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13.2 part 2
13.2 part 2

... not produce any muscle contraction, whereas anything 2 mv and over produces the same force of muscle contraction. This experiment shows us two important things: All neurons have a threshold level or a minimum level that must be reached in order for an action potential to be generated.  In our examp ...
Lecture_30_2014
Lecture_30_2014

... presynaptic neurons Dendrites of postsynaptic neuron Cell body of postsynaptic neuron ...
November 2000 Volume 3 Number Supp pp 1205
November 2000 Volume 3 Number Supp pp 1205

... First, devise real-time computational models that describe as much of the known behavioral and physiological evidence as possible. Second, devise an implementation scheme that aligns features of the model with the neural circuits involved. Third, test implications of the model and its implementation ...
Divisions of the Nervous System
Divisions of the Nervous System

...  “Information” travels within the nervous system as propagated electrical signals (action potentials)  The most important information (vision, balance, motor commands) is carried by large-diameter, myelinated axons ...
Feedback — Exam
Feedback — Exam

... strengthens/weakens as a function of the timing of prevs. postsynaptic spikes (STDP). Mark the correct sentences. When the pre synaptic cell fires a spike immediately after the post synaptic cell – no change in the synaptic strength When the postsynaptic spike fires before the pre-synaptic spike, th ...
Opium Poppy - thblack.com
Opium Poppy - thblack.com

... When enkephalins bind to the opiate receptors they inhibit neurons from transmitting pain signal - pain signal does not reach brain Inhibit release of neurotransmitter “Substance P” Substance P used by the sensory neurons involved in the perception of chronic and/or intense pain ...
Stereological estimation of dendritic coverage in the capybara SCG
Stereological estimation of dendritic coverage in the capybara SCG

... The functional importance of the superior cervical ganglion (SCG) including its complex arborisation in mammals is defined by the fact that this autonomic ganglion supplies sympathetic nerve fibres to the large cerebral vessels and iris and hence SCG is implicated in the neural control of cerebral b ...
Neurotransmitter Flashcards
Neurotransmitter Flashcards

... 95. In a dually innervated organ, how will the organ know if sympathetic or parasympathetic is barking louder? 96. Why are a lot of organs dually innervated? 97. What neurons can cause excitation in one organ yet inhibition in another? 98. What happens when the parasympathetic system is suppressed? ...
Cerebellum_seminar
Cerebellum_seminar

... more than half of all its neurons.  arranged in a highly regular manner as repeating units but with input and outputs from different parts similar computational operations but on different inputs.  the cerebellum is provided with extensive information (40 times more axons project into the cerebell ...
Cells of the Nervous System
Cells of the Nervous System

... and the triceps). There are inhibitory neurons that work to prevent antagonistic muscles from working at the same time. In this case the biceps receiving acetylcholine would contract and cause flexion but the triceps receiving GABA would be inhibited. Tetanus toxin (produced by bacteria) prevents th ...
Full text - Ip Lab - Hong Kong University of Science and Technology
Full text - Ip Lab - Hong Kong University of Science and Technology

... Mechanisms underlying the role of EphB forward and ephrinB reverse signaling in synapse formation and maturation. The motility of immature filopodia, which is crucial during synaptogenesis, is increased upon activation of EphB receptors via the serine/ threonine kinase PAK1. The initial axon–dendrit ...
Assessing the Chaotic Nature of Neural Networks
Assessing the Chaotic Nature of Neural Networks

... Concomitant with synaptic pruning is the strengthening of those synapses not pruned. It is believed that those synapses not pruned are the ones encoding useful information, and therefore their influence on network activity is increased, not only by eliminating those synapses not contributing to info ...
CHAPTER 12- Nervous Tissue
CHAPTER 12- Nervous Tissue

... C) resulting from simultaneous stimulation from several presynaptic end bulbs is called temporal. D) resulting from many stimulations from the same presynaptic end bulb is spatial. E) has no effect on the electrical activity of the postsynaptic neuron. 34) A postsynaptic neuron receives a greater nu ...
ANS and sympathetic division pharm
ANS and sympathetic division pharm

... Autonomic Nervous System is a division of the nervous system separate from the somatic system which maintains body homeostasis by integrating signals from afferent somatic and visceral sensors to modulate organ perfusion and function. These signals are integrated in medulla and modulated by the cent ...
Drug-drug interactions in inpatient and outpatient settings in Iran: a
Drug-drug interactions in inpatient and outpatient settings in Iran: a

... [8]. These receptors can be classified as postsynaptic or presynaptic. Neurotransmitters in postsynaptic receptors usually trigger an electrical signal into the cell that cause activation or inhibition but pre-synaptic receptor provide feedback and mediate regulatory action on neurotransmitter relea ...
W5D3H3: Sensory Receptors
W5D3H3: Sensory Receptors

... It is in the somatosensory cortex that the brain recognizes where the ascending sensory tracts ...
초록리스트
초록리스트

... Glutamate is a major excitatory neurotransmitter in the midbrain dopamine neurons which activates AMPA- and NMDA-type glutamate receptors. Dendrites of midbrain dopamine neurons have rare spines and thus do not possess a clear morphological basis for synapse-specific compartmentalization. Therefore, ...
Slide 1 - Elsevier Store
Slide 1 - Elsevier Store

... cells, and other dendrites. Several changes occur at sites of contact between axons and dendrites, marked by 1 and 3 in the image, including local changes in enzyme activity, such as CaM kinase and phosphatases, receptor trafficking, and local protein synthesis. Interactions between glia and neurons ...
[j26]Chapter 7#
[j26]Chapter 7#

... next cell in the sequence via electrical synapses or gap junctions, or indirectly are responsible for activating the release of specialized neurotransmitter chemicals. Released from vesicles into the synaptic space, these neurotransmitters diffuse a short distance, bind to specialized receptors inte ...
[j26]Chapter 7#
[j26]Chapter 7#

... This chapter begins a four-chapter unit (chapters 7 through 10) on the basic structure and function of neurons and synapses in the nervous system. The electrical membrane potential of a neuron at rest that was introduced in the last chapter, now “comes to life” as appropriate stimuli alter the perme ...
Name
Name

... 4. _____ When repolarization has occurred, an impulse cannot be conducted. 5. _____ The action potential is an all-or-none response. 6. _____ In an adult, the nervous system is replete with both electrical and chemical synapses. 7. _____ Rapid succession stimulation of a postsynaptic neuron by a syn ...
Information Processing in the Central Nervous System
Information Processing in the Central Nervous System

... Sodium-potassium pump ...
Abbreviations: LTP= long
Abbreviations: LTP= long

... c. We know this because we all have pneumonics that we use to remember things. d. The reason associative memory is useful is because it is like storing information by imagining it like a puzzle, the information is different parts of the puzzle but we only need to see little parts of the puzzle to re ...
[j26]Chapter 7#
[j26]Chapter 7#

... ___ 63. ACh is transported into the postsynaptic cell cytoplasm, where it produces its effects. ___ 64. Neurotransmitters operating chemically regulated gates, do not directly result in action potentials, but rather initially produce EPSPs and IPSPs. ___ 65. Acetylcholinesterase (AChE) is an enzyme ...
Anatomy of the Sympathetic (Thoracolumbar) Division
Anatomy of the Sympathetic (Thoracolumbar) Division

... neuron that exits the CNS) and the postganglionic neuron (the neuron that innervates the target organ). The presynaptic sympathetic fibers entering the sympathetic chain may: 1. synapse immediately on the postsynaptic neuron in the ganglion located at the same level it entered; 2. ascend or descend ...
< 1 ... 16 17 18 19 20 21 22 23 24 ... 41 >

Long-term depression

Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different types of neurons that release various neurotransmitters, however, the most common neurotransmitter involved in LTD is L-glutamate. L-glutamate acts on the N-methyl-D- asparate receptors (NMDARs), α-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptors (AMPARs), kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak synaptic stimulation (as in the hippocampus). Long-term potentiation (LTP) is the opposing process to LTD; it is the long-lasting increase of synaptic strength. In conjunction, LTD and LTP are factors affecting neuronal synaptic plasticity. LTD is thought to result mainly from a decrease in postsynaptic receptor density, although a decrease in presynaptic neurotransmitter release may also play a role. Cerebellar LTD has been hypothesized to be important for motor learning. However, it is likely that other plasticity mechanisms play a role as well. Hippocampal LTD may be important for the clearing of old memory traces. Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. The result of the underlying-LTD molecular mechanism is the phosphorylation of AMPA glutamate receptors and their elimination from the surface of the parallel fiber-Purkinje cell (PF-PC) synapse.LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information.
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