Journal of Pharmacognosy and Phytochemistry Moringa Perspective
... effect of M. oleifera seeds and chitosan (an essential and abundant component of exoskeletons – the mucoadhesive polymer which is derived from chitin) on antibacterial activity against Bacillus subtilis and Pseudomonas putida found the individual samples to be more effective than the two combined. H ...
... effect of M. oleifera seeds and chitosan (an essential and abundant component of exoskeletons – the mucoadhesive polymer which is derived from chitin) on antibacterial activity against Bacillus subtilis and Pseudomonas putida found the individual samples to be more effective than the two combined. H ...
Ceftriaxone-AFT
... Microorganisms should be tested with the ceftriaxone disk since it has been shown by in vitro tests to be active against certain strains resistant to cephalosporin class disks. Where NCCLS recommendations are not in daily use, alternative, well standardised, susceptibility interpretative guidelines ...
... Microorganisms should be tested with the ceftriaxone disk since it has been shown by in vitro tests to be active against certain strains resistant to cephalosporin class disks. Where NCCLS recommendations are not in daily use, alternative, well standardised, susceptibility interpretative guidelines ...
In vitro metabolism and drug-drug interaction potential of irosustat, a
... metabolites (those having the desired activity to an extent similar to/or greater than the parent drug). In some of these cases, the drug is called prodrug and the clearance of all active metabolites needs to be considered. A third possible fate of drug metabolism is the formation of toxic metabolit ...
... metabolites (those having the desired activity to an extent similar to/or greater than the parent drug). In some of these cases, the drug is called prodrug and the clearance of all active metabolites needs to be considered. A third possible fate of drug metabolism is the formation of toxic metabolit ...
Binding of Imipramine to Phospholipid Bilayers Using
... the lipid bilayer is a dynamic fluid structure, there are stable separate domains in which specific interactions can occur. Specific interactions of some ligands with phospholipid acyl chains may also occur (Bäuerle and Seelig 1991; Jørgensen et al. ...
... the lipid bilayer is a dynamic fluid structure, there are stable separate domains in which specific interactions can occur. Specific interactions of some ligands with phospholipid acyl chains may also occur (Bäuerle and Seelig 1991; Jørgensen et al. ...
6. Kelly CP. A 76-year-old man with recurrent
... His clinical experience includes 16 years of ICU and ER experience and over 20 years of as a ...
... His clinical experience includes 16 years of ICU and ER experience and over 20 years of as a ...
An Update on Artemisinin- A Multifaceted Drug
... (five-carbon) molecules. The molecule contains an endoperoxide bridge (1,2,4-trioxane structure). This peroxide bridge is believed to be responsible for the drug's mechanism of action. Very few natural compounds are known with such a peroxide bridge.6 ...
... (five-carbon) molecules. The molecule contains an endoperoxide bridge (1,2,4-trioxane structure). This peroxide bridge is believed to be responsible for the drug's mechanism of action. Very few natural compounds are known with such a peroxide bridge.6 ...
Pharmacokinetic interactions related to the chemical structures of
... Derivative no. 11, on the other hand, exhibited steric hindrance between its essential skeleton quinolone ring and its piperazine substituent, which resulted in a lack of planar conformation (Figure 3) (Mizuki et al., 1996). Miyamoto et al. (1990) reported X-ray crystallographic data on sparfloxacin ...
... Derivative no. 11, on the other hand, exhibited steric hindrance between its essential skeleton quinolone ring and its piperazine substituent, which resulted in a lack of planar conformation (Figure 3) (Mizuki et al., 1996). Miyamoto et al. (1990) reported X-ray crystallographic data on sparfloxacin ...
... 1-1- Perspectives of metal ions in medicine Metals and metal complexes have played key role in the development of modern chemotherapy [1]. For example, anticancer platinum drugs appear in more chemotherapy regimens than any other class of anticancer agents and have contributed substantially to the s ...
Prodrug Strategies of Antiviral Nucleotides
... protecting groups. Once inside the cell, the protecting groups are removed by enzymatic or chemical processes. Many prodrug strategies apply biodegradable protecting groups, the removal of which is triggered by esterase enzymes. Several studies have, however, demonstrated that the removal rate of th ...
... protecting groups. Once inside the cell, the protecting groups are removed by enzymatic or chemical processes. Many prodrug strategies apply biodegradable protecting groups, the removal of which is triggered by esterase enzymes. Several studies have, however, demonstrated that the removal rate of th ...
Hospital antibiotic use in Norway PhD thesis - UiO
... seriously restricted by a lack of investments, partly due to a concern shared by most companies that resistance will render a new antibiotic – developed at a high cost – ineffective after a relatively short time. The final and maybe most easily accessible element of the resistance problem deals with ...
... seriously restricted by a lack of investments, partly due to a concern shared by most companies that resistance will render a new antibiotic – developed at a high cost – ineffective after a relatively short time. The final and maybe most easily accessible element of the resistance problem deals with ...
Effect of levetiracetam on penicillin induced epileptic activity in rats
... waves in EEG and these waves are converted to ictal discharges. As a result of GABA A receptor antagonism, low doses of penicillin selectively block inhibitory postsynaptic potentials (Wong and Prince 1979, Dingledine and Gjerstad 1980). Higher doses of penicillin may have some nonspesific effects ( ...
... waves in EEG and these waves are converted to ictal discharges. As a result of GABA A receptor antagonism, low doses of penicillin selectively block inhibitory postsynaptic potentials (Wong and Prince 1979, Dingledine and Gjerstad 1980). Higher doses of penicillin may have some nonspesific effects ( ...
Extract from the Clinical Evaluation Report for Ceftobiprole
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
Local Antibiotic Therapy in the Treatment of Bone
... 2. Criteria for the production of a local delivery system for antimicrobial agents Despite the reduction in the risk of contamination due to improved material, implant, and clean room technique as well as peri-operative antibiotic prophylaxis, infections still remain a feared complication in orthope ...
... 2. Criteria for the production of a local delivery system for antimicrobial agents Despite the reduction in the risk of contamination due to improved material, implant, and clean room technique as well as peri-operative antibiotic prophylaxis, infections still remain a feared complication in orthope ...
Doc - World Noni Research Foundation
... in the extracts of Noni fruits. Looking to all parameters that were envisaged to study the herbal plant, Morinda citrifolia (Noni), it can be concluded that both aqueous and alcoholic extracts of Noni fruit contain several phytochemicals viz., alkaloid, amino acid, reducing sugar, glycosides, tannin ...
... in the extracts of Noni fruits. Looking to all parameters that were envisaged to study the herbal plant, Morinda citrifolia (Noni), it can be concluded that both aqueous and alcoholic extracts of Noni fruit contain several phytochemicals viz., alkaloid, amino acid, reducing sugar, glycosides, tannin ...
Medical importance of Cupressus sempervirens
... tannin 0.31%, saponins 1.9% and phenols 0.067%(81-82). It appeared that the essential and volatile oils of the plant were differ according to the plant location and variety. Selim et al., isolated 20 compounds from the oil of Mediterranean cypress (Cupressus sempervirens), included: tricyclene, α-th ...
... tannin 0.31%, saponins 1.9% and phenols 0.067%(81-82). It appeared that the essential and volatile oils of the plant were differ according to the plant location and variety. Selim et al., isolated 20 compounds from the oil of Mediterranean cypress (Cupressus sempervirens), included: tricyclene, α-th ...
Full-Text PDF
... regions of the world [49–51]. In clinical practice, urine culture is usually not performed in the setting of community-acquired, uncomplicated cystitis. Antibiotic therapy is therefore mostly empiric and more or less based upon knowledge of national or international surveillance studies. The local r ...
... regions of the world [49–51]. In clinical practice, urine culture is usually not performed in the setting of community-acquired, uncomplicated cystitis. Antibiotic therapy is therefore mostly empiric and more or less based upon knowledge of national or international surveillance studies. The local r ...
Clindamycin in 0.9% Sodium Chloride Injection
... antibacterial agents, including Clindamycin in 0.9% Sodium Chloride Injection and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. Because Clindamycin in 0.9% Sodium Chloride Inj ...
... antibacterial agents, including Clindamycin in 0.9% Sodium Chloride Injection and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. Because Clindamycin in 0.9% Sodium Chloride Inj ...
Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects
... Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Policlinico Universitario, 98125 – Messina, Italy; Abstract: Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly s ...
... Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Policlinico Universitario, 98125 – Messina, Italy; Abstract: Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly s ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... preincubation period. The mean residual CYP2C9 activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 act ...
... preincubation period. The mean residual CYP2C9 activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 act ...
Promega`s P450-GloTM Luminescent Cytochrome
... A large group of enzymes known as cytochromes P450 (CYP or P450) are responsible for the oxidative metabolism of many xenobiotic, hydrophobic chemicals, which include most therapeutic drugs1. P450 metabolism can influence the clearance rate of drugs, their toxicity, and their interactions with other ...
... A large group of enzymes known as cytochromes P450 (CYP or P450) are responsible for the oxidative metabolism of many xenobiotic, hydrophobic chemicals, which include most therapeutic drugs1. P450 metabolism can influence the clearance rate of drugs, their toxicity, and their interactions with other ...
Reichenbach_final.pd
... consistent with a several hundred–fold accumulation of epothilones within cells.[47] HeLa cells, for example, accumulate 4.2 and 2.6 μM epothilone A and B, respectively, within 2 hours in the presence of 10 nM drugs in the medium; and at a higher drug exposure (above 100 nM) the epothilones reach sa ...
... consistent with a several hundred–fold accumulation of epothilones within cells.[47] HeLa cells, for example, accumulate 4.2 and 2.6 μM epothilone A and B, respectively, within 2 hours in the presence of 10 nM drugs in the medium; and at a higher drug exposure (above 100 nM) the epothilones reach sa ...
Characterization of Two Pharmacophores on the Multidrug
... Pascaud et al., 1998; Wang et al., 2000) all led to the same conclusion of several different specific sites on P-glycoprotein. However, the number of sites, their chemical selectivities, and their mutual relationships remain unclear. The molecular mechanism underlying the “multispecific” recognition ...
... Pascaud et al., 1998; Wang et al., 2000) all led to the same conclusion of several different specific sites on P-glycoprotein. However, the number of sites, their chemical selectivities, and their mutual relationships remain unclear. The molecular mechanism underlying the “multispecific” recognition ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... This potent anti- inflammatory, antioxidant, antibacterial effect and immunomodulatory effect of garlic suggest that it has a therapeutic potential in different oral diseases. Garlic produced a significant reduction in the inflammatory infiltrate and potentially inhibited innate immune response asso ...
... This potent anti- inflammatory, antioxidant, antibacterial effect and immunomodulatory effect of garlic suggest that it has a therapeutic potential in different oral diseases. Garlic produced a significant reduction in the inflammatory infiltrate and potentially inhibited innate immune response asso ...
Madhuca Indica JF Gmel. (Sapotaceae): An Overview
... indica flowers was carried out to evaluate the free radicals scavenging effect of flower extract. The Total antioxidant activity of flower extract was found to be 0.29±0.02 mM Ascorbic acid/mg extract of Mahua flowers. Extract showed the potent antioxidant activity. The Ferric reducing antioxidant p ...
... indica flowers was carried out to evaluate the free radicals scavenging effect of flower extract. The Total antioxidant activity of flower extract was found to be 0.29±0.02 mM Ascorbic acid/mg extract of Mahua flowers. Extract showed the potent antioxidant activity. The Ferric reducing antioxidant p ...
Discovery and development of cephalosporins
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g. penicillins, carbapenems and monobactams). The cephalosporins (and other β-lactams) have the ability to kill bacteria by inhibiting essential steps in the bacterial cell wall synthesis which in the end results in osmotic lysis and death of the bacterial cell. Cephalosporins are widely used antibiotics because of their clinical efficiency and desirable safety profile.The cephalosporins are diverse in their antibacterial spectrum, water solubility, acid tolerability, oral bioavailability, biological half-life and other properties. Therefore the cephalosporins can be further classified into generations depending on antibacterial activity, time of invention and structural basis.