MCQ - North West Urology
... A) Lamm’s protocol use 28 doses BCG over a period of 3 years-F (27 doses over 3 yrs) B) SWOG trial protocol uses maintenance BCG for 1 year only-F (used Lamm’s) C) BCG maintenance drop out rate is as high as 84% according to SWOG trial-T D) There is good evidence to suggest that Immuncyst BCG is mor ...
... A) Lamm’s protocol use 28 doses BCG over a period of 3 years-F (27 doses over 3 yrs) B) SWOG trial protocol uses maintenance BCG for 1 year only-F (used Lamm’s) C) BCG maintenance drop out rate is as high as 84% according to SWOG trial-T D) There is good evidence to suggest that Immuncyst BCG is mor ...
In vitro metabolism of sirolimus: role of CYP3A4 and - HAL
... We provide here experimental evidence that the CYP3A5*1/*3 genotype does not influence the hepatic metabolism of everolimus. In contrast, the metabolism of tacrolimus, used as positive control, was substantially higher in microsomes derived from CYP3A5 expressers, a genotype effect consistent with n ...
... We provide here experimental evidence that the CYP3A5*1/*3 genotype does not influence the hepatic metabolism of everolimus. In contrast, the metabolism of tacrolimus, used as positive control, was substantially higher in microsomes derived from CYP3A5 expressers, a genotype effect consistent with n ...
Lamictal - GSK Source
... WARNING: SERIOUS SKIN RASHES LAMICTAL® can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 to 17 years) and 0.08% to 0.3% in adult ...
... WARNING: SERIOUS SKIN RASHES LAMICTAL® can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 to 17 years) and 0.08% to 0.3% in adult ...
Utilisation of ocular lubricants by patient category
... prescriptions, 1994-2013 (end September) Prescribers of ocular lubricants The last three years (end September 2011 to end September 2013) of prescription data for ocular lubricants was investigated by major specialty prescriber code, including optometrists. Figure 6 shows the sum of prescriptions su ...
... prescriptions, 1994-2013 (end September) Prescribers of ocular lubricants The last three years (end September 2011 to end September 2013) of prescription data for ocular lubricants was investigated by major specialty prescriber code, including optometrists. Figure 6 shows the sum of prescriptions su ...
NALTREXONE HYDROCHLORIDE TABLETS USP 50 mg Rx only
... While naltrexone is a potent antagonist with a prolonged pharmacologic effect (24 to 72 hours), the blockade produced by naltrexone is surmountable. This is useful in patients who may require analgesia, but poses a potential risk to individuals who attempt, on their own, to overcome the blockade by ...
... While naltrexone is a potent antagonist with a prolonged pharmacologic effect (24 to 72 hours), the blockade produced by naltrexone is surmountable. This is useful in patients who may require analgesia, but poses a potential risk to individuals who attempt, on their own, to overcome the blockade by ...
Inderal (propranolol hydrochloride) Tablets Rx only
... centers (plus one in Canada) in 3,837 persons without history of severe congestive heart failure or presence of recent heart failure; certain conduction defects; angina since infarction, who had survived the acute phase of myocardial infarction. Propranolol was administered at either 60 or 80 mg t.i ...
... centers (plus one in Canada) in 3,837 persons without history of severe congestive heart failure or presence of recent heart failure; certain conduction defects; angina since infarction, who had survived the acute phase of myocardial infarction. Propranolol was administered at either 60 or 80 mg t.i ...
they look for answers. Men don’t look for excuses.
... Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 ve ...
... Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 ve ...
antidotes in depth (a20) - Goldfrank`s Toxicologic Emergencies
... as excretion and catabolism. Free serum digoxin concentrations were undetectable for the first 9 hours, then rose to a peak of 2 ng/mL at 16 hours, and fell to 1.5 ng/mL at both 36 hours and 56 hours at which time sampling stopped. An analysis of renal elimination based on an incomplete collection s ...
... as excretion and catabolism. Free serum digoxin concentrations were undetectable for the first 9 hours, then rose to a peak of 2 ng/mL at 16 hours, and fell to 1.5 ng/mL at both 36 hours and 56 hours at which time sampling stopped. An analysis of renal elimination based on an incomplete collection s ...
Acute onset concomitant esotropia - British Journal of Ophthalmology
... Yet many of the patients with brain tumour and acute onset concomitant esotropia that have been reported do not show signs of either abducens nerve paresis or hydrocephalus. Only two of the six patients with brain tumour and acute onset concomitant esotropia described by Williams and Hoyt had elevat ...
... Yet many of the patients with brain tumour and acute onset concomitant esotropia that have been reported do not show signs of either abducens nerve paresis or hydrocephalus. Only two of the six patients with brain tumour and acute onset concomitant esotropia described by Williams and Hoyt had elevat ...
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended
... over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of ...
... over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of ...
Warnings and Precautions
... Quetiapine fumarate dose should be increased up to 5 fold of the original dose when used in combination with a chronic treatment (e.g., greater than 7 to 14 days) of a potent CYP3A4 inducer (e.g. phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort, etc.). The dose should be titrated based ...
... Quetiapine fumarate dose should be increased up to 5 fold of the original dose when used in combination with a chronic treatment (e.g., greater than 7 to 14 days) of a potent CYP3A4 inducer (e.g. phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort, etc.). The dose should be titrated based ...
Gastrointestinal bleeding with the new oral anticoagulants â
... drug in this setting. Rivaroxaban and apixaban are eliminated by both renal excretion and hepatic metabolism. With all three drugs, non-absorbed, active NOAC traverses the luminal GI tract and is excreted into the faeces (7–9). ...
... drug in this setting. Rivaroxaban and apixaban are eliminated by both renal excretion and hepatic metabolism. With all three drugs, non-absorbed, active NOAC traverses the luminal GI tract and is excreted into the faeces (7–9). ...
Product Monograph Template - Standard - GlaxoSmithKline
... Patients should be clearly instructed to use rapid onset, short duration, inhaled beta2agonists only for symptomatic relief if they develop asthma or COPD symptoms while taking ADVAIR®. When beginning treatment with ADVAIR®, patients who have been taking rapid onset, short duration, inhaled beta2-ag ...
... Patients should be clearly instructed to use rapid onset, short duration, inhaled beta2agonists only for symptomatic relief if they develop asthma or COPD symptoms while taking ADVAIR®. When beginning treatment with ADVAIR®, patients who have been taking rapid onset, short duration, inhaled beta2-ag ...
Recommendations for Management of Clinically Significant Drug
... an asterisk followed by a number (and in some cases an additional letter) may also be used (eg, CYP2C19*2, a variant associated with diminished function compared with the wild-type allele).12 e2 ...
... an asterisk followed by a number (and in some cases an additional letter) may also be used (eg, CYP2C19*2, a variant associated with diminished function compared with the wild-type allele).12 e2 ...
Alexander Fleming and Penicillin: The Accidental Discovery? By Joanna Martin
... of the Most Important Events in Medical History • For the first time, doctors had a way to treat infections and miraculously save lives • Prior to the discovery of penicillin patients often died from trivial injuries or infections • Today in the United States, deaths by infectious bacterial diseases ...
... of the Most Important Events in Medical History • For the first time, doctors had a way to treat infections and miraculously save lives • Prior to the discovery of penicillin patients often died from trivial injuries or infections • Today in the United States, deaths by infectious bacterial diseases ...
Alexander Fleming and Penicillin: The Accidental Discovery?
... of the Most Important Events in Medical History • For the first time, doctors had a way to treat infections and miraculously save lives • Prior to the discovery of penicillin patients often died from trivial injuries or infections • Today in the United States, deaths by infectious bacterial diseases ...
... of the Most Important Events in Medical History • For the first time, doctors had a way to treat infections and miraculously save lives • Prior to the discovery of penicillin patients often died from trivial injuries or infections • Today in the United States, deaths by infectious bacterial diseases ...
Martindale: The Complete Drug Reference
... Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with diclofenac in doses of 10 to 25 mg1 and the UK CSM has received a report of an aspirinsensitive patient who died from acute asthma 4 hours after a single 25-mg dos ...
... Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with diclofenac in doses of 10 to 25 mg1 and the UK CSM has received a report of an aspirinsensitive patient who died from acute asthma 4 hours after a single 25-mg dos ...
product monograph - Sobi North America
... lasted for 14 to 28 days (first ISR encountered to last ISR resolved). The development of ISRs in patients who had not previously experienced ISRs were uncommon after the first month of therapy. The overall withdrawal rate due to ISRs across the pivotal studies was 6%. The occurrence of severe ISRs ...
... lasted for 14 to 28 days (first ISR encountered to last ISR resolved). The development of ISRs in patients who had not previously experienced ISRs were uncommon after the first month of therapy. The overall withdrawal rate due to ISRs across the pivotal studies was 6%. The occurrence of severe ISRs ...
Full Text of PDF
... cheaper in price, lighter in weight, stronger than, and not as fragile as, HA. Extraocular muscles can be directly sutured to its surface, so that there is no need to use preserved scleral tissues as with HA. Moreover, there is a difference in the method of pegging; the MCP insertion technique leave ...
... cheaper in price, lighter in weight, stronger than, and not as fragile as, HA. Extraocular muscles can be directly sutured to its surface, so that there is no need to use preserved scleral tissues as with HA. Moreover, there is a difference in the method of pegging; the MCP insertion technique leave ...
... response to furosemide is absent if the patient is dehydrated or treated with prostaglandin inhibitors (e.g. NSAIDs) [37], suggesting that dehydration and NSAIDs may counteract the diuretic response to furosemide and any protective effect of furosemide on medullary ischaemia [39]. Furthermore, furos ...
Astelin
... There have been no reported overdosages with Astelin Nasal Spray. Acute overdosage by adults with this dosage form is unlikely to result in clinically significant adverse reactions, other than increased somnolence, since one bottle of Astelin Nasal Spray contains 30 mg of azelastine hydrochloride. C ...
... There have been no reported overdosages with Astelin Nasal Spray. Acute overdosage by adults with this dosage form is unlikely to result in clinically significant adverse reactions, other than increased somnolence, since one bottle of Astelin Nasal Spray contains 30 mg of azelastine hydrochloride. C ...
Benefits and risks of furosemide in acute kidney injury
... response to furosemide is absent if the patient is dehydrated or treated with prostaglandin inhibitors (e.g. NSAIDs) [37], suggesting that dehydration and NSAIDs may counteract the diuretic response to furosemide and any protective effect of furosemide on medullary ischaemia [39]. Furthermore, furos ...
... response to furosemide is absent if the patient is dehydrated or treated with prostaglandin inhibitors (e.g. NSAIDs) [37], suggesting that dehydration and NSAIDs may counteract the diuretic response to furosemide and any protective effect of furosemide on medullary ischaemia [39]. Furthermore, furos ...
IS THAT CORNEAL INFILTRATE STERILE OR INFECTIOUS?
... in certain cases, including those that involve a corneal infiltrate that is central, large and extends to the mid to deep stroma, particularly with significant thinning of the cornea or scleral extension; those chronic in nature or unresponsive to broadspectrum antibiotics; and those that present wi ...
... in certain cases, including those that involve a corneal infiltrate that is central, large and extends to the mid to deep stroma, particularly with significant thinning of the cornea or scleral extension; those chronic in nature or unresponsive to broadspectrum antibiotics; and those that present wi ...
labetalol hydrochloride injection usp
... seen with the use of intravenous labetalol hydrochloride, a number of other adverse reactions including cerebral infarction and optic nerve infarction have been reported with other agents when severely elevated blood pressure was reduced over time-courses of several hours to as long as 1 or 2 days. ...
... seen with the use of intravenous labetalol hydrochloride, a number of other adverse reactions including cerebral infarction and optic nerve infarction have been reported with other agents when severely elevated blood pressure was reduced over time-courses of several hours to as long as 1 or 2 days. ...
Prescribing Information Only Fluticasone Propionate Nasal Spray
... patients with seasonal allergic rhinitis. Patients were instructed to take the study medication only on days when they thought they needed the medication for symptom control, not to exceed 2 sprays per nostril on any day, and not more than once daily. "As-needed" use was prospectively defined as ave ...
... patients with seasonal allergic rhinitis. Patients were instructed to take the study medication only on days when they thought they needed the medication for symptom control, not to exceed 2 sprays per nostril on any day, and not more than once daily. "As-needed" use was prospectively defined as ave ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.