Immunol-mol-med-3
... • Identification of T and B cells • How these cells bind antigen - receptors • How cells become activated • The involvement of MHC molecules in T cell function ...
... • Identification of T and B cells • How these cells bind antigen - receptors • How cells become activated • The involvement of MHC molecules in T cell function ...
Document
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
(2) Viral and bacterial superantigens
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
Expansion of Autoreactive T cells
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
... peptides presented by up-regulated MHC Class II molecules and produce many different cytokines, some of which may have antiviral effects on target cells and others, which affect adjacent lymphocyte activity. Alternatively, CD4 T-cells may require presentation of viral antigens via Class II MHC molec ...
www.informatics.indiana.edu
... antigens that have been partly degraded inside the antigenpresenting cell. The peptide fragments are then carried to the surface of the presenting cell on special molecules called MHC proteins; The second difference is that, once activated, effector T cells act only at short range, either within a s ...
... antigens that have been partly degraded inside the antigenpresenting cell. The peptide fragments are then carried to the surface of the presenting cell on special molecules called MHC proteins; The second difference is that, once activated, effector T cells act only at short range, either within a s ...
MHC Molecules
... • The 2 classes of MHC molecule are specialised to present different sources of antigen • MHC class I molecules present endogenously synthesised antigens, e.g. viral proteins • MHC class II molecules present exogenously derived proteins, e.g. bacterial products or viral capsid proteins • The cell bi ...
... • The 2 classes of MHC molecule are specialised to present different sources of antigen • MHC class I molecules present endogenously synthesised antigens, e.g. viral proteins • MHC class II molecules present exogenously derived proteins, e.g. bacterial products or viral capsid proteins • The cell bi ...
Antigen processing and presentation
... On the surface of a single cell, MHC class I molecules provide a readout of the expression level of up to 10,000 proteins. This array is interpreted by cytotoxic T lymphocytes and Natural Killer cells, allowing them to monitor the events inside the cell and detect infection and tumorigenesis. MHC cl ...
... On the surface of a single cell, MHC class I molecules provide a readout of the expression level of up to 10,000 proteins. This array is interpreted by cytotoxic T lymphocytes and Natural Killer cells, allowing them to monitor the events inside the cell and detect infection and tumorigenesis. MHC cl ...
Antigen processing and presentation
... On the surface of a single cell, MHC class I molecules provide a readout of the expression level of up to 10,000 proteins. This array is interpreted by cytotoxic T lymphocytes and Natural Killer cells, allowing them to monitor the events inside the cell and detect infection and tumorigenesis. MHC cl ...
... On the surface of a single cell, MHC class I molecules provide a readout of the expression level of up to 10,000 proteins. This array is interpreted by cytotoxic T lymphocytes and Natural Killer cells, allowing them to monitor the events inside the cell and detect infection and tumorigenesis. MHC cl ...
Antigens
... loci, from both chromosomes. Between the class I and class II gene loci is a third locus, sometimes called class III. This locus ...
... loci, from both chromosomes. Between the class I and class II gene loci is a third locus, sometimes called class III. This locus ...
Different MHC alleles confer different functional properties on the
... Each different allelic MHC molecule (allotype) confers the ability to bind different peptides Consequences for regulation of adaptive immunity: ...
... Each different allelic MHC molecule (allotype) confers the ability to bind different peptides Consequences for regulation of adaptive immunity: ...
Lecture_6
... Genotype: the collection of genes in an individual, usually referring to a small segment of a chromosome Alleles: the alternative forms of a gene found at the same locus in different individuals Allotypes or allomorphs: different protein forms encoded by alleles Haplotype: the genes (alleles) contri ...
... Genotype: the collection of genes in an individual, usually referring to a small segment of a chromosome Alleles: the alternative forms of a gene found at the same locus in different individuals Allotypes or allomorphs: different protein forms encoded by alleles Haplotype: the genes (alleles) contri ...
Immunogens, Antigens, and Haptens Initiation of immune response
... Polymorphism allows the population to handle a variety of pathogens. ...
... Polymorphism allows the population to handle a variety of pathogens. ...
Name:
... 6. Which of the following properties are characteristic of antigen recognition by B cells? A. Membrane-bound Ig binds antigen B. Peptides. but not oligosaccharides can be bound C. Soluble antigens are not bound D. Internal linear peptides derived from antigen processing are required for successful ...
... 6. Which of the following properties are characteristic of antigen recognition by B cells? A. Membrane-bound Ig binds antigen B. Peptides. but not oligosaccharides can be bound C. Soluble antigens are not bound D. Internal linear peptides derived from antigen processing are required for successful ...
T Cell Receptor (TCR)
... 1. TCR functions to recognize Ag peptides presented by MHC complexes => Ag peptide specificity => MHC restriction 2. Two classes of MHC molecules. - Class-I MHC => peptides from cytosolic (intracellular) proteins => CD8 T cells - Class-II MHC => peptides from extracellular (exogenous) proteins from ...
... 1. TCR functions to recognize Ag peptides presented by MHC complexes => Ag peptide specificity => MHC restriction 2. Two classes of MHC molecules. - Class-I MHC => peptides from cytosolic (intracellular) proteins => CD8 T cells - Class-II MHC => peptides from extracellular (exogenous) proteins from ...
Social Behavior
... prevents recognition and cannibals will happily eat anyone. • Avoiding eating a relative improves one's inclusive fitness. Discrimination leads to > 2x siblings surviving at virtually 0 cost ...
... prevents recognition and cannibals will happily eat anyone. • Avoiding eating a relative improves one's inclusive fitness. Discrimination leads to > 2x siblings surviving at virtually 0 cost ...
MHC
... The important point is that peptide binding by a given MHC protein is selective but less specific than antigen binding by a TCR or a ...
... The important point is that peptide binding by a given MHC protein is selective but less specific than antigen binding by a TCR or a ...
BIOLOGY PRESENTATION
... Third that there systemic immunosuppression The last theory is that after successive pregnancies, there will be a transferable tolerance to paternal grafts. NK cells and HLA G We talked earlier about HLA C and how it helped prevent killing by the NK cells. It has been found however that the syncytio ...
... Third that there systemic immunosuppression The last theory is that after successive pregnancies, there will be a transferable tolerance to paternal grafts. NK cells and HLA G We talked earlier about HLA C and how it helped prevent killing by the NK cells. It has been found however that the syncytio ...
Chapter 16
... vigorous allograft rejection are within MHC complex ○ Test donors to get matching haplotype Mismatches with Class II are more likely to lead to rejection than mismatches with Class I ○ Also test for blood type ...
... vigorous allograft rejection are within MHC complex ○ Test donors to get matching haplotype Mismatches with Class II are more likely to lead to rejection than mismatches with Class I ○ Also test for blood type ...
Document
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
Immunological tolerance
... Unresponsiveness to a given antigen induced by the interaction of that antigen with the lymphocytes; Antigen specific!!! Unlike immunosuppresion. ...
... Unresponsiveness to a given antigen induced by the interaction of that antigen with the lymphocytes; Antigen specific!!! Unlike immunosuppresion. ...
(MHC) molecules
... : MHC class I molecules - intrinsic antigens 인식 - antigenic peptides from viruses or other pathogens that inhabit the cell - present antigen to cytotoxic T cells (CD8+ T cells) - controlling viral infections by lysing infected cells : MHC class II molecules – extrinsic antigens 인식 - present antigen ...
... : MHC class I molecules - intrinsic antigens 인식 - antigenic peptides from viruses or other pathogens that inhabit the cell - present antigen to cytotoxic T cells (CD8+ T cells) - controlling viral infections by lysing infected cells : MHC class II molecules – extrinsic antigens 인식 - present antigen ...
Chapter 8
... Activation and effector phases of T cell-mediated adaptive immune responses are triggered by antigen recognition by T lymphocytes ...
... Activation and effector phases of T cell-mediated adaptive immune responses are triggered by antigen recognition by T lymphocytes ...
Major histocompatibility complex
The major histocompatibility complex (MHC) is a set of cell surface molecules encoded by a large gene family which controls a major part of the immune system in all vertebrates. The major function of major histocompatibility complexes is to bind to peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization. In humans, the MHC is also called the human leukocyte antigen (HLA).In a cell, protein molecules of the host's own phenotype or of other biologic entities are continually synthesized and degraded. Each MHC molecule on the cell surface displays a molecular fraction of a protein, called epitope. The presented antigen can be either 'self' or 'nonself', thus preventing an organism`s immune system targeting its own cells. In its entirety, the MHC population is like a meter indicating the balance of proteins within the cell.The MHC gene family is divided into three subgroups: class I, class II, and class III. Class I MHC molecules have β2 subunits so can only be recognised by CD8 co-receptors. Class II MHC molecules have no β2 subunits so can be recognised by CD4 co-receptors. In this way MHC molecules chaperones which type of lymphocytes may bind to the given antigen with high affinity, since different lymphocytes express different TCR co-receptors. Diversity of antigen presentation, mediated by MHC classes I and II, is attained in at least three ways: (1) an organism's MHC repertoire is polygenic (via multiple, interacting genes); (2) MHC expression is codominant (from both sets of inherited alleles); (3) MHC gene variants are highly polymorphic (diversely varying from organism to organism within a species). Major histocompatibility complex and sexual selection has been observed in male mice making mate choices of females with different MHCs and thus demonstrating sexual selection.