Fentanyl Citrate Injection, USP
... the pregnancy rate of all experimental groups. This decrease was most pronounced in the high dose group (1.25 mg/kg–12.5X human dose) in which one of twenty animals became pregnant. Pregnancy – Category C: Fentanyl citrate has been shown to impair fertility and to have an embryocidal effect in rats ...
... the pregnancy rate of all experimental groups. This decrease was most pronounced in the high dose group (1.25 mg/kg–12.5X human dose) in which one of twenty animals became pregnant. Pregnancy – Category C: Fentanyl citrate has been shown to impair fertility and to have an embryocidal effect in rats ...
20110503_Manuscript - international journal of advances in
... from more than 1,000 centres in about 40 countries. The study drug was apixaban 5 mg BD and warfarin 2 mg was used as a control for the reduction of stroke in atrial fibrillation. The primary efficacy outcome is the time to first occurrence of stroke or systemic embolism and the primary safety endpo ...
... from more than 1,000 centres in about 40 countries. The study drug was apixaban 5 mg BD and warfarin 2 mg was used as a control for the reduction of stroke in atrial fibrillation. The primary efficacy outcome is the time to first occurrence of stroke or systemic embolism and the primary safety endpo ...
Simvastatin
... levels and in such patients measurements should be repeated promptly and then performed more frequently. If the transaminase levels show evidence of progression, particularly if they rise to three times the upper limit of normal and are persistent, the drug should be discontinued. Liver biopsy shoul ...
... levels and in such patients measurements should be repeated promptly and then performed more frequently. If the transaminase levels show evidence of progression, particularly if they rise to three times the upper limit of normal and are persistent, the drug should be discontinued. Liver biopsy shoul ...
Product Information
... Treatment of caffeine overdose is primarily symptomatic and supportive. Caffeine levels have been shown to decrease after exchange transfusions. Convulsions may be treated with intravenous administration of diazepam or a barbiturate such as pentobarbital sodium. In Australia, contact the Poisons Inf ...
... Treatment of caffeine overdose is primarily symptomatic and supportive. Caffeine levels have been shown to decrease after exchange transfusions. Convulsions may be treated with intravenous administration of diazepam or a barbiturate such as pentobarbital sodium. In Australia, contact the Poisons Inf ...
Neonatal Seizures
... Use of Maintenance Anticonvulsants 2 AEDs can prevent the recurrence of febrile seizures: Phenobarbital and Valproate However routine use as maintenance anticonvulsants are not recommended for Simple Febrile Seizures Phenobarbital-decreases cognitive function in treated children Valproate – May cau ...
... Use of Maintenance Anticonvulsants 2 AEDs can prevent the recurrence of febrile seizures: Phenobarbital and Valproate However routine use as maintenance anticonvulsants are not recommended for Simple Febrile Seizures Phenobarbital-decreases cognitive function in treated children Valproate – May cau ...
METOPROLOL ACTAVIS
... coronary artery disease. Severe exacerbation of angina and precipitation of myocardial infarction and ventricular arrhythmias have occurred following abrupt discontinuation of beta-blockade in patients with ischaemic heart disease. Therefore, it is recommended that the dosage be reduced gradually ov ...
... coronary artery disease. Severe exacerbation of angina and precipitation of myocardial infarction and ventricular arrhythmias have occurred following abrupt discontinuation of beta-blockade in patients with ischaemic heart disease. Therefore, it is recommended that the dosage be reduced gradually ov ...
pharmacokinetics, tissue distribution, metabolism, and excretion of
... Urine and feces were collected at ⫺18 to 0 h predose and at 24-h intervals for the five consecutive days after dose administration. Urine was collected into containers surrounded by dry ice. Feces were frozen immediately on dry ice at the end of each collection interval. Urine and feces were stored ...
... Urine and feces were collected at ⫺18 to 0 h predose and at 24-h intervals for the five consecutive days after dose administration. Urine was collected into containers surrounded by dry ice. Feces were frozen immediately on dry ice at the end of each collection interval. Urine and feces were stored ...
Medication Guide
... Doses may be increased in 18 mg increments at weekly intervals for patients who have not achieved an optimal response at a lower dose. Daily dosages above 54 mg in children and 72 mg in adolescents have not been studied and are not recommended. Daily dosages above 72 mg in adults are not recommended ...
... Doses may be increased in 18 mg increments at weekly intervals for patients who have not achieved an optimal response at a lower dose. Daily dosages above 54 mg in children and 72 mg in adolescents have not been studied and are not recommended. Daily dosages above 72 mg in adults are not recommended ...
US Product Labeling @std Template for PLR
... inhibitors, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (1) ...
... inhibitors, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (1) ...
guideline for the management of tricyclic antidepressant overdose
... suspected lone TCA overdose. The key aspects this is designed to include are initial assessment, decontamination, active management and disposition of the patient from the ED. The initial assessment and management recommendations can be followed using resources available in any UK ED. Disposition ma ...
... suspected lone TCA overdose. The key aspects this is designed to include are initial assessment, decontamination, active management and disposition of the patient from the ED. The initial assessment and management recommendations can be followed using resources available in any UK ED. Disposition ma ...
Ciclosporin - IARC Monographs
... with increasing dose (Awni & Sawchuk, 1985). The mean half-time after intravenous administration of 15 mglg bw to male New Zealand rabbits was 229.7 min (D'Souza et al., 1988). ln rabbits, the concentrations of ciclosporin in blood were about 100 nglml ...
... with increasing dose (Awni & Sawchuk, 1985). The mean half-time after intravenous administration of 15 mglg bw to male New Zealand rabbits was 229.7 min (D'Souza et al., 1988). ln rabbits, the concentrations of ciclosporin in blood were about 100 nglml ...
Morphine - Waitemata District Health Board
... • Calculate the total amount of PRN morphine the patient has required over the last 24 hours and prescribe this amount as a 24 hour continuous infusion 2 • Also chart about 1/6th of the total dose as a PRN dose q 30min for breakthrough pain • Review doses of background and PRN morphine daily If the ...
... • Calculate the total amount of PRN morphine the patient has required over the last 24 hours and prescribe this amount as a 24 hour continuous infusion 2 • Also chart about 1/6th of the total dose as a PRN dose q 30min for breakthrough pain • Review doses of background and PRN morphine daily If the ...
Paroxetine
... The recommended dose is 20mg (one tablet) daily. Many patients will respond to a 20mg daily dose. Patients not responding to a 20mg dose may benefit from dose increases in 10mg /day increments, up to a maximum of 50 mg/day according to the patient's response. As with all antidepressant drugs, dosage ...
... The recommended dose is 20mg (one tablet) daily. Many patients will respond to a 20mg daily dose. Patients not responding to a 20mg dose may benefit from dose increases in 10mg /day increments, up to a maximum of 50 mg/day according to the patient's response. As with all antidepressant drugs, dosage ...
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF
... Human Leukocyte Antigen (HLA) allele B*1502 increases the risk for developing SJS/TEN in patients treated with carbamazepine. The chemical structure of oxcarbazepine is similar to that of carbamazepine. Available clinical evidence, and data from nonclinical studies showing a direct interaction betwe ...
... Human Leukocyte Antigen (HLA) allele B*1502 increases the risk for developing SJS/TEN in patients treated with carbamazepine. The chemical structure of oxcarbazepine is similar to that of carbamazepine. Available clinical evidence, and data from nonclinical studies showing a direct interaction betwe ...
methotrexate
... DL to be administered over 10 – 15 min., followed by an IV infusion of 30mg/hrs for the next 36 hrs. He will then receive a 20mg (approximately 10mg/m2) dose of leucovorin every 6 hrs. IV for the 1st 4 doses followed by 8 doses orally at 6 hrs. The LCO. Regimen will begin immediately after the 36 hr ...
... DL to be administered over 10 – 15 min., followed by an IV infusion of 30mg/hrs for the next 36 hrs. He will then receive a 20mg (approximately 10mg/m2) dose of leucovorin every 6 hrs. IV for the 1st 4 doses followed by 8 doses orally at 6 hrs. The LCO. Regimen will begin immediately after the 36 hr ...
Copyright Information of the Article Published Online TITLE Oral
... with transient increased transaminases, which they observed with IV paracetamol use. Moreover, serious acute liver toxicity events have been reported in neonates when using intravenous formulation of paracetamol[49-52]. The slow oxidative metabolism of neonates, production of toxic metabolites in th ...
... with transient increased transaminases, which they observed with IV paracetamol use. Moreover, serious acute liver toxicity events have been reported in neonates when using intravenous formulation of paracetamol[49-52]. The slow oxidative metabolism of neonates, production of toxic metabolites in th ...
Policosanol: A New Treatment for
... scintigraphy (TL-MPS) and Doppler-ultrasound, and decreases symptoms of cardiovascular disease assessed by the Specific Activity Scale. In post-marketing studies, only 0.31 percent of patients have had adverse events. Furthermore, in animal toxicity studies doses up to 1500 times normal human doses ...
... scintigraphy (TL-MPS) and Doppler-ultrasound, and decreases symptoms of cardiovascular disease assessed by the Specific Activity Scale. In post-marketing studies, only 0.31 percent of patients have had adverse events. Furthermore, in animal toxicity studies doses up to 1500 times normal human doses ...
Humulin R (U-500) - Eli Lilly and Company
... hypoglycemia or hyperglycemia. These changes should be made cautiously and only under medical supervision and the frequency of blood glucose monitoring should be increased. For patients with type 2 diabetes, adjustments in concomitant oral anti-diabetic treatment may be needed. ...
... hypoglycemia or hyperglycemia. These changes should be made cautiously and only under medical supervision and the frequency of blood glucose monitoring should be increased. For patients with type 2 diabetes, adjustments in concomitant oral anti-diabetic treatment may be needed. ...
- Wiley Online Library
... Parenteral sulbactam–ampicillin has been widely used in cases of community and ⁄ or hospitalacquired pneumonia, including those due to aspiration of oropharyngeal secretions, and in several mixed infections, including intraabdominal infections, diabetic foot infections, brain abscesses, staphylococc ...
... Parenteral sulbactam–ampicillin has been widely used in cases of community and ⁄ or hospitalacquired pneumonia, including those due to aspiration of oropharyngeal secretions, and in several mixed infections, including intraabdominal infections, diabetic foot infections, brain abscesses, staphylococc ...
P R E S C R I B I N G I N F O R M A T I O N
... Immediate-Release KEPPRA Tablets In controlled trials of immediate-release KEPPRA tablets in patients experiencing partial onset seizures, immediaterelease KEPPRA causes the occurrence of central nervous system adverse reactions that can be classified into the following categories: 1) somnolence and ...
... Immediate-Release KEPPRA Tablets In controlled trials of immediate-release KEPPRA tablets in patients experiencing partial onset seizures, immediaterelease KEPPRA causes the occurrence of central nervous system adverse reactions that can be classified into the following categories: 1) somnolence and ...
Reyataz ® (atazanavir) - Bristol
... Clinical studies of REYATAZ did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. In general, dose selection for an elderly patient should reflect the greater frequency of decreased hepatic, renal, or cardiac function, an ...
... Clinical studies of REYATAZ did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. In general, dose selection for an elderly patient should reflect the greater frequency of decreased hepatic, renal, or cardiac function, an ...
QA_18_6_AmlodipinevsfelodipineAUG_15_FINAL
... smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihypertensive effects of amlodipine last longer and its plasma levels fluctuate less ...
... smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihypertensive effects of amlodipine last longer and its plasma levels fluctuate less ...
N N S H N CH3 N CH3
... significant (Childs Pugh Classification A and B) cirrhosis revealed little effect on the pharmacokinetics of olanzapine. Age — In a study involving 24 healthy subjects, the mean elimination half-life of olanzapine was about 1.5 times greater in elderly (>65 years) than in non-elderly subjects (≤65 y ...
... significant (Childs Pugh Classification A and B) cirrhosis revealed little effect on the pharmacokinetics of olanzapine. Age — In a study involving 24 healthy subjects, the mean elimination half-life of olanzapine was about 1.5 times greater in elderly (>65 years) than in non-elderly subjects (≤65 y ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.