occurs during the subsequent opening of the porphyrin macrocycle of pheophorbide (pheide) a by the coupled action of pheide a oxygenase (PAO) and red chl c ...
Sequential Elimination of Major-Effect Contributors Identifies
... and RHO2 encodes a small GTPase involved in establishment of cell polarity and in microtubule assembly. Moreover, common, rare, coding and noncoding polymorphisms were found to be causative, with alleles having additive and epistatic effects (Steinmetz et al. 2002; Sinha et al. 2006). Interactions b ...
... and RHO2 encodes a small GTPase involved in establishment of cell polarity and in microtubule assembly. Moreover, common, rare, coding and noncoding polymorphisms were found to be causative, with alleles having additive and epistatic effects (Steinmetz et al. 2002; Sinha et al. 2006). Interactions b ...
PPT File
... • In the beginning of telophase I, each half of the cell has a haploid set of chromosomes; each chromosome still consists of two sister chromatids ...
... • In the beginning of telophase I, each half of the cell has a haploid set of chromosomes; each chromosome still consists of two sister chromatids ...
Development, 121, 4303-4308
... nucleus in a cell that is somewhat indented into the overlying ectoderm, and smaller nuclei which lie more within the mesodermal sheet. There is no doubt that all these cells are mesodermal in provenance: in those control mosaics (that is mosaics in which both donor and host cells are wingless+), wh ...
... nucleus in a cell that is somewhat indented into the overlying ectoderm, and smaller nuclei which lie more within the mesodermal sheet. There is no doubt that all these cells are mesodermal in provenance: in those control mosaics (that is mosaics in which both donor and host cells are wingless+), wh ...
X-Chromosome dosage compensation
... dosage compensation complex and to nucleate spreading of the complex to X regions that lack recruitment sites. In this manner, a repressed chromatin state is spread in cis over short or long distances, thus establishing the global, epigenetic regulation of X chromosomes that is maintained throughout ...
... dosage compensation complex and to nucleate spreading of the complex to X regions that lack recruitment sites. In this manner, a repressed chromatin state is spread in cis over short or long distances, thus establishing the global, epigenetic regulation of X chromosomes that is maintained throughout ...
Genetic characterization of the mitochondrial DNA - (BORA)
... and ND6), cytochrome c oxidase subunits I – III (COI, COII and COIII), two rRNA genes (12S rRNA and 16S rRNA) and 22 tRNAs. Two copies of tRNA-Lys are present in the mtDNA of L. salmonis, while tRNA-Cys was not identified. Both DNA strands contain coding regions in the salmon louse, in contrast to t ...
... and ND6), cytochrome c oxidase subunits I – III (COI, COII and COIII), two rRNA genes (12S rRNA and 16S rRNA) and 22 tRNAs. Two copies of tRNA-Lys are present in the mtDNA of L. salmonis, while tRNA-Cys was not identified. Both DNA strands contain coding regions in the salmon louse, in contrast to t ...
UNIT 3 - davis.k12.ut.us
... that control the same inherited traits. For instance, the gene for earlobe type will be located at the same position on both homologous chromosomes. Although these genes each code for earlobe type, they might not code for the exact same type of earlobe. ...
... that control the same inherited traits. For instance, the gene for earlobe type will be located at the same position on both homologous chromosomes. Although these genes each code for earlobe type, they might not code for the exact same type of earlobe. ...
Gene Section HRK (harakiri, BCL2 interacting protein (contains only BH3 domain))
... human tissues, it was reported that the HRK transcript was detected in spleen, lymph nodes, thymus, bone marrow and appendix (Inohara et al., 1997). However, in the rat and mouse the expression of the HRK transcript is much more restricted and HRK is detected in the brain but not the spleen, thymus, ...
... human tissues, it was reported that the HRK transcript was detected in spleen, lymph nodes, thymus, bone marrow and appendix (Inohara et al., 1997). However, in the rat and mouse the expression of the HRK transcript is much more restricted and HRK is detected in the brain but not the spleen, thymus, ...
The importance of having two X chromosomes - Neuroscience
... Because X inactivation is a random process in somatic tissues derived from the embryonic epiblast, each XX cell expresses most gene variants and parental imprints from only one of the two X chromosomes. Adult XX tissues and individuals are therefore mosaics of cells that exhibit the effects of eithe ...
... Because X inactivation is a random process in somatic tissues derived from the embryonic epiblast, each XX cell expresses most gene variants and parental imprints from only one of the two X chromosomes. Adult XX tissues and individuals are therefore mosaics of cells that exhibit the effects of eithe ...
Chapter 1 Introduction
... Cytogenetics is a branch of genetics concerned with the study of the structure of chromosomes and their role in heredity. Conventional chromosome analysis using G-banding is widely used for clinical diagnostics and genomic research. However, over the past 30 years the development of new techniques w ...
... Cytogenetics is a branch of genetics concerned with the study of the structure of chromosomes and their role in heredity. Conventional chromosome analysis using G-banding is widely used for clinical diagnostics and genomic research. However, over the past 30 years the development of new techniques w ...
HOM-C/Hox genes and four interacting loci
... et al., 1991). From these studies we concluded that the rays were not morphogenetically equivalent. In spite of the fact that they arose from repetition of a stereotyped cell sublineage (Sulston and Horvitz, 1977) (Fig. 1C) and comprised cells of the same three cell types (Sulston et al., 1980), eac ...
... et al., 1991). From these studies we concluded that the rays were not morphogenetically equivalent. In spite of the fact that they arose from repetition of a stereotyped cell sublineage (Sulston and Horvitz, 1977) (Fig. 1C) and comprised cells of the same three cell types (Sulston et al., 1980), eac ...
PATO5.08
... • UO – an ontology of units – UO’s top-level division is between primary base units of a particular measure and units that are derived ...
... • UO – an ontology of units – UO’s top-level division is between primary base units of a particular measure and units that are derived ...
Youngson and Whitelaw, 2008
... defense mechanism (140). In times of increased environmental stress, such as when more predators are present, there is less time for maternal care in the form of postnatal maternal licking/grooming and arched-back nursing (LG-ABN). Low levels of LG-ABN in the first week after birth cause offspring to ...
... defense mechanism (140). In times of increased environmental stress, such as when more predators are present, there is less time for maternal care in the form of postnatal maternal licking/grooming and arched-back nursing (LG-ABN). Low levels of LG-ABN in the first week after birth cause offspring to ...
Opposite deletions/duplications of the X chromosome: two
... Figure 2 DNA analysis of cases 1, 2 and 3 and their relatives by Southern blot a and PCR b, c, d, e, f. a, b the proposita shows only the maternal alleles at loci CRI-S232 (Xp22.1) and DMD-STR49 (Xp21), both in the deleted region of the abnormal X. c, d proposita’s alleles at loci DXS1223 (Xp22.31) ...
... Figure 2 DNA analysis of cases 1, 2 and 3 and their relatives by Southern blot a and PCR b, c, d, e, f. a, b the proposita shows only the maternal alleles at loci CRI-S232 (Xp22.1) and DMD-STR49 (Xp21), both in the deleted region of the abnormal X. c, d proposita’s alleles at loci DXS1223 (Xp22.31) ...
Molecular Genetic Improvement of Protein Quality in Maize
... Although maize grain is a valuable source of dietary energy, it is typically comprised of only 8-10% protein. Furthermore, maize is an inadequate source of essential amino acids in many diets. For monogastric animals, including humans, maize protein is deficient in lysine and tryptophan; and in many ...
... Although maize grain is a valuable source of dietary energy, it is typically comprised of only 8-10% protein. Furthermore, maize is an inadequate source of essential amino acids in many diets. For monogastric animals, including humans, maize protein is deficient in lysine and tryptophan; and in many ...
Molecular and cellular basis of calpainopathy
... apparently neutral polymorphic or unclassified variants [23] (Table 1). These mutations were documented in patients covering wide geographic areas. All types of mutations have been found, from gene inactivating mutations such as point mutations leading to premature stop codons, splice sites or frame ...
... apparently neutral polymorphic or unclassified variants [23] (Table 1). These mutations were documented in patients covering wide geographic areas. All types of mutations have been found, from gene inactivating mutations such as point mutations leading to premature stop codons, splice sites or frame ...
Cell division: The renaissance of the centriole
... might act as organizing centers to recruit microtubulenucleating factors, such as γ-tubulin, into a single focus in the cell, thus creating a centrosome. To simplify discussion, we use the general term microtubule-nucleating material to describe the factors involved in microtubule nucleation, which ...
... might act as organizing centers to recruit microtubulenucleating factors, such as γ-tubulin, into a single focus in the cell, thus creating a centrosome. To simplify discussion, we use the general term microtubule-nucleating material to describe the factors involved in microtubule nucleation, which ...
Wk12-DeanApop
... • In short, the carboxyl terminus of the HBx protein is necessary and sufficient for transcription/activation ...
... • In short, the carboxyl terminus of the HBx protein is necessary and sufficient for transcription/activation ...
Understanding Lynch Syndrome - Hereditary Nonpolyposis
... whose tumour was tested. The goal of this test is to try to find a specific mutation in one of the Lynch syndrome genes. It is possible that index genetic testing may not identify a specific mutation. In such cases, it is still possible that a gene mutation is being passed down in the family, but it ...
... whose tumour was tested. The goal of this test is to try to find a specific mutation in one of the Lynch syndrome genes. It is possible that index genetic testing may not identify a specific mutation. In such cases, it is still possible that a gene mutation is being passed down in the family, but it ...
Dear Friend - the website of Nottingham Prostate Cancer Support
... microscope. The normal prostate gland contains densely packed and well-organized cellular structures. In prostate cancer, these structures begin to lose their shape and organization and cancer cells look irregular. In the 1960s Professor Donald F. Gleason was the first to show that how prostate canc ...
... microscope. The normal prostate gland contains densely packed and well-organized cellular structures. In prostate cancer, these structures begin to lose their shape and organization and cancer cells look irregular. In the 1960s Professor Donald F. Gleason was the first to show that how prostate canc ...
Epigenetic Control of Apomixis
... methylated. The level of 5-mC is determined by DNA methylation and demethylation processes. Methylation can be removed from the DNA by active and/or passive mechanisms. Promiscuous methylation requires to be pruned by demethylases to create a desired methylation pattern. Demethylation may also be re ...
... methylated. The level of 5-mC is determined by DNA methylation and demethylation processes. Methylation can be removed from the DNA by active and/or passive mechanisms. Promiscuous methylation requires to be pruned by demethylases to create a desired methylation pattern. Demethylation may also be re ...