Isoniazid-Related Hepatitis among Pregnant and
... • Only more common adverse events will be detected during clinical development • Safety data from populations of great interest difficult to obtain • Cannot predict toxicity indirectly, e.g., HRZ vs. RZ hepatoxicity • Discussions about acceptable rates of serious AEs for new TB drugs are needed (> 1 ...
... • Only more common adverse events will be detected during clinical development • Safety data from populations of great interest difficult to obtain • Cannot predict toxicity indirectly, e.g., HRZ vs. RZ hepatoxicity • Discussions about acceptable rates of serious AEs for new TB drugs are needed (> 1 ...
? RHEUMATOID ARTHRITIS .– DEFERRED
... (HLR) were not recommended for addition to the AHWDBL. With regard to MERIDIA, the Committee referenced the March 2002 Health Canada Advisory that advised that a safety review of this product is currently being undertaken and that other countries have identified safety concerns which have led to sus ...
... (HLR) were not recommended for addition to the AHWDBL. With regard to MERIDIA, the Committee referenced the March 2002 Health Canada Advisory that advised that a safety review of this product is currently being undertaken and that other countries have identified safety concerns which have led to sus ...
~ ~ Lupin Pharmaceuticals Inc, ,
... require drug firms to study certain drugs in pediatric patients if the agency felt that such study would provide beneficial health data for that patient population . The act also provided a provision for a waiver from such requirement if: (iii) the drug or biological product- ...
... require drug firms to study certain drugs in pediatric patients if the agency felt that such study would provide beneficial health data for that patient population . The act also provided a provision for a waiver from such requirement if: (iii) the drug or biological product- ...
3Ts Depression Treatment Pathway
... Venlafaxine - less risk of discontinuation symptoms with MR formulation. 75mg dose acts as an SSRI so little benefit. BP should be measured in patients on doses above 150mg. Associated with greater risk of death from overdose [prescribe as the branded generic ‘Venlalic’] Titrate to therapeutic dose. ...
... Venlafaxine - less risk of discontinuation symptoms with MR formulation. 75mg dose acts as an SSRI so little benefit. BP should be measured in patients on doses above 150mg. Associated with greater risk of death from overdose [prescribe as the branded generic ‘Venlalic’] Titrate to therapeutic dose. ...
Algorithm for adding lamotrigine to valproate
... Lamotrigine metabolism is inhibited by valproate and serum concentrations will be higher and increase more rapidly at a given dose or change in dose than when added to other AEDs lamotrigine (Lamictal) Initiate dose at 25mg/every other day if on concomitant valproate (monitor CBC and for rash) for t ...
... Lamotrigine metabolism is inhibited by valproate and serum concentrations will be higher and increase more rapidly at a given dose or change in dose than when added to other AEDs lamotrigine (Lamictal) Initiate dose at 25mg/every other day if on concomitant valproate (monitor CBC and for rash) for t ...
In The Name of Allah
... A single IV dose is recommended for surgical procedures lasting less than 4 hours Redosing is recommended for procedures lasting more than 4 hours or when blood loss occurs or the patient is obese. Redosing is indicated every 1 to 2 half lives of antibiotic in patients with normal renal function ...
... A single IV dose is recommended for surgical procedures lasting less than 4 hours Redosing is recommended for procedures lasting more than 4 hours or when blood loss occurs or the patient is obese. Redosing is indicated every 1 to 2 half lives of antibiotic in patients with normal renal function ...
Aller-Chlor - DavisPlus
... Absorption: Well absorbed following oral and parenteral administration. Distribution: Widely distributed. Minimal amounts excreted in breast milk. Crosses the blood-brain barrier. ...
... Absorption: Well absorbed following oral and parenteral administration. Distribution: Widely distributed. Minimal amounts excreted in breast milk. Crosses the blood-brain barrier. ...
APPROVED LONG-TERM TREATMENTS FOR MS Self
... mild increase in blood pressure; macular edema (swelling behind the eye); reversible elevation of liver enzymes; and a slight increase in lung infections (primarily bronchitis). Infections, including herpes infection, are also of concern. A six-hour observation period is required immediately after t ...
... mild increase in blood pressure; macular edema (swelling behind the eye); reversible elevation of liver enzymes; and a slight increase in lung infections (primarily bronchitis). Infections, including herpes infection, are also of concern. A six-hour observation period is required immediately after t ...
USC Journal club April 28, 2009
... SHIFT also higher dose of BB did not cause greater HR: 15.4 bpm in entire cohort vs 15.5 bpm those on > 50% target dose. Unlikely that use of higher BB doses in SHIFT would have caused a further HR or altered the outcomes • In real world, clinicians are unable to doses of BB to target levels ...
... SHIFT also higher dose of BB did not cause greater HR: 15.4 bpm in entire cohort vs 15.5 bpm those on > 50% target dose. Unlikely that use of higher BB doses in SHIFT would have caused a further HR or altered the outcomes • In real world, clinicians are unable to doses of BB to target levels ...
Protein synthesis inhibitors Tetracyclines
... ribosomes to those of bacteria, protein and ATP synthesis in these organelles may be inhibited at high circulating chloramphenicol levels, producing bone marrow toxicity. ...
... ribosomes to those of bacteria, protein and ATP synthesis in these organelles may be inhibited at high circulating chloramphenicol levels, producing bone marrow toxicity. ...
amoxicillin (a-mox-i-sill-in) - DavisPlus
... Drug-Drug: Probenecidprenal excretion andqblood levels of amoxicillin— ...
... Drug-Drug: Probenecidprenal excretion andqblood levels of amoxicillin— ...
VIROPTIC Solution, 1% Sterile Ophthalmic
... and rabbits, 1 mg/kg/day (5 times the estimated human exposure) was a no-effect level. There were no teratogenic or fetotoxic effects after topical application of VIROPTIC Ophthalmic Solution, 1% (approximately 5 times the estimated human exposure) to the eyes of rabbits on the 6th through the 18th ...
... and rabbits, 1 mg/kg/day (5 times the estimated human exposure) was a no-effect level. There were no teratogenic or fetotoxic effects after topical application of VIROPTIC Ophthalmic Solution, 1% (approximately 5 times the estimated human exposure) to the eyes of rabbits on the 6th through the 18th ...
Cabozantinib: A Novel Tyrosine Kinase Receptor
... Cabozantinib’s approval was based on the results of a phase III randomized clinical trial comparing the drug with everolimus, which the FDA approved in 2009 for patients with kidney cancer whose disease has progressed after prior treatment. It is concluded that cabozantinib is an orally active and n ...
... Cabozantinib’s approval was based on the results of a phase III randomized clinical trial comparing the drug with everolimus, which the FDA approved in 2009 for patients with kidney cancer whose disease has progressed after prior treatment. It is concluded that cabozantinib is an orally active and n ...
antiseptic
... antiviral effect on viruses. The drug is highly active against antibiotic-resistant microorganisms. Creation of decamethoxin-resistant forms during prolonged therapy is slow and does not exceed the effective concentrations of the drug. Bacteriostatic (fungistatic) concentrations are similar to its b ...
... antiviral effect on viruses. The drug is highly active against antibiotic-resistant microorganisms. Creation of decamethoxin-resistant forms during prolonged therapy is slow and does not exceed the effective concentrations of the drug. Bacteriostatic (fungistatic) concentrations are similar to its b ...
SPC - Servier
... Trimetazidine can cause or worsen parkinsonian symptoms (tremor, akinesia, hypertonia), which should be regularly investigated, especially in elderly patients. In doubtful cases, patients should be referred to a neurologist for appropriate investigations. The occurrence of movement disorders such as ...
... Trimetazidine can cause or worsen parkinsonian symptoms (tremor, akinesia, hypertonia), which should be regularly investigated, especially in elderly patients. In doubtful cases, patients should be referred to a neurologist for appropriate investigations. The occurrence of movement disorders such as ...
Should we change the recommendations related to
... for self-limiting infections Self-limiting infections are successfully cleared with “shorter” duration of therapy Shorter durations with therapy exert less selection of resistance in normal flora, but give slightly longer duration of symptoms ...
... for self-limiting infections Self-limiting infections are successfully cleared with “shorter” duration of therapy Shorter durations with therapy exert less selection of resistance in normal flora, but give slightly longer duration of symptoms ...
Define therapeutic index and briefly outline its significance. Briefly
... o Can safely give large bolus doses with low frequency o Nil plasma monitoring required - Low TI drug: Theophylline, digoxin o In general, need lower doses, ↑freq administration (to limit peak toxicity) (Exception, gentamicin which has toxicity not conc-related) o Need to monitor plasma levels of dr ...
... o Can safely give large bolus doses with low frequency o Nil plasma monitoring required - Low TI drug: Theophylline, digoxin o In general, need lower doses, ↑freq administration (to limit peak toxicity) (Exception, gentamicin which has toxicity not conc-related) o Need to monitor plasma levels of dr ...
YONDELIS - Caremark
... sarcomas – liposarcoma or leiomyosarcoma. In soft tissue sarcomas, cancer cells form in the soft tissues of the body, including the muscles, tendons, fat, blood vessels, lymph vessels, nerves and tissues around joints. Liposarcoma and leiomyosarcoma are specific types of soft tissue sarcoma that occ ...
... sarcomas – liposarcoma or leiomyosarcoma. In soft tissue sarcomas, cancer cells form in the soft tissues of the body, including the muscles, tendons, fat, blood vessels, lymph vessels, nerves and tissues around joints. Liposarcoma and leiomyosarcoma are specific types of soft tissue sarcoma that occ ...
anthelmintic drugs
... Pharmacokinetics Plasma half life 8-12 hours sulfoxide is mostly protein bound distributes well to tissues and enters bile, CSF & hydatid cysts. Metabolites are excreted in urine ...
... Pharmacokinetics Plasma half life 8-12 hours sulfoxide is mostly protein bound distributes well to tissues and enters bile, CSF & hydatid cysts. Metabolites are excreted in urine ...
Introducing NUEDEXTA™—the first and only FDA
... suggestive of torsades de pointes, in patients with heart failure as well as patients with, or at risk of, complete atrioventricular (AV) block, unless the patient has an implanted pacemaker. NUEDEXTA causes dose-dependent QTc prolongation. When initiating NUEDEXTA in patients at risk of QT prolonga ...
... suggestive of torsades de pointes, in patients with heart failure as well as patients with, or at risk of, complete atrioventricular (AV) block, unless the patient has an implanted pacemaker. NUEDEXTA causes dose-dependent QTc prolongation. When initiating NUEDEXTA in patients at risk of QT prolonga ...
Antimycobacterial drugs
... infections (TB) mainly in multidrug resistance cases. It is important in short –course (6 months) regimens with isoniazid and rifampicin. Prophylaxis of TB in combination with ciprofloxacin. ...
... infections (TB) mainly in multidrug resistance cases. It is important in short –course (6 months) regimens with isoniazid and rifampicin. Prophylaxis of TB in combination with ciprofloxacin. ...
Express Scripts Drug Information & Wellness Center Drug Information Updates
... Drug Information Question A patient states that they cannot take albuterol due to the development of hives, but they tolerate levalbuterol (Xopenex) with no complications. Is there any evidence that supports that this could be related to the active ingredient? Micromedex DrugDex states that a hypers ...
... Drug Information Question A patient states that they cannot take albuterol due to the development of hives, but they tolerate levalbuterol (Xopenex) with no complications. Is there any evidence that supports that this could be related to the active ingredient? Micromedex DrugDex states that a hypers ...
Slides_2
... Not active against tissue trophozoites. In the gut, it splits into diloxanide and furoic acid; about 90% of the diloxanide is rapidly absorbed. The unabsorbed diloxanide is the active antiamebic The mechanism of action is unknown. Used with a tissue amebicide, usually metronidazole, to treat serious ...
... Not active against tissue trophozoites. In the gut, it splits into diloxanide and furoic acid; about 90% of the diloxanide is rapidly absorbed. The unabsorbed diloxanide is the active antiamebic The mechanism of action is unknown. Used with a tissue amebicide, usually metronidazole, to treat serious ...
Acute kidney injury and sick day rules
... experiences and also the available literature. We thought it valuable to share our concerns, so members involved in local discussion might use them. We also welcome feedback from any members in this respect. Angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) are e ...
... experiences and also the available literature. We thought it valuable to share our concerns, so members involved in local discussion might use them. We also welcome feedback from any members in this respect. Angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) are e ...
Norma-H Tablet - Renata Limited
... Altematively, patients with duodenal ulceration, gastric ulceration or esophageal reflux disease may be treated with a single bed time dose of 300mg. It is not necessary to time the dose in relation to meals. In most cases of duodenal ulcer, benign gastric ulcer and post-operative ulcer, healing occ ...
... Altematively, patients with duodenal ulceration, gastric ulceration or esophageal reflux disease may be treated with a single bed time dose of 300mg. It is not necessary to time the dose in relation to meals. In most cases of duodenal ulcer, benign gastric ulcer and post-operative ulcer, healing occ ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.