MUKOSA-SISTEM-IMMUN-BAKTERI-VIRUS-CACING
... The concept of mucosal tolerance. Prolonged mucosally administered antigens induce both systemic and mucosal unresponsiveness to the same Ag when challenged in the presence of adjuvant. ...
... The concept of mucosal tolerance. Prolonged mucosally administered antigens induce both systemic and mucosal unresponsiveness to the same Ag when challenged in the presence of adjuvant. ...
Mucosal Vaccines
... The current challenge is to apply this knowledge to vaccine design and to carry out collaborative, comparative clinical trials that systematically monitor all parameters of the immune response — humoral and cellular, mucosal and systemic — in serum, local secretions and mucosal tissues. Availabl ...
... The current challenge is to apply this knowledge to vaccine design and to carry out collaborative, comparative clinical trials that systematically monitor all parameters of the immune response — humoral and cellular, mucosal and systemic — in serum, local secretions and mucosal tissues. Availabl ...
Monoclonal Antibody Pharmacokinetics and
... The majority of marketed antibodies are labeled for intravenous (IV) administration; however, several antibodies have been approved for extravascular administration. For example, certolizumab pegol, adalimumab, efalizumab, and omalizumab are all approved for subcutaneous (SC) administration. Paliviz ...
... The majority of marketed antibodies are labeled for intravenous (IV) administration; however, several antibodies have been approved for extravascular administration. For example, certolizumab pegol, adalimumab, efalizumab, and omalizumab are all approved for subcutaneous (SC) administration. Paliviz ...
(From the Variety Club Heart Hospital Pediatric Research
... as lysozymes in body fluids, polyelectrolytes, complement, non-specific bactericidal substances, and phagocytosis are among the innate mechanisms of resistance. Although some of these are well developed in invertebrates and m a y indeed be the effective mechanisms of defense, they have been reviewed ...
... as lysozymes in body fluids, polyelectrolytes, complement, non-specific bactericidal substances, and phagocytosis are among the innate mechanisms of resistance. Although some of these are well developed in invertebrates and m a y indeed be the effective mechanisms of defense, they have been reviewed ...
Stress and immunity in wild vertebrates: Timing is everything
... inflammatory states to be relayed quickly to the brain (via IL-1 receptors; Sternberg, 2006). When systemic pro-inflammatory states occur, effects on phenotype can extend beyond the immune system. The adrenal glands can release IL6, and TNFa in response to pathogen-associated molecular pattern (PAMPs) ...
... inflammatory states to be relayed quickly to the brain (via IL-1 receptors; Sternberg, 2006). When systemic pro-inflammatory states occur, effects on phenotype can extend beyond the immune system. The adrenal glands can release IL6, and TNFa in response to pathogen-associated molecular pattern (PAMPs) ...
Detection of Post-Transplant Anti-HLA Donor
... of antibody-mediated hyper-acute or acute allograft rejection. In order to select recipients without donor-specific antiHLA antibodies the complement-dependent cytotoxicity crossmatch assay (CDC-CM) was established as standard procedure more than forty years ago. This assay, however, is characterize ...
... of antibody-mediated hyper-acute or acute allograft rejection. In order to select recipients without donor-specific antiHLA antibodies the complement-dependent cytotoxicity crossmatch assay (CDC-CM) was established as standard procedure more than forty years ago. This assay, however, is characterize ...
Axonal Transport of Monoclonal Antibodies
... method of Stemberger (1978), by the procedure detailed previously (Ritchie et al., 1985b), using goat anti-mouse IgG (heavy and light chains specific, without cross-reactivity to rat immunoglobulin; Cappel) and mouse PAP (Stemberger-Meyer). The species-specific anti-mouse IgG was used successfully t ...
... method of Stemberger (1978), by the procedure detailed previously (Ritchie et al., 1985b), using goat anti-mouse IgG (heavy and light chains specific, without cross-reactivity to rat immunoglobulin; Cappel) and mouse PAP (Stemberger-Meyer). The species-specific anti-mouse IgG was used successfully t ...
immunology core notes
... can be disrupted by a variety of influences, resulting in damaging and potentially lethal reactivity to normal "self" components. Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are two examples of many such autoimmune reactions. Graft rejection; the rejection of foreign tissues and ...
... can be disrupted by a variety of influences, resulting in damaging and potentially lethal reactivity to normal "self" components. Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are two examples of many such autoimmune reactions. Graft rejection; the rejection of foreign tissues and ...
A. Classical Adjuvants (Gel Suspensions, FDA Approved, used in
... These gels non-specifically adsorb vaccine components such as proteins. Alum composition provides differences in net charge. Some proteins may adsorb better on Alum, Adjuphos or Calcium phosphate. Alum-based adjuvants remain the only category of adjuvants that have been used in humans and animals fo ...
... These gels non-specifically adsorb vaccine components such as proteins. Alum composition provides differences in net charge. Some proteins may adsorb better on Alum, Adjuphos or Calcium phosphate. Alum-based adjuvants remain the only category of adjuvants that have been used in humans and animals fo ...
Dangerous exercise: lessons learned from dysregulated
... The usual balance between the pro- and anti-inflammatory exercise responses is occasionally upset, however, and when it is, disease may result. In the following, we review several examples of failed homeostatic inflammatory responses to exercise. Injury and overuse. Musculoskeletal sports injuries r ...
... The usual balance between the pro- and anti-inflammatory exercise responses is occasionally upset, however, and when it is, disease may result. In the following, we review several examples of failed homeostatic inflammatory responses to exercise. Injury and overuse. Musculoskeletal sports injuries r ...
Role of Fusobacterium nucleatum in Periodontal Health and Disease
... hβD-3. Both peptides were active against selected grampositive and gram-negative bacteria. Therefore, hβD-3 demonstrated greater activity against a broader array of organisms than hβD-2 and greater antimicrobial activity than hβD-2: this difference could be due to the capacity of hβD-3 to interact w ...
... hβD-3. Both peptides were active against selected grampositive and gram-negative bacteria. Therefore, hβD-3 demonstrated greater activity against a broader array of organisms than hβD-2 and greater antimicrobial activity than hβD-2: this difference could be due to the capacity of hβD-3 to interact w ...
Preparation of polyclonal antibody against porcine - Funpec-RP
... Infectious diseases are responsible for significant economic loss in the porcine industry, and multidrug-resistant bacteria are a serious global problem, which affect the morbidity and mortality of infected pigs. Therefore, it is important to find new antimicrobial treatments for use in these diseas ...
... Infectious diseases are responsible for significant economic loss in the porcine industry, and multidrug-resistant bacteria are a serious global problem, which affect the morbidity and mortality of infected pigs. Therefore, it is important to find new antimicrobial treatments for use in these diseas ...
Mapping of linear epitopes on the capsid proteins of swine vesicular
... and 3070, while peptide 3210 (amino acids 201–220) was recognized by all mAbs also reacting with peptide 3020. The high number of antibodies showing the same pattern of reactivity indicates that this was not an artefact but a real reactivity. The amino acid sequence target of mAbs was then compared ...
... and 3070, while peptide 3210 (amino acids 201–220) was recognized by all mAbs also reacting with peptide 3020. The high number of antibodies showing the same pattern of reactivity indicates that this was not an artefact but a real reactivity. The amino acid sequence target of mAbs was then compared ...
Anti-inflammatory properties of peptides derived Ornithodoros savignyi
... RAW 264.7 cells exposed simultaneously to LPS/IFN-γ and Os or Os-C showed that both peptides attenuated the LPS-induced production of NO, as well as TNF-α, in a dosage-dependant manner. In contrast, a 90 minute pre-incubation of RAW 264.7 cells with peptides, followed by LPS/IFNγ stimulation, showed ...
... RAW 264.7 cells exposed simultaneously to LPS/IFN-γ and Os or Os-C showed that both peptides attenuated the LPS-induced production of NO, as well as TNF-α, in a dosage-dependant manner. In contrast, a 90 minute pre-incubation of RAW 264.7 cells with peptides, followed by LPS/IFNγ stimulation, showed ...
Memory and Specificity in the Insect Immune System: Current
... In line with TgIP, offspring whose mother had been primed with P. larvae displayed decreased mortality compared to progeny of non-primed honeybees. Further, larval offspring of primed adults contained three times more differentiated hemocytes compared to offspring of non-primed controls. Therefore, ...
... In line with TgIP, offspring whose mother had been primed with P. larvae displayed decreased mortality compared to progeny of non-primed honeybees. Further, larval offspring of primed adults contained three times more differentiated hemocytes compared to offspring of non-primed controls. Therefore, ...
Integr. Comp. Biol.-2011-Rollins-Smith-552
... immune defense against B. dendrobatidis Previous studies of the ontogenetic development of the immune system of anuran amphibians showed that the immune system develops in two phases. The first is a rapid expansion during the tadpole’s life followed by a significant loss of lymphocytes during the cl ...
... immune defense against B. dendrobatidis Previous studies of the ontogenetic development of the immune system of anuran amphibians showed that the immune system develops in two phases. The first is a rapid expansion during the tadpole’s life followed by a significant loss of lymphocytes during the cl ...
IFN-γ + CD4 T Cells
... Experimental design for the protection studies in Guinea pigs. Different groups of Duncan-Hartley Guinea pigs were immunized with L91 or controls (F91, LH, BCG and placebo). Peptides were given at a dose of 100 nmol (primary immunization) and 50 nmol (booster). BCG (106 CFU/ animal) was given as a c ...
... Experimental design for the protection studies in Guinea pigs. Different groups of Duncan-Hartley Guinea pigs were immunized with L91 or controls (F91, LH, BCG and placebo). Peptides were given at a dose of 100 nmol (primary immunization) and 50 nmol (booster). BCG (106 CFU/ animal) was given as a c ...
Artificial Immune Systems - Spletna učilnica FRI 16/17
... body. Furthermore, this model cannot explain the phenomena of autoimmunity and its relatively high frequency of occurrence in the western world. Despite the addition of a second costimulatory signal to the self–nonself model, it became apparent that a piece of the immunological puzzle was still miss ...
... body. Furthermore, this model cannot explain the phenomena of autoimmunity and its relatively high frequency of occurrence in the western world. Despite the addition of a second costimulatory signal to the self–nonself model, it became apparent that a piece of the immunological puzzle was still miss ...
Immune System
... in your spleen or lymph nodes and be activated with the help of a helper-T cell (discussed shortly). The B-cell will undergo mitosis forming plasma and memory B-cells, which all make the same antibody (it is mitosis so they are all ALMOST genetically identical clones). Plasma cells will make and sec ...
... in your spleen or lymph nodes and be activated with the help of a helper-T cell (discussed shortly). The B-cell will undergo mitosis forming plasma and memory B-cells, which all make the same antibody (it is mitosis so they are all ALMOST genetically identical clones). Plasma cells will make and sec ...
28-29_Per_tolerance_Regulatory T-cells_LA
... the non-redundant function of IL-2 is in controlling immune responses (generalized autoimmune disease). In humans, CD25 deficiency causes a syndrome described as IPEX-like. Extensive lymphocytic infiltration of tissues, including lung, liver, gut and bone is observed, accompanied by tissue atrophy a ...
... the non-redundant function of IL-2 is in controlling immune responses (generalized autoimmune disease). In humans, CD25 deficiency causes a syndrome described as IPEX-like. Extensive lymphocytic infiltration of tissues, including lung, liver, gut and bone is observed, accompanied by tissue atrophy a ...
Immune Recognition HLA-E, F, and G in Maternal
... temperature for 45 min and stopped by the addition of an equal volume of 1 M H2SO4. Hybridomas were screened by reading the yellow product at 450 nm using an EAR 400AT plate reader (SLT Labinstruments, Salzburg, Austria). Positive clones were subcloned, and secondary and tertiary screenings were don ...
... temperature for 45 min and stopped by the addition of an equal volume of 1 M H2SO4. Hybridomas were screened by reading the yellow product at 450 nm using an EAR 400AT plate reader (SLT Labinstruments, Salzburg, Austria). Positive clones were subcloned, and secondary and tertiary screenings were don ...
Colostrum and the Health of Newborn Kids By Jack Mauldin I have
... for easier reading. Antibody is a disease-fighting protein. There are other medical names but I will only use the word “antibody” in this article for ease of reading. Antibodies are produced by animals in response to bacteria or bacterial toxins in the body and are very specific for that specific ba ...
... for easier reading. Antibody is a disease-fighting protein. There are other medical names but I will only use the word “antibody” in this article for ease of reading. Antibodies are produced by animals in response to bacteria or bacterial toxins in the body and are very specific for that specific ba ...
MSM Immune Health Science Brief
... MSM Immune Health Science Brief released by neutrophils. In research evaluation, the immune activator LPS can trigger macrophages to activate NF- Kß, which induces the expression of various inflammatory factors such as nitric oxide (NO), prostaglandins and cytokines. The inhibition of NF- Kß occurs ...
... MSM Immune Health Science Brief released by neutrophils. In research evaluation, the immune activator LPS can trigger macrophages to activate NF- Kß, which induces the expression of various inflammatory factors such as nitric oxide (NO), prostaglandins and cytokines. The inhibition of NF- Kß occurs ...
Chapter 13 - IARC Publications
... the two fundamental properties of acquired immunity recognized since ancient times: memory and specificity. Memory comes from the expanded population of lymphocytes that persists after initial antigen exposure, which allows a more rapid and sizeable secondary response. Specificity comes from the fac ...
... the two fundamental properties of acquired immunity recognized since ancient times: memory and specificity. Memory comes from the expanded population of lymphocytes that persists after initial antigen exposure, which allows a more rapid and sizeable secondary response. Specificity comes from the fac ...
Gluten immunochemistry
The immunochemistry of Triticeae glutens is important in several inflammatory diseases. It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition. The responses to gluten proteins and polypeptide regions differs according to the type of gluten sensitivity. The response is also dependent on the genetic makeup of the human leukocyte antigen genes. In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase. With idiopathic gluten sensitivity only antibody recognition to gliadin has been resolved. In wheat allergy, the response pathways are mediated through IgE against other wheat proteins and other forms of gliadin.