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NHS Herefordshire Low Priority Treatment Policy
NHS Herefordshire Low Priority Treatment Policy

... clinical circumstances. These are defined as referring to a patient who has clinical circumstances which, taken as a whole, are outside the range of clinical circumstances presented by a patient within the normal population of patients with the same medical condition and at the same stage of progres ...
Micronised Purified Flavonoid Fraction
Micronised Purified Flavonoid Fraction

... of MPFF 500mg daily was cost-effective in the treatment of venous ulcers compared with the control group receiving standard venous ulcer treatment. Based on the cost per healed ulcer over 6 months, the cost-effectiveness ratio in the MPFF group was 1026 euros (EUR) compared with EUR1872 in the contr ...
AVYCAZ (ceftazidime and avibactam) for Injection, for
AVYCAZ (ceftazidime and avibactam) for Injection, for

... freundii, Proteus spp., and Pseudomonas aeruginosa in patients 18 years or older. In the treatment of cUTI, as only limited clinical safety and efficacy data for AVYCAZ are currently available, reserve AVYCAZ for use in patients with cUTI who have limited or no alternative treatment options [see Cli ...
Testing Treatments interactive
Testing Treatments interactive

... an element of uncertainty. In practice, good medicine routinely requires good guesswork. But too often in the past many medical professionals have blurred the distinction between guessing and good evidence. Sometimes they even proclaim certainty when there is really considerable doubt. They eschew r ...
K3 - Sheffield Teaching Hospital
K3 - Sheffield Teaching Hospital

... medicine may determine the route of supply (e.g. goods from a wholesaler may be obtained in a matter of hours whereas those directly from the manufacturer may take several days). The majority of dressings and appliances are ordered through supplies. Nursing staff are responsible for ordering supplie ...
ADPE02B0805 - Piracetam
ADPE02B0805 - Piracetam

... Summary: Piracetam is an effective symptomatic treatment for some types of myoclonus in adults. To survey the efficacy and safety ofpiracetam in pediatric opsoclonus– myoclonus, we conducted an open, randomized, two-period, dose-ranging, doubleblind, crossover, clinical trial of five children compar ...
RECENT NEUROAID PUBLICATIONS IN PEER REVIEW
RECENT NEUROAID PUBLICATIONS IN PEER REVIEW

... viability, which is calculated by dividing the absorbance value of MLC601/MLC901treated samples by that of the untreated controls within each group. Neuronal injury was quantitatively assessed by the measurement of LDH release from cultured neurons at Day 8, 10, 12 and 14 of cell culture and at 5, 8 ...
U.S. Food and Drug Administration Notice: Archived Document
U.S. Food and Drug Administration Notice: Archived Document

... Table 18:  Response Profiles Based on the Rate of Opioid-Free Weeks during the Last 20 Weeks of the Double-blind Period ........................................................................92  Table 19:  Days to Discontinuation during Part A (Full Analysis Set) ................................... ...
(PSD) November 2016 PBAC Meeting - (Word 618KB)
(PSD) November 2016 PBAC Meeting - (Word 618KB)

... Progressive disease is defined as at least 1 of the following: (a) at least a 25% increase and an absolute increase of at least 5 g per L in serum M protein (monoclonal protein); or (b) at least a 25% increase in 24-hour urinary light chain M protein excretion, and an absolute increase of at least 2 ...
I2326E-IF2326E- Savage NITROBID
I2326E-IF2326E- Savage NITROBID

... Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testing to assess the ...
42-Maeda_2012_NDT_on_line.
42-Maeda_2012_NDT_on_line.

... three consecutive days. Baseline blood pressure, serum creatinine, 24h proteinuria and hematuria score were calculated as the average of the three measurements. The results of dipstick urinalysis were interpreted as (), (), (1), (21) or (31). Results of () or less in dipstick urinalysis were rega ...
fulltext
fulltext

... increases (Pogue JM et al. 2014). To be able to treat a patient adequately, it is necessary to identify the causative agent (Uematsu H et al. 2014). Several different tools can be used to identify bacteria. Most important is the bacterial culture, which makes it possible to perform a susceptibility ...
EPI 1: Antiepileptic medications for management of acute convulsive
EPI 1: Antiepileptic medications for management of acute convulsive

... The following additional terms were used: (status epilepticus OR acute seizures) AND (midazolam OR diazepam OR lorazepam OR paraldehyde) and the search included studies from 2008 to October 2014. Inclusion and exclusion criteria for new systematic review A new systematic review and meta-analysis was ...
Isentress - Merck.com
Isentress - Merck.com

... studies: STARTMRK evaluated ISENTRESS 400 mg twice daily versus efavirenz, both in combination with emtricitabine (+) tenofovir disoproxil fumarate (TDF), and ONCEMRK evaluated ISENTRESS HD 1200 mg (2 x 600 mg) once daily versus ISENTRESS 400 mg twice daily, both in combination with emtricitabine (+ ...
Macrolides and associated antibiotics based on similar mechanism
Macrolides and associated antibiotics based on similar mechanism

... the delayed action of the molecule [16, 27, 28]. Only one clinical multicentre study of azithromycin for the treatment of acute uncomplicated P. falciparum malaria was conducted in India on 15 participants. In this study, patients were randomly assigned to groups treated with either azithromycin or ...
A New Spinal Cord Stimulation System Effectively Relieves Chronic
A New Spinal Cord Stimulation System Effectively Relieves Chronic

... physicians used one implant technique or another. We stratified the implanting technique by diagnosis, and found that approximately two-thirds of the subjects with FBSS and other etiologies of pain (68% and 62%, respectively) underwent internalizations of their leads after the trial period, while on ...
AusPAR Attachment 2: Extract from the Clinical Evaluation Report
AusPAR Attachment 2: Extract from the Clinical Evaluation Report

... The Therapeutic Goods Administration (TGA) is part of the Australian Government Department of Health, and is responsible for regulating medicines and medical ...
PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): Waitman
PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): Waitman

... Children’s Mercy Hospital (CMH); IA, University of Iowa Healthcare; WI, the University of Wisconsin-Madison, the Medical College of Wisconsin, and Marshfield Clinic; MN, the University of Minnesota Academic Health Center; NE, the University of Nebraska Medical Center; and TX, the University of Texas ...
- St George`s, University of London
- St George`s, University of London

... to avoid evaporation. Clinical signs- vital signs There will be instances where blood loss is difficult to assess, not documented, or not known (e.g. with patient transferred from the community to a facility). The working group agreed that these cases should fit into definition, especially when they ...
Product Monograph
Product Monograph

... lanthanum and six commonly used medications (warfarin, digoxin, furosemide, phenytoin, metoprolol and enalapril) was investigated in simulated gastric fluid. The results suggest that precipitation in the stomach of insoluble complexes of these drugs with lanthanum is unlikely. In Vivo Drug Interacti ...
fosrenol - Shire Canada
fosrenol - Shire Canada

... lanthanum and six commonly used medications (warfarin, digoxin, furosemide, phenytoin, metoprolol and enalapril) was investigated in simulated gastric fluid. The results suggest that precipitation in the stomach of insoluble complexes of these drugs with lanthanum is unlikely. In Vivo Drug Interacti ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION

... dizziness and hypersensitivity. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of one drug cannot be directly compared to rates in clinical trials of another drug and may not reflect the ra ...
Combined pharmacotherapy and psychological therapies for post
Combined pharmacotherapy and psychological therapies for post

... A number of systematic reviews have been prepared about psychological interventions for preventing and treating PTSD. Neither single session (Rose 2002) nor multiple session (Roberts 2009) interventions were recommended as interventions to prevent PTSD. Bisson 2007, in a Cochrane systematic review, ...
Chorioamnionitis: from pathogenesis to treatment
Chorioamnionitis: from pathogenesis to treatment

... placenta. These have been correlated with stages of histological chorioamnionitis, grades of choriodeciduitis and amnionitis [44]. Furthermore, they have been associated with an increased risk of neonatal sepsis [45]. Currently, proteomics is a research technique, and is not used in clinical practic ...
ramelteon
ramelteon

... and safety of the product, the occurrence of impaired consciousness (memory impairment during interim periods of wakefulness, etc.), the occurrence of withdrawal symptoms, rebound insomnia, abuse and dependence, and muscle relaxation such as staggering, which are problematic events associated with c ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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